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公开(公告)号：US20120245038A1
公开(公告)日：2012-09-27
申请号：US13491989
申请日：2012-06-08
Applicant: John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
Inventor： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
CPC classification number: C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
Abstract translation: 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。
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公开(公告)号：US20110251084A1
公开(公告)日：2011-10-13
申请号：US12809568
申请日：2008-12-22
Applicant: Colin Brenan , Thomas Morrison
Inventor： Colin Brenan , Thomas Morrison
CPC classification number: C12Q1/6851 , B01L7/525 , B01L2300/0816 , B01L2300/0883 , B01L2400/0487 , G01N33/569 , Y02A50/52 , C12Q2561/113
Abstract: The invention features compositions and methods that are useful for the detection of a target analyte, such as a pathogen, in a sample.
Abstract translation: 本发明的特征在于可用于检测样品中目标分析物如病原体的组合物和方法。
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公开(公告)号：US20090062134A1
公开(公告)日：2009-03-05
申请号：US12245027
申请日：2008-10-03
Applicant: John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
Inventor： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC: C40B30/00
CPC classification number: C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect.
Abstract translation: 提供了对多个样品进行测定的方法。 该方法包括以下步骤：在具有大于100个样品位点的样品阵列中的每个样品位置处进行测定，同时使用一个或多个LED照亮每个样品位点，并且同时对每个样品位点成像以产生与光学相关的成像数据 每个网站的效果。 每个测定提供光学效果。
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公开(公告)号：US08697452B2
公开(公告)日：2014-04-15
申请号：US13491989
申请日：2012-06-08
Applicant: John Linton , Arrin Katz , Colin Brenan , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya Kanigan , Kristine Friesen , Thomas Morrison , Javier Garcia
Inventor： John Linton , Arrin Katz , Colin Brenan , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya Kanigan , Kristine Friesen , Thomas Morrison , Javier Garcia
CPC classification number: C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
Abstract translation: 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。
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5.发明申请Apparatus for Assay, Synthesis and Storage, and Methods of Manufacture, Use, and Manipulation Thereof 有权用于测定，合成和储存的装置及其制造，使用和操作方法公开(公告)号：US20120021951A1
公开(公告)日：2012-01-26
申请号：US13188337
申请日：2011-07-21
Applicant: Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
Inventor： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
CPC classification number: B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/0036 , B01J2219/00369 , B01J2219/00387 , B01J2219/00389 , B01J2219/00423 , B01J2219/0043 , B01J2219/00479 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00673 , B01L3/0244 , B01L3/0262 , B01L3/0268 , B01L3/5025 , B01L3/50255 , B01L3/5085 , B01L3/50857 , B01L99/00 , B01L2200/0657 , B01L2300/0845 , C12M23/12 , C40B60/14 , G01N30/466 , G01N30/6091 , G01N30/6095 , G01N30/82 , G01N2030/8417
Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
Abstract translation: 本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。 本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。 本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。 此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。
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Patent Agency Ranking
公开(公告)号：US20110003699A1
公开(公告)日：2011-01-06
申请号：US12642715
申请日：2009-12-18
Applicant: Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
Inventor： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
CPC classification number: B01L3/508 , B01L3/50857 , B01L7/02 , B01L7/52 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/1822 , B01L2300/1838 , B01L2300/185
Abstract: A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
Abstract translation: 一种用于热循环多个样品的系统。 该系统包括具有限定内部容积的流体密封腔的壳体。 微流体阵列设置在内部体积中，该阵列包括具有一对相对表面的材料片，厚度和穿过表面之间的厚度的多个通孔。 具有至少一个热控表面的热循环器适于热接触壳体。
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公开(公告)号：US20090062152A1
公开(公告)日：2009-03-05
申请号：US12243503
申请日：2008-10-01
Applicant: John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
Inventor： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC: C40B60/12
CPC classification number: C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.
Abstract translation: 提供热循环装置和热循环方法。 热循环装置包括流体装置系统，壳体和循环头部。 流体输送系统产生受控温度流体的流动。 该壳体具有用于保持微流体阵列的流体密封腔。 阵列包括具有一对相对表面的厚度的材料片和穿过表面之间的厚度的多个通孔。 循环头部保持壳体，并将流体流过壳体。
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公开(公告)号：US20070043341A1
公开(公告)日：2007-02-22
申请号：US11583434
申请日：2006-10-19
Applicant: R. Anderson , Ian Hunter , Colin Brenan , Keng Lim , Elizabeth Sebern
Inventor： R. Anderson , Ian Hunter , Colin Brenan , Keng Lim , Elizabeth Sebern
CPC classification number: A61B18/20 , A61B5/0059 , A61B5/0095 , A61B5/448 , A61B5/4836 , A61B5/489 , A61B5/72 , A61B18/203 , A61B34/35 , A61B34/71 , A61B34/72 , A61B90/37 , A61B2017/00061 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61B2018/00636 , A61B2018/00904
Abstract: A platform Smart Scalpel system using rapid real-time feedback for effecting laser treatment. The platform system includes an imaging system for rapid real-time detection of tissue characteristics, a processing system for processing the detected characteristics, and a treatment system for effecting treatment in accordance with results of the processing. The platform system provides for preprogramming and real-time inputting conditions and parameters for diagnosis using the imaging system and/or treatment using the treatment system.
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公开(公告)号：US20060094108A1
公开(公告)日：2006-05-04
申请号：US11227425
申请日：2005-09-15
Applicant: Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
Inventor： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
IPC: C12M1/34
CPC classification number: B01L3/508 , B01L3/50857 , B01L7/02 , B01L7/52 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/1822 , B01L2300/1838 , B01L2300/185
Abstract: A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
Abstract translation: 一种用于热循环多个样品的系统。 该系统包括具有限定内部容积的流体密封腔的壳体。 微流体阵列设置在内部体积中，该阵列包括具有一对相对表面的材料片，厚度和穿过表面之间的厚度的多个通孔。 具有至少一个热控表面的热循环器适于热接触壳体。
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公开(公告)号：US07682565B2
公开(公告)日：2010-03-23
申请号：US10744580
申请日：2003-12-22
Applicant: John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
Inventor： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
CPC classification number: C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
Abstract translation: 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。
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