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公开(公告)号：US20180318838A1
公开(公告)日：2018-11-08
申请号：US16032183
申请日：2018-07-11
申请人： LUMINEX CORPORATION
IPC分类号： B01L7/00 , C12Q1/6806 , C12Q1/686 , B01F5/12 , B01F11/00 , B01L3/00 , B01F15/02 , G01N1/38 , G01N35/04 , G01N35/10
CPC分类号： B01L7/52 , B01F5/12 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F2015/0221 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/50851 , B01L3/523 , B01L3/527 , B01L7/00 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/044 , B01L2300/0627 , B01L2300/0654 , B01L2300/0672 , B01L2300/0829 , B01L2300/0867 , B01L2300/087 , B01L2300/1805 , B01L2400/0406 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , C12Q1/6806 , C12Q1/686 , G01N1/38 , G01N35/1079 , G01N2035/0436 , Y10T436/118339 , Y10T436/25375 , Y10T436/255
摘要： Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided, as are methods for using such cartridges. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.
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公开(公告)号：US20170080427A1
公开(公告)日：2017-03-23
申请号：US15366186
申请日：2016-12-01
申请人： LUMINEX CORPORATION
CPC分类号： B01L7/52 , B01F5/12 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F2015/0221 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/50851 , B01L3/523 , B01L3/527 , B01L7/00 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/044 , B01L2300/0627 , B01L2300/0654 , B01L2300/0672 , B01L2300/0829 , B01L2300/0867 , B01L2300/087 , B01L2300/1805 , B01L2400/0406 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , C12Q1/6806 , C12Q1/686 , G01N1/38 , G01N35/1079 , G01N2035/0436 , Y10T436/118339 , Y10T436/25375 , Y10T436/255
摘要： Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided, as are methods for using such cartridges. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.
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公开(公告)号：US20150191776A1
公开(公告)日：2015-07-09
申请号：US14666573
申请日：2015-03-24
申请人： LUMINEX CORPORATION
IPC分类号： C12Q1/68
CPC分类号： C12N15/1013 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F15/06 , B01F2015/0221 , B01F2015/062 , B01F2215/0037 , B01L3/502 , B01L7/00 , B01L2200/026 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/0672 , B01L2300/0867 , B01L2300/0887 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , B03C1/01 , B03C1/286 , B03C2201/18 , B03C2201/20 , C12Q1/6806 , G01N1/38 , Y10T137/0402 , Y10T137/0407 , Y10T137/0413 , Y10T137/0419 , Y10T137/0424 , Y10T436/10 , Y10T436/11 , Y10T436/115831 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.
摘要翻译： 本文公开了用于制备样品的装置。 所述设备包括室，至少部分地设置在第一室中的第一阀，至少部分地设置在第一室中的第二阀，以及包括致动器和喷嘴的泵。
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公开(公告)号：US20150050726A1
公开(公告)日：2015-02-19
申请号：US14525976
申请日：2014-10-28
申请人： LUMINEX CORPORATION
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
摘要： A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
摘要翻译： 描述了用于处理样本的并行处理系统。 在一个实施例中，并行处理系统包括用于控制托盘电机驱动系统的仪器接口并行控制器，闭环加热器控制和检测系统，磁性粒子传递系统，试剂释放系统，试剂预混泵送系统 和洗涤缓冲液泵送系统。
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公开(公告)号：US20180100186A1
公开(公告)日：2018-04-12
申请号：US15838812
申请日：2017-12-12
申请人： LUMINEX CORPORATION
IPC分类号： C12Q1/6806 , G01N35/00 , C12N15/10 , B01L3/00
CPC分类号： C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
摘要： A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
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公开(公告)号：US20180346965A1
公开(公告)日：2018-12-06
申请号：US16058076
申请日：2018-08-08
申请人： LUMINEX CORPORATION
IPC分类号： C12Q1/6806 , C12N15/10 , G01N35/00 , B01L3/00 , G01N35/08 , G01N35/02 , G01N35/04 , B01F15/02
CPC分类号： C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
摘要： A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and direction system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
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公开(公告)号：US20170175106A1
公开(公告)日：2017-06-22
申请号：US15456029
申请日：2017-03-10
申请人： LUMINEX CORPORATION
CPC分类号： C12N15/1013 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F15/06 , B01F2015/0221 , B01F2015/062 , B01F2215/0037 , B01L3/502 , B01L7/00 , B01L2200/026 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/0672 , B01L2300/0867 , B01L2300/0887 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , B03C1/01 , B03C1/286 , B03C2201/18 , B03C2201/20 , C12Q1/6806 , G01N1/38 , Y10T137/0402 , Y10T137/0407 , Y10T137/0413 , Y10T137/0419 , Y10T137/0424 , Y10T436/10 , Y10T436/11 , Y10T436/115831 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.
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公开(公告)号：US20160348154A1
公开(公告)日：2016-12-01
申请号：US15232980
申请日：2016-08-10
申请人： LUMINEX CORPORATION
CPC分类号： C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
摘要： A parallel preceding system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
摘要翻译： 描述用于处理样品的并行的前一系统。 在一个实施例中，并行处理系统包括用于控制托盘电机驱动系统的仪器接口并行控制器，闭环加热器控制和检测系统，磁性粒子传递系统，试剂释放系统，试剂预混泵送系统 和洗涤缓冲液泵送系统。
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公开(公告)号：US20160138010A1
公开(公告)日：2016-05-19
申请号：US15006494
申请日：2016-01-26
申请人： LUMINEX CORPORATION
CPC分类号： C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
摘要： A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
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10.发明申请APPARATUS AND METHODS FOR INTEGRATED SAMPLE PREPARATION, REACTION AND DETECTION 审中-公开集成样品制备，反应和检测的装置和方法公开(公告)号：US20160101421A1
公开(公告)日：2016-04-14
申请号：US14974382
申请日：2015-12-18
申请人： LUMINEX CORPORATION
IPC分类号： B01L7/00
CPC分类号： B01L7/525 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F2015/0221 , B01L3/0265 , B01L3/502 , B01L3/527 , B01L7/52 , B01L2200/026 , B01L2200/028 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/0672 , B01L2300/0864 , B01L2300/0867 , B01L2400/0478 , B01L2400/0481 , B01L2400/049 , B01L2400/0622 , B01L2400/0644 , B01L2400/0683
摘要： An apparatus includes a housing, a reaction vial and a transfer mechanism. The housing defines a first flow path and a second flow path. The housing has transfer port defining an opening in fluid communication with the second flow path and a volume outside of the housing. The transfer port includes a flow control member to limit flow through the opening. The reaction vial is coupled to the housing and defines a reaction volume, which is in fluid communication with the transfer port via the second flow path. The transfer mechanism is configured to transfer a sample from an isolation chamber of an isolation module to the reaction chamber via at least the first flow path when the transfer mechanism is actuated. The transfer mechanism configured to produce a vacuum in the reaction vial to produce a flow of a sample from the isolation chamber to the reaction volume.
摘要翻译： 一种装置包括壳体，反应瓶和传送机构。 壳体限定第一流动路径和第二流动路径。 壳体具有限定与第二流动路径流体连通的开口的传送端口和壳体外部的体积。 传送端口包括用于限制通过开口的流动的流量控制构件。 反应小瓶联接到壳体并限定反应体积，其经由第二流动路径与转移口流体连通。 传送机构被配置为当传动机构被致动时，将样品从隔离模块的隔离室传送到至少第一流动路径的反应室。 传送机构被配置为在反应小瓶中产生真空以产生样品从分离室到反应体积的流动。
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