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    Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples
    2.
    发明授权
    Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples 有权
    方法和使用化学 - 机械微型阀装置，用于从多组分流体样品中选择性分离组分

    公开(公告)号：US06783992B2

    公开(公告)日：2004-08-31

    申请号：US09754687

    申请日：2001-01-03

    Applicant: Karla M. Robotti ,  Hongfeng Yin

    Inventor： Karla M. Robotti ,  Hongfeng Yin

    IPC: G01N118

    CPC classification number: B01L3/502738 ,  B01L2300/0681 ,  B01L2400/0661 ,  B01L2400/0677 ,  G01N30/08 ,  G01N30/14 ,  G01N30/20 ,  Y10T436/25375 ,  Y10T436/255

    Abstract: Methods for selectively separating at least one component from a multi-component componant fluidic sample are provided. In the subject methods, the fluidic sample is introduced into a micro-fluidic device that includes at least one micro-valve made up of a phase reversible material. The multi-component fluidic sample is then contacted with the microvalve in a microfluidic device under conditions sufficient for the at least one component to enter the microvalve, while the remaining constituents of the fluidic sample remain outside of the microvalve. Also provided are kits for use in practicing the subject methods, where the kits include at least a microfluidic device having a microvalve and instructional material (or means for obtaining the same) on how to use the device in the subject methods. The subject devices find use in a variety of applications, including sample desalting and concentration applications.

    Abstract translation: 提供了从多成分组分流体样品中选择性分离至少一种组分的方法。 在本发明的方法中，将流体样品引入微流体装置，其包括由相位可逆材料构成的至少一个微型阀。 然后在足以使至少一种组分进入微型阀的条件下，多组分流体样品与微流体装置中的微型阀接触，而流体样品的剩余组分保留在微型阀的外部。 还提供了用于实践主题方法的试剂盒，其中试剂盒包括至少一种具有微血管和微量元素的微流体装置（或用于获得本发明的方法的方法）。 主题装置可用于各种应用，包括样品脱盐和浓缩应用。

    Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry
    4.
    发明授权
    Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry 有权

    公开(公告)号：US06610978B2

    公开(公告)日：2003-08-26

    申请号：US09820321

    申请日：2001-03-27

    Applicant: Hongfeng Yin ,  Thomas P. Doherty ,  Sally A Swedberg

    Inventor： Hongfeng Yin ,  Thomas P. Doherty ,  Sally A Swedberg

    IPC: H01J4900

    CPC classification number: H01J49/045 ,  H01J49/0018 ,  H01J49/105

    Abstract: The present invention relates to microdevices for introducing a small volume of a fluid sample into an ionization chamber. The microdevices are constructed from a substrate having a first and second opposing surfaces, the substrate having a microchannel formed in the first surface, and a cover plate arranged over the first surface, the cover plate in combination with the microchannel defining a conduit for conveying the sample. A sample inlet port is provided in fluid communication with the microchannel, wherein the sample inlet port allows the fluid sample from an external source to be conveyed in a defined sample flow path that travels, in order, through the sample inlet port, the conduit and a sample outlet port and into the ionization chamber. Optionally, the fluid sample undergoes a chemical or biochemical reaction within an integrated portion of the microdevice before reaching the ionization chamber. A nebulizing means nebulizes the fluid sample in a nebulizing region adjacent to the sample outlet port. The invention also relates to a method for introducing a fluid sample using the microdevice.

    TANDEM IONIZER ION SOURCE FOR MASS SPECTROMETER AND METHOD OF USE
    6.
    发明申请
    TANDEM IONIZER ION SOURCE FOR MASS SPECTROMETER AND METHOD OF USE 有权
    用于质谱仪的串联离子源和使用方法

    公开(公告)号：US20100193702A1

    公开(公告)日：2010-08-05

    申请号：US12363685

    申请日：2009-01-30

    Applicant: Gangqiang Li ,  Hongfeng Yin

    Inventor： Gangqiang Li ,  Hongfeng Yin

    IPC: H01J27/02 ,  H01J49/04 ,  H01J49/10 ,  H01J49/14 ,  H01J27/20

    CPC classification number: H01J49/107 ,  H01J49/165

    Abstract: An ion source a first ionizer comprising: an electrospray needle comprising a tip; and a conduit disposed annularly about the needle and configured to pass an inert gas in proximity of the tip to nebulize a fluid emerging from the tip, the nebulized fluid comprising analytes and a mobile phase. The ion source comprises a capillary in tandem with the first ionizer and configured to receive the droplets; a heater configured to heat the capillary to a temperature at which mobile phase vaporizes; and a second ionizer in tandem with the capillary and configured to receive the vaporized mobile phase and the analytes. A method is also described.

    Abstract translation: 离子源，第一离子发生器，包括：电喷针，包括尖端; 以及围绕所述针环设置的导管，其被配置成使所述尖端附近的惰性气体通过，以使从所述尖端出来的流体雾化，所述雾化流体包含分析物和流动相。 离子源包括与第一离子发生器串联的毛细管并且构造成接收液滴; 加热器，被配置为将毛细管加热至流动相蒸发的温度; 以及第二离子发生器，其与所述毛细管串联并且被配置为接收蒸发的流动相和所述分析物。 还描述了一种方法。

    Incremental update of long-term and short-term user profile scores in a behavioral targeting system
    7.
    发明申请
    Incremental update of long-term and short-term user profile scores in a behavioral targeting system 有权
    在行为定位系统中增加长期和短期用户配置文件分数

    公开(公告)号：US20070260624A1

    公开(公告)日：2007-11-08

    申请号：US11394358

    申请日：2006-03-29

    Applicant: Christina Chung ,  Abhinav Gupta ,  Joshua Koran ,  Long-Ji Lin ,  Hongfeng Yin

    Inventor： Christina Chung ,  Abhinav Gupta ,  Joshua Koran ,  Long-Ji Lin ,  Hongfeng Yin

    IPC: G06F7/00

    CPC classification number: G06Q30/02

    Abstract: A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.

    Abstract translation: 行为定位系统从在线活动确定用户个人资料。 该系统包括多个模型，其定义用于确定用户简档分数的参数。 事件信息，包括用户的在线活动，在一个实体被接收。 要生成用户配置文件分数，选择一个模型。 该模型包括近似度，强度和频率尺寸参数。 行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接回应广告。 应用来自模型的参数以在类别中生成用户简档分数。 行为定位系统具有在在线用户的广告投放中使用的应用。

    Behavioral targeting system that generates user profiles for target objectives
    8.
    发明申请
    Behavioral targeting system that generates user profiles for target objectives 有权
    为目标目标生成用户配置文件的行为定位系统

    公开(公告)号：US20070239535A1

    公开(公告)日：2007-10-11

    申请号：US11394332

    申请日：2006-03-29

    Applicant: Joshua Koran ,  Christina Chung ,  Long-Ji Lin ,  Hongfeng Yin

    Inventor： Joshua Koran ,  Christina Chung ,  Long-Ji Lin ,  Hongfeng Yin

    IPC: G06Q30/00

    CPC classification number: G06F17/30528 ,  G06F17/30294 ,  G06F17/30587 ,  G06F17/30876 ,  G06Q30/02 ,  G06Q30/0224 ,  G06Q30/0251

    Abstract: A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.

    Abstract translation: 行为定位系统从在线活动确定用户个人资料。 该系统包括多个模型，其定义用于确定用户简档分数的参数。 事件信息，包括用户的在线活动，在一个实体被接收。 要生成用户配置文件分数，选择一个模型。 该模型包括近似度，强度和频率尺寸参数。 行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接回应广告。 应用来自模型的参数以在类别中生成用户简档分数。 行为定位系统具有在在线用户的广告投放中使用的应用。

    Fluidic separation devices and methods with reduced sample broadening
    10.
    发明申请
    Fluidic separation devices and methods with reduced sample broadening 审中-公开
    流体分离装置和减少样品扩增的方法

    公开(公告)号：US20070140918A1

    公开(公告)日：2007-06-21

    申请号：US11311960

    申请日：2005-12-19

    Applicant: Hongfeng Yin ,  Kevin Killeen ,  Reid Brennen

    Inventor： Hongfeng Yin ,  Kevin Killeen ,  Reid Brennen

    IPC: B01L11/00

    CPC classification number: G01N30/20 ,  G01N30/02 ,  G01N30/6095 ,  G01N30/7266 ,  G01N2030/202 ,  Y10T436/25 ,  B01D15/14

    Abstract: Fluidic separation devices and methods with reduced sample broadening are provided. A column is located downstream from a holding chamber, and a flow providing means provides fluid flow effective to convey a sample along a flow path that extends from the holding chamber into the separation column. The sample is typically focused in the flow path upstream from the separation column. Optionally, the invention may be employed with electrospray mass spectrometry and in microfluidic applications.

    Abstract translation: 提供了流体分离装置和减少样品加宽的方法。 柱位于保持室的下游，并且流动提供装置提供有效地沿着沿着从保持室延伸到分离柱的流动路径输送样品的流体流。 样品通常聚焦在分离柱上游的流路中。 任选地，本发明可以与电喷雾质谱法和微流体应用一起使用。

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