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    Sonophoretic enhanced transdermal transport
    7.
    发明授权
    Sonophoretic enhanced transdermal transport 失效
    超声波增强透皮运输

    公开(公告)号：US06190315B1

    公开(公告)日：2001-02-20

    申请号：US09227623

    申请日：1999-01-08

    申请人： Joseph Kost ,  Samir S. Mitragotri ,  Robert S. Langer

    发明人： Joseph Kost ,  Samir S. Mitragotri ,  Robert S. Langer

    IPC分类号： A61B6520

    CPC分类号： A61M37/0092 ,  A61B5/14532 ,  A61M2037/0007

    摘要： Methods for enhanced transdermal transport wherein the application of ultrasound is required only once for repeated or sustained transdermal extraction or delivery, over a period of time, rather than prior to each extraction or delivery. The method is applicable to analyte extraction, as well as for drug delivery. The method involves the initial application of an amount of low frequency ultrasound effective to permeabilize the skin or membrane followed by analyte extraction or drug delivery over a period of time. The initial application of ultrasound is effective to permeabilize the skin or membrane for at least about 30 minutes, preferably at least one to two hours, and more preferably up to four to ten hours. The ultrasound is preferably low frequency ultrasound, less than 2.5 MHz, more preferably less than 1 MHz. The transdermal transport can be enhanced by the application of a secondary driving force such as suction, osmotic pressure gradient, concentration gradient, iontophoresis, electroporation, magnetic field, additional ultrasound, or mechanical pressure.

    摘要翻译： 用于增强透皮转运的方法，其中在一段时间内而不是在每次提取或递送之前，仅需要超声应用一次以重复或持续经皮提取或递送。 该方法适用于分析物提取以及药物递送。 该方法包括初始应用一定量的低频超声，其有效地使皮肤或膜透化，随后经过一段时间的分析物提取或药物递送。 超声的初始应用有效地使皮肤或膜透化至少约30分钟，优选至少1至2小时，更优选至多4至10小时。 超声波优选为低频超声波，小于2.5MHz，更优选小于1MHz。 可以通过施加诸如吸力，渗透压梯度，浓度梯度，离子电渗疗法，电穿孔，磁场，附加超声或机械压力的次级驱动力来增强透皮转运。

    Chemical and physical enhancers and ultrasound for transdermal drug delivery
    8.
    发明授权
    Chemical and physical enhancers and ultrasound for transdermal drug delivery 失效
    用于透皮给药的化学和物理增强剂和超声波

    公开(公告)号：US5947921A

    公开(公告)日：1999-09-07

    申请号：US574377

    申请日：1995-12-18

    申请人： Mark E. Johnson ,  Samir S. Mitragotri ,  Daniel Blankschtein ,  Robert S. Langer ,  Michael Pishko ,  Joseph Kost

    发明人： Mark E. Johnson ,  Samir S. Mitragotri ,  Daniel Blankschtein ,  Robert S. Langer ,  Michael Pishko ,  Joseph Kost

    IPC分类号： A61K9/00 ,  A61K41/00 ,  A61M37/00 ,  A61N1/32 ,  A61B17/00

    CPC分类号： A61B5/14514 ,  A61K41/0047 ,  A61K9/0009 ,  A61M37/0092 ,  A61N1/325 ,  A61N1/327 ,  A61M2037/0007

    摘要： Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by providing chemical enhancers which increase the solubility of the compound to be transported and/or lipid bilayer solubility, and/or additional driving forces for transport, such as mechanical or osmotic pressure, magnetic fields, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities and other forces or concentrations than that required if each means of enhancing transport is used individually.

    摘要翻译： 可以通过提供增加待运输的化合物和/或脂质双层溶解度的溶解度的化学增强剂和/或用于运输的附加驱动力（例如机械或渗透）来进一步增强超声波输送（递送或提取）期间分子的透皮转运 压力，磁场，电穿孔或离子电渗疗法。 在优选实施例中，超声是低频超声，其引起角质层（SC）的脂质层的空化。 该方法提供较高的药物透皮通量，允许快速控制经皮通量，并允许在较低的超声强度下进行药物递送或分析物提取，以及如果分别使用增强转运的每种手段所需的其他力或浓度。