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公开(公告)号：US11260129B2
公开(公告)日：2022-03-01
申请号：US16074707
申请日：2017-02-02
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Harold Walder , Frederic A. Bourke, Jr. , Zakaryae Fathi , Wayne Beyer , Mark Oldham , Justus Adamson , Michael Nolan
摘要： A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+ and (3Ca3 (PO4)2Ca(F, Cl)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.
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公开(公告)号：US10232190B2
公开(公告)日：2019-03-19
申请号：US15649917
申请日：2017-07-14
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.
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公开(公告)号：US09649832B2
公开(公告)日：2017-05-16
申请号：US14593049
申请日：2015-01-09
申请人： Immunolight, LLC , Duke University
发明人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, Jr. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
IPC分类号： B32B38/00 , C09J4/00 , C09J133/08 , B41J2/175 , C08K3/00 , A61B17/00 , A61L24/06 , B32B37/12 , B32B37/18
CPC分类号： H01L24/83 , A61B17/0057 , A61L24/06 , B32B3/266 , B32B7/14 , B32B9/04 , B32B37/1284 , B32B37/18 , B32B38/0008 , B32B2037/1253 , B32B2457/00 , B32B2457/08 , B32B2457/14 , B41J2/17559 , C08K3/00 , C09J4/00 , C09J9/02 , C09J11/04 , C09J11/06 , C09J133/08 , C09K11/02 , C09K11/7769 , C09K11/777 , H01L23/5226 , H01L24/32 , H01L25/0657 , H01L25/50 , H01L2224/16225 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73204 , H01L2224/73253 , H01L2224/73265 , H01L2224/83192 , H01L2224/83855 , H01L2224/92125 , H01L2225/06524 , H01L2225/06589 , H01L2924/07811 , H01L2924/1461 , H01L2924/15311 , Y10T428/2852 , H01L2924/00014 , H01L2924/00
摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
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公开(公告)号：US20180317307A1
公开(公告)日：2018-11-01
申请号：US16012901
申请日：2018-06-20
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Frederic A. BOURKE, JR. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo Maccarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt
CPC分类号： H05B41/2806 , A61L2/10 , A61N1/40 , A61N1/44 , A61N2/00 , A61N5/10 , C02F1/32 , H01J65/042 , Y02B20/22 , Y02W10/37
摘要： Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength λ1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.
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公开(公告)号：US20170319868A1
公开(公告)日：2017-11-09
申请号：US15649917
申请日：2017-07-14
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Frederic A. Bourke, JR. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
CPC分类号： A61N5/062 , A61K41/0085 , A61N5/0622 , A61N5/1077 , A61N2005/0661 , A61N2005/1091 , A61N2005/1098
摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.
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公开(公告)号：US11992697B2
公开(公告)日：2024-05-28
申请号：US17655683
申请日：2022-03-21
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Mark Oldham , Zakaryae Fathi , Wayne F. Beyer , Frederic A. Bourke, Jr. , Harold Walder , Mark Dewhirst , Neil L. Spector , Paul Yoon , Justus Adamson , David Alcorta , Kim Lyerly , Leihua Liu , Takuya Osada
IPC分类号： A61N5/06 , A61K31/352 , A61K41/00 , A61N5/10
CPC分类号： A61N5/062 , A61K31/352 , A61K41/0066 , A61N2005/0661 , A61N2005/0662 , A61N5/10 , A61N2005/1089 , A61N2005/1098
摘要： A method for treating a diseased site in a human or animal body is provided which includes injecting in a diseased site one or more phosphors which are capable of emitting ultraviolet or visible light into the body;
infusing the diseased site with a photoactivatable drug;
applying an initiation energy from an initiation energy source comprising an x-ray, gamma ray, or electron source to thereby initiate emission of ultraviolet or visible light into the body; and
controlling a dose of the initiation energy with a processor to produce (i) a cytotoxicity inside the diseased site of greater than 20% or (ii) a day-25 stable tumor volume,
wherein the processor is programmed to apply the initiation energy in a pulsed manner, wherein the initiation energy is delivered in either (i) a radiograph mode, or (ii) a pulsed fluoroscopy mode.-
公开(公告)号：US11786595B2
公开(公告)日：2023-10-17
申请号：US17227753
申请日：2021-04-12
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Mark Oldham , Justus Adamson , Mark W. Dewhirst , Paul Yoon , Harold Walder , Frederic A. Bourke, Jr. , Zakaryae Fathi , Wayne F. Beyer, Jr.
IPC分类号： A61K41/00 , A61N5/06 , A61K31/655 , A61K33/02 , A61K31/409 , A61K31/525 , A61K31/352 , A61K31/403 , A61K33/242 , A61K33/244 , A61K33/24 , A61N5/10 , A61K31/426 , A61K31/47 , B82Y5/00
CPC分类号： A61K41/0066 , A61K31/352 , A61K31/403 , A61K31/409 , A61K31/525 , A61K31/655 , A61K33/02 , A61K33/24 , A61K33/242 , A61K33/244 , A61N5/062 , A61N5/0624 , A61N5/10 , A61K31/426 , A61K31/47 , A61K2300/00 , A61N2005/065 , A61N2005/1095 , A61N2005/1098 , B82Y5/00 , Y02A50/30
摘要： A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.
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公开(公告)号：US11589432B2
公开(公告)日：2023-02-21
申请号：US16012901
申请日：2018-06-20
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Frederic A. Bourke, Jr. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo Maccarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt
摘要： Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength λ1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.
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公开(公告)号：US10940329B2
公开(公告)日：2021-03-09
申请号：US15819130
申请日：2017-11-21
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Mark Oldham , Justus Adamson , Paul Yoon , Harold Walder , Frederic A. Bourke, Jr. , Zakaryae Fathi , Wayne F. Beyer
IPC分类号： A61K49/00 , A61N5/10 , C09K11/59 , C09K11/73 , C09K11/02 , A61K31/37 , A61P35/00 , A61K41/00 , A61K49/04
摘要： A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug.
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公开(公告)号：US20200222711A1
公开(公告)日：2020-07-16
申请号：US16728803
申请日：2019-12-27
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Harold WALDER , Frederic A. Bourke, JR. , Zakaryae Fathi , Wayne F. Beyer, JR. , Mark Dewhirst , Mark Oldham , Justus Adamson , Michael Nolan
摘要： A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.
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