摘要:
A method for producing a capillary bead array comprises the steps of: dispensing beads into a liquid pool, outside a capillary, having a depth of almost the same length as the particle diameter of a bead; leveling the excessive beads by moving a leveling member which is in contact with and relatively capable of be moved to the liquid pool to remove excessive beads that the liquid pool cannot contain; aligning the beads in the liquid pool one- or two-dimensionally; bonding adjacent individual beads to each other; producing a structure having the plurality of beads bonded and aligned one- or two-dimensionally; removing the structure from the liquid pool; and disposing the structure in the capillary formed of soft resin, so that the beads comprising the plurality of beads retaining the one- or two-dimensional alignment can be introduced simultaneously into the capillary. This method reduces the time and cost necessary for bead array production and retains the bead alignment in the capillary, resulting in improved accuracy and reliability in experiments using the capillary array.
摘要:
A test chip, which allows a number of solution delivery steps much faster and accurate is provided. The test chip incorporates a sample flow path for containing a sample solution, a reaction flow path for inducing a predetermined reaction with the sample solution, a waste drain path for receiving the used sample, and the washing solution flow paths for containing washing solutions. The reaction flow path contains a plurality of beads having probes of mutually different types fixed thereon. The sample flow path, washing solution flow paths, and sample waste drain path have their respective solution detector units. The solution detector unit detects whether the solution is fed to the path. The detector units adjoiningly provided in the adjacent paths are arranged collinearly.
摘要:
A method for producing a capillary bead array comprises the steps of: dispensing beads into a liquid pool, outside a capillary, having a depth of almost the same length as the particle diameter of a bead; leveling the excessive beads by moving a leveling member which is in contact with and relatively capable of be moved to the liquid pool to remove excessive beads that the liquid pool cannot contain; aligning the beads in the liquid pool one- or two-dimensionally; bonding adjacent individual beads to each other; producing a structure having the plurality of beads bonded and aligned one- or two-dimensionally; removing the structure from the liquid pool; and disposing the structure in the capillary formed of soft resin, so that the beads comprising the plurality of beads retaining the one- or two-dimensional alignment can be introduced simultaneously into the capillary. This method reduces the time and cost necessary for bead array production and retains the bead alignment in the capillary, resulting in improved accuracy and reliability in experiments using the capillary array.
摘要:
There is provided an inspection chip capable of performing a number of solution feeding processes promptly and accurately. The inspection chip has one continuous flow path comprising a reaction flow path for accommodating a plurality of beads with immobilized probes of types different each other, a first and second solution holding flow path for holding a plurality of solutions each separated by an air gap. The solution is moved from one solution holding flow path to other solution holding flow path via a reaction flow path by utilizing pressure difference.
摘要:
An apparatus and a method for arraying beads that allow a bead array having been difficult in mass production to be manufactured easily and accurately are provided. Beads are once arrayed in a separate container using an inclined bead array apparatus while controlling the number of beads to be inserted simply by the use of a bead control rod. When the whole arraying is completed, the arrayed beads are transferred onto a plate for use in an actual reaction.
摘要:
The present invention enables the accurate management of the total number of spotting counts for each spotting pin. An IC chip is installed on the spotting pin to allow the IC chip to accumulate spotting-count information, and during each spotting time the information is loaded up and displayed.
摘要:
A slide mechanism for a shutter, installed on a cartridge case of a disk cartridge, which is slidable in both right and left directions relative to the cartridge case from a neutral position at which a head access opening is closed by the shutter, and which is constituted by a smaller number of components and easy to assemble. The case has a groove which forms between a pair of counterparts forming the case itself; the shutter is biased toward a neutral position at which the shutter closes the head access opening; and the shutter has a projecting part which slidably engages the groove. The shutter is divided by a connecting portion of the upper wall side shutter plate and the lower wall side shutter plate, and the shutter is fixed together after the shutter plates are assembled to the cartridge case.
摘要:
An improved feedforward amplifier capable of enhancing accuracy of extraction of an error signal corresponding to a distortion component while preventing outflow of an pilot signal. A switch is disposed between a pilot signal oscillator and a third power combiner for superimposing the pilot signal on an output signal from a main amplifier, and third control means is connected with the switch so that the switch is opened at the time of error signal extraction and closed at the time of error signal elimination.
摘要:
The present invention is directed to provide a preparation chip system having a simpler configuration and improved reliability while addressing the case where a plurality of reagents have to be fed as in a preparation of extracting DNA from a sample solution. The preparation chip system includes a sample chamber, a dissolving solution chamber, a cleaning solution chamber, an eluting solution chamber, a mixing passage connected to the sample chamber and the dissolving solution chamber and mixing the sample and the dissolving solution with each other, a carrier part connected to the mixing passage, a waste chamber connected to the carrier part via a holding passage, a collection chamber holding the eluting solution passed through the carrier part, and a plurality of resistive materials forming a passage resistor disposed in a first passage connecting the cleaning solution chamber with both the mixing passage and the carrier part. The eluting solution is passed through the carrier part by pressure from a pressure source.
摘要:
Within an inside of a bead chip forming a reactor flow pass therein, rinsing liquid flow passes are also provided in one body. For the purpose of promoting reaction upon a bead array, a turbulence generator or an flow separation stop guide is provided within the reactor flow pass, in which the beads are received. The bead chip is made of a PDMS (Polydimethylsiloxane: (C2H6SiO)n), thereby enabling the reactor flow pass and the rinsing liquid flow passes to be formed freely in the configurations thereof.
摘要翻译:在形成反应器流动通道的珠粒的内部,冲洗液体流动通道也设置在一体中。 为了促进珠粒阵列上的反应,在反应器流动通道内提供湍流发生器或流动分离停止引导件,其中容纳珠子。 珠芯片由PDMS(聚二甲基硅氧烷:(C 2 H 6 SiO)SiO)N)制成,从而使反应器流过, 冲洗液流在其结构中自由形成。