公开(公告)号：US4207312A

公开(公告)日：1980-06-10

申请号：US654452

申请日：1976-02-02

申请人： Mitsuharu Fujii ,  Tatsuo Kuoka ,  Tatsuo Setsuta ,  Yutaka Iwao ,  Yasumi Yugari ,  Tsuyoshi Shiio ,  Takashi Yoshihama ,  Junji Hamuro

发明人： Mitsuharu Fujii ,  Tatsuo Kuoka ,  Tatsuo Setsuta ,  Yutaka Iwao ,  Yasumi Yugari ,  Tsuyoshi Shiio ,  Takashi Yoshihama ,  Junji Hamuro

IPC分类号： A61K31/715 ,  A61K9/08 ,  A61K36/07 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K31/70 ,  A61K31/00

CPC分类号： A61K31/70 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K9/0019

摘要： The glucans and glucan derivatives which inhibit the growth of sarcoma 180 in mice are only sparingly soluble in water, and their aqueous solutions are unstable. In the presence of 0.1 to 1.0 g/dl water soluble dextran, hydroxyethyl starch, carboxymethyl cellulose, or polyethylene glycol, they form relatively concentrated and stable solutions, particularly in the presence of hexoses, pentoses or sugar alcohols having 5 or 6 carbon atoms.

摘要翻译： 抑制小鼠肉瘤180生长的葡聚糖和葡聚糖衍生物只能微溶于水，其水溶液不稳定。 在0.1至1.0g / dl水溶性葡聚糖，羟乙基淀粉，羧甲基纤维素或聚乙二醇的存在下，它们形成相对浓缩和稳定的溶液，特别是在具有5或6个碳原子的己糖，戊糖或糖醇的存在下。

公开(公告)号：US20060252700A1

公开(公告)日：2006-11-09

申请号：US11484605

申请日：2006-07-12

申请人： Junji Hamuro ,  Yukie Murata

发明人： Junji Hamuro ,  Yukie Murata

IPC分类号： A61K38/05 ,  A61K31/353 ,  C12Q1/00 ,  A61K31/385 ,  G06F19/00

CPC分类号： A61K31/353 ,  A23L33/175 ,  A61K31/225 ,  A61K31/385 ,  A61K38/05 ,  A61K38/063 ,  A61K38/2013 ,  A61K47/62 ,  A61K2300/00

摘要： An immunomodulator is provided which is capable of oral intake for improvement, treatment and prevention of human immunological diseases and which is used to treat, improve and prevent human immunological diseases, especially, autoimmune diseases and allergic diseases such as hepatic cirrhosis, hepatitis, diabetes, inflammatory bowel diseases, chronic rheumatoid arthritis, asthma and cutaneous atopy, allergic diseases and cancers by a new method that can control the redox state of macrophages or monocytes, and can be incorporated into a drug, a food, a nutrient, and an infusion. The contents of oxidative glutathione and reductive glutathione in macrophages are monitored, and the ratio of oxidative glutathione and reductive glutathione is examined, whereby macrophages are classified into oxidative macrophages and reductive macrophages having different functions. The degree of progression of various autoimmune diseases is analyzed from this standpoint. On the basis of the results, an immunomodulator capable of oral intake which contains a substance having an activity of changing a content of reductive glutathione in macrophages to solve the above-mentioned problem and which is intended to treat, improve and prevent human immune diseases is provided.

公开(公告)号：US06444800B1

公开(公告)日：2002-09-03

申请号：US09348265

申请日：1999-07-07

申请人： Kokichi Kikuchi ,  Noriyuki Sato ,  Toshihiko Torigoe ,  Hiroeki Sahara ,  Manabu Suzuki ,  Junji Hamuro

发明人： Kokichi Kikuchi ,  Noriyuki Sato ,  Toshihiko Torigoe ,  Hiroeki Sahara ,  Manabu Suzuki ,  Junji Hamuro

IPC分类号： C07H2102

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00

摘要： A tumor antigen gene is identified by screening a cDNA library derived from a gastric cancer cell line that can induce gastric cancer antigen specific cytotoxic T cell (CTL) by means of hybridization and PCR utilizing an amino acid sequence of peptide fragment of a known gastric cancer antigen protein, introducing a selected cDNA clone into a cell of gastric cancer cell line that cannot induce gastric cancer antigen specific CTL so that the clone should be expressed in the cell, and selecting a transgenic cell that has acquired the ability to induce CTL. According to the present invention, there are provided a protein capable of inducing immune response against human gastric cancer, DNA encoding the protein, as well as vaccine for treatment and prevention of human gastric cancer, and agent for treatment and prevention of human gastric cancer.

公开(公告)号：US5856140A

公开(公告)日：1999-01-05

申请号：US636936

申请日：1996-04-24

申请人： Toshiro Shimamura ,  Junji Hamuro ,  Harumi Nakazawa ,  Yuka Kanayama ,  Kazuo Sugamura ,  Toshikazu Takeshita

发明人： Toshiro Shimamura ,  Junji Hamuro ,  Harumi Nakazawa ,  Yuka Kanayama ,  Kazuo Sugamura ,  Toshikazu Takeshita

IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K16/28 ,  C12N1/21 ,  C12N15/13 ,  C12P21/08 ,  C12P21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P21/06

CPC分类号： C07K14/7155 ,  C07K16/2866 ,  A61K38/00

摘要： A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.

摘要翻译： 提供了特异性结合人白细胞介素-2受体的γ-链的多肽，并选择性地抑制人白细胞介素-2受体的γ-链与β-链的结合。 该多肽具有阻断人白介素-2应答的活性。 还提供了含有多肽的免疫抑制剂，编码该多肽的DNA基因，具有该基因的重组DNA，具有该重组DNA的转化体，以及通过温育该转化体来制备该多肽的方法。 该新型多肽可以独立使用，也可以与能够抑制白介素-2与白细胞介素-2受体结合的物质用作防止移植后移植物排斥的药物，还可用于治疗炎性疾病如过敏性疾病和自身免疫性 疾病

公开(公告)号：US5801003A

公开(公告)日：1998-09-01

申请号：US568427

申请日：1995-12-06

申请人： Toshiro Shimamura ,  Junji Hamuro ,  Kazuo Sugamura

发明人： Toshiro Shimamura ,  Junji Hamuro ,  Kazuo Sugamura

IPC分类号： G01N33/53 ,  C07K16/28 ,  G01N33/564 ,  G01N33/574 ,  G01N33/577 ,  G01N33/68 ,  C12Q1/70 ,  G01N33/543

CPC分类号： C07K16/2866 ,  G01N33/6869

摘要： The invention provides a method for detecting (1) leukemia, (2) cancer, (3) autoimmune disorder, (4) inflammatory disorder, (5) allergic disorder or (6) viral infection, characterized by measuring soluble, human interleukin-2 receptor .gamma.-chain molecules existing in a human body fluid by an immunochemical method using an antibody/antibodies specifically reacting with human interleukin-2 receptor .gamma.-chain molecule, and a reagent for the detection.

摘要翻译： 本发明提供一种检测白血病，（2）癌症，（3）自身免疫性疾病，（4）炎症性疾病，（5）过敏性疾病或（6）病毒感染的方法，其特征在于测量可溶性人白介素-2 通过使用与人白细胞介素-2受体γ链分子特异性反应的抗体/抗体的免疫化学方法和用于检测的试剂，存在于人体液中的受体γ链分子。

公开(公告)号：US20080113007A1

公开(公告)日：2008-05-15

申请号：US11795302

申请日：2006-01-11

申请人： Eiji Kurihara ,  Junji Hamuro ,  Takahiro Nakamura

发明人： Eiji Kurihara ,  Junji Hamuro ,  Takahiro Nakamura

IPC分类号： A61K35/12 ,  A61K38/48 ,  A61K9/70

CPC分类号： A61L27/3839 ,  A61L15/40 ,  A61L27/3604 ,  A61L27/3683

摘要： A sheet-shaped composition that is applicable to a wide spectrum of uses and can be transplanted through simple and easy transplanting technique. There is provided a sheet-shaped composition comprising amniotic membrane and, attached to the surface thereof, fibrinogen and thrombin. In one form, a cell layer is formed on the amnion on its side opposite to the side of adhesive component attachment.

摘要翻译： 一种适用于广泛用途的片状组合物，可通过简单易用的移植技术移植。 提供了包含羊膜的片状组合物，并附着在其表面上的纤维蛋白原和凝血酶。 在一种形式中，在羊膜上在与粘合剂组件附件侧相反的一侧上形成细胞层。

公开(公告)号：US5837248A

公开(公告)日：1998-11-17

申请号：US723116

申请日：1996-09-30

申请人： Kokichi Kikuchi ,  Noriyuki Sato ,  Hiromitsu Sahara ,  Takahiro Yasojima ,  Yoshimasa Wada ,  Manabu Suzuki ,  Junji Hamuro

发明人： Kokichi Kikuchi ,  Noriyuki Sato ,  Hiromitsu Sahara ,  Takahiro Yasojima ,  Yoshimasa Wada ,  Manabu Suzuki ,  Junji Hamuro

IPC分类号： C12N15/09 ,  A61K35/14 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P1/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H21/04 ,  C07K7/06 ,  C07K14/47 ,  C07K14/705 ,  C07K14/82 ,  C12N1/21 ,  C12N7/00 ,  C12N15/12 ,  C12R1/19 ,  A61K38/08

CPC分类号： C07K7/06 ,  C07H21/04 ,  C07K14/4748 ,  C07K14/705 ,  A61K38/00 ,  A61K39/00

摘要： A peptide that induces CTL against human gastric cancer cells is provided. A peptide having a specific amino-acid sequence and induces cytotoxic T cells that targets gastric cancer cells may be used as an agent for preventing or treating gastric cancer.

公开(公告)号：US5464751A

公开(公告)日：1995-11-07

申请号：US927422

申请日：1992-09-24

申请人： Mark I. Greene ,  Kunio Dobashi ,  James G. Davis ,  Junji Hamuro

发明人： Mark I. Greene ,  Kunio Dobashi ,  James G. Davis ,  Junji Hamuro

IPC分类号： A61K38/00 ,  A61K38/22 ,  A61P3/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/485 ,  C07K14/52 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C12N9/00 ,  C12P21/00 ,  C12R1/91 ,  G01N33/53 ,  G01N33/574

CPC分类号： C07K14/71 ,  A61K38/00 ,  Y10S436/813 ,  Y10S530/828

摘要： A purified proteinaceous substance bindable with p185, the translation product of the neu oncogene is disclosed. The purified proteinaceous substance may be characterized in that it increases the activity of the tyrosine kinase contained in the neu oncogene product but does not increase the activity of tyrosine kinase of epidermal growth factor receptor; induces p185 dimerization and internalization; affects the growth of cells which express p185 in a dose dependent manner; is heat stable from about 56.degree. C. to about 100.degree. C.; is degradable by protease; and has a molecular weight of from about 7,000 to about 14,000 daltons in its smallest active form as determined by gel filtration and ultrafiltration membrane analysis. Methods of detecting p185 on the surfaces of tumor cells are also disclosed.

摘要翻译： PCT No.PCT / US91 / 02331 Sec。 371日期：1992年9月24日 102（e）日期1992年9月24日PCT 1991年4月4日PCT PCT。 出版物WO91 / 15230 PCT 日期为1991年10月17日。公开了一种与p185结合的纯化蛋白质物质，即neu致癌基因的翻译产物。 纯化的蛋白质物质的特征在于其增加neu致癌基因产物中所含的酪氨酸激酶的活性，但不增加表皮生长因子受体酪氨酸激酶的活性; 诱导p185二聚化和内化; 以剂量依赖的方式影响表达p185的细胞的生长; 从约56℃至约100℃是热稳定的。 可通过蛋白酶降解; 并且通过凝胶过滤和超滤膜分析测定，其最小活性形式的分子量为约7,000至约14,000道尔顿。 还公开了在肿瘤细胞表面检测p185的方法。

公开(公告)号：US20080039940A1

公开(公告)日：2008-02-14

申请号：US10592256

申请日：2005-02-16

申请人： Kouji Hashimoto ,  Yuuji Shirakata ,  Yuuichi Ohashi ,  Junji Hamuro

发明人： Kouji Hashimoto ,  Yuuji Shirakata ,  Yuuichi Ohashi ,  Junji Hamuro

IPC分类号： A61F2/10 ,  A01N1/00 ,  A61P43/00

CPC分类号： C12N5/0621 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/3869 ,  C12M25/02 ,  C12N5/0629 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/92

摘要： A biological tissue sheet which is expected as exerting a favorable therapeutic effect and a high safety in transplantation. The biological tissue sheet formed by (a) preparing in vivo-derived cells; (b) sowing the in vivo-derived cells on amniotic membrane; and (c) culturing and proliferating the in vivo-derived cells in the absence of any xenogeneic animal cells. As the cells of a biological origin, for example, cells originating in corneal epithelium, conjunctival epithelium, skin epidermis, hair follicle epithelium, oral mucosa, respiratory tract mucosa, or intestinal tract mucosa.

摘要翻译： 预期在生物组织片中具有良好的治疗效果和高的移植安全性。 通过（a）制备体内衍生的细胞而形成的生物组织片; （b）在羊膜上播种体内衍生的细胞; 和（c）在不存在任何异种动物细胞的情况下培养和增殖体内衍生的细胞。 作为生物来源的细胞，例如来自角膜上皮，结膜上皮，皮肤表皮，毛囊上皮，口腔粘膜，呼吸道粘膜或肠道粘膜的细胞。

公开(公告)号：US20070280993A1

公开(公告)日：2007-12-06

申请号：US10592114

申请日：2005-02-14

申请人： Kouji Hashimoto ,  Yuuji Shirakata ,  Yuuichi Ohashi ,  Junji Hamuro

发明人： Kouji Hashimoto ,  Yuuji Shirakata ,  Yuuichi Ohashi ,  Junji Hamuro

IPC分类号： A61F2/14 ,  C12N5/02

CPC分类号： C12N5/0621 ,  A61L27/24 ,  A61L27/3813 ,  A61L27/3869 ,  A61L27/3895 ,  C12N2502/1323 ,  C12N2533/54

摘要： A corneal epithelial sheet having potential for the achievement of a favorable therapeutic effect and being highly safe in transplantation. The corneal epithelial sheet is constructed by: (a) preparing corneal epithelial cells; (b) separately culturing human fibroblasts in a collagen gel; (c) sowing or placing the corneal epithelial cells on the collagen gel; and (d) culturing and proliferating the corneal epithelial cells in the absence of xenogeneic animal cells.

摘要翻译： 角膜上皮片具有获得良好治疗效果和在移植中高度安全的潜力。 角膜上皮片由以下构成：（a）制备角膜上皮细胞; （b）在胶原凝胶中分别培养人成纤维细胞; （c）将角膜上皮细胞播种或放置在胶原凝胶上; 和（d）在不存在异种动物细胞的情况下培养和增殖角膜上皮细胞。