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公开(公告)号：US20080227823A1
公开(公告)日：2008-09-18
申请号：US12042277
申请日：2008-03-04
IPC分类号： A61K31/4439 , C07D401/12 , C07D209/04 , A61K31/404 , C07D211/06 , A61K31/4468
CPC分类号： A61K31/4045 , A61K31/4468 , A61K31/454 , C07C233/51 , C07C237/24 , C07C2601/14 , C07D209/14 , C07D211/66 , C07D213/56 , C07D401/04 , C07D401/12 , C07D405/14
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both a diamide and aromatic functionality are disclosed of the general formula (1) where X1 and X2 are linkers.
摘要翻译： 公开了有效改善特征在于不希望的钙通道活性，特别是不希望的T型钙通道活性的病症的方法和化合物。 具体地，公开了一系列含有二酰胺和芳族官能团的化合物，通式（1）其中X 1和X 2 2是连接体。
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公开(公告)号：US08377968B2
公开(公告)日：2013-02-19
申请号：US12420793
申请日：2009-04-08
申请人： Hassan Pajouhesh , Ramesh Kaul , Yanbing Ding , Yongbao Zhu , Lingyun Zhang , Nagasree Chakka , Mike Grimwood , Jason Tan , Yuanxi Zhou
发明人： Hassan Pajouhesh , Ramesh Kaul , Yanbing Ding , Yongbao Zhu , Lingyun Zhang , Nagasree Chakka , Mike Grimwood , Jason Tan , Yuanxi Zhou
IPC分类号： A61K31/454 , A61K31/445 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/30 , A61P25/00 , A61P3/10 , A61P29/00 , A61P35/00 , A61P13/10 , A61P13/12 , A61P15/16
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , C07D211/26 , C07D211/28 , C07D211/38 , C07D211/46 , C07D211/62 , C07D211/66 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).
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公开(公告)号：US20140011996A1
公开(公告)日：2014-01-09
申请号：US14013934
申请日：2013-08-29
申请人： Hassan Pajouhesh , Ramesh Kaul , Yanbing Ding , Yongbao Zhu , Lingyun Zhang , Nagasree Chakka , MIchael Edward Grimwood , Jason Tan , Yuanxi Zhou
发明人： Hassan Pajouhesh , Ramesh Kaul , Yanbing Ding , Yongbao Zhu , Lingyun Zhang , Nagasree Chakka , MIchael Edward Grimwood , Jason Tan , Yuanxi Zhou
IPC分类号： C07D211/28 , C07D401/06 , C07D211/62 , C07D409/12 , C07D405/06 , C07D413/12 , C07D211/26 , C07D401/12 , C07D211/66 , C07D405/14 , C07D211/46 , C07D211/38 , C07D405/12 , C07D417/12
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , C07D211/26 , C07D211/28 , C07D211/38 , C07D211/46 , C07D211/62 , C07D211/66 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).
摘要翻译： 公开了有助于改善由不希望的钙通道活性，特别是不希望的T型钙通道活性表征的病症的方法和化合物。 具体而言，是一系列含有式（1）所示的N-哌啶基乙酰胺衍生物的化合物。
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公开(公告)号：US08569344B2
公开(公告)日：2013-10-29
申请号：US13601357
申请日：2012-08-31
申请人： Hassan Pajouhesh , Ramesh Kaul , Yanbing Ding , Yongbao Zhu , Lingyun Zhang , Nagasree Chakka , Mike Grimwood , Jason Tan , Yuanxi Zhou
发明人： Hassan Pajouhesh , Ramesh Kaul , Yanbing Ding , Yongbao Zhu , Lingyun Zhang , Nagasree Chakka , Mike Grimwood , Jason Tan , Yuanxi Zhou
IPC分类号： A61K31/445 , A61P29/00
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , C07D211/26 , C07D211/28 , C07D211/38 , C07D211/46 , C07D211/62 , C07D211/66 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).
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公开(公告)号：US20120220564A1
公开(公告)日：2012-08-30
申请号：US13496648
申请日：2010-09-17
IPC分类号： A61K31/4523 , A61K31/4545 , C07D211/34 , A61K31/445 , C07D413/06 , A61K31/5377 , C07D401/12 , C07D413/12 , A61K31/454 , C07D207/09 , A61K31/40 , C07D205/04 , A61K31/397 , C07D211/48 , A61P29/00 , A61P25/16 , A61P25/24 , A61P25/18 , A61P27/16 , A61P25/06 , C07D401/06
CPC分类号： C07D401/12 , C07D205/04 , C07D207/08 , C07D207/09 , C07D211/22 , C07D211/34 , C07D211/48 , C07D211/58 , C07D401/06 , C07D413/06
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed using a series of compounds containing N-acylated cyclic amines linked to an aπl ring as shown in formula (I).
摘要翻译： 公开了使用一系列含有与式（I）所示的连接在环上的N-酰化的环胺的化合物有效改善特征在于不希望的钙通道活性，特别是不希望的T型钙通道活性的条件的方法和化合物。
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6.发明申请4-(AMINOMETHYL)CYCLOHEXANAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS 审中-公开4-（氨基甲基）环己烷胺衍生物作为钙通道阻断剂公开(公告)号：US20090298834A1
公开(公告)日：2009-12-03
申请号：US12420785
申请日：2009-04-08
申请人： Hassan PAJOUHESH , Ramesh Kaul , Mike Grimwood , Jason Tan , Yuanxi Zhou
发明人： Hassan PAJOUHESH , Ramesh Kaul , Mike Grimwood , Jason Tan , Yuanxi Zhou
IPC分类号： A61K31/5375 , C07C233/74 , A61K31/166 , A61K31/27 , C07C271/24 , C07D295/108
CPC分类号： A61K31/27 , A61K31/166 , A61K31/5375 , C07C233/78 , C07C235/50 , C07C237/10 , C07C271/20 , C07C271/24 , C07D207/16 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D213/61 , C07D213/65 , C07D213/75 , C07D261/08 , C07D263/20 , C07D271/06 , C07D271/08 , C07D277/28 , C07D277/42 , C07D277/46 , C07D295/185 , C07D295/32 , C07D309/14 , C07D417/12
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing 4-(aminomethyl)cyclohexanamine derivatives as shown in formula (1).
摘要翻译： 公开了有助于改善由不希望的钙通道活性，特别是不希望的T型钙通道活性表征的病症的方法和化合物。 具体而言，是一系列含有式（1）所示的4-（氨基甲基）环己胺衍生物的化合物。
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公开(公告)号：US09718854B2
公开(公告)日：2017-08-01
申请号：US14008388
申请日：2012-03-20
申请人： Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
发明人： Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
IPC分类号： C07H19/24 , C07D513/04 , A61K31/429 , C12N9/99 , C12Q1/34 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , A61K31/7056
CPC分类号： C07H19/24 , A61K31/7056 , C07D513/04 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , C12N9/99 , C12Q1/34 , C12Y302/01169
摘要： The invention provides compounds of formula (I) with substituents as specified in claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.
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公开(公告)号：US20140296205A1
公开(公告)日：2014-10-02
申请号：US14129177
申请日：2012-06-27
申请人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
发明人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
IPC分类号： C07D513/04 , G01N33/50 , C12Q1/34
CPC分类号： C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N33/5038 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号：US07790747B2
公开(公告)日：2010-09-07
申请号：US11453221
申请日：2006-06-14
申请人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号： A61K31/4545 , C07D409/14
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及趋化因子受体结合化合物，药物组合物及其用途。 更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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公开(公告)号：US07498346B2
公开(公告)日：2009-03-03
申请号：US11152589
申请日：2005-06-14
申请人： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号： A61K31/4453 , C07D211/58
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及趋化因子受体结合化合物，药物组合物及其用途。 更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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