公开(公告)号：US09848821B2

公开(公告)日：2017-12-26

申请号：US13162315

申请日：2011-06-16

Applicant: Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/00 ,  B65D33/00 ,  B65D81/00 ,  A61D5/00 ,  A61M1/00 ,  A61M27/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/153 ,  A61B5/157 ,  A61M5/14 ,  A61M5/172 ,  A61M5/145 ,  A61M5/142

CPC classification number: A61B5/4839 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/157 ,  A61B5/6866 ,  A61M5/1415 ,  A61M5/1452 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/201

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.

公开(公告)号：US09414782B2

公开(公告)日：2016-08-16

申请号：US13619825

申请日：2012-09-14

Applicant: James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

Inventor： James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

IPC: A61M5/172 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G06F19/00 ,  A61M5/168 ,  A61M5/14 ,  A61M5/142

CPC classification number: A61B5/4839 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/7475 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/3303 ,  A61M2209/084 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

公开(公告)号：US20100249547A1

公开(公告)日：2010-09-30

申请号：US12815372

申请日：2010-06-14

Applicant: James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: A61B5/15

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US07785258B2

公开(公告)日：2010-08-31

申请号：US11316523

申请日：2005-12-21

Applicant: James R. Braig ,  Peter Rule

Inventor： James R. Braig ,  Peter Rule

IPC: A61B5/00 ,  A61B5/05 ,  C12M1/34 ,  C12M3/00 ,  C12M1/36 ,  C12M1/00

CPC classification number: G06F19/3468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M2230/20 ,  G01N21/274 ,  G01N21/35 ,  G01N2201/1293 ,  G06F19/00

Abstract: In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.

Abstract translation: 在某些实施例中，维持患者健康的方法使用分析物检测系统。 分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。 该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。 该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。

公开(公告)号：US20090131861A1

公开(公告)日：2009-05-21

申请号：US12249831

申请日：2008-10-10

Applicant: James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

Inventor： James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

IPC: A61M5/172

CPC classification number: A61B5/4839 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/7475 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/3303 ,  A61M2209/084 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g. insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

Abstract translation: 公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。 本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。 治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

公开(公告)号：US20080268486A1

公开(公告)日：2008-10-30

申请号：US12171205

申请日：2008-07-10

Applicant: James R. Braig ,  Peter Rule ,  Kenneth G. Witte ,  Philip C. Hartstein ,  Bernhard B. Sterling

Inventor： James R. Braig ,  Peter Rule ,  Kenneth G. Witte ,  Philip C. Hartstein ,  Bernhard B. Sterling

IPC: C12Q1/54 ,  C12M1/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546

Abstract: An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.

Abstract translation: 分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。 第二分析物的测量可以对第一次测量的定量或定性结果进行调节。 在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。 根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

公开(公告)号：US06631282B2

公开(公告)日：2003-10-07

申请号：US09970021

申请日：2001-10-02

Applicant: Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian Cortella ,  Mark D. Agostino

Inventor： Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian Cortella ,  Mark D. Agostino

IPC: A61B500

CPC classification number: A61B5/6841 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455

Abstract: A device and method are provided for use with a non-invasive optical measurement system, such as a thermal gradient spectrometer for improved determination of analyte concentrations within living tissue. In a preferred embodiment, a site selector is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.

Abstract translation: 提供了一种用于非侵入式光学测量系统的装置和方法，所述非侵入性光学测量系统例如用于改善生物体内分析物浓度测定的热梯度光谱仪。 在优选实施例中，站点选择器被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。 当光谱仪必须临时从病人的皮肤上移除时，例如允许患者移动，将场地选择器固定在前臂上，以保持皮肤上一致的测量部位。 当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

公开(公告)号：US08140140B2

公开(公告)日：2012-03-20

申请号：US11314176

申请日：2005-12-21

Applicant: Bernhard B. Sterling ,  James R. Braig ,  Kenneth G. Witte ,  Peter Rule ,  Richard Keenan ,  W. Dale Hall

Inventor： Bernhard B. Sterling ,  James R. Braig ,  Kenneth G. Witte ,  Peter Rule ,  Richard Keenan ,  W. Dale Hall

IPC: A61B5/1455

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

Abstract: An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.

Abstract translation: 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。 在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

公开(公告)号：US20110306856A1

公开(公告)日：2011-12-15

申请号：US13156295

申请日：2011-06-08

Applicant: Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

IPC: A61B5/157 ,  A61B6/00

CPC classification number: G01N33/491 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150801 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/7275 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0437 ,  A61B2560/0443 ,  A61B2562/0238 ,  A61B2562/08 ,  G01N21/35 ,  G01N2021/3174 ,  G01N2201/1215 ,  G01N2201/1293 ,  G06F19/00

Abstract: Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.

Abstract translation: 提供了用于分析流体样品的多个组分的系统和方法。 在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。 在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。 在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。 在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分 的样品分离后。

公开(公告)号：US07999927B2

公开(公告)日：2011-08-16

申请号：US13007502

申请日：2011-01-14

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。