中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

30 records (took 0.018 seconds)

    Method for producing high-structure area texturing of a substrate, substrates prepared thereby and masks for use therein
    1.
    发明授权
    Method for producing high-structure area texturing of a substrate, substrates prepared thereby and masks for use therein 失效
    用于生产基底的高结构区域纹理的方法，由此制备的基底和用于其中的掩模

    公开(公告)号：US06919162B1

    公开(公告)日：2005-07-19

    申请号：US09233694

    申请日：1999-01-19

    Applicant: Reid A. Brennen ,  Sally A. Swedberg

    Inventor： Reid A. Brennen ,  Sally A. Swedberg

    IPC: B23K26/06 ,  B23K26/36 ,  G01N30/60 ,  B23K26/00

    CPC classification number: G01N30/6095 ,  B23K26/066 ,  B23K26/355 ,  B23K26/361 ,  B23K26/40 ,  B23K2103/42 ,  B23K2103/50 ,  B23K2103/52 ,  B41M5/24 ,  Y10S430/146

    Abstract: A method is provided for preparing high-surface area texturing of a substrate using methods by which material from a substrate is subtracted from or added to the surface of the substrate. In one embodiment, the method is a subtractive lithographic method that involves exposing a laser-ablatable substrate, such as a polymeric or ceramic substrate, to laser light. A mask may be used to define the pattern of light incident on the substrate. High-surface area textured substrates, in particular, miniaturized planar analysis devices having high-surface area textured features, prepared by the methods disclosed herein are also provided. A method by which the high-surface area textured substrate or the miniaturized planar analysis device is used as a master from which replicate copies thereof may be made is also provided.

    Abstract translation: 提供了一种用于使用从衬底中的材料从衬底的表面减去或添加到衬底的表面的方法来制备衬底的高表面区域纹理的方法。 在一个实施例中，该方法是一种减法光刻方法，其涉及将激光可烧蚀基底（例如聚合物或陶瓷基底）暴露于激光。 可以使用掩模来限定入射在基板上的光的图案。 还提供了通过本文公开的方法制备的高表面积织构化基材，特别是具有高表面积纹理特征的小型化平面分析装置。 还提供了高表面积纹理基板或小型化平面分析装置作为可以从其制作复制副本的主体的方法。

    Surfaces with reduced protein interactions
    6.
    发明授权
    Surfaces with reduced protein interactions 失效
    表面蛋白质相互作用降低

    公开(公告)号：US5114768A

    公开(公告)日：1992-05-19

    申请号：US507937

    申请日：1990-04-11

    Applicant: Sally A. Swedberg

    Inventor： Sally A. Swedberg

    IPC: G01N27/447

    CPC classification number: G01N27/44752 ,  G01N27/44704 ,  Y10T428/1393 ,  Y10T428/31536

    Abstract: A solid surface that is exposed to protein solutes in use, such as medical implants or capillary tubes useful in capillary zone electrophoresis, is defined by or carries a polymer. An interfacial layer is covalently bound to the polymer and functions to reduce interactions between the surface and protein solutes. The interfacial layer includes either a hydratable amphoteric phase or a plurality of halogen atoms bound in the interfacial layer through at least one heteroatom.

    Abstract translation: 在使用中暴露于蛋白质溶质的固体表面，例如可用于毛细管区带电泳的医用植入物或毛细管，由聚合物定义或携带聚合物。 界面层与聚合物共价结合，起减少表面和蛋白质溶质之间的相互作用的作用。 界面层包括通过至少一个杂原子在界面层中结合的可水合两性相或多个卤素原子。

    Integrated miniaturized device for processing and NMR detection of liquid phase samples
    9.
    发明授权
    Integrated miniaturized device for processing and NMR detection of liquid phase samples 失效
    用于液相样品的加工和NMR检测的集成小型化装置

    公开(公告)号：US06194900B1

    公开(公告)日：2001-02-27

    申请号：US09100495

    申请日：1998-06-19

    Applicant: Dominique M. Freeman ,  Sally A. Swedberg

    Inventor： Dominique M. Freeman ,  Sally A. Swedberg

    IPC: G01R3320

    CPC classification number: G01R33/302

    Abstract: A miniaturized total analysis system with an in-line NMR detection compartment and an NMR rf microcoil detector is described for use in liquid phase analysis. The device is formed by microfabrication of microstructures in novel support substrates. The NMR detector coil may be fabricated directly in the support body at the point of detection or, alternatively, may be formed as part of a modular structure that is insertable into the device at the point of detection. In addition, an integrated device for sample preparation and NMR detection is provided comprising the miniaturized total analysis system and a miniature magnet configured to accept the miniaturized total analysis system, wherein the device is capable of generating an NMR spectrum. The invention herein is used for the analysis of small and/or macromolecular and/or other solutes in the liquid phase.

    Abstract translation: 描述了具有串联NMR检测室和NMR rf微线圈检测器的小型化总分析系统用于液相分析。 该装置通过在新型支撑基底中微细加工而形成。 NMR检测器线圈可以在检测点处直接制造在支撑体中，或者可以形成为在检测点处可插入到装置中的模块化结构的一部分。 此外，提供了用于样品制备和NMR检测的集成装置，其包括小型化总分析系统和构造成接受小型化总分析系统的微型磁体，其中该装置能够产生NMR光谱。 本发明用于分析液相中的小分子和/或大分子和/或其它溶质。

    Capillary tube with reversible protein interaction and method
    10.
    发明授权
    Capillary tube with reversible protein interaction and method 失效
    毛细管与可逆蛋白相互作用和方法

    公开(公告)号：US5314593A

    公开(公告)日：1994-05-24

    申请号：US32913

    申请日：1993-03-18

    Applicant: Sally A. Swedberg

    Inventor： Sally A. Swedberg

    IPC: C07K1/26 ,  G01N27/447 ,  G01N27/26

    CPC classification number: G01N27/44752

    Abstract: A method for treating capillary walls exposable to protein solutes is provided that promotes reversible interactions between the protein solutes and the wall. Thus a small bore capillary tube, useful for reproducible protein electrophoretic separations, includes an interfacial phase comprising agarose that is bonded to the bore. Pretreatment of the capillary walls with silylation reagents forms an intermediate layer that provides a determinable cathodic electroosmotic flow magnitude that remains constant even if the buffer pH fluctuates between 4-7. The modified capillaries can be used repeatedly and they exhibit selectivity in protein separations.

    Abstract translation: 提供了一种治疗可暴露于蛋白质溶质的毛细血管壁的方法，其促进蛋白质溶质和壁之间的可逆相互作用。 因此，可用于可再现的蛋白质电泳分离的小孔毛细管包括界面相，其包含结合到孔的琼脂糖。 用甲硅烷基化试剂预处理毛细管壁形成中间层，其提供可确定的阴极电渗流量，即使缓冲液pH在4-7之间波动时也保持恒定。 修饰的毛细管可以重复使用，并且它们在蛋白质分离中表现出选择性。

Patent Agency Ranking