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公开(公告)号：US08697452B2
公开(公告)日：2014-04-15
申请号：US13491989
申请日：2012-06-08
申请人： John Linton , Arrin Katz , Colin Brenan , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya Kanigan , Kristine Friesen , Thomas Morrison , Javier Garcia
发明人： John Linton , Arrin Katz , Colin Brenan , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya Kanigan , Kristine Friesen , Thomas Morrison , Javier Garcia
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译： 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。
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公开(公告)号：US07682565B2
公开(公告)日：2010-03-23
申请号：US10744580
申请日：2003-12-22
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译： 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。
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公开(公告)号：US20120245038A1
公开(公告)日：2012-09-27
申请号：US13491989
申请日：2012-06-08
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译： 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。
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公开(公告)号：US20090062134A1
公开(公告)日：2009-03-05
申请号：US12245027
申请日：2008-10-03
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： C40B30/00
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect.
摘要翻译： 提供了对多个样品进行测定的方法。 该方法包括以下步骤：在具有大于100个样品位点的样品阵列中的每个样品位置处进行测定，同时使用一个或多个LED照亮每个样品位点，并且同时对每个样品位点成像以产生与光学相关的成像数据 每个网站的效果。 每个测定提供光学效果。
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公开(公告)号：US20090062152A1
公开(公告)日：2009-03-05
申请号：US12243503
申请日：2008-10-01
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： C40B60/12
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.
摘要翻译： 提供热循环装置和热循环方法。 热循环装置包括流体装置系统，壳体和循环头部。 流体输送系统产生受控温度流体的流动。 该壳体具有用于保持微流体阵列的流体密封腔。 阵列包括具有一对相对表面的厚度的材料片和穿过表面之间的厚度的多个通孔。 循环头部保持壳体，并将流体流过壳体。
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公开(公告)号：US20110003699A1
公开(公告)日：2011-01-06
申请号：US12642715
申请日：2009-12-18
申请人： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
发明人： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
CPC分类号： B01L3/508 , B01L3/50857 , B01L7/02 , B01L7/52 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/1822 , B01L2300/1838 , B01L2300/185
摘要： A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
摘要翻译： 一种用于热循环多个样品的系统。 该系统包括具有限定内部容积的流体密封腔的壳体。 微流体阵列设置在内部体积中，该阵列包括具有一对相对表面的材料片，厚度和穿过表面之间的厚度的多个通孔。 具有至少一个热控表面的热循环器适于热接触壳体。
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公开(公告)号：US20060094108A1
公开(公告)日：2006-05-04
申请号：US11227425
申请日：2005-09-15
申请人： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
发明人： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
IPC分类号： C12M1/34
CPC分类号： B01L3/508 , B01L3/50857 , B01L7/02 , B01L7/52 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/1822 , B01L2300/1838 , B01L2300/185
摘要： A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
摘要翻译： 一种用于热循环多个样品的系统。 该系统包括具有限定内部容积的流体密封腔的壳体。 微流体阵列设置在内部体积中，该阵列包括具有一对相对表面的材料片，厚度和穿过表面之间的厚度的多个通孔。 具有至少一个热控表面的热循环器适于热接触壳体。
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公开(公告)号：US08888713B2
公开(公告)日：2014-11-18
申请号：US12206299
申请日：2008-09-08
申请人： Jamieson Crawford , Robert Ellis , Bradley M. Wilkinson , Benjamin Bartfeld , C. Mark Newby , Chee Leong Alvin Tan , Jon Moh , Stanley Sim , Neville Yu Leng Chia
发明人： Jamieson Crawford , Robert Ellis , Bradley M. Wilkinson , Benjamin Bartfeld , C. Mark Newby , Chee Leong Alvin Tan , Jon Moh , Stanley Sim , Neville Yu Leng Chia
CPC分类号： A61B5/1535 , A61B5/1422 , A61B5/1444 , A61B5/15003 , A61B5/150213 , A61B5/150259 , A61B5/150389 , A61B5/150496 , A61B5/150572 , A61B5/150587 , A61B5/150603 , A61B5/150641 , A61B5/150656 , A61B5/150671 , A61B5/150717 , A61B5/150732 , A61B5/1545 , A61M5/3202 , A61M5/3216 , A61M5/5086 , A61M2005/3217
摘要： A blood collection assembly includes a housing and a cannula extending distally from the housing including a patient end, and a cannula shield removably engaged with a portion of the housing. The cannula shield is capable of shielding at least the patient end of the cannula, and includes a safety shield engagement. The assembly includes a pivoting safety shield engaged with a portion of the housing, which is transitionable from a retracted position in which the patient end of the cannula is exposed, to an extended position in which the patient end of the cannula is shielded by at least a portion of the safety shield. The safety shield includes at least one locking tab releasably engageable with the safety shield engagement, wherein the locking tab is fixedly engageable with a portion of the housing in the extended position.
摘要翻译： 采血组件包括壳体和从壳体向远侧延伸的套管，包括患者端，以及可拆卸地与壳体的一部分接合的套管屏蔽。 插管屏蔽能够至少屏蔽插管的患者端，并且包括安全屏蔽接合。 该组件包括与壳体的一部分接合的枢转安全护罩，其可从套管的患者端露出的缩回位置转换到其中插管的患者端至少被屏蔽的延伸位置 安全护罩的一部分。 安全护罩包括可释放地与安全屏蔽接合部接合的至少一个锁定突舌，其中锁定突出部可在伸出位置与壳体的一部分牢固地接合。
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公开(公告)号：US08548633B2
公开(公告)日：2013-10-01
申请号：US12956990
申请日：2010-11-30
申请人： Paul Adams , Robert Ellis , James Newton
发明人： Paul Adams , Robert Ellis , James Newton
IPC分类号： G05D3/12
CPC分类号： F21V29/70 , F21L4/005 , H01M10/052 , H01M10/345 , H01M10/425 , H01M10/48
摘要： A heat sink for a handheld device is formed as a one piece chassis for supporting heat-producing circuits inside the device while having heat radiating surfaces outside the device. In another embodiment a battery pack control circuit under microprocessor control allows battery packs having different battery chemistries and characteristics to be interchanged in the same device without switches or adapters. Control of operating modes of the device despite changes in the battery pack including battery chemistry, state of charge, available voltage, or desired operating mode are automatic. The microprocessor measures the battery pack characteristics, using look up tables in a suitable program to adjust the circuit operating modes. The microprocessor also responds to sequential switch contact closures in setting operating modes.
摘要翻译： 用于手持设备的散热器形成为一体式底架，用于在设备内部具有热辐射表面的同时支撑设备内部的发热电路。 在另一个实施例中，微处理器控制下的电池组控制电路允许具有不同电池化学性质和特性的电池组在没有开关或适配器的同一装置中互换。 尽管包括电池化学，充电状态，可用电压或所需的操作模式在内的电池组发生变化，但是控制器件的工作模式是自动的。 微处理器测量电池组特性，使用适当程序中的查找表来调整电路工作模式。 在设置工作模式时，微处理器还会响应顺序开关触点闭合。
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公开(公告)号：US20100211402A1
公开(公告)日：2010-08-19
申请号：US12377301
申请日：2008-01-03
申请人： Timothy Eggena , Bryan Rosenberger , Robert Hale , Robert Nary , Robert Ellis , Patrick Cline
发明人： Timothy Eggena , Bryan Rosenberger , Robert Hale , Robert Nary , Robert Ellis , Patrick Cline
CPC分类号： G06F19/327 , G06F19/00 , G06Q10/10 , G06Q50/22 , G16H40/20
摘要： A medical guideline integration engine is presented. The engine imports medical guideline information from disparate sources based on various guideline standards into a knowledge base. The knowledge base houses the information in a database. Upon request, the engine retrieves the information from the knowledge base and converts the information into a desired guideline format.
摘要翻译： 介绍了医疗指南整合引擎。 引擎根据各种指导标准将不同来源的医疗指南信息输入知识库。 知识库将信息存储在数据库中。 根据请求，引擎从知识库中检索信息，并将信息转换成所需的准则格式。
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