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1.发明申请HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES 有权HEMATOPOIETIC GROWTH FACTOR MIMETIC小分子化合物及其用途公开(公告)号：US20120295904A1
公开(公告)日：2012-11-22
申请号：US13501622
申请日：2010-10-12
申请人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Bijan Pedram , Yixing Shen , Lino J. Valdez , Jillian Basinger , Virginia Heather Sharron Grant , Jason C. Pickens
发明人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Bijan Pedram , Yixing Shen , Lino J. Valdez , Jillian Basinger , Virginia Heather Sharron Grant , Jason C. Pickens
IPC分类号： C07D401/12 , C07D471/04 , A61K31/4545 , A61K31/454 , C07D403/12 , C12Q1/02 , C07D413/14 , A61K31/5377 , A61P7/00 , C12N5/078 , G01N21/76 , A61K31/506 , A61K31/496
CPC分类号： A61K31/15 , A61K31/167 , A61K31/18 , A61K31/245 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/421 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/438 , A61K31/4409 , A61K31/4418 , A61K31/4439 , A61K31/4468 , A61K31/4535 , A61K31/454 , A61K31/4747 , A61K31/495 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/541 , C07C233/78 , C07C233/80 , C07C235/56 , C07C237/40 , C07C237/42 , C07C243/38 , C07C247/18 , C07C251/48 , C07C251/66 , C07C251/68 , C07C251/86 , C07C271/28 , C07C311/08 , C07D207/12 , C07D207/27 , C07D207/273 , C07D207/32 , C07D207/327 , C07D207/34 , C07D207/416 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/24 , C07D209/34 , C07D209/42 , C07D211/46 , C07D211/58 , C07D213/12 , C07D213/53 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D231/26 , C07D231/40 , C07D231/56 , C07D233/60 , C07D233/61 , C07D233/90 , C07D235/06 , C07D235/14 , C07D235/20 , C07D235/24 , C07D235/30 , C07D237/24 , C07D239/28 , C07D241/04 , C07D241/24 , C07D249/04 , C07D261/18 , C07D263/04 , C07D263/16 , C07D263/57 , C07D265/36 , C07D277/56 , C07D285/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/68 , C07D317/62 , C07D317/68 , C07D333/24 , C07D333/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113
摘要： The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
摘要翻译： 本实施方案涉及具有生理作用的化合物，例如造血生长因子受体的活化。 本实施方案还涉及该化合物用于治疗多种病症，疾病和疾病如造血条件和病症的用途。
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2.发明授权公开(公告)号：US09144557B2
公开(公告)日：2015-09-29
申请号：US13501622
申请日：2010-10-12
申请人： Lin Zhi , Andrew R Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Bijan Pedram , Yixing Shen , Lino J. Valdez , Jillian Basinger , Virginia Heather Sharron Grant , Jason C. Pickens
发明人： Lin Zhi , Andrew R Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Bijan Pedram , Yixing Shen , Lino J. Valdez , Jillian Basinger , Virginia Heather Sharron Grant , Jason C. Pickens
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/445 , A61K31/44 , C07D401/04 , C07D413/02 , C07D403/02 , C07D211/68 , C07D239/42 , A61K31/15 , A61K31/167 , A61K31/18 , A61K31/245 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/421 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/438 , A61K31/4409 , A61K31/4418 , A61K31/4439 , A61K31/4468 , A61K31/4535 , A61K31/454 , A61K31/4747 , A61K31/495 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/541 , C07C233/78 , C07C233/80 , C07C235/56 , C07C237/40 , C07C237/42 , C07C243/38 , C07C247/18 , C07C251/48 , C07C251/66 , C07C251/68 , C07C251/86 , C07C271/28 , C07C311/08 , C07D207/12 , C07D207/27 , C07D207/273 , C07D207/32 , C07D207/327 , C07D207/34 , C07D207/416 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/24 , C07D209/34 , C07D209/42 , C07D211/46 , C07D211/58 , C07D213/12 , C07D213/53 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D231/26 , C07D231/40 , C07D231/56 , C07D233/60 , C07D233/61 , C07D233/90 , C07D235/06 , C07D235/14 , C07D235/20 , C07D235/24 , C07D235/30 , C07D237/24 , C07D239/28 , C07D241/04 , C07D241/24 , C07D249/04 , C07D261/18 , C07D263/04 , C07D263/16 , C07D263/57 , C07D265/36 , C07D277/56 , C07D285/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/68 , C07D317/62 , C07D317/68 , C07D333/24 , C07D333/38 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D471/04 , C07D491/113
CPC分类号： A61K31/15 , A61K31/167 , A61K31/18 , A61K31/245 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/421 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/438 , A61K31/4409 , A61K31/4418 , A61K31/4439 , A61K31/4468 , A61K31/4535 , A61K31/454 , A61K31/4747 , A61K31/495 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/541 , C07C233/78 , C07C233/80 , C07C235/56 , C07C237/40 , C07C237/42 , C07C243/38 , C07C247/18 , C07C251/48 , C07C251/66 , C07C251/68 , C07C251/86 , C07C271/28 , C07C311/08 , C07D207/12 , C07D207/27 , C07D207/273 , C07D207/32 , C07D207/327 , C07D207/34 , C07D207/416 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/24 , C07D209/34 , C07D209/42 , C07D211/46 , C07D211/58 , C07D213/12 , C07D213/53 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D231/26 , C07D231/40 , C07D231/56 , C07D233/60 , C07D233/61 , C07D233/90 , C07D235/06 , C07D235/14 , C07D235/20 , C07D235/24 , C07D235/30 , C07D237/24 , C07D239/28 , C07D241/04 , C07D241/24 , C07D249/04 , C07D261/18 , C07D263/04 , C07D263/16 , C07D263/57 , C07D265/36 , C07D277/56 , C07D285/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/68 , C07D317/62 , C07D317/68 , C07D333/24 , C07D333/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113
摘要： The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
摘要翻译： 本实施方案涉及具有生理作用的化合物，例如造血生长因子受体的活化。 本实施方案还涉及该化合物用于治疗多种病症，疾病和疾病如造血条件和病症的用途。
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3.发明授权Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors 有权激活造血生长因子受体的小分子造血生长因子模拟化合物公开(公告)号：US08680150B2
公开(公告)日：2014-03-25
申请号：US12775331
申请日：2010-05-06
申请人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Jason C. Pickens , Yixing Shen , Catalina Cuervo , Lino J. Valdez , Jillian Basinger , Virgina H. Grant
发明人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Jason C. Pickens , Yixing Shen , Catalina Cuervo , Lino J. Valdez , Jillian Basinger , Virgina H. Grant
IPC分类号： A61K31/16 , A61K31/165
CPC分类号： C07D417/04 , C07C251/86 , C07D207/27 , C07D207/327 , C07D209/08 , C07D209/30 , C07D209/42 , C07D231/14 , C07D231/46 , C07D233/61 , C07D263/32 , C07D277/24 , C07D307/85 , C07D401/04 , C07D417/14 , G01N2500/10
摘要： The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
摘要翻译： 本实施方案涉及具有生理作用的化合物，例如造血生长因子受体的活化。 本实施方案还涉及该化合物用于治疗多种病症，疾病和疾病如造血条件和病症的用途。
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4.发明申请SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS THAT ACTIVATE HEMATOPOIETIC GROWTH FACTOR RECEPTORS 有权激活人造血细胞生长因子受体的小分子HEMATOPOIETIC GROWTH FACTOR MIME化合物公开(公告)号：US20110003851A1
公开(公告)日：2011-01-06
申请号：US12775331
申请日：2010-05-06
申请人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Jason C. Pickens , Yixing Shen , Catalina Cuervo , Lino J. Valdez , Jillian Basinger , Virgina H. Grant
发明人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Jason C. Pickens , Yixing Shen , Catalina Cuervo , Lino J. Valdez , Jillian Basinger , Virgina H. Grant
IPC分类号： A61K31/4709 , C12Q1/02 , C12N5/071 , A61K31/4439 , A61K31/427 , A61K31/40 , C07D401/04 , C07D417/04 , C07D209/42 , A61P9/00 , A61P31/00 , A61P25/00 , A61P37/00
CPC分类号： C07D417/04 , C07C251/86 , C07D207/27 , C07D207/327 , C07D209/08 , C07D209/30 , C07D209/42 , C07D231/14 , C07D231/46 , C07D233/61 , C07D263/32 , C07D277/24 , C07D307/85 , C07D401/04 , C07D417/14 , G01N2500/10
摘要： The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
摘要翻译： 本实施方案涉及具有生理作用的化合物，例如造血生长因子受体的活化。 本实施方案还涉及该化合物用于治疗多种病症，疾病和疾病如造血条件和病症的用途。
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公开(公告)号：US08580811B2
公开(公告)日：2013-11-12
申请号：US13385802
申请日：2012-03-06
申请人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
发明人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
CPC分类号： C07D471/04
摘要： Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
摘要翻译： 本文提供了结合雄激素受体和/或调节雄激素受体活性的化合物，以及制备和使用这些化合物的方法。 还提供了包含这些化合物的组合物和用于制备和使用这些组合物的方法。
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公开(公告)号：US08193357B2
公开(公告)日：2012-06-05
申请号：US11883247
申请日：2006-06-12
申请人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
发明人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
摘要翻译： 本文提供了结合雄激素受体和/或调节雄激素受体活性的化合物，以及制备和使用这些化合物的方法。 还提供了包含这些化合物的组合物和用于制备和使用这些组合物的方法。
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公开(公告)号：US20090227571A1
公开(公告)日：2009-09-10
申请号：US11921366
申请日：2006-06-30
申请人： Jon C. Loren , Todd Miller , Bijan Pedram , Charlene V. Rowley , Yixing Shen , Cornelis Arjan Van Oeveren , Lin Zhi
发明人： Jon C. Loren , Todd Miller , Bijan Pedram , Charlene V. Rowley , Yixing Shen , Cornelis Arjan Van Oeveren , Lin Zhi
IPC分类号： A61K31/54 , C12N5/02 , C12Q1/02 , C07C237/00 , A61K31/16 , C07D209/04 , A61K31/405 , C07C303/00 , A61K31/18 , A61K31/445 , C07D211/00 , C07D215/00 , A61K31/47 , A61K31/4427 , C07D471/00 , C07D401/14 , A61K31/497 , C07D413/00 , C07D417/00 , A61K31/5377
CPC分类号： C07C229/18 , C07C237/02 , C07C237/06 , C07C275/42 , C07C311/16 , C07C317/32 , C07C2601/14 , C07D209/16 , C07D215/38 , C07D295/185 , C07D295/26 , C07D401/04 , C07D471/04
摘要： Provided herein are compounds that bind to androgen receptors and modulate the activity and/or the amount of androgen receptors and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
摘要翻译： 本文提供了结合雄激素受体并调节雄激素受体的活性和/或量的化合物以及制备和使用这些化合物的方法。 还提供了包含这些化合物的组合物和用于制备和使用这些组合物的方法。
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公开(公告)号：US20120165362A1
公开(公告)日：2012-06-28
申请号：US13385802
申请日：2012-03-06
申请人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
发明人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
IPC分类号： A61K31/4745 , A61P1/02 , A61P9/00 , A61P7/02 , A61P3/00 , A61P1/00 , A61P1/04 , A61P3/04 , A61P19/08 , A61P19/02 , A61P25/24 , A61P3/08 , A61P37/06 , A61P5/48 , A61P9/04 , A61P3/06 , A61P21/00 , A61P17/10 , A61P17/08 , A61P17/14 , A61P7/06 , A61P13/08 , A61P35/00 , A61P35/04 , A61P15/00 , A61P15/06 , A61P15/08 , A61P15/16 , A61P15/18 , A61P19/10 , A61P15/10 , A61P7/04 , C07K1/00 , C12Q1/02 , A61P25/00
CPC分类号： C07D471/04
摘要： Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
摘要翻译： 本文提供了结合雄激素受体和/或调节雄激素受体活性的化合物，以及制备和使用这些化合物的方法。 还提供了包含这些化合物的组合物和用于制备和使用这些组合物的方法。
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公开(公告)号：US20090030027A1
公开(公告)日：2009-01-29
申请号：US11883247
申请日：2006-06-12
申请人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
发明人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
IPC分类号： A61K31/437 , C07D471/04 , C07K14/71 , C12N5/06 , C12Q1/02 , A61P19/08 , A61P35/00
CPC分类号： C07D471/04
摘要： Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
摘要翻译： 本文提供了结合雄激素受体和/或调节雄激素受体活性的化合物，以及制备和使用这些化合物的方法。 还提供了包含这些化合物的组合物和用于制备和使用这些组合物的方法。
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公开(公告)号：US20090264455A9
公开(公告)日：2009-10-22
申请号：US11883247
申请日：2006-06-12
申请人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
发明人： Bijan Pedram , Cornelis Arjan Van Oeveren , Lin Zhi , Shuo Zhao , Yixing Shen
IPC分类号： A61K31/437 , C07D471/04 , C07K14/71 , C12N5/06 , C12Q1/02 , A61P19/08 , A61P35/00
CPC分类号： C07D471/04
摘要： Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
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