公开(公告)号：US06759060B2

公开(公告)日：2004-07-06

申请号：US09112367

申请日：1998-07-09

Applicant: Daniel Samain ,  Igancio De Miguel ,  Frédérique N'guyen ,  Pascal Delrieu ,  Li Ding ,  Nadine Candelotto ,  Corinne Segreto ,  Didier Betbeder ,  Roger Kravtzoff ,  Michel Major

Inventor： Daniel Samain ,  Igancio De Miguel ,  Frédérique N'guyen ,  Pascal Delrieu ,  Li Ding ,  Nadine Candelotto ,  Corinne Segreto ,  Didier Betbeder ,  Roger Kravtzoff ,  Michel Major

IPC: A61K916

CPC classification number: A61K9/5123 ,  A23L27/70 ,  A23L27/72 ,  A61K8/11 ,  A61K8/14 ,  A61K8/66 ,  A61K8/97 ,  A61K9/1652 ,  A61K9/5015 ,  A61K9/5161 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/951 ,  Y10S514/952 ,  Y10T428/2991

Abstract: A synthetic particulate vector comprising a non-liquid hydrophilic nucleus which does not have an external lipid layer grafted thereon. A method for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtainable through said method, and pharmaceutical, cosmetological or food compositions containing such vectors are also disclosed.

Abstract translation: 包含不具有接枝在其上的外部脂质层的非液体亲水核的合成颗粒载体。 还公开了通过包封可电离活性成分制备颗粒载体的方法，通过所述方法可获得的载体和含有这些载体的药物，美容组合物或食物组合物的方法。

公开(公告)号：US5736371A

公开(公告)日：1998-04-07

申请号：US243079

申请日：1994-05-16

Applicant: Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

Inventor： Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

IPC: A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  C12N11/12 ,  A61K38/43 ,  C07K17/12 ,  C12N11/10

CPC classification number: A61K9/5161 ,  A61K9/127 ,  A61K9/167 ,  A61K9/5192 ,  Y10S530/813 ,  Y10S530/814

Abstract: A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus for containing a biologically active molecule, a first layer of fatty acid compounds covalently bonded to the nucleus and a second layer of phospholipids hydrophobically bonded to the first layer. The nucleus is between 10 nm and 10 .mu.m in size and is formed of a cross-linked polysaccharide or oligosaccharide matrix onto which ionic ligands are uniformly grafted. The cross-linked polysaccharide may be dextran, cellulose or starch cross-linked with epichlorohydrin. The ligand may be an acidic compound selected from succinic acid, phosphoric acid, citric acid, glycine, alanine, glutamic acid and aspartic acid, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino)ethylamine fastened onto the matrix via the acidic compound. The polysaccharide or oligosaccharide may be co-cross-linked with a protein such as keratin/collagen or elastase. The vector may be prepared by reacting succinic acid monochloride in aqueous solution with a cross-linked polysaccharide or oligosaccharide matrix to graft succinic acid onto the matrix to form the nucleus, grinding the nucleus to a size between 10 nm and 10 .mu.m, drying the ground nucleus, coupling fatty acid compounds to the nucleus to form a first layer and hydrophobically bonding phospholipids to the first layer to form a second layer. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

Abstract translation: 制备用于输送生物活性分子的可生物降解的颗粒载体，其包含含有生物活性分子的核，与核共价键合的第一层脂肪酸化合物和与第一层疏水结合的第二层磷脂。 核的尺寸在10nm和10μm之间，并且由交联的多糖或寡糖基质形成，其上离子配体被均匀地接枝到其上。 交联多糖可以是与表氯醇交联的葡聚糖，纤维素或淀粉。 配体可以是选自琥珀酸，磷酸，柠檬酸，甘氨酸，丙氨酸，谷氨酸和天冬氨酸的酸性化合物，或碱性化合物如胆碱，羟基胆碱，2-（二甲基氨基）乙醇或2-（二甲基氨基） 乙胺通过酸性化合物固定在基质上。 多糖或寡糖可以与蛋白质如角蛋白/胶原或弹性蛋白酶共交联。 载体可以通过使琥珀酸一氯化物在水溶液中与交联的多糖或寡糖基质反应来将琥珀酸接枝到基质上以形成核，将细胞核研磨至10nm至10μm的大小，干燥 研磨核，将脂肪酸化合物偶联到细胞核上形成第一层，并将磷脂与第一层疏水结合形成第二层。 琥珀酸一氯化物优选通过琥珀酸二氯化物与游离琥珀酸反应形成纯结晶琥珀酸一氯化物来制备。

公开(公告)号：US6013284A

公开(公告)日：2000-01-11

申请号：US513853

申请日：1996-05-01

Applicant: Daniel Samain ,  Pascal Delrieu ,  Joelle Gibilaro ,  Roselyne Dirson ,  Monique Cervilla ,  Ignacio De Miguel ,  Li Ding ,  Frederique Nguyen ,  Nadine Soulet ,  Corinne Soler

Inventor： Daniel Samain ,  Pascal Delrieu ,  Joelle Gibilaro ,  Roselyne Dirson ,  Monique Cervilla ,  Ignacio De Miguel ,  Li Ding ,  Frederique Nguyen ,  Nadine Soulet ,  Corinne Soler

IPC: A23L27/00 ,  A61K8/00 ,  A61K8/11 ,  A61K8/14 ,  A61K8/36 ,  A61K8/42 ,  A61K8/64 ,  A61K8/66 ,  A61K8/68 ,  A61K8/73 ,  A61K8/92 ,  A61K8/97 ,  A61K8/99 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61Q19/00 ,  A61Q90/00

CPC classification number: A61K9/5123 ,  A23L27/70 ,  A23L27/72 ,  A61K8/11 ,  A61K8/14 ,  A61K8/66 ,  A61K8/97 ,  A61K9/1652 ,  A61K9/5015 ,  A61K9/5161 ,  A61Q19/00 ,  B82Y5/00 ,  A61K2800/412 ,  A61K2800/413 ,  Y10S514/951 ,  Y10S514/952 ,  Y10T428/2991

Abstract: A synthetic particulate vector comprising a non-liquid hydrophilic nucleus and an outer layer at least partially consisting of amphiphilic compounds, which is combined with the nucleus by hydrophobic interactions and/or ionic bonds. A process for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtained according to such a process, and pharmaceutical, cosmeticological and food compositions comprising such vectors are also disclosed.

Abstract translation: PCT No.PCT / FR94 / 00228 Sec。 371日期：1996年5月1日 102（e）日期1996年5月1日PCT 1994年3月1日PCT公布。 WO94 / 20078 PCT公开号 日期1994年9月15日一种包含非液体亲水核和至少部分由两亲化合物组成的外层的合成颗粒载体，其通过疏水相互作用和/或离子键与核结合。 还公开了通过包封可离子化活性成分，根据这种方法获得的载体以及包含这种载体的药物，美容和食用组合物来制备颗粒载体的方法。

公开(公告)号：US5961990A

公开(公告)日：1999-10-05

申请号：US850167

申请日：1997-05-02

Applicant: Pascal Delrieu ,  Li Ding

Inventor： Pascal Delrieu ,  Li Ding

IPC: A61K8/02 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/29 ,  A61K8/33 ,  A61K8/36 ,  A61K8/49 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/73 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61K9/14

CPC classification number: A61K8/042 ,  A61K8/0287 ,  A61K8/73 ,  A61K8/737 ,  A61Q17/04 ,  A61Q19/00 ,  A61K2800/56 ,  A61K2800/654 ,  Y10S514/937 ,  Y10S514/944

Abstract: A protective cosmetic particulate gel delivery system for a topically applied active agent employs an agar gel and a restraining polymer to retain the actve agent in the gel. The particles have an average particle diameter of at least 0.05 mm while the restraining polymer has a molecular weight of at least 50,000 daltons and has retention groups to bind the active agent. The restraining polymers can be selected from the group consisting of polyquaternium 24, laurdimonium hydroxyethylcellulose, cocodimonium hydroxyethylcellulose, steardimonium hydroxyethylcellulose, quaternary ammonium substituted water-soluble polysaccharides, alleyl quaternary celluloses and polypeptides having or provided with retention groups to retain the active agent. The gel particles of the invention are manually crushable on the skin to increase the surface area of the gel particle material and expose the restraining polymer to the skin or other body surface for release of the active agent. The delivery system can be incorporated in multiphase cosmetic formulations such as gels, creams and lotions.

Abstract translation: 用于局部施用的活性剂的保护性化妆品颗粒状凝胶递送系统使用琼脂凝胶和约束聚合物将活性剂保留在凝胶中。 颗粒的平均粒径至少为0.05mm，而抑制聚合物的分子量至少为50,000道尔顿，并具有结合活性剂的保留基团。 约束聚合物可以选自聚季铵盐24，月桂基二甲基羟乙基纤维素，椰子二甲基羟乙基纤维素，聚对苯二甲酸羟乙基纤维素，季铵取代的水溶性多糖，等位基季铵纤维素和具有或具有保留活性剂的保留基团的多肽。 本发明的凝胶颗粒可手动压碎在皮肤上以增加凝胶颗粒材料的表面积，并将约束聚合物暴露于皮肤或其他身体表面以释放活性剂。 递送系统可以并入多相化妆品配方如凝胶，乳膏和洗剂中。

公开(公告)号：US5968794A

公开(公告)日：1999-10-19

申请号：US12645

申请日：1998-01-23

Applicant: Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

Inventor： Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

IPC: A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  C12N11/12 ,  A61K38/43 ,  C07H1/02 ,  C07K1/04

CPC classification number: A61K9/5161 ,  A61K9/127 ,  A61K9/167 ,  A61K9/5192 ,  Y10S530/813 ,  Y10S530/814

Abstract: A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus formed of a cross-linked polysaccharide or oligosaccharide matrix having grafted ionic ligands, a layer of fatty acid compounds covalently bonded to the nucleus and a layer of phospholipids hydrophobically bonded to the layer of fatty acid compounds. Dextran, cellulose or starch may be cross-linked with epichlorohydrin to form a cross-linked polysaccharide matrix. Ionic ligands may be grafted using an acidic compound such as succinic acid, phosphoric acid or phosphorous oxychloride, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino) ethylamine fastened onto the grafted acidic compound. Phosphoric acid or phosphorous oxychloride in one step provide both cross-linking and ionic ligands. Co-cross-linking can be obtained using a protein such as keratin, collagen or elastase. The vector may be prepared by reacting succinic acid monochloride with a cross-linked polysaccharide matrix to graft succinic acid onto the matrix to form the nucleus having ionic ligands, grinding the nucleus to a size between 10 .mu.nm and 10 .mu.m, drying, coupling fatty acid compounds to the nucleus and hydrophobically bonding phospholipids to the fatty acid compounds. After coupling the fatty acid compounds and before bonding the phospholipids, a molecule having biological activity may be added. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

Abstract translation: 制备用于输送生物活性分子的可生物降解的颗粒载体，其含有由具有接枝离子配体的交联多糖或寡糖基质形成的核，与核共价键合的脂肪酸化合物层和与层疏水结合的磷脂层 的脂肪酸化合物。 葡聚糖，纤维素或淀粉可以与表氯醇交联以形成交联的多糖基质。 离子配体可以使用酸性化合物如琥珀酸，磷酸或三氯氧磷，或碱性化合物如胆碱，羟基胆碱，2-（二甲基氨基）乙醇或2-（二甲基氨基）乙胺接枝在接枝的酸性化合物上。 磷酸或磷酰氯在一个步骤中提供交联和离子配体。 可以使用蛋白质如角蛋白，胶原或弹性蛋白酶获得共交联。 载体可以通过使琥珀酸一氯化物与交联的多糖基质反应来制备，以将琥珀酸接枝到基质上以形成具有离子配体的核，将细胞核研磨至10μm至10μm之间的大小，干燥，偶联 脂肪酸化合物到细胞核并将磷脂疏水性结合到脂肪酸化合物上。 偶联脂肪酸化合物之后，在磷脂结合之前，可以加入具有生物活性的分子。 琥珀酸一氯化物优选通过琥珀酸二氯化物与游离琥珀酸反应形成纯结晶琥珀酸一氯化物来制备。

公开(公告)号：US5962015A

公开(公告)日：1999-10-05

申请号：US850052

申请日：1997-05-02

Applicant: Pascal Delrieu ,  Li Ding

Inventor： Pascal Delrieu ,  Li Ding

IPC: A61K9/127

CPC classification number: A61K9/1273

Abstract: Lecithin-type liposomes are stabilized with quaternized alkyated polymers, such as steardimonium hydroxyethylcellulose, to provide excellent stability for cosmetic and pharmaceutical formulations. Temperature, storage, solvent, and acidity stability are described. The stabilized liposomes can serve as vectors for alpha-hydroxy acids and showed no aggregation even after 4 months of storage at pH 2.

Abstract translation: 卵磷脂型脂质体通过季铵化的烷基化聚合物例如羟乙基纤维素钠稳定化，为化妆品和药物制剂提供优异的稳定性。 描述了温度，储存，溶剂和酸度稳定性。 稳定的脂质体可以用作α-羟基酸的载体，即使在pH 2下储存4个月后也不显示聚集。

公开(公告)号：US20240341483A1

公开(公告)日：2024-10-17

申请号：US18300768

申请日：2023-04-14

Applicant: Li Ding

Inventor： Li Ding

IPC: A47C7/46

CPC classification number: A47C7/462

Abstract: A lumbar pillow that can move with the load bearing of the waist in 3D, comprising the lumbar pillow body, the middle part of the rear end of the lumbar pillow body is provided with a spring central axis mechanism; the spring central axis mechanism comprises the upper bottom plate, the spring and the lower bottom plate, the upper bottom plate is arranged in the middle of the rear end of the lumbar pillow body, the upper bottom plate is provided with a spring, and the other end of the spring is provided with a lower bottom plate; the middle part of the rear end of the lumbar pillow body is provided with a spring central axis mechanism, so that the upper bottom plate will be supported on the backrest of the seat, when the waist leans on the lumbar pillow, the spring will support the lumbar pillow.

公开(公告)号：US09633143B2

公开(公告)日：2017-04-25

申请号：US14110703

申请日：2012-04-05

Applicant: Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

Inventor： Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

IPC: G06G7/48 ,  G06F17/50

CPC classification number: G06F17/5009 ,  G06F17/5095

Abstract: A method, apparatus, media and signals for generating a computer representation of a three-dimensional swept envelope of a vehicle having a wheeled chassis operable to support a vehicle body for movement along a terrain is disclosed. The method involves receiving terrain data representing a 3D terrain, receiving data defining parameters of the vehicle, and receiving data defining a path for movement of the vehicle from an initial position on the terrain to a displaced position on the terrain. The method also involves disposing a computer representation of the vehicle on the 3D representation of the terrain at successive locations along the path using the parameters. Disposing involves determining points of engagement between wheels of the wheeled chassis and the 3D representation of the terrain to dispose the chassis with respect to the terrain, and determining a corresponding 3D location of the vehicle body with respect to the terrain. The method further involves generating a plurality of spatial extents of the vehicle at the successive locations, the spatial extents defining the 3D swept envelope of the vehicle when moving between the initial position and the displaced position. In another aspect a method for generating a computer representation of a three-dimensional swept envelope of an object moving along a guideway disposed with respect to a 3D representation of a terrain is disclosed.

公开(公告)号：US20130138093A1

公开(公告)日：2013-05-30

申请号：US13686952

申请日：2012-11-28

Applicant: Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

Inventor： Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

IPC: A61B18/20 ,  A61F2/14

CPC classification number: A61F2/14 ,  A61B18/20 ,  A61F2/142 ,  A61F2/1451 ,  A61F2/147 ,  A61F2/16 ,  A61F9/008 ,  A61L27/16 ,  A61L27/18 ,  A61L27/52 ,  B29D11/00355 ,  B29D11/00461 ,  B29D11/023 ,  B29K2083/00 ,  B29K2105/0061 ,  C08J7/12 ,  C08J7/123 ,  C08J2333/14 ,  C08J2339/06 ,  C08J2383/04 ,  G02B1/041 ,  G02C7/022 ,  G02C2202/12 ,  G02C2202/14

Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

Abstract translation: 一种光学装置，包括具有已经用激光照射的选择区域的光学水凝胶，所述激光具有0.01nJ至50nJ的脉冲能量和600nm至900nm的波长。 照射区域的特征在于折射率的正变化为0.01至0.06，并且表现出很小的或没有散射损失。 用亲水性单体制备光学水凝胶。

公开(公告)号：US20130026359A1

公开(公告)日：2013-01-31

申请号：US13634190

申请日：2011-04-22

Applicant: Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

Inventor： Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

IPC: H01J49/26 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/10 ,  G01N27/622 ,  H01J49/066 ,  H01J49/161 ,  H01J49/164 ,  H01J49/165 ,  H01J49/24

Abstract: The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.

Abstract translation: 本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。 气态中性分子通过解吸法在大气压下解吸。 然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。 然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。