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公开(公告)号：US06613278B1
公开(公告)日：2003-09-02
申请号：US09390174
申请日：1999-09-07
申请人： C. Randal Mills , John F. Wironen , Sean Hanstke , Russell S. Donda , Jamie M. Grooms , John Bianchi
发明人： C. Randal Mills , John F. Wironen , Sean Hanstke , Russell S. Donda , Jamie M. Grooms , John Bianchi
IPC分类号： H61L200
CPC分类号： A61F2/28 , A61F2/08 , A61F2/0811 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
摘要翻译： 本发明包括一种用于在植入有需要的接受者之前安全，有效和有效地汇集用于治疗的组织的新方法。 在一个实施方案中，该方法包括灌注多孔植入物，其实现期望因子的有效相互渗透和植入物孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。 该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。 该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少 植入抗原性。
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公开(公告)号：US06652818B1
公开(公告)日：2003-11-25
申请号：US09378527
申请日：1999-08-20
IPC分类号： A61L200
CPC分类号： A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
摘要翻译： 本发明包括一种用于在植入有需要的接受者之前安全，有效和有效地汇集用于治疗的组织的新方法。 在一个实施方案中，该方法包括灌注多孔植入物，其实现期望因子的有效相互渗透和植入物孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。 该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。 该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少 植入抗原性。
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公开(公告)号：US06290718B1
公开(公告)日：2001-09-18
申请号：US09017472
申请日：1998-02-02
申请人： Jamie M. Grooms , Russell S. Donda
发明人： Jamie M. Grooms , Russell S. Donda
IPC分类号： A61F206
CPC分类号： A61L27/3804 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/065 , A61F2002/30059 , A61F2250/0039 , A61L27/3608 , A61L27/3683 , A61L31/005
摘要： This invention relates to implants useful as stents for opening or strengthening biological conduits, or as grafts or conduits for replacing or connecting portions of biological tissues having a lumen. Accordingly, the implants of this invention may be applied in portions of the peripheral and coronary vascular system, biliary, urinary, esophageal, digestive, ocular, tracheal, bronchial, reproductive, and neural systems. The implant comprises a segment of bone having a lumen through at least a part thereof, and wherein at least a portion of the implant is demineralized so as to be pliable.
摘要翻译： 本发明涉及可用作打开或加强生物管道的支架的植入物，或用于替换或连接具有内腔的生物组织的部分的移植物或导管。 因此，本发明的植入物可以应用于周边和冠状动脉血管系统，胆汁，尿液，食管，消化，眼，气管，支气管，生殖和神经系统的部分。 植入物包括具有通过其至少一部分的内腔的骨段，并且其中植入物的至少一部分被软化以便是柔韧的。
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公开(公告)号：US08652503B2
公开(公告)日：2014-02-18
申请号：US11152548
申请日：2005-06-14
申请人： John F. Wironen , Jamie M. Grooms
发明人： John F. Wironen , Jamie M. Grooms
CPC分类号： A61L27/3608 , A61F2/28 , A61F2/2875 , A61F2/4455 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30622 , A61F2210/0004 , A61F2310/00179 , A61F2310/00293 , A61F2310/00329 , A61F2310/00383 , A61L24/0005 , A61L24/0084 , A61L24/0094 , A61L24/043 , A61L24/104 , A61L27/222 , A61L27/227 , A61L27/26 , A61L27/36 , A61L27/3645 , A61L27/46 , A61L27/48 , A61L2430/02 , A61L27/58 , A61L27/54 , C08L89/00 , A61L24/0042 , A61L24/0015
摘要： A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-β, PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).
摘要翻译： 可用于矫形技术的骨膏，例如在修复非联合骨折，牙周脊隆起，颅面手术，植入物固定，撞击移植或认为需要新骨生成的任何其他过程中提供了骨膏 一种在明胶基质中包含基本上生物可吸收的成骨化合物的组合物。 在各种实施方案中，成骨化合物选自（i）去矿化骨基质（DBM）; （ii）生物活性玻璃陶瓷，BIOGLASS®，生物活性陶瓷，磷酸钙陶瓷，羟基磷灰石，羟基磷灰石碳酸盐，舍洛尔羟基磷灰石，煅烧骨，磷酸三钙等; （iii）天然或重组的骨形态发生蛋白，TGF-β，PDGF或其混合物; 和（iv）（i） - （iii）的混合物。
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公开(公告)号：US06652592B1
公开(公告)日：2003-11-25
申请号：US09417401
申请日：1999-10-13
IPC分类号： A61F236
CPC分类号： A61L27/3683 , A61B17/06166 , A61B17/86 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/2846 , A61F2/2875 , A61F2/30771 , A61F2/3094 , A61F2/30965 , A61F2/4241 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2002/0829 , A61F2002/087 , A61F2002/2817 , A61F2002/2839 , A61F2002/30009 , A61F2002/30016 , A61F2002/30059 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30153 , A61F2002/30156 , A61F2002/30172 , A61F2002/30179 , A61F2002/302 , A61F2002/30224 , A61F2002/30228 , A61F2002/3023 , A61F2002/30235 , A61F2002/30261 , A61F2002/30265 , A61F2002/30266 , A61F2002/30293 , A61F2002/30563 , A61F2002/30594 , A61F2002/30677 , A61F2002/30772 , A61F2002/30774 , A61F2002/30784 , A61F2002/30787 , A61F2002/3082 , A61F2002/30828 , A61F2002/30831 , A61F2002/3085 , A61F2002/30878 , A61F2002/30879 , A61F2002/30892 , A61F2002/30904 , A61F2002/30971 , A61F2002/4251 , A61F2002/4649 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0019 , A61F2230/0023 , A61F2230/0052 , A61F2230/0058 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61F2230/0091 , A61F2240/001 , A61F2250/0019 , A61F2250/0028 , A61L27/3608 , A61L27/38 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： This application provides a novel unitary bone implant having at least one rigid, mineralized bone segment, which may be machined to include threads, grooves, a driver head, perforations, a recess, or a symmetric shape, and a flexible, demineralized segment, which may also be machined to any desired shape prior to demineralization, or after demineralization. The disclosed implant has wide orthopedic applicability, including but not limited to repair or replacement of ligaments, tendons, and joints and for inducing vertebral fusions and fractured bone repair.
摘要翻译： 该应用提供了一种新颖的单一骨植入物，其具有至少一个刚性的，矿化的骨段，其可被加工成包括螺纹，凹槽，驱动头，穿孔，凹陷或对称形状，以及柔性脱矿质区段 也可以在去矿化之前或脱矿质后加工成任何所需的形状。 所公开的植入物具有广泛的矫形适用性，包括但不限于韧带，腱和关节的修复或替换以及用于诱导椎体融合和骨折骨修复。
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公开(公告)号：US6096081A
公开(公告)日：2000-08-01
申请号：US101903
申请日：1998-07-13
IPC分类号： A61B17/16 , A61B17/56 , A61B17/88 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/00
CPC分类号： A61B17/1671 , A61B17/1635 , A61F2/28 , A61F2/446 , A61F2/3094 , A61F2/442 , A61F2/4601 , A61F2/4611 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30224 , A61F2002/30225 , A61F2002/30617 , A61F2002/30622 , A61F2002/30772 , A61F2002/30774 , A61F2002/30777 , A61F2002/30797 , A61F2002/3082 , A61F2002/3085 , A61F2002/30871 , A61F2002/30879 , A61F2002/30971 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61F2250/0097 , A61F2310/00179 , A61F2310/00293 , Y10S623/901
摘要： A dowel (300) is provided by obtaining a plug from the shaft (diaphysis) of various long bones. The dowel (300) has an intra-medullary canal (30) which can be packed with any of a variety of osteogenic materials. The dowel (300) has a cortical surface (10) into which an instrument attachment hole (15) may be machined and onto which an alignment mark (16) may be inscribed for proper orientation of the intra-medullary canal (30) or a driver slot (56) which may be used to assist in further machining of the bone dowel (300). The dowel (300) ha a chamfered insertion end and has improved biomechanical and vertebral fusion induction properties as compared to standard dowels known in the art. A threaded (31) or grooved (32) dowel (300) and an apparatus (400) for efficient production thereof are also provided.
摘要翻译： PCT No.PCT / US97 / 00630 Sec。 371日期：1998年7月16日 102（e）日期1998年7月16日PCT 1997年1月16日PCT PCT。 公开号WO97 / 25945 日期1997年7月24日通过从各种长骨的轴（骨干）获得塞子来提供定位销（300）。 榫钉（300）具有可以用各种成骨材料包装的髓内管（30）。 定位销（300）具有皮质表面（10），仪器安装孔（15）可被加工到皮质表面（10）中，对准标记（16）可以被内接到其上以正确定向髓内管（30）或 驱动器槽（56），其可用于辅助进一步加工骨榫（300）。 定位销（300）具有倒角的插入端，并且与本领域已知的标准销钉相比具有改进的生物力学和椎体融合感应特性。 还提供了一种用于有效生产螺纹（31）或带槽（32）销钉（300）和装置（400）。
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公开(公告)号：US6090998A
公开(公告)日：2000-07-18
申请号：US958364
申请日：1997-10-27
IPC分类号： A61L27/00 , A61B17/06 , A61B17/86 , A61F2/00 , A61F2/08 , A61F2/28 , A61F2/30 , A61F2/42 , A61F2/44 , A61F2/46 , A61L27/36 , A61L27/38 , A61L27/54
CPC分类号： A61L27/3683 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30965 , A61F2/4241 , A61L27/3608 , A61L27/3645 , A61L27/365 , A61L27/3662 , A61L27/3834 , A61L27/3843 , A61L27/3847 , A61L27/386 , A61L27/54 , A61B17/06166 , A61B17/86 , A61F2/2846 , A61F2/2875 , A61F2/30771 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2002/0829 , A61F2002/0858 , A61F2002/087 , A61F2002/0882 , A61F2002/2817 , A61F2002/2839 , A61F2002/30009 , A61F2002/30016 , A61F2002/30059 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30153 , A61F2002/30156 , A61F2002/30172 , A61F2002/30179 , A61F2002/302 , A61F2002/30224 , A61F2002/30228 , A61F2002/3023 , A61F2002/30235 , A61F2002/30261 , A61F2002/30265 , A61F2002/30266 , A61F2002/30293 , A61F2002/30563 , A61F2002/30594 , A61F2002/30677 , A61F2002/30772 , A61F2002/30774 , A61F2002/30784 , A61F2002/30787 , A61F2002/3082 , A61F2002/30828 , A61F2002/30831 , A61F2002/3085 , A61F2002/30878 , A61F2002/30879 , A61F2002/30892 , A61F2002/30904 , A61F2002/30971 , A61F2002/4251 , A61F2002/4649 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0019 , A61F2230/0023 , A61F2230/0052 , A61F2230/0058 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61F2230/0091 , A61F2240/001 , A61F2250/0019 , A61F2250/0028 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2430/02
摘要： This invention provides a novel unitary bone implant having at least one rigid, mineralized bone segment, which may be machined to include threads, grooves, a driver head, a recess or a symmetric or asymmetric shape, and a flexible, demineralized segment, which may also be machined to any desired shape prior to demineralization, or after demineralization. The implant of this invention has wide orthopedic applicability, including for repair or replacement of ligaments, tendons and joints.
摘要翻译： 本发明提供了一种新颖的单一骨植入物，其具有至少一个刚性的，矿化的骨段，其可被加工成包括螺纹，凹槽，驱动头，凹槽或对称或不对称形状，以及柔性脱矿质段， 在去矿化之前或脱矿质后也可加工成任何所需的形状。 本发明的植入物具有广泛的矫形适用性，包括用于修复或替换韧带，腱和关节。
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公开(公告)号：US07048765B1
公开(公告)日：2006-05-23
申请号：US09722205
申请日：2000-11-25
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/3094 , A61F2/442 , A61F2/4644 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/2892 , A61F2002/30057 , A61F2002/30187 , A61F2002/30403 , A61F2002/30551 , A61F2002/30599 , A61F2002/30828 , A61F2002/30879 , A61F2002/30904 , A61F2002/30975 , A61F2002/4475 , A61F2002/448 , A61F2002/4649 , A61F2220/0025 , A61F2230/0034 , A61F2250/0063 , A61F2310/00293
摘要： An implant composed substantially of cortical bone is provided for use in cervical Smith-Robinson vertebral fusion procedures. The implant is derived from allograft or autograft cortical bone sources, is machined to form a symmetrically or asymmetrically shaped (e.g. a substantially “D”-shaped) implant having a canal running therethrough according to methods of this invention, and inserted into the space between adjacent cervical vertebrae to provide support and induce fusion of the adjacent vertebrae. Osteogenic, osteoinductive or osteoconductive materials may be packed into the canal of the implant to expedite vertebral fusion and to allow autologous bony ingrowth.
摘要翻译： 提供基本上由皮质骨构成的植入物用于宫颈Smith-Robinson椎体融合术。 植入物衍生自同种异体移植物或自体移植皮质骨源，根据本发明的方法被加工形成对称或不对称成形（例如基本上为“D”形）的植入物，其具有穿过其中的管道，并且插入到 相邻的颈椎提供支撑并诱导相邻椎骨的融合。 成骨，骨诱导或骨传导性材料可以装入植入物的管道中以加速脊椎融合并允许自体骨向内生长。
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公开(公告)号：US5918821A
公开(公告)日：1999-07-06
申请号：US683948
申请日：1996-07-19
CPC分类号： A22C17/06 , A61F2/4644 , B02C18/14 , B02C19/0056 , A61F2002/4645
摘要： The bone grinder of this invention is capable of consistently producing ground bone particles of varying particle sizes, depending on the grinder head employed. The device provides the ability to easily interchange grinder heads according to the needs of a surgeon and the novel grinder head design optimizes the use of available bone stock by cutting the bone rather than crushing the bone.
摘要翻译： 根据所使用的研磨头，本发明的骨磨机能够一贯地生产不同粒度的磨碎的骨颗粒。 该设备提供了根据外科医生的需要容易地交换研磨机头部的能力，并且新型研磨机头部设计通过切割骨骼而不是破碎骨骼来优化可用骨库存的使用。
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公开(公告)号：US08291572B2
公开(公告)日：2012-10-23
申请号：US12690072
申请日：2010-01-19
申请人： Jamie M. Grooms , Kevin C. Carter , Diane Carter, legal representative , Tom Sander , David H. Dulebohn
CPC分类号： A61F2/4644 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2002/2835 , A61F2002/2839 , A61F2002/30187 , A61F2002/30828 , A61F2002/30879 , A61F2002/4475 , A61F2002/448 , A61F2002/4649 , A61F2230/0034 , Y10T29/49947
摘要： An implant composed substantially of cortical bone is provided for use in cervical Smith-Robinson vertebral fusion procedures. The implant is derived from allograft or autograft cortical bone sources, is machined to form a symmetrically or asymmetrically shaped (e.g. a substantially “D”-shaped) implant having a canal running therethrough according to methods of this invention, and inserted into the space between adjacent cervical vertebrae to provide support and induce fusion of the adjacent vertebrae. Osteogenic, osteoinductive or osteoconductive materials may be packed into the canal of the implant to expedite vertebral fusion and to allow autologous bony ingrowth.
摘要翻译： 提供基本上由皮质骨构成的植入物用于宫颈Smith-Robinson椎体融合术。 植入物来源于同种异体移植物或自体移植皮质骨源，根据本发明的方法被加工形成对称或不对称形状（例如基本上D形）的植入物，其具有穿过其中的通道，并且插入相邻子宫颈之间的空间 椎骨提供支撑并诱导相邻椎骨的融合。 成骨，骨诱导或骨传导性材料可以装入植入物的管道中以加速脊椎融合并允许自体骨向内生长。
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