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    Methods and compositions for modifying the surface of a polymeric substrate
    2.
    发明授权
    Methods and compositions for modifying the surface of a polymeric substrate 失效
    用于改性聚合物基材表面的方法和组合物

    公开(公告)号：US07201834B2

    公开(公告)日：2007-04-10

    申请号：US10386581

    申请日：2003-03-11

    Applicant: Sally A. Swedberg ,  Karla M. Robotti ,  Karin Caldwell

    Inventor： Sally A. Swedberg ,  Karla M. Robotti ,  Karin Caldwell

    IPC: G01N27/453

    CPC classification number: C08J7/047 ,  C08G65/329 ,  C08G65/33303 ,  C08G65/334 ,  C08J2471/00 ,  C09D171/02 ,  C25D13/22

    Abstract: Methods and compositions for modifying the surface of a polymeric substrate are provided. In the subject methods, at least a portion of the surface of the polymeric substrate is contacted with a biofouling resistant surfactant composition. At least a portion of the surfactant molecules of the composition are end modified with a non-reactive, charged end group that is charge stable over a pH range of about 2 to 12. The subject methods and compositions find particular use with electrophoretic devices, such as capillary electrophoretic devices.

    Abstract translation: 提供了改性聚合物基材表面的方法和组合物。 在本方法中，聚合物基材的表面的至少一部分与生物结垢的表面活性剂组合物接触。 组合物的表面活性剂分子的至少一部分用在约2至12的pH范围内电荷稳定的非反应性带电端基末端修饰。本发明方法和组合物特别用于电泳装置，例如 作为毛细管电泳装置。

    Methods and compositions for modifying the surface of a polymeric substrate
    3.
    发明授权
    Methods and compositions for modifying the surface of a polymeric substrate 失效
    用于改性聚合物基材表面的方法和组合物

    公开(公告)号：US06706161B1

    公开(公告)日：2004-03-16

    申请号：US09095493

    申请日：1998-06-10

    Applicant: Sally A. Swedberg ,  Karla M. Robotti ,  Karin Caldwell

    Inventor： Sally A. Swedberg ,  Karla M. Robotti ,  Karin Caldwell

    IPC: G01N2726

    CPC classification number: C08J7/047 ,  C08G65/329 ,  C08G65/33303 ,  C08G65/334 ,  C08J2471/00 ,  C09D171/02 ,  C25D13/22

    Abstract: Methods and compositions for modifying the surface of a polymeric substrate are provided. In the subject methods, at least a portion of the surface of the polymeric substrate is contacted with a biofouling resistant surfactant composition. At least a portion of the surfactant molecules of the composition are end modified with a non-reactive, charged end group that is charge stable over a pH range of a bout 2 to 12. The subject methods and compositions find particular use with electrophoretic devices, such as capillary electrophoretic devices.

    Abstract translation: 提供了改性聚合物基材表面的方法和组合物。 在本方法中，聚合物基材的表面的至少一部分与生物结垢的表面活性剂组合物接触。 组合物的表面活性剂分子的至少一部分用在反应2-12的pH范围内电荷稳定的非反应性带电端基末端修饰。本发明的方法和组合物特别用于电泳装置， 如毛细管电泳装置。

    Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples
    4.
    发明授权
    Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples 有权
    方法和使用化学 - 机械微型阀装置，用于从多组分流体样品中选择性分离组分

    公开(公告)号：US06783992B2

    公开(公告)日：2004-08-31

    申请号：US09754687

    申请日：2001-01-03

    Applicant: Karla M. Robotti ,  Hongfeng Yin

    Inventor： Karla M. Robotti ,  Hongfeng Yin

    IPC: G01N118

    CPC classification number: B01L3/502738 ,  B01L2300/0681 ,  B01L2400/0661 ,  B01L2400/0677 ,  G01N30/08 ,  G01N30/14 ,  G01N30/20 ,  Y10T436/25375 ,  Y10T436/255

    Abstract: Methods for selectively separating at least one component from a multi-component componant fluidic sample are provided. In the subject methods, the fluidic sample is introduced into a micro-fluidic device that includes at least one micro-valve made up of a phase reversible material. The multi-component fluidic sample is then contacted with the microvalve in a microfluidic device under conditions sufficient for the at least one component to enter the microvalve, while the remaining constituents of the fluidic sample remain outside of the microvalve. Also provided are kits for use in practicing the subject methods, where the kits include at least a microfluidic device having a microvalve and instructional material (or means for obtaining the same) on how to use the device in the subject methods. The subject devices find use in a variety of applications, including sample desalting and concentration applications.

    Abstract translation: 提供了从多成分组分流体样品中选择性分离至少一种组分的方法。 在本发明的方法中，将流体样品引入微流体装置，其包括由相位可逆材料构成的至少一个微型阀。 然后在足以使至少一种组分进入微型阀的条件下，多组分流体样品与微流体装置中的微型阀接触，而流体样品的剩余组分保留在微型阀的外部。 还提供了用于实践主题方法的试剂盒，其中试剂盒包括至少一种具有微血管和微量元素的微流体装置（或用于获得本发明的方法的方法）。 主题装置可用于各种应用，包括样品脱盐和浓缩应用。

    Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
    8.
    发明授权
    Triazine derivatives as universal peptide isotope tag reagents (U-PIT) 失效
    三嗪衍生物作为通用肽同位素标签试剂（U-PIT）

    公开(公告)号：US07425451B2

    公开(公告)日：2008-09-16

    申请号：US10318845

    申请日：2002-12-13

    Applicant: Karla M. Robotti ,  James Alexander Apffel, Jr.

    Inventor： Karla M. Robotti ,  James Alexander Apffel, Jr.

    IPC: G01N33/00 ,  C07D403/00 ,  A01N43/66 ,  A61K31/53

    CPC classification number: C07D403/12 ,  C07D401/14

    Abstract: Compounds, compositions, methods for sequencing proteins and peptides, and methods for identifying proteins and peptides in a mixture, are disclosed. Compounds of formula A-B-C wherein A is a nucleophilic reactive group, B is a detectable moiety capable of being isotopically labeled, and C is a charge replacement group, are used to label the peptides at the N-terminus or the C-terminus. The tagged peptides can then be analyzed by mass spectroscopy.

    Abstract translation: 公开了用于测定蛋白质和肽的化合物，组合物，方法以及用于鉴定混合物中的蛋白质和肽的方法。 其中A是亲核反应性基团的式A-B-C化合物，B是能够同位素标记的可检测部分，C是电荷取代基，用于在N末端或C末端标记肽。 然后可以通过质谱法分析标记的肽。

    Evanescent wave sensor with attached ligand
    9.
    发明授权
    Evanescent wave sensor with attached ligand 有权
    具有附着配体的渐逝波传感器

    公开(公告)号：US07396676B2

    公开(公告)日：2008-07-08

    申请号：US11143358

    申请日：2005-05-31

    Applicant: Karla M. Robotti ,  Daniel B. Roitman

    Inventor： Karla M. Robotti ,  Daniel B. Roitman

    IPC: C12M1/34

    CPC classification number: G01N21/553 ,  G01N33/54353 ,  Y10S435/808 ,  Y10S436/805

    Abstract: The invention in particular embodiments provides an evanescent wave sensor which includes a ligand bound to a sensor substrate via a NCYX linker moiety, as defined herein. Methods of making the subject evanescent wave sensors are also provided which include contacting a first reactive moiety which has an isocyanato (or isothiocyanato) moiety with a second reactive moiety which has an hydroxyl, thiol, or amino moiety, as further described herein. Also provided by the invention are methods in which a subject evanescent wave sensor is contacted with a sample, and binding of analytes in the sample to the sensor is assessed by evanescent wave detection. The invention also provides kits and systems for performing the subject methods.

    Abstract translation: 本发明在特定实施方案中提供了一种ev逝波传感器，其包括通过如本文所定义的NCYX接头部分与传感器底物结合的配体。 还提供了制备对象ev逝波传感器的方法，其包括使具有异氰酸酯基（或异硫氰酸酯基）部分的第一反应性部分与具有羟基，硫醇或氨基部分的第二反应性部分接触，如本文进一步描述的。 本发明还提供了一种方法，其中对象ev逝波传感器与样品接触，并且通过ev逝波检测来评估样品中的分析物与传感器的结合。 本发明还提供用于执行主题方法的套件和系统。

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