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    Method of optically coupling optical fiber to waveguide on substrate, and optical device produced by the method
    1.
    发明授权
    Method of optically coupling optical fiber to waveguide on substrate, and optical device produced by the method 失效
    将光纤耦合到基板上的波导的方法以及通过该方法制造的光学器件的方法

    公开(公告)号：US5018817A

    公开(公告)日：1991-05-28

    申请号：US447421

    申请日：1989-12-07

    申请人： Makoto Suzuki ,  Satoshi Watanabe ,  Takashi Tsukamoto ,  Hikoharu Aoki ,  Hitomi Ohri ,  Yukihiro Sako

    发明人： Makoto Suzuki ,  Satoshi Watanabe ,  Takashi Tsukamoto ,  Hikoharu Aoki ,  Hitomi Ohri ,  Yukihiro Sako

    IPC分类号： B23K26/36 ,  B23K26/40 ,  C04B37/04 ,  G02B6/255 ,  G02B6/30 ,  G02B6/36

    CPC分类号： G02B6/3688 ,  B23K26/40 ,  G02B6/25 ,  G02B6/2552 ,  G02B6/30 ,  G02B6/3636 ,  B23K2203/52 ,  G02B6/3652

    摘要： A method of optically coupling one end of an optical fiber to a waveguide formed on a substrate, such that an end portion of the fiber is fitted in a groove formed in the substrate. The groove is formed by forming a beam-shielding mask having a cutout, on the substrate such that the cutout is aligned with a part of the substrate in which the groove is formed, and by irradiating the above-indicated part of the substrate with a high-energy beam. Alternatively, the groove is formed by a cutting tool. An inclined end surface of the groove left uncut by the tool may be irradiated with a high-energy beam, through a beam-shielding mask which has a cutout aligned with the inclined end surface. The end of the optical fiber, which has a flat face or has a coned or hemi-spherical shape, is positioned for optical coupling with a portion of the waveguide which is exposed to the groove.

    摘要翻译： 将光纤的一端光学耦合到形成在基板上的波导的方法，使得光纤的端部装配在形成在基板中的凹槽中。 通过在基板上形成具有切口的光束屏蔽掩模，使得切口与形成有凹槽的基板的一部分对准，并且通过用基板的上述部分照射来形成凹槽 高能束。 或者，槽由切削工具形成。 通过工具未切割的槽的倾斜端面可以通过具有与倾斜端面对准的切口的束屏蔽掩模用高能束照射。 具有平面或具有锥形或半球形形状的光纤的端部定位成与暴露于凹槽的波导的一部分进行光学耦合。

    Thiolactones
    2.
    发明授权
    Thiolactones 失效
    硫内酯

    公开(公告)号：US07968593B2

    公开(公告)日：2011-06-28

    申请号：US12472251

    申请日：2009-05-26

    申请人： Barbara S. Slusher ,  Takashi Tsukamoto

    发明人： Barbara S. Slusher ,  Takashi Tsukamoto

    IPC分类号： A61K31/382 ,  A61K31/381 ,  C07D335/06 ,  C07D335/04

    CPC分类号： C07D335/02 ,  C07D335/06

    摘要： This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.

    摘要翻译： 本发明提供新的化合物，药物组合物和包含这些化合物的诊断试剂，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平被改变的疾病，抑制血管发生，影响TGF- 活动或神经元活动，以及治疗谷氨酸异常，强迫症，神经病，疼痛，前列腺疾病，癌症，亨廷顿氏病，糖尿病，视网膜病症或青光眼。

    Plug and waterproof connector with plug
    3.
    发明授权
    Plug and waterproof connector with plug 有权
    插头和防水连接器插头

    公开(公告)号：US07207840B2

    公开(公告)日：2007-04-24

    申请号：US11181865

    申请日：2005-07-15

    申请人： Hirotaka Fukushima ,  Takashi Tsukamoto

    发明人： Hirotaka Fukushima ,  Takashi Tsukamoto

    IPC分类号： H01R13/40

    CPC分类号： H01R13/5221

    摘要： A waterproof connector includes annular plug receiving chambers formed within a connector housing in surrounding relation respectively to outer peripheral surfaces of insulating sheaths of wires, and are disposed adjacent respectively to terminal receiving chambers in a longitudinal direction of the wires, plugs received respectively in the plug receiving chambers, and a cover attached to the connector housing from a side of the other end portions of the wires, covering the plug receiving chambers. The plug includes an annular elastic rubber member and an annular resin member molded integrally with the rubber member in concentric relation thereto. An inner peripheral surface of the rubber member is held in contact with a part of the outer peripheral surface of the insulating sheath of the wire over an entire periphery thereof, while an outer peripheral surface of the rubber member is held in contact with an inner peripheral surface of a peripheral wall of the plug receiving chamber over an entire periphery thereof.

    摘要翻译： 防水连接器包括分别形成在连接器壳体内的环形插塞接收室，分别围绕导线的绝缘护套的外周表面，并且分别设置在电线的纵向方向上的端子接收室附近，分别容纳在插头中的插头 接收室，以及从电线的另一端部的一侧附接到连接器壳体的盖子，覆盖插头接收室。 塞子包括环形弹性橡胶构件和与橡胶构件一体地与其成同心关系的环形树脂构件。 橡胶构件的内周面在其整个外周与导线的绝缘护套的外周面的一部分保持接触，同时橡胶构件的外周面与内周面 插塞接收室的周壁的表面在其整个周边上。

    Thiolactones
    4.
    发明授权
    Thiolactones 失效

    公开(公告)号：US07125907B2

    公开(公告)日：2006-10-24

    申请号：US10791278

    申请日：2004-03-03

    申请人： Barbara S. Slusher ,  Takashi Tsukamoto

    发明人： Barbara S. Slusher ,  Takashi Tsukamoto

    IPC分类号： C07D335/02 ,  A61K31/382

    CPC分类号： C07D335/02 ,  C07D335/06

    摘要： This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.

    Plug and waterproof connector with plug
    5.
    发明申请
    Plug and waterproof connector with plug 有权
    插头和防水连接器插头

    公开(公告)号：US20060019535A1

    公开(公告)日：2006-01-26

    申请号：US11181865

    申请日：2005-07-15

    申请人： Hirotaka Fukushima ,  Takashi Tsukamoto

    发明人： Hirotaka Fukushima ,  Takashi Tsukamoto

    IPC分类号： H01R13/40

    CPC分类号： H01R13/5221

    摘要： A waterproof connector includes annular plug receiving chambers formed within a connector housing in surrounding relation respectively to outer peripheral surfaces of insulating sheaths of wires, and are disposed adjacent respectively to terminal receiving chambers in a longitudinal direction of the wires, plugs received respectively in the plug receiving chambers, and a cover attached to the connector housing from a side of the other end portions of the wires, covering the plug receiving chambers. The plug includes an annular elastic rubber member and an annular resin member molded integrally with the rubber member in concentric relation thereto. An inner peripheral surface of the rubber member is held in contact with a part of the outer peripheral surface of the insulating sheath of the wire over an entire periphery thereof, while an outer peripheral surface of the rubber member is held in contact with an inner peripheral surface of a peripheral wall of the plug receiving chamber over an entire periphery thereof.

    摘要翻译： 防水连接器包括分别形成在连接器壳体内的环形插塞接收室，分别围绕导线的绝缘护套的外周表面，并且分别设置在电线的纵向方向上的端子接收室附近，分别容纳在插头中的插头 接收室，以及从电线的另一端部的一侧附接到连接器壳体的盖子，覆盖插头接收室。 塞子包括环形弹性橡胶构件和与橡胶构件一体地与其成同心关系的环形树脂构件。 橡胶构件的内周面在其整个外周与导线的绝缘护套的外周面的一部分保持接触，同时橡胶构件的外周面与内周面 插塞接收室的周壁的表面在其整个周边上。

    Indoles as naaladase inhibitors
    9.
    发明申请
    Indoles as naaladase inhibitors 失效
    吲哚作为纳拉肽酶抑制剂

    公开(公告)号：US20050080128A1

    公开(公告)日：2005-04-14

    申请号：US10500319

    申请日：2002-12-19

    申请人： Takashi Tsukamoto ,  Brian Grella ,  Pavel Majer

    发明人： Takashi Tsukamoto ,  Brian Grella ,  Pavel Majer

    IPC分类号： A61K31/405 ,  A61P43/00 ,  C07D209/02 ,  C07D209/42 ,  C07D43/02

    CPC分类号： C07D209/42

    摘要： This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALAdase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

    摘要翻译： 本发明涉及包含这些化合物的新化合物，药物组合物和诊断试剂盒，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALAdase水平被改变，影响神经元活性，影响TGF-β活性，抑制血管发生的疾病，以及 治疗谷氨酸异常，神经病，疼痛，强迫症，前列腺疾病，癌症和青光眼。

    Thiol-based NAALADase inhibitors
    10.
    发明授权
    Thiol-based NAALADase inhibitors 失效
    基于硫醇的NAALADase抑制剂

    公开(公告)号：US06586623B2

    公开(公告)日：2003-07-01

    申请号：US10046917

    申请日：2002-01-17

    申请人： Takashi Tsukamoto ,  Pavel Majer ,  Doris Stoermer ,  Barbara S. Slusher

    发明人： Takashi Tsukamoto ,  Pavel Majer ,  Doris Stoermer ,  Barbara S. Slusher

    IPC分类号： C07C32106

    CPC分类号： C07C323/56 ,  C07C323/52 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65

    摘要： This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

    摘要翻译： 本发明涉及包含这些化合物的新化合物，药物组合物和诊断试剂盒，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平改变，影响神经元活性，影响TGF-β活性，抑制血管生成的疾病，以及 治疗谷氨酸异常，糖尿病性神经病，疼痛，强迫症，前列腺疾病，癌症和青光眼。