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公开(公告)号:US20090120504A1
公开(公告)日:2009-05-14
申请号:US11911408
申请日:2006-04-13
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号: B81B1/00
CPC分类号: F16K99/0017 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , Y10T137/0753
摘要: A rotatable microfluidic device that comprises a hydrophilic microchannel structure in which there is a) an upstream microcavity I with a liquid outlet I, b) a microconduit I connected to liquid outlet I, and c) a capillary valve I associated with microconduit I. The inlet end of the microconduit is closer to the spin axis than the outlet end of the microconduit. The difference in radial distance between the inlet end and the outlet end of microconduit I is typically ≧5%, such as ≧10% or ≧100% or ≧500%, of the difference in radial distance between the uppermost part of the upstream microcavity and liquid outlet I.
摘要翻译: 一种可旋转微流体装置,其包括亲水性微通道结构,其中存在a)具有液体出口I的上游微腔I,b)连接到液体出口I的微型管I,以及c)与微型管I相关联的毛细管阀I. 微型管道的入口端比微型管道的出口端更靠近旋转轴线。 微通道I的入口端和出口端之间的径向距离差异通常>最大部分之间的径向距离差> = 5%,例如> = 10%或> = 100%或> = 500% 的上游微腔和液体出口I.
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公开(公告)号:US07947235B2
公开(公告)日:2011-05-24
申请号:US11911414
申请日:2006-04-13
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号: G01N1/10
CPC分类号: G01N21/07 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0806 , B01L2300/087 , B01L2300/161 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N21/05 , G01N2021/0325 , G01N2021/0346
摘要: A microfluidic device (1) comprising a hydrophilic microchannel structure (2) in which there is a functional unit that comprises a microconduit I (17) in which there is an inlet end (16), an outlet end (18), and a capillary stop function I (24) in the form of a local non-wettable surface area (44). The capillary stop function (24) defines a segment of microconduit I (17). Microconduit I (17) is within at least a part of this segment (46) divided into two or more microchannels (42). A part of the non-wettable surface area (44a,b) is associated with an inner wall of each of the microchannels (42).
摘要翻译: 一种微流体装置(1),包括亲水性微通道结构(2),其中存在包括其中存在入口端(16),出口端(18)和毛细管(18)的微管I(17)的功能单元 停止功能I(24)以局部不可润湿表面区域(44)的形式。 毛细管停止功能(24)限定了微管I(17)的一段。 微通道I(17)在该段(46)的至少一部分内分成两个或更多个微通道(42)。 不可润湿表面区域(44a,b)的一部分与每个微通道(42)的内壁相关联。
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公开(公告)号:US07833478B2
公开(公告)日:2010-11-16
申请号:US11871614
申请日:2007-10-12
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
摘要: A centrifugal-based microfluidic device (1) that comprises a hydrophilic microchannel structure (2) in which there is a A) a separation microcavity I (4) that comprises i) a liquid inlet I (5), and ii) a liquid outlet I (6) that is at a level below the level of liquid inlet I (5) and above the level of the bottom (8) of the microcavity (4) thereby defining a lower part (4b) and an upper part (4a) of the microcavity (4), and B) a microconduit I (17) that has an inlet end I (16) directly connected to liquid outlet I (6), and an outlet end I (18) that is at a lower level than inlet end I (6). A capillary valve I (24) is associated with microconduit I (17). The flow direction through liquid outlet I (6) is directed upwards and/or liquid outlet I (6) is placed in a downwardly turned part of an inner wall of the separation microcavity (4), and/or the part of microconduit I (17) next to liquid outlet I (6) is directed upwards.
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公开(公告)号:US20080206110A1
公开(公告)日:2008-08-28
申请号:US11871614
申请日:2007-10-12
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号: B01L11/00
CPC分类号: B01L3/502738 , B01L3/502723 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2200/0684 , B01L2300/0654 , B01L2300/0806 , B01L2300/0861 , B01L2300/161 , B01L2400/0409 , B01L2400/0688
摘要: A centrifugal-based microfluidic device (1) that comprises a hydrophilic microchannel structure (2) in which there is a A) a separation microcavity I (4) that comprises i) a liquid inlet I (5), and ii) a liquid outlet I (6) that is at a level below the level of liquid inlet I (5) and above the level of the bottom (8) of the microcavity (4) thereby defining a lower part (4b) and an upper part (4a) of the microcavity (4), and B) a microconduit I (17) that has an inlet end I (16) directly connected to liquid outlet I (6), and an outlet end I (18) that is at a lower level than inlet end I (6). A capillary valve I (24) is associated with microconduit I (17). The flow direction through liquid outlet I (6) is directed upwards and/or liquid outlet I (6) is placed in a downwardly turned part of an inner wall of the separation microcavity (4), and/or the part of microconduit I (17) next to liquid outlet I (6) is directed upwards.
摘要翻译: 一种离心式微流体装置(1),其包括亲水性微通道结构(2),其中存在A)分离微腔I(4),其包括i)液体入口I(5),和ii)液体出口 I(6)处于低于液体入口I(5)的水平并且高于微腔(4)的底部(8)的水平的水平面,由此限定下部(4b)和上部(4) a)的微腔(4),以及B)具有直接连接到液体出口I(6)的入口端I(16)的微型管I(17)和位于下部的出口端I(18) 水平高于入口端I(6)。 毛细管阀I(24)与微管I(17)相关联。 通过液体出口I(6)的流动方向被向上引导和/或液体出口I(6)放置在分离微腔(4)的内壁的向下转动的部分中,和/或微管I 液体出口I(6)旁边的图17所示向上。
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公开(公告)号:US20090111190A1
公开(公告)日:2009-04-30
申请号:US11911403
申请日:2006-04-13
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
CPC分类号: F16K99/0017 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2300/0806 , B01L2300/0864 , B01L2400/0688 , F16K99/0001 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N35/00069
摘要: A centrifugal based microfluidic device that comprises a microchannel structure in which there is a detection microcavity which in the upstream direction is attached to an inlet microconduit for transport of liquid (transport microconduit) to the detection microcavity and which is used for detecting the result of a reaction taking place in the detection microcavity or in a reaction microcavity positioned upstream of the detection microcavity. The detection microcavity comprises a detection microconduit having an inlet part and an outlet part and therebetween an upward or a downward meander.
摘要翻译: 一种基于离心的微流体装置,其包括微通道结构,其中存在检测微腔,其在上游方向上附接到用于将液体(运输微管)输送到检测微腔的入口微管,并且用于检测结果 在检测微腔中或在位于检测微腔上游的反应微腔中发生反应。 检测微腔包括具有入口部分和出口部分的检测微管,并且其间具有向上或向下弯曲。
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公开(公告)号:US20080286156A1
公开(公告)日:2008-11-20
申请号:US11911417
申请日:2006-04-13
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号: B01L3/02
CPC分类号: B01L3/502738 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086
摘要: A microfluidic device comprising a hydrophilic microchannel structure in which there is a functional unit that comprises a microconduit which a) is intended for the transportation of liquid aliquots, and b) has an inlet end and an outlet end between which there is a capillary valve I. Microconduit I comprises an upwardly directed section that extends over a part of or over the full length of microconduit I. Capillary valve I is preferably placed in this section.
摘要翻译: 一种微流体装置,其包括亲水性微通道结构,其中存在包含用于输送液体等分试样的微管道的功能单元,以及b)具有入口端和出口端,在该入口端和出口端之间存在毛细管阀I 微通道I包括在微管1的整个长度上延伸的向上指向的部分。毛细管阀I优选放置在该部分中。
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公开(公告)号:US20080226501A1
公开(公告)日:2008-09-18
申请号:US11911414
申请日:2006-04-13
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号: B01J19/00
CPC分类号: G01N21/07 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0806 , B01L2300/087 , B01L2300/161 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N21/05 , G01N2021/0325 , G01N2021/0346
摘要: A microfluidic device (1) comprising a hydrophilic microchannel structure (2) in which there is a functional unit that comprises a microconduit I (17) in which there is an inlet end (16), an outlet end (18), and a capillary stop function I (24) in the form of a local non-wettable surface area (44). The capillary stop function (24) defines a segment of microconduit I (17). Microconduit I (17) is within at least a part of this segment (46) divided into two or more microchannels (42). A part of the non-wettable surface area (44a,b) is associated with an inner wall of each of the microchannels (42).
摘要翻译: 一种微流体装置(1),包括亲水性微通道结构(2),其中存在包括其中存在入口端(16),出口端(18)和毛细管(18)的微管I(17)的功能单元 停止功能I(24)以局部不可润湿表面区域(44)的形式。 毛细管停止功能(24)限定了微管I(17)的一段。 微通道I(17)在该段(46)的至少一部分内分成两个或更多个微通道(42)。 不可润湿表面区域(44a,b)的一部分与每个微通道(42)的内壁相关联。
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公开(公告)号:US20080101993A1
公开(公告)日:2008-05-01
申请号:US11871577
申请日:2007-10-12
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
CPC分类号: F16K99/0017 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0806 , B01L2300/087 , B01L2300/161 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N21/05 , G01N21/07 , G01N2021/0325 , G01N2021/0346
摘要: A microfluidic device comprising a hydrophilic microchannel structure in which there is a functional unit that comprises a microconduit which a) is intended for the transportation of liquid aliquots, and b) has an inlet end and an outlet end between which there is a capillary valve I, which preferably is based on the presence of a local non-wettable surface area. Microconduit I further comprises one or more additional capillary valves, typically one. At least one of the additional valves is upstream of capillary valve I, such as at the inlet end of the microconduit.
摘要翻译: 一种微流体装置,其包括亲水性微通道结构,其中存在包含用于输送液体等分试样的微管道的功能单元,以及b)具有入口端和出口端,在该入口端和出口端之间存在毛细管阀I ,其优选基于局部不可润湿表面积的存在。 微管道I还包括一个或多个另外的毛细阀,通常为一个。 附加阀中的至少一个在毛细管阀I的上游,例如在微管的入口端。
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公开(公告)号:US07459129B2
公开(公告)日:2008-12-02
申请号:US11010869
申请日:2004-12-13
申请人: Per Andersson , Gunnar Ekstrand , Derand Helene
发明人: Per Andersson , Gunnar Ekstrand , Derand Helene
IPC分类号: B01L3/00
CPC分类号: G01N35/00069 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J19/0093 , B01J2219/00536 , B01J2219/00725 , B01J2219/00738 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L2200/027 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2200/142 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/087 , B01L2300/14 , B01L2300/16 , B01L2400/0409 , B01L2400/0418 , B01L2400/0633 , B01L2400/0688 , C40B40/10 , G01N30/466 , G01N30/6095 , G01N33/54366 , G01N2035/00504 , H01J49/04 , Y10S366/04
摘要: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).
摘要翻译: 一种微流体装置,其包括几个微通道结构,其中存在入口,出口以及其间包括流体功能的结构单元。 可以在单元之间选择结构单元,使得能够保持包含通过在微流体装置(单元A)内混合等分试样而定义的组分的n1等分试样,b)混合等分试样的液体(单元B),c)分隔 将较大等分的液体分装成更小等分的液体并分别分配后者并且平行于同一微流体装置(单元C)的不同微通道结构,d)快速渗入分配到入口的液体等分试样的微通道结构 微通道结构的端口(单元D),以及e)集成在微通道结构(单元E)内的体积定义。
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公开(公告)号:US07429354B2
公开(公告)日:2008-09-30
申请号:US10472255
申请日:2002-03-19
申请人: Per Andersson , Gunnar Ekstrand , Ulrike Selditz , Sussanne Wallenborg , Helene Derand , Gunnar Thorsen , Ebru Togan-Tekin
发明人: Per Andersson , Gunnar Ekstrand , Ulrike Selditz , Sussanne Wallenborg , Helene Derand , Gunnar Thorsen , Ebru Togan-Tekin
IPC分类号: G01N21/00
CPC分类号: G01N33/54366 , B01J19/0093 , B01L3/5025 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0678 , B01L2200/0684 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/086 , G01N35/00069
摘要: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances. The invention also refers to several other substructures. The substructure are primarily adapted for transporting liquid aliquots that have a surface tnsion >5 mN/m with centrifugal force.
摘要翻译: 一种微流体装置,其包括几个微通道结构,其中存在入口端口,出口以及其间具有流体功能的子结构。 该装置具有对称轴,微通道结构围绕该轴布置为两个或更多个同心的环形区域。 对于相同微通道结构的入口和出口,入口通常比出口更接近对称轴。 每个微通道结构包括一个子结构,其可以在圆盘围绕轴线旋转时保持液体,和/或入口端口与路径分离,离开开放废料出口的废液在旋转时将跟随盘的表面。 对于环形区域的微通道结构,相应的子结构基本上处于相同的径向距离,而不同环形区域的微通道结构中的相应子结构处于不同的径向距离。 本发明还涉及几个其他子结构。 子结构主要适用于输送具有离心力的表面尺寸> 5mN / m的液体等分试样。
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