公开(公告)号：US5603871A

公开(公告)日：1997-02-18

申请号：US533714

申请日：1995-09-26

申请人： Hisaaki Koseko ,  Wataru Ohtani ,  Hidenori Ito ,  Toshihiro Kanematsu ,  Akio Hirano ,  Shinya Senoo ,  Jun Watanabe ,  Kiyotaka Sawada

发明人： Hisaaki Koseko ,  Wataru Ohtani ,  Hidenori Ito ,  Toshihiro Kanematsu ,  Akio Hirano ,  Shinya Senoo ,  Jun Watanabe ,  Kiyotaka Sawada

IPC分类号： B29C33/04 ,  B29C33/42 ,  B29C43/18 ,  B29C43/36 ,  B29C65/00 ,  B29C71/02 ,  B29D11/00 ,  F28D15/02

CPC分类号： F28D15/02 ,  B29C33/04 ,  B29C43/183 ,  B29C43/36 ,  B29C45/7331 ,  B29C65/02 ,  B29C65/18 ,  B29C65/26 ,  B29C65/4815 ,  B29C66/71 ,  B29C66/712 ,  B29C66/73115 ,  B29C66/73116 ,  B29C66/91212 ,  B29C66/91231 ,  B29C66/91411 ,  B29C66/91421 ,  B29C66/91431 ,  B29C66/91443 ,  B29C66/91641 ,  B29C66/961 ,  B29C71/02 ,  B29D11/00596 ,  B29C2791/001 ,  B29C33/046 ,  B29C33/42 ,  B29C65/4835 ,  B29C66/962 ,  B29K2033/12 ,  B29K2069/00 ,  Y10S425/808

摘要： In an aging device used to manufacture a plastic molded product, injecting and aging processes are separated from each other. Namely, a plastic base material is approximately processed in advance in a final shape by injection molding. Thereafter, the plastic base material is inserted into an aging die having plural cavities and attached to a press machine such that the aging die is clamped and opened. Next, the plastic base material is heated and melted until a temperature equal to or higher than a glass transition point so as to generate an internal resin pressure. Next, the plastic base material is gradually cooled to transfer a mirror face thereto. The aging device has a die cooling device having plural heat pipes for cooling the die and has a die heating device having plural heaters for heating the die. The heat pipes and the heaters are arranged in a die plate of the press machine. In this aging device, the aging die can be uniformly and rapidly heated and cooled and a cooling speed of the aging die can be easily controlled.

摘要翻译： 在用于制造塑料模制产品的老化装置中，注射和老化过程彼此分离。 即，塑料基材通过注塑成型预先大致加工成最终形状。 此后，将塑料基材插入具有多个空腔的老化模具中，并附着在冲压机上，使得老化模被夹紧和打开。 接着，将塑料基材加热熔融直至玻璃化转变点以上，以产生内部树脂压力。 接下来，将塑料基材逐渐冷却以将镜面转印到其上。 老化装置具有模具冷却装置，该模具冷却装置具有用于冷却模具的多个热管，并且具有具有多个用于加热模具的加热器的模具加热装置。 热管和加热器布置在压机的模板中。 在这种老化装置中，老化的模具可以被均匀和快速地加热和冷却，并且可以容易地控制老化模具的冷却速度。

公开(公告)号：US5440018A

公开(公告)日：1995-08-08

申请号：US36387

申请日：1993-03-24

申请人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Fuluhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama

发明人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Fuluhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama

IPC分类号： A61K38/00 ,  C07K1/14 ,  C07K14/765 ,  C12N15/14 ,  A61K38/38 ,  C07K1/16 ,  C07K1/36

CPC分类号： C07K14/765 ,  A61K38/00

摘要： Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.

摘要翻译： 通过基因操作技术获得的人血清白蛋白可以通过特定步骤的组合来纯化，其中将得自人血清白蛋白的宿主的培养上清液进行超滤，热处理，酸处理和另一次超滤，然后用 阳离子交换剂，疏水性色谱载体和阴离子交换剂，并通过盐析，从而获得纯的形式的人血清白蛋白，其基本上不含有配制成药物制剂的蛋白质和多糖污染物。 该方法使得可以有效地纯化重组人血清白蛋白并提供基本上纯的人血清白蛋白，其不含生产者宿主相关物质和其它污染物，并且没有着色。

公开(公告)号：US5710253A

公开(公告)日：1998-01-20

申请号：US358302

申请日：1994-12-19

申请人： Wataru Ohtani ,  Naoto Furuhata ,  Akinori Sumi ,  Munehiro Noda ,  Takao Ohmura

发明人： Wataru Ohtani ,  Naoto Furuhata ,  Akinori Sumi ,  Munehiro Noda ,  Takao Ohmura

IPC分类号： C12P21/00 ,  A61K38/16 ,  A61P7/00 ,  C07K1/14 ,  C07K1/20 ,  C07K14/76 ,  C07K14/765 ,  C12N15/00 ,  C12R1/84 ,  C07K1/36 ,  A61K38/38 ,  C07K1/16

CPC分类号： C07K14/765

摘要： A method for decoloring a recombinant human serum albumin by treating the albumin with a reducing agent is disclosed. Also, a method for decoloring a recombinant human serum albumin by treating the albumin with a method removing free polysaccharides with a cation exchanger followed by heat treatment is disclosed. The present invention provides a recombinant human serum albumin, coloring of which is fully suppressed by preventing binding of certain coloring components, which are contained in the raw materials or contaminants secreted by a microorganism, to human serum albumin so as not to cause coloring of the human serum albumin.

摘要翻译： 公开了通过用还原剂处理白蛋白来使重组人血清白蛋白脱色的方法。 另外，公开了一种通过用阳离子交换剂随后热处理除去游离多糖的方法处理白蛋白来对重组人血清白蛋白进行脱色的方法。 本发明提供一种重组人血清白蛋白，通过防止原料中含有的某些着色成分或微生物分泌的污染物与人血清白蛋白结合，使其着色得到完全抑制，从而不引起 人血清白蛋白。

公开(公告)号：US4694074A

公开(公告)日：1987-09-15

申请号：US792081

申请日：1985-10-28

申请人： Yahiro Uemura ,  Takao Ohmura ,  Akimasa Ohmizu ,  Akinori Sumi ,  Wataru Ohtani ,  Yoshitaka Sakanishi ,  Hiroshi Morise ,  Hirofumi Arimura ,  Tadakazu Suyama

发明人： Yahiro Uemura ,  Takao Ohmura ,  Akimasa Ohmizu ,  Akinori Sumi ,  Wataru Ohtani ,  Yoshitaka Sakanishi ,  Hiroshi Morise ,  Hirofumi Arimura ,  Tadakazu Suyama

IPC分类号： C12N15/09 ,  A61K39/29 ,  A61P1/16 ,  C07K1/16 ,  C07K1/22 ,  C07K14/005 ,  C07K14/02 ,  C07K14/195 ,  C07K14/435 ,  C12N5/00 ,  C12N15/00 ,  C12P21/00 ,  C12P21/08 ,  C07K3/18 ,  C07K3/28

CPC分类号： C07K14/005 ,  C12N2730/10122 ,  Y10S530/806 ,  Y10S530/808

摘要： A process for the purification of HBsAg is disclosed, which comprises adsorbing specifically on a carrier, in the presence of an inorganic salt in an amount of 5 to 25 W/V %, an HBsAg obtained by gene engineering.

摘要翻译： 公开了一种用于纯化HBsAg的方法，其包括在载体上以5至25W / V％的无机盐存在下特异性吸附通过基因工程获得的HBsAg。

公开(公告)号：US07273534B2

公开(公告)日：2007-09-25

申请号：US10896046

申请日：2004-07-22

申请人： Kazunori Ito ,  Katsunari Hanaoka ,  Hiroshi Deguchi ,  Nobuaki Onagi ,  Hiroko Tashiro ,  Kiyoto Shibata ,  Yasutomo Aman ,  Hiroshi Miura ,  Wataru Ohtani ,  Hajime Yuzurihara ,  Masaru Shinkai

发明人： Kazunori Ito ,  Katsunari Hanaoka ,  Hiroshi Deguchi ,  Nobuaki Onagi ,  Hiroko Tashiro ,  Kiyoto Shibata ,  Yasutomo Aman ,  Hiroshi Miura ,  Wataru Ohtani ,  Hajime Yuzurihara ,  Masaru Shinkai

IPC分类号： C23C14/34 ,  C23C16/00

CPC分类号： C23C14/50 ,  B25B11/005 ,  C23C14/568 ,  G11B7/252 ,  G11B7/258 ,  G11B7/265 ,  G11B2007/24308 ,  G11B2007/2431 ,  G11B2007/24312 ,  G11B2007/24314 ,  G11B2007/24316 ,  Y02T50/67

摘要： In an optical disk substrate film-formation apparatus which prepared an optical disk by forming a thin film on a substrate, the optical disk substrate is held by a holder section. A contact support surface is provided to the holder section which closely contacts at least a portion of the surface of the optical disk substrate rear to the surface where the think film is formed.

摘要翻译： 在通过在基板上形成薄膜来制备光盘的光盘基片成膜装置中，光盘基片被保持部保持。 将接触支撑面设置在保持部上，该保持部与形成思维膜的表面的后方紧贴至光盘基板的表面的至少一部分。

公开(公告)号：US6097914A

公开(公告)日：2000-08-01

申请号：US9331

申请日：1998-01-20

申请人： Masaru Tanaka ,  Takeo Suda ,  Sadao Takahashi ,  Takerou Kurenuma ,  Wataru Ohtani ,  Itaru Ohtsuka

发明人： Masaru Tanaka ,  Takeo Suda ,  Sadao Takahashi ,  Takerou Kurenuma ,  Wataru Ohtani ,  Itaru Ohtsuka

IPC分类号： G03G5/10 ,  G03G15/00

CPC分类号： G03G15/751 ,  G03G5/10

摘要： An image bearing member utilized in an image forming apparatus includes a cylindrical member on which an image is formed on a peripheral surface thereof. An image bearing member further includes a filling-up member which suppresses vibration of the cylindrical member by being inserted into an inner part of the cylindrical member, and an anaerobic adhesive which adheres and fixes an outer peripheral surface of the filling-up member to an inner peripheral surface of the cylindrical member by osmosing into a clearance formed between the inner peripheral surface of the cylindrical member and the outer peripheral surface of the filling-up member. The anaerobic adhesive is placed inside of an end face of at least one side of the outer peripheral surface of the filling-up member, and an adhesion width is formed wherein the anaerobic adhesive is spread around an entire periphery of the outer peripheral surface of the filling-up member from an end face of the filling-up member. The adhesive can be hardened by use of ultraviolet rays or a lid. Furthermore, gas can be sealed in the inner part of the cylindrical member. A method for manufacturing an image bearing member for an image forming apparatus includes vertically positioning a filling-up member inside a cylindrical member, injecting an anaerobic adhesive between the filling-up member and the cylindrical member, and hardening the anaerobic adhesive after the anaerobic adhesive has osmosed into the clearance between the cylindrical member and the filling-up member.

摘要翻译： 在图像形成装置中使用的图像承载部件包括在其圆周表面上形成有图像的圆柱形部件。 图像承载部件还包括填充部件，其通过插入到筒状部件的内部而抑制圆筒部件的振动，以及厌氧粘合剂，其将填充部件的外周面粘附并固定到 通过渗透到形成在圆筒形构件的内周表面和填充构件的外周表面之间的间隙中的圆筒构件的内周面。 厌氧粘合剂被放置在填充部件的外周面的至少一侧的端面的内侧，并且形成粘合宽度，其中厌氧粘合剂围绕着填充部件的外周面的整个周边扩散 填充部件的填充部件。 粘合剂可以通过使用紫外线或盖子来硬化。 此外，气体可以密封在圆柱形构件的内部。 一种用于制造图像形成装置的图像承载部件的方法包括：将填充部件垂直定位在圆柱形部件内部，在填充部件和圆柱形部件之间注入厌氧粘合剂，并在厌氧粘合剂之后硬化厌氧粘合剂 已经渗透到圆柱形构件和填充构件之间的间隙中。

公开(公告)号：US5369020A

公开(公告)日：1994-11-29

申请号：US031823

申请日：1993-03-16

申请人： Akinori Sumi ,  Wataru Ohtani ,  Naoto Furuhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Takao Ohmura ,  Kazumasa Yokoyama

发明人： Akinori Sumi ,  Wataru Ohtani ,  Naoto Furuhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Takao Ohmura ,  Kazumasa Yokoyama

IPC分类号： A61K38/16 ,  A61P7/00 ,  B01D15/00 ,  C07K14/765 ,  C12N1/15 ,  C12N1/19 ,  C12N15/09 ,  C12N15/14 ,  C12P21/00 ,  C12P21/02 ,  C12R1/84 ,  C12R1/865 ,  C12P1/02

CPC分类号： C12P21/02 ,  C07K14/765

摘要： A method for suppressing coloring of human serum albumin expressed by genetic engineering, which comprises culture and/or purification in the presence of an amine compound selected from the group consisting of alkylamines, diamines, guanidines, benzamidines, basic amino acids, and aminophenylacetic acids. According to the present invention, coloring of HSA expressed by genetic engineering can be suppressed to from one-half to one-tenth of that without treatment for coloring suppression. In addition, HSA can be recovered in high yields, and the treatment of the invention does not affect the inherent properties of HSA.

摘要翻译： 一种用于抑制由遗传工程表达的人血清白蛋白着色的方法，其包括在选自烷基胺，二胺，胍胺，苯甲脒，碱性氨基酸和氨基苯基乙酸的胺化合物存在下培养和/或纯化。 根据本发明，通过遗传工程表达的HSA的着色可以抑制在不进行着色抑制处理的情况下的一半到十分之一。 另外，HSA可以以高收率回收，本发明的处理不影响HSA的固有特性。

公开(公告)号：US5739602A

公开(公告)日：1998-04-14

申请号：US624025

申请日：1996-03-27

申请人： Mitsuo Suzuki ,  Yukio Itami ,  Wataru Ohtani ,  Wataru Kashima ,  Yoshihiro Takahashi ,  Noriyuki Kadowaki

发明人： Mitsuo Suzuki ,  Yukio Itami ,  Wataru Ohtani ,  Wataru Kashima ,  Yoshihiro Takahashi ,  Noriyuki Kadowaki

IPC分类号： G02B26/12 ,  H02K1/27 ,  H02K1/28 ,  H02K7/04 ,  H02K29/00 ,  H02K7/00 ,  G02B26/08 ,  H02K1/22

CPC分类号： H02K7/04 ,  G02B26/121 ,  H02K1/2793 ,  H02K1/28

摘要： The current invention is directed to a high-speed optical deflector which includes a brushless motor operating in a high-temperature environment. The brushless motor components include rotatable parts made of various materials whose thermal expansion coefficients significantly vary. These rotational components include a steel rotor flange, a magnet rotor, and an aluminum shaft. To substantially eliminate rotational imbalance or vibration caused by the thermal expansion, the above described components are fixed with a certain adhesive which prevents these components from causing the rotational imbalance. A certain heat-resistant adhesive provides a sufficient structural strength to substantially minimize a rotational imbalance caused by the thermally expanding components in an operating temperature range.

摘要翻译： 本发明涉及一种包括在高温环境中工作的无刷电机的高速光偏转器。 无刷电动机部件包括由热膨胀系数显着变化的各种材料制成的可旋转部件。 这些旋转部件包括钢转子凸缘，磁体转子和铝轴。 为了基本上消除由热膨胀引起的旋转不平衡或振动，上述部件用某种粘合剂固定，防止这些部件引起旋转不平衡。 一定的耐热粘合剂提供足够的结构强度，以在工作温度范围内基本上最小化由热膨胀部件引起的旋转失衡。

公开(公告)号：US5521287A

公开(公告)日：1996-05-28

申请号：US202130

申请日：1994-02-25

申请人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Furuhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama ,  Nagatoshi Fujiwara

发明人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Furuhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama ,  Nagatoshi Fujiwara

IPC分类号： A61K38/00 ,  C07K14/765 ,  A61K38/38 ,  C07K1/16 ,  C07K1/36

CPC分类号： C07K14/765 ,  A61K2039/545 ,  A61K38/00

摘要： Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. The thus obtained human serum albumin can further be purified by treating recombinant human serum albumin with a hydrophobic chromatography carrier at pH of 2 to 5 and a salt concentration of 0.4 to 1 and exposing the carrier to a pH of 6 to 8 and a salt concentration of 0.01 to 0.3 M, or treating the culture supernatant with boric acid or a salt thereof at pH 8 to 11 for 1 to 10 hours and recovering the supernatant. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.

公开(公告)号：US5294699A

公开(公告)日：1994-03-15

申请号：US719443

申请日：1991-06-24

申请人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Fuluhata ,  Kaoru Kobayashi ,  Shinobu Kuwae ,  Hirotoshi Fukutsuka ,  Tomoshi Ohya ,  Hiroshi Morise

发明人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Fuluhata ,  Kaoru Kobayashi ,  Shinobu Kuwae ,  Hirotoshi Fukutsuka ,  Tomoshi Ohya ,  Hiroshi Morise

IPC分类号： A61K38/16 ,  A61K38/00 ,  B01D15/00 ,  B01D15/04 ,  C07K1/14 ,  C07K1/20 ,  C07K14/435 ,  C07K14/76 ,  C07K14/765 ,  C12N15/09 ,  C12N15/14 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  C07K3/28 ,  A61K45/02

CPC分类号： C07K14/765 ,  C12N15/81 ,  A61K38/00 ,  C07K2319/02

摘要： A method of inhibiting the coloration of human serum albumin expressed by using the gene manipulation technology which method comprises separating coloring contaminants from said human serum albumin before said coloring contaminants bind to the human serum albumin.

摘要翻译： 通过使用基因操作技术抑制人血清白蛋白的着色的方法，该方法包括在所述着色污染物与人血清白蛋白结合之前从所述人血清白蛋白中分离着色污染物。