公开(公告)号：US07147905B2

公开(公告)日：2006-12-12

申请号：US10491901

申请日：2002-10-16

申请人： Motohiro Fukuda ,  Naoto Fukuhara ,  Yukihiro Fujieda ,  Toshihide Nakashima ,  Koji Inai ,  Toshiji Ichikawa ,  Akira Ishida

发明人： Motohiro Fukuda ,  Naoto Fukuhara ,  Yukihiro Fujieda ,  Toshihide Nakashima ,  Koji Inai ,  Toshiji Ichikawa ,  Akira Ishida

IPC分类号： B32B1/08 ,  B32B27/08

CPC分类号： B32B25/14 ,  A61L29/085 ,  A61L31/10 ,  B32B1/08 ,  B32B25/08 ,  B32B27/32 ,  B32B2305/72 ,  B32B2535/00 ,  B32B2597/00 ,  Y10T428/1393 ,  Y10T428/31855 ,  Y10T428/31909 ,  Y10T428/31917 ,  Y10T428/31931 ,  Y10T428/31938 ,  C08L53/02

摘要： A laminate comprising at least a surface layer (I) and an adjacent layer (II) thereto, characterized in that the surface layer (I) comprises a cross-linked copolymer formed by cross-linking a copolymer prepared by using as monomers at least one vinyl aromatic compound and at least one conjugated diene compound, and the adjacent layer (II) comprises a hydrogenated copolymer formed by hydrogenating a copolymer prepared by using as monomers at least one vinyl aromatic compound and at least one conjugated diene compound; a multilayer tube comprising the laminate; and a medical device comprising the laminate, and/or the multilayer tube.

摘要翻译： 一种至少包含表面层（I）和其相邻层（II）的层压体，其特征在于，所述表面层（I）包含交联共聚物，所述交联共聚物通过将通过使用至少一种 乙烯基芳族化合物和至少一种共轭二烯化合物，相邻层（II）包含通过氢化作为单体至少一种乙烯基芳族化合物和至少一种共轭二烯化合物制备的共聚物形成的氢化共聚物; 包括层压体的多层管; 以及包括层压体和/或多层管的医疗装置。

公开(公告)号：US06977105B1

公开(公告)日：2005-12-20

申请号：US09926817

申请日：2000-09-22

申请人： Yukihiro Fujieda ,  Masayasu Ogushi ,  Motohiro Fukuda ,  Toshiyuki Zento ,  Koichi Wada ,  Toshiji Ichikawa ,  Akira Ishida

发明人： Yukihiro Fujieda ,  Masayasu Ogushi ,  Motohiro Fukuda ,  Toshiyuki Zento ,  Koichi Wada ,  Toshiji Ichikawa ,  Akira Ishida

IPC分类号： A61L29/12 ,  A61L31/12 ,  A61M25/00 ,  A61M25/16 ,  B32B1/08 ,  B32B27/28 ,  B32B27/32 ,  C08L23/10 ,  C08L53/02 ,  F16L11/06 ,  F16L11/12 ,  F16L11/04 ,  F16L11/20

CPC分类号： B32B1/08 ,  A61L29/126 ,  A61L31/129 ,  A61M25/0045 ,  B32B27/08 ,  B32B27/28 ,  B32B27/302 ,  B32B27/32 ,  B32B2037/1215 ,  B32B2323/10 ,  B32B2535/00 ,  C08C19/02 ,  C08L9/00 ,  C08L15/00 ,  C08L23/10 ,  C08L23/12 ,  C08L53/00 ,  C08L53/025 ,  F16L11/06 ,  F16L11/12 ,  Y10T428/139 ,  Y10T428/1393 ,  C08L2666/24 ,  C08L2666/02 ,  C08L2666/04

摘要： A multi-layered tube composed of at least two layers, each formed from a different resin, e.g. resin (I) or resin (II). Resin (I) contains 5 to 40 mass % of a polypropylene resin and 95 to 60 mass % of at least one hydrogenated copolymer. Resin (II) contains 45 to 100 mass % of a polypropylene resin and 55 to 0 mass % of a hydrogenated copolymer. The multi-layered tubes may be used in the field of medicine and provide tubing which is excellent in transparency, flexibility and anti-kinking properties, and which is durable during sterilization procedures with high-pressure steam. The multilayer tubing may also be safely disposed of as it generates no toxic gases, such as dioxin, when incinerated. The multilayered tubing has excellent connectability and may be bonded to other tubing using hot solvent bonding or solvent adhesion. The multilayered tubing which is free from generation of any toxic gas when incinerated, and which is excellent in hot solvent bonding or solvent adhesion to other tube.

摘要翻译： 由至少两层构成的多层管，每层由不同的树脂形成。 树脂（I）或树脂（II）。 树脂（I）含有5〜40质量％的聚丙烯树脂和95〜60质量％的至少一种氢化共聚物。 树脂（II）含有45〜100质量％的聚丙烯树脂和55〜0质量％的氢化共聚物。 多层管可用于医药领域，并提供透明性，柔韧性和抗扭结性优异的管，并且在用高压蒸汽灭菌过程中是耐用的。 当焚烧时，多层管也可以安全地处理，因为它不产生有毒气体，例如二恶英。 多层管具有优异的连接性，并且可以使用热溶剂粘合或溶剂粘合将其粘合到其它管上。 焚烧时不产生任何有毒气体的多层管，其热溶剂粘合性优异，与其他管的溶剂粘合性优异。

公开(公告)号：US4595021A

公开(公告)日：1986-06-17

申请号：US741036

申请日：1985-06-04

申请人： Atsushi Shimizu ,  Toshiji Ichikawa

发明人： Atsushi Shimizu ,  Toshiji Ichikawa

IPC分类号： A61B5/15 ,  A61B5/153 ,  A61B5/14

CPC分类号： A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/150259

摘要： A blood collector includes a cylindrical body having a closed end and an open end, and a hollow body is arranged coaxially at the closed end of the cylindrical body and has a hole communicating with the interior of the cylindrical body. A columnar body is arranged within the cylindrical body to be in tight contact with an inner wall thereof, with a distal end defining a blood collection space with the closed end of the cylindrical body. Further, the columnar body has a hole which allows the blood collection space to communicate with the outside. A freeze-dried blood anticoagulant mass is placed inside the blood collection space to cover an inner surface of the closed end of the cylindrical body and to block the hole of the hollow body. A filter is arranged across the hole of the columnar body. The filter is permeable to gases and impermeable to blood at least before being brought into contact with blood in the collection space.

摘要翻译： 血液收集器包括具有封闭端和开口端的筒状体，中空体同轴地配置在筒状体的封闭端部并具有与筒体内部连通的孔。 柱状体设置在圆柱体内以与其内壁紧密接触，其远端限定具有圆柱体的封闭端的血液收集空间。 此外，柱状体具有允许采血空间与外部连通的孔。 冷冻干燥的血液抗凝剂块放置在采血空间内以覆盖圆柱体的封闭端的内表面并阻塞中空体的孔。 过滤器布置在柱状体的孔的两端。 至少在与收集空间中的血液接触之前，过滤器对气体是可渗透的，并且不透血。

公开(公告)号：US4560720A

公开(公告)日：1985-12-24

申请号：US542355

申请日：1983-10-17

申请人： Juuro Aoyagi ,  Toshiji Ichikawa ,  Mikio Koide ,  Takeshi Shimomura

发明人： Juuro Aoyagi ,  Toshiji Ichikawa ,  Mikio Koide ,  Takeshi Shimomura

IPC分类号： A61L29/00 ,  A61J1/00 ,  A61J1/05 ,  C08K5/12 ,  C08K5/375 ,  C08K5/41 ,  C08K5/10

CPC分类号： A61J1/10 ,  C08K5/12 ,  C08K5/375 ,  C08K5/41

摘要： Medical articles made of a resin composition comprising a polyvinyl chloride and a tetracarboxylic tetraester are provided. As examples of the tetracarboxylic tetraester are mentioned tetra(2-ethylhexyl) 3,3',4,4'-biphenylethertetracarboxylate, tetra(2-ethylhexyl) 3,3',4,4'-biphenylmethanetetracarboxylate, tetra(n-dodecyl) 2,3,3',4'-biphenyl-1,1-ethanetetracarboxylate, tetra(2-ethylhexyl) 3,3',4,4'-biphenyl-2,2-propanetetracarboxylate and the like. The tetracarboxylic tetraester is incorporated in an amount from 20 to 120, preferably from 30 to 100 parts by weight per 100 parts by weight of the polyvinyl chloride. As dissolution and migration to the surface of the article of the plasticizer tetracarboxylic tetraester are low in the medical articles, said medical articles produce no adverse effects upon body fluids such as blood when contacted. Examples of preferred medical articles are blood preservation vessels, catheters and blood transfusion sets.

摘要翻译： 提供由包含聚氯乙烯和四羧酸四酯的树脂组合物制成的医疗制品。 提到四羧酸四酯的四（2-乙基己基）3,3'，4,4'-联苯基醚四羧酸四（2-乙基己基）3,3'，4,4'-联苯甲烷四羧酸四（正十二烷基）酯， 2,3,3'，4'-联苯-1,1-乙烷四羧酸酯，3,3'，4,4'-联苯基-2,2-丙烷四羧酸四（2-乙基己基）酯，4,4'-联苯基-2,2-丙烷四羧酸酯等。 四羧酸四酯的含量为每100重量份聚氯乙烯20至120重量份，优选30至100重量份。 由于溶解和向塑化剂四羧酸四酯的制品的表面迁移到医疗制品中，所以医疗制品在接触时不会对体液如血液产生不利影响。 优选医疗制品的实例是保血管，导管和输血组。

公开(公告)号：US4507415A

公开(公告)日：1985-03-26

申请号：US478073

申请日：1983-03-23

申请人： Masaaki Kasai ,  Toshiji Ichikawa ,  Kimiho Kosegaki

发明人： Masaaki Kasai ,  Toshiji Ichikawa ,  Kimiho Kosegaki

IPC分类号： A61L2/08 ,  C08K5/13 ,  C08K5/3415 ,  C08K5/3435 ,  C08K5/3477 ,  C08K5/526 ,  C08K5/34

CPC分类号： C08K5/3477 ,  A61L2/08 ,  C08K5/13 ,  C08K5/3415 ,  C08K5/3435 ,  C08K5/526

摘要： Irradiation-sterilizable medical articles molded from a propylene polymer composition in which stabilizers are incorporated. Said composition comprises from 0.01 to 0.4 part by weight of each of a specific hindered amine and a specific phenol or its phosphite ester compound incorporated per 100 parts by weight of a propylene polymer with a weight-average molecular-weight to number-average molecular-weight ratio of 5 or below. The above-mentioned composition may additionally contain a sorbitol derivative as the nucleating agent. Medical articles produced from said composition by molding, for example, syringes are suitable for irradiation sterilization. Said medical articles when irradiated undergo little reduction in quality of the material and are accompanied by little bleeding or degradation of the incorporated stabilizers and nucleating agent.

摘要翻译： 由其中加入稳定剂的丙烯聚合物组合物模塑的可辐照消毒的医疗制品。 所述组合物包含0.01至0.4重量份的特定受阻胺和每100重量份具有重均分子量至数均分子量的丙烯聚合物的特定苯酚或其亚磷酸酯化合物， 重量比在5以下。 上述组合物可另外含有山梨糖醇衍生物作为成核剂。 通过成型例如注射器由所述组合物制备的医疗制品适用于照射灭菌。 所述医疗制品在照射时几乎不会降低材料的质量，并伴随着引入的稳定剂和成核剂的少量渗色或降解。

公开(公告)号：US4770779A

公开(公告)日：1988-09-13

申请号：US70673

申请日：1987-07-01

申请人： Toshiji Ichikawa ,  Teruko Watanabe ,  Yoshimitsu Asada

发明人： Toshiji Ichikawa ,  Teruko Watanabe ,  Yoshimitsu Asada

IPC分类号： B01D21/26 ,  B01D43/00 ,  B01L3/14 ,  G01N20060101 ,  G01N33/49 ,  C09K3/00

CPC分类号： B01D43/00 ,  B01L3/50215 ,  G01N33/491 ,  Y10T436/25375 ,  Y10T436/255

摘要： An apparatus for separating blood is provided with a closed end and a thixotropic gel-like sealant with a specific gravity intermediate between the gravities of serum and clot phases. A cavity is formed on the upper surface of said sealant. The sealant consists essentially of an .alpha.-olefin-dimaleate copolymer having a viscosity from 10,000 to 120,000 c.p. (25.degree. C.), to which a viscosity-specific gravity adjusting agent is added to adjust the specific gravity to 1.035-1.055. The cavity is formed in such a size that diameter of the upper surface is from 0.15 to 0.7 times the inner diameter of the apparatus and its depth is from 0.13 to 0.65 times the thickness of said sealant.

摘要翻译： 具有分离血液的装置设置有封闭端和触变性凝胶状密封剂，比重介于血清重量和凝块相之间。 在所述密封剂的上表面上形成空腔。 密封剂基本上由一种粘度为10,000至120,000厘泊的α-烯烃 - 二马来酸共聚物组成。 （25℃），向其中加入粘度比重调节剂以将比重调节至1.035-1.055。 空腔形成为这样的尺寸，使得上表面的直径为设备内径的0.15至0.7倍，其深度为所述密封剂的厚度的0.13至0.65倍。

公开(公告)号：US4177182A

公开(公告)日：1979-12-04

申请号：US615978

申请日：1975-09-23

申请人： Toshiji Ichikawa ,  Osamu Minoo

发明人： Toshiji Ichikawa ,  Osamu Minoo

IPC分类号： A61J1/00 ,  A61J1/05 ,  A61L29/04 ,  A61L33/00 ,  C08L27/06 ,  C08L83/04 ,  C08J3/00

CPC分类号： A61L33/0052 ,  A61L29/049 ,  C08L27/06 ,  A61J1/10 ,  C08L83/04

摘要： Polyvinyl chloride series resin compositions comprising 100 parts by weight of polyvinyl chloride series resin, 20 to 80 parts by weight of a plasticizer and 0.2 to 7 parts by weight of silicone oil, which minimize the elution of the plasticizer, and a method of manufacturing polyvinyl chloride series resin compositions which is characterized by emulsifying said silicone oil in advance with part of said plasticizer and adding an emulsion thus formed to said resin compositions.

摘要翻译： 包含100重量份聚氯乙烯系树脂，20-80重量份增塑剂和0.2-7重量份硅油的聚氯乙烯系树脂组合物，其使增塑剂的洗脱最小化，以及制造聚乙烯 氯化物系列树脂组合物，其特征在于预先用部分所述增塑剂乳化所述硅油，并将如此形成的乳液加入到所述树脂组合物中。

公开(公告)号：US4774963A

公开(公告)日：1988-10-04

申请号：US888091

申请日：1986-07-17

申请人： Toshiji Ichikawa ,  Atsushi Shimizu

发明人： Toshiji Ichikawa ,  Atsushi Shimizu

IPC分类号： A61B5/153 ,  A61B5/15 ,  A61M5/178 ,  A61B5/14

CPC分类号： A61B5/1535 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150732

摘要： A blood collector comprising a collection container in the form of a tube having a forward end adapted for drawing of blood into the container and an opened rear end, a closure unit adapted for closing the opened rear end of the collection container, and a mechanism including a valving element for allowing passage of air when blood is flowing into said container and preventing passage of air and blood when said container is filled with blood, said valving element of said mechanism including an air passage and a filter member communicating with the air passage, said filter member comprising water insoluble but water-swellable polymeric material and provided at least at the contact portion of the closure member with collected blood. Air contained in the blood collecting space of the collection container is expelled through the valving element by the collected blood which rises to a desired level for expelling air from said space practically completely. As the blood contacts the water insoluble but water-swellable high polymeric material contained in filter member of the valving element, the material swells into gel body to block the air passage in the valving element connecting to outside of the collector. Thus blood analysis may be effected without influences by outside air and air otherwise contained in the blood collecting space.

公开(公告)号：US4708800A

公开(公告)日：1987-11-24

申请号：US782523

申请日：1985-10-01

申请人： Toshiji Ichikawa ,  Kazuaki Takahara ,  Kazuhiro Shimoda ,  Yukio Seita ,  Makoto Emi

发明人： Toshiji Ichikawa ,  Kazuaki Takahara ,  Kazuhiro Shimoda ,  Yukio Seita ,  Makoto Emi

IPC分类号： A61M1/18 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/26 ,  D01F6/06 ,  B01D47/10 ,  B01D59/10 ,  D02G3/00

CPC分类号： B01D71/26 ,  B01D67/003 ,  B01D69/02 ,  B01D69/08 ,  B01D2325/04 ,  B01D2325/20 ,  Y10T428/2927 ,  Y10T428/2935 ,  Y10T428/2975

摘要： A porous hollow fiber membrane, comprising a polyolefin hollow fiber membrane of an annular cross section of substantial circle 150 to 300 .mu.m in inside diameter and 10 to 150 .mu.m in wall thickness, said hollow fiber membrane forming on the inner wall side thereof a tight layer of intimately bound fine polyolefin particles and on the outer wall side thereof a porous texture of fine polyolefin particles bound in chains and containing fine pores extended continuously form said inner wall side to said outer wall side.

摘要翻译： 一种多孔中空纤维膜，其特征在于，具有内径为150〜300μm，壁厚为10〜150μm的大致圆的环状截面的聚烯烃中空纤维膜，所述中空纤维膜的内壁侧为 紧密结合的细聚烯烃颗粒的紧密层，并且在其外壁侧具有链状结合并且包含从所述内壁侧连续延伸到所述外壁侧的细孔的细聚烯烃颗粒的多孔织构。

公开(公告)号：US4547191A

公开(公告)日：1985-10-15

申请号：US640386

申请日：1984-08-13

申请人： Toshiji Ichikawa ,  Yoshinori Ohhachi ,  Zensho Kanda

发明人： Toshiji Ichikawa ,  Yoshinori Ohhachi ,  Zensho Kanda

IPC分类号： A61M5/168 ,  A61L29/00 ,  A61M1/36 ,  A61M5/14 ,  A61M5/16

CPC分类号： A61M5/14

摘要： A medical solution transfusion circuit has a transparent cylindrical pumping body, a hard cap mounted on at least one end of said transparent cylindrical pumping body, and a flexible tube for communicating with said transparent cylindrical pumping body to transport a medical solution. The transparent cylindrical pumping body comprises a propylene/.alpha.-olefin copolymer.

摘要翻译： 医疗解决方案输液回路具有透明圆柱形泵送体，安装在所述透明圆柱形抽吸体的至少一端的硬帽，以及用于与所述透明圆柱形抽吸体连通以运输医用溶液的柔性管。 透明圆柱形泵送体包括丙烯/α-烯烃共聚物。