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149 条记录 (耗时 0.038 秒)

    Process for refolding recombinantly produced TGF-.beta.-like proteins
    1.
    发明授权
    Process for refolding recombinantly produced TGF-.beta.-like proteins 失效
    重组重组产生的TGF-β样蛋白的方法

    公开(公告)号：US5650494A

    公开(公告)日：1997-07-22

    申请号：US486057

    申请日：1995-06-07

    申请人： Nico Cerletti ,  Gary Kent McMaster ,  David Cox ,  Albert Schmitz ,  Bernd Meyhack

    发明人： Nico Cerletti ,  Gary Kent McMaster ,  David Cox ,  Albert Schmitz ,  Bernd Meyhack

    IPC分类号： C12P21/02 ,  A61K38/00 ,  A61K38/18 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/06 ,  A61P43/00 ,  C07K1/113 ,  C07K1/20 ,  C07K1/36 ,  C07K14/00 ,  C07K14/495 ,  C07K14/51 ,  C07K14/52 ,  C12N15/09 ,  C12N15/16 ,  C12R1/19 ,  C12R1/865 ,  C07K1/14 ,  C12P21/04

    CPC分类号： C07K1/1136 ,  A61K38/1841 ,  C07K1/1133 ,  C07K14/495

    摘要： The process for the production of a dimeric, biologically active Transforming Growth Factor type .beta. (TGF-.beta.)-like protein or a salt thereof, comprising refolding the denatured monomeric form of the protein in the presence of a mild detergent that permits folding of the monomeric protein into a spatial conformation, which after dimerization, is the conformation associated with the biological activity, while retaining the monomeric protein in soluble form. Mild detergents include sulfobetaines, 3-(3-chlolamidopropyl)dimethylammonio-1-propanesulfonate, 3-(3-chlolamidopropyl)dimethylammonio-2-hydroxy-1-propane-sulfonate, digitonin, cholate and deoxycholate at a concentration of about 1 to 100 mM. Compositions containing a TGF-.beta.-like protein produced according the invention can be used for the promotion and acceleration of wound healing and bone and tissue repair, cancer treatment, bone marrow protective agent, as a mediator of cardio-protection, as an anti-inflammatory or immunosuppressive agent, or as a growth regulator in mammalian cell cultures.

    摘要翻译： 用于生产二聚体，生物活性的转化生长因子β（TGF-β）样蛋白或其盐的方法，包括在温和洗涤剂存在下重折叠变性单体形式的蛋白质，其允许折叠 单体蛋白转化为空间构象，其在二聚后是与生物活性相关的构象，同时保留单体蛋白质的可溶形式。 轻度洗涤剂包括浓度为约1至100的磺基甜菜碱，3-（3-氯丙酰氨基丙基）二甲基氨基-1-丙磺酸盐，3-（3-氯丙酰胺丙基）二甲基铵-2-羟基-1-丙磺酸盐，赤藓糖醇，胆酸和脱氧胆酸盐 mM。 含有根据本发明生产的TGF-β样蛋白质的组合物可用于促进和加速伤口愈合和骨组织修复，癌症治疗，骨髓保护剂作为心脏保护的介质，作为抗 - 炎症或免疫抑制剂，或作为哺乳动物细胞培养物中的生长调节剂。

    Fastener
    3.
    发明授权
    Fastener 有权

    公开(公告)号：US11466795B2

    公开(公告)日：2022-10-11

    申请号：US17248790

    申请日：2021-02-08

    申请人： David Cox

    发明人： David Cox

    IPC分类号： F16L3/04 ,  F16B15/00

    摘要： A fastener for fastening pipes or electrical conduit can be installed with the optional use of nails or screws. The fastener includes sharp teeth or spikes which can be hammered into an external surface, such as wood or masonry. The teeth or spikes are positioned, oriented, and otherwise configured to best suit the intended application. Installation can be accomplished using only the fastener itself and force exceeding a minimal threshold.

    Internal combustion engines
    8.
    发明授权
    Internal combustion engines 有权
    内燃机

    公开(公告)号：US08499726B2

    公开(公告)日：2013-08-06

    申请号：US12663519

    申请日：2008-05-28

    申请人： David Cox

    发明人： David Cox

    IPC分类号： F01B7/12 ,  F02B25/08 ,  F02B75/28

    CPC分类号： F01B9/023 ,  F01B1/08 ,  F01B7/04 ,  F01B7/10 ,  F02B25/08 ,  F02B75/24 ,  F02B75/28 ,  F02B2075/025 ,  F02B2075/1808 ,  F02B2275/40 ,  F02F1/22 ,  F02F3/0015 ,  Y02T10/125

    摘要： The invention provides a 2-stroke internal combustion engine comprising two opposed cylinders, each cylinder housing two opposed pistons and having at least one exhaust port and at least one intake port, and a crankshaft having asymmetrically arranged journals and scotch-yoke mechanisms for driving the journals from the pistons. The pistons in each cylinder operate to open its exhaust port or ports before its intake port or ports and to close its exhaust port or ports before its intake port or ports.

    摘要翻译： 本发明提供一种二冲程内燃机，其包括两个相对的气缸，每个气缸容纳两个相对的活塞并且具有至少一个排气口和至少一个进气口，以及具有不对称排列的轴颈和用于驱动 来自活塞的期刊。 每个气缸中的活塞在其进气口或端口之前操作以打开其排气端口，并在其进气口或端口之前关闭其排气口或端口。

    METHOD AND SYSTEM FOR AUTHORIZATION OF PRESENCE INFORMATION
    9.
    发明申请
    METHOD AND SYSTEM FOR AUTHORIZATION OF PRESENCE INFORMATION 有权
    用于授权存在信息的方法和系统

    公开(公告)号：US20120304252A1

    公开(公告)日：2012-11-29

    申请号：US13574696

    申请日：2010-01-27

    申请人： Christer Boberg ,  Mikael Klein ,  Anders Lindgren ,  Sofie Lassborn ,  David Cox

    发明人： Christer Boberg ,  Mikael Klein ,  Anders Lindgren ,  Sofie Lassborn ,  David Cox

    IPC分类号： G06F21/00

    CPC分类号： H04L67/24 ,  H04L63/105

    摘要： Embodiments of the present invention include a system and method for implementing a presence system. According to an embodiment of the present invention, responsive to receiving a request for presence information associated with a presentity from a watcher, the presence system receives instructions indicating that an authorization instance other than the presentity shall be given an opportunity to change or verify an authorization rule associated with the request for presence information. As a consequence, the presence system notifies the authorization instance of the request for presence information, thereby enabling the authorization instance to change or verify the authorization rule. The presence system also makes a final decision on the authorization rule on the basis of the instructions and a notification indicating a change or verification of the authorization rule.

    摘要翻译： 本发明的实施例包括用于实现存在系统的系统和方法。 根据本发明的实施例，响应于从观察者接收到与呈现体相关联的存在信息的请求，存在系统接收指示，指示除了呈现体之外的授权实例有机会改变或验证授权 与存在信息请求相关联的规则。 因此，存在系统通知授权实例对存在信息的请求，从而使授权实例能够改变或验证授权规则。 存在系统还根据指令和指示更改或验证授权规则的通知对授权规则作出最终决定。

    INTERVERTEBRAL DISC ACCESS ASSEMBLY
    10.
    发明申请
    INTERVERTEBRAL DISC ACCESS ASSEMBLY 审中-公开

    公开(公告)号：US20100114110A1

    公开(公告)日：2010-05-06

    申请号：US12261142

    申请日：2008-10-30

    申请人： Richard J. Taft ,  Robert Nucci ,  George Morrison ,  David Cox

    发明人： Richard J. Taft ,  Robert Nucci ,  George Morrison ,  David Cox

    IPC分类号： A61F11/00 ,  A61B18/14 ,  A61M5/24

    CPC分类号： A61B17/025 ,  A61B17/3421 ,  A61B17/3494 ,  A61B18/1482 ,  A61B90/11 ,  A61B90/39 ,  A61B2017/00261 ,  A61B2017/0256 ,  A61B2017/347 ,  A61B2090/034 ,  A61B2090/376

    摘要： A surgical access system for managing the minimally invasive access of treatment electrodes to an intervertebral disc, when treating spine abnormalities such as disc herniations. The system includes an access port and a cannula assembly. The access port provides atraumatic access to the target area for the cannula system and a subsequent treatment electrode. The access port also manages the insertion travel and penetration depth of the cannula assembly, so as to minimize unintended damage to local tissue during use. The cannula system includes an adjustable and removable stop to mate with the access port that limits the extension of the cannula beyond the distal tip of the access port and into the target tissue.

    摘要翻译： 一种手术进入系统，用于在治疗椎间盘异常（如椎间盘突出）时，将治疗电极的微创入路管理到椎间盘。 该系统包括进入口和插管组件。 进入端口提供对插管系统的目标区域的无创访问和随后的治疗电极。 进出口还管理插管组件的插入行程和穿透深度，以便在使用期间最小化对局部组织的意外伤害。 插管系统包括可调节和可移除的止动件，以与入口端口配合，限制套管延伸超出进入端口的远端并进入目标组织。