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    Polyvalent multimeric composition containing active polypeptides, pharmaceutical compositions and methods of using the same
    5.
    发明申请
    Polyvalent multimeric composition containing active polypeptides, pharmaceutical compositions and methods of using the same 审中-公开
    含有活性多肽的多价多聚体组合物，药物组合物及其使用方法

    公开(公告)号：US20070053934A1

    公开(公告)日：2007-03-08

    申请号：US11510493

    申请日：2006-08-25

    申请人： Neville Kallenbach ,  Daniel Malamud ,  Zhigang Liu ,  William Abrams ,  Paramjit Arora

    发明人： Neville Kallenbach ,  Daniel Malamud ,  Zhigang Liu ,  William Abrams ,  Paramjit Arora

    IPC分类号： A61K31/70 ,  A61K39/12 ,  A01N43/04

    CPC分类号： C12N7/00 ,  A61K38/1709 ,  A61K47/58 ,  A61K47/595 ,  C07K14/47 ,  C07K14/4723 ,  C07K14/705 ,  C12N2740/16061

    摘要： The invention is directed to compositions comprising polyvalent complexes containing a biocompatible polymer backbone to which is attached a plurality of monomeric anti-microbial peptides and to methods for using such complexes to stabilize anti-microbial peptides for treating or preventing a disease or condition resulting from infection with a microbe. Multivalent derivatives of existing antimicrobial peptides in which several peptides are covalently linked have been investigated. The resulting construct may contain up to 30 or more units, and exhibits a significant enhancement of anti-microbial effect relative to the free peptides: on the order of a ten fold improvement in effectiveness, suggesting that higher multimerization can indeed lead to more effective agents. The invention is also directed to the use of such complexes for delivery of anti-viral peptides, in particular, peptides and peptide fragments obtained from salivary agglutinin protein (gp-340) for use in treating or preventing infection with HIV.

    摘要翻译： 本发明涉及包含含有多个单体抗微生物肽的生物相容性聚合物骨架的多价复合物的组合物，以及使用这些复合物来稳定抗微生物肽以治疗或预防感染引起的疾病或病症的方法 用微生物。 已经研究了几种肽共价连接的现有抗微生物肽的多价衍生物。 所得构建体可以含有多达30个或更多个单元，并且相对于游离肽显示出显着增强的抗微生物效应：有效性提高十倍，这表明更高的多聚化确实会导致更有效的试剂 。 本发明还涉及这种复合物用于递送抗病毒肽，特别是从用于治疗或预防HIV感染的唾液凝集素蛋白（gp-340）获得的肽和肽片段的用途。

    System, method and computer program product for managing and organizing pieces of content
    6.
    发明申请
    System, method and computer program product for managing and organizing pieces of content 有权
    用于管理和组织内容的系统，方法和计算机程序产品

    公开(公告)号：US20050278310A1

    公开(公告)日：2005-12-15

    申请号：US10860994

    申请日：2004-06-04

    申请人： William Abrams ,  Ricky Johnson

    发明人： William Abrams ,  Ricky Johnson

    IPC分类号： G06F17/30 ,  G06F7/00

    CPC分类号： G06F17/30598 ,  G06F7/36 ,  G06F17/30731

    摘要： A system for managing and organizing content includes a source capable of operating at least one application (i.e., content manager, taxonomy manager, etc.). The application(s) are capable of providing a plurality of pieces of content and a plurality of master taxonomies, each master taxonomy including at least one piece of content placed at one or more locations. After providing the pieces of content and the master taxonomies, the application(s) can identify a subset of the pieces of content and at least one master taxonomy, where the subset includes at least one piece of content. The application(s) can then generate at least one client taxonomy based upon the identified subset and the master taxonom(ies) such that the subset of the pieces of content can thereafter be organized in the client taxonom(ies). The system can also include a client capable of organizing the subset in the client taxonom(ies).

    摘要翻译： 用于管理和组织内容的系统包括能够操作至少一个应用（即，内容管理器，分类管理器等）的源。 应用程序能够提供多个内容片段和多个主分类法，每个主分类法包括放置在一个或多个位置处的至少一个内容片段。 在提供内容和主分类之后，应用可以识别内容片段的一部分以及至少一个主分类，其中该子集包括至少一片内容。 然后，应用程序可以基于所识别的子集和主分类法生成至少一个客户端分类，使得此后片段的子集可以此后被组织在客户分类中。 该系统还可以包括能够在客户分类中组织子集的客户机。

    System, method and computer program product for providing digital rights management of protected content
    7.
    发明申请
    System, method and computer program product for providing digital rights management of protected content 审中-公开
    用于提供受保护内容的数字版权管理的系统，方法和计算机程序产品

    公开(公告)号：US20050273629A1

    公开(公告)日：2005-12-08

    申请号：US10860627

    申请日：2004-06-04

    申请人： William Abrams ,  Ricky Johnson

    发明人： William Abrams ,  Ricky Johnson

    IPC分类号： G06F21/00 ,  H04L9/32

    CPC分类号： H04L63/0428 ,  G06F21/10 ,  H04L9/0816 ,  H04L2209/24

    摘要： A system for providing digial rights management of protected content includes a client and a DRM manager. The client is capable of receiving at least one piece of content, the piece(s) of content being encrypted with at least one encryption key regardless of client user(s) authorized to access the piece(s) of encrypted content. To facilitate the client accessing one or more of the piece(s) of content, the DRM manager is capable of transferring the encryption key(s) to the client, the encryption key(s) being encrypted with a private key of a public key/private key pair unique to a client user associated with the client. The client can thereafter decrypt the encryption key(s) using the public key of the public key/private key pair unique to the client user. Then, the client can decrypt the piece(s) of content using the decrypted encryption key(s), and access the decrypted piece(s) of content.

    摘要翻译： 用于提供受保护内容的数字权限管理的系统包括客户机和DRM管理器。 客户端能够接收至少一条内容，该内容片段使用至少一个加密密钥进行加密，而不管授权访问加密内容片段的客户端用户。 为了便于客户端访问一个或多个内容，DRM管理器能够将加密密钥传送到客户端，加密密钥用公钥的专用密钥加密 /与客户端相关联的客户端用户唯一的私钥对。 客户端此后可以使用客户端用户唯一的公钥/私钥对的公开密钥来解密加密密钥。 然后，客户端可以使用解密的加密密钥来解密内容片段，并访问解密的内容片段。

    System, method and computer program product for providing content based upon a representation of the same
    8.
    发明申请
    System, method and computer program product for providing content based upon a representation of the same 有权
    用于基于其表示来提供内容的系统，方法和计算机程序产品

    公开(公告)号：US20050273460A1

    公开(公告)日：2005-12-08

    申请号：US10860980

    申请日：2004-06-04

    申请人： William Abrams ,  Ricky Johnson

    发明人： William Abrams ,  Ricky Johnson

    IPC分类号： G06F17/00 ,  G06F17/30

    CPC分类号： G06F17/3092

    摘要： A system for providing content includes a source and a client. The source is capable of generating a representation of the content, the content being hierarchically-structured and including at least one item having an associated type. The source is capable of generating a representation including an identity table and at least one type table, each item of content being included in the identity table, and included in a type table based upon the type of the item. Thereafter, the source can be capable of providing the representation of the content. The client is capable of receiving the representation of the content, and accessing at least a portion of the content based upon the representation. The client can also be capable of receiving a query for at least one item of content, searching the representation for the item(s), and accessing at least a portion of the content including the item(s).

    摘要翻译： 用于提供内容的系统包括源和客户端。 源能够生成内容的表示，内容是分层结构的，并且包括至少一个具有关联类型的项。 源能够生成包括身份表和至少一个类型表的表示，每个内容项被包括在身份表中，并且基于项的类型包括在类型表中。 此后，源可以提供内容的表示。 客户端能够接收内容的表示，并且基于表示访问内容的至少一部分。 客户端还能够接收至少一个内容项目的查询，搜索该表示的项目，以及访问包括该项目的内容的至少一部分。

    Flip top golf ball container assembly provided with moisture barrier properties
    9.
    发明授权
    Flip top golf ball container assembly provided with moisture barrier properties 失效
    翻转高尔夫球容器组件具有防潮性能

    公开(公告)号：US06705463B1

    公开(公告)日：2004-03-16

    申请号：US09876381

    申请日：2001-06-07

    申请人： Michael Bucholtz ,  William Abrams ,  Ronald Supranowicz

    发明人： Michael Bucholtz ,  William Abrams ,  Ronald Supranowicz

    IPC分类号： B65D8558

    CPC分类号： A63B57/20 ,  A63B47/00 ,  B65D43/162 ,  B65D81/268 ,  B65D85/58 ,  B65D2543/00148

    摘要： A golf ball and package assembly, comprising: at least one golf ball; a package separable from said golf ball defining a cavity within which said golf ball is positioned, said package comprising: (a) a moisture proof, resealable container and an integrally attached cap, wherein the package has a base, an internal cavity, an outer surface, an upper portion and lower portion, a rim at the upper portion, the cap has a base and a skirt extending perpendicularly around the outer periphery of the base, the cap is provided with a thumb tab for facilitating the opening and closing of the container, and is attached to the package by a hinge; (b) the cap and container are non-circular in shape having curved sides and flat sides, joined by rounded corners; (c) an outer wall of the ridge and wall surfaces of the cap rim define a gap into which rim is fitted to form a moisture proof seal when the cap is in the closed position; and (d) a desiccant insert.

    摘要翻译： 一种高尔夫球和包装组件，包括：至少一个高尔夫球; 一个与所述高尔夫球分离的包装件，其限定所述高尔夫球定位在其中的空腔，所述包装包括：（a）防潮，可再密封的容器和整体连接的盖，其中所述包装具有底座，内腔， 表面，上部和下部，在上部的边缘，所述盖具有基部和围绕所述基部的外周垂直延伸的裙部，所述盖设置有拇指突片，以便于打开和关闭 容器，并通过铰链附接到包装; （b）盖和容器是非圆形的，具有弯曲的侧面和平坦的边，由圆角连接; （c）凸缘的外壁和盖边缘的壁表面限定了一个间隙，当盖处于关闭位置时，边缘被装配到该间隙中以形成防潮密封; 和（d）干燥剂插入物。