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公开(公告)号:US07429354B2
公开(公告)日:2008-09-30
申请号:US10472255
申请日:2002-03-19
申请人: Per Andersson , Gunnar Ekstrand , Ulrike Selditz , Sussanne Wallenborg , Helene Derand , Gunnar Thorsen , Ebru Togan-Tekin
发明人: Per Andersson , Gunnar Ekstrand , Ulrike Selditz , Sussanne Wallenborg , Helene Derand , Gunnar Thorsen , Ebru Togan-Tekin
IPC分类号: G01N21/00
CPC分类号: G01N33/54366 , B01J19/0093 , B01L3/5025 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0678 , B01L2200/0684 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/086 , G01N35/00069
摘要: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances. The invention also refers to several other substructures. The substructure are primarily adapted for transporting liquid aliquots that have a surface tnsion >5 mN/m with centrifugal force.
摘要翻译: 一种微流体装置,其包括几个微通道结构,其中存在入口端口,出口以及其间具有流体功能的子结构。 该装置具有对称轴,微通道结构围绕该轴布置为两个或更多个同心的环形区域。 对于相同微通道结构的入口和出口,入口通常比出口更接近对称轴。 每个微通道结构包括一个子结构,其可以在圆盘围绕轴线旋转时保持液体,和/或入口端口与路径分离,离开开放废料出口的废液在旋转时将跟随盘的表面。 对于环形区域的微通道结构,相应的子结构基本上处于相同的径向距离,而不同环形区域的微通道结构中的相应子结构处于不同的径向距离。 本发明还涉及几个其他子结构。 子结构主要适用于输送具有离心力的表面尺寸> 5mN / m的液体等分试样。
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公开(公告)号:US06717136B2
公开(公告)日:2004-04-06
申请号:US09812123
申请日:2001-03-19
IPC分类号: B01D1508
CPC分类号: B82Y30/00 , B01J19/0093 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N33/54366 , G01N35/00069 , G01N2035/00504 , H01J49/04 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要: A microfluidic device comprising an MS-analyte presentation unit for a EDI-MS apparatus, said unit comprising an essentially planar support plate which on one side has one, two or more ports (MS-ports) comprising an area (EDI area) for presenting the MS-analyte to a mass spectrometer. The EDI area comprises a layer I of conducting material. The characteristic feature of the device is that layer (I) has a conductive connection and/or that there is a calibrator area in the proximity of the MS-port.
摘要翻译: 一种微流体装置,包括用于EDI-MS装置的MS分析物呈现单元,所述单元包括基本上平面的支撑板,其一侧具有一个,两个或更多个端口(MS端口),其包括用于呈现的区域(EDI区域) MS分析物到质谱仪。 EDI区域包括导电材料层I。 该设备的特征在于,层(I)具有导电连接和/或在MS端口附近存在校准器区域。
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公开(公告)号:US07148476B2
公开(公告)日:2006-12-12
申请号:US10867893
申请日:2004-06-15
CPC分类号: B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
摘要翻译: 本发明涉及一种用于将液体样品的分析物作为MS分析物呈现给质谱仪的方法。 更具体地,该方法包括以下步骤:将含有分析物的液体样品施加到微流体装置的微通道结构的样品入口端口,所述结构还包括出口端口(MS端口),其能够与 质谱仪,将分析物通入MS端口,从而将其转化为MS分析物,并通过MS端口将MS分析物呈现给质谱仪。
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公开(公告)号:US20050153431A1
公开(公告)日:2005-07-14
申请号:US11010869
申请日:2004-12-13
申请人: Per Andersson , Gunnar Ekstrand , Helene Derand
发明人: Per Andersson , Gunnar Ekstrand , Helene Derand
IPC分类号: B01F5/06 , B01F13/00 , B01F15/02 , B01J19/00 , B01L3/00 , C40B40/10 , G01N30/46 , G01N30/60 , G01N33/543 , G01N35/00 , H01J49/04 , C12M1/34
CPC分类号: G01N35/00069 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J19/0093 , B01J2219/00536 , B01J2219/00725 , B01J2219/00738 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L2200/027 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2200/142 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/087 , B01L2300/14 , B01L2300/16 , B01L2400/0409 , B01L2400/0418 , B01L2400/0633 , B01L2400/0688 , C40B40/10 , G01N30/466 , G01N30/6095 , G01N33/54366 , G01N2035/00504 , H01J49/04 , Y10S366/04
摘要: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).
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公开(公告)号:US06653625B2
公开(公告)日:2003-11-25
申请号:US09811741
申请日:2001-03-19
IPC分类号: B01D2726
CPC分类号: B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
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公开(公告)号:US06812457B2
公开(公告)日:2004-11-02
申请号:US10621868
申请日:2003-07-17
IPC分类号: B01D2726
CPC分类号: B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
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公开(公告)号:US07104517B1
公开(公告)日:2006-09-12
申请号:US10030297
申请日:2000-06-30
申请人: Helene Derand , Per Andersson , Anders Larsson
发明人: Helene Derand , Per Andersson , Anders Larsson
IPC分类号: F16K31/00
CPC分类号: F16K99/0001 , B01J19/0093 , B01J2219/00783 , B01J2219/00891 , B01L3/502738 , B01L2200/12 , B01L2300/0806 , B01L2300/1861 , B01L2400/0661 , F15C5/00 , F16K13/10 , F16K99/0019 , F16K99/0034 , F16K99/0036
摘要: The invention relates to a method of controlling flow of liquids in a micro channel structure. It comprises providing in said micro channel structure plugs (34) of polymer material in said structure, said polymer material in a first state blocking said channel from liquid flow, and in a second state providing a free path-way (32) for liquid flow. Energy is selectively applied so as to cause said polymer to enter a desired one of said first or second states. It also relates to a micro channel valve system, comprising a plurality of such plugs (34). Additionally it comprises a chemical reactor, comprising a plurality of micro chambers interconnected by micro channels, having a valve system according to the invention.
摘要翻译: 本发明涉及一种控制微通道结构中液体流动的方法。 它包括在所述微通道结构中提供在所述结构中的聚合物材料的塞子(34),所述聚合物材料处于第一状态,从而阻止所述通道从液体流动,并且在第二状态下提供用于液体流动的自由通路(32) 。 选择性地施加能量以使所述聚合物进入所述第一或第二状态中的期望的一种。 它还涉及一种微通道阀系统,其包括多个这样的塞子(34)。 另外,它包括化学反应器,包括通过微通道互连的多个微室,具有根据本发明的阀系统。
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公开(公告)号:US20050279925A1
公开(公告)日:2005-12-22
申请号:US10867893
申请日:2004-06-15
CPC分类号: B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
摘要翻译: 本发明涉及一种用于将液体样品的分析物作为MS分析物呈现给质谱仪的方法。 更具体地,该方法包括以下步骤:将含有分析物的液体样品施加到微流体装置的微通道结构的样品入口端口,所述结构还包括出口端口(MS端口),其能够与 质谱仪,将分析物通入MS端口,从而将其转化为MS分析物,并通过MS端口将MS分析物呈现给质谱仪。
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公开(公告)号:US07947235B2
公开(公告)日:2011-05-24
申请号:US11911414
申请日:2006-04-13
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号: G01N1/10
CPC分类号: G01N21/07 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0806 , B01L2300/087 , B01L2300/161 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N21/05 , G01N2021/0325 , G01N2021/0346
摘要: A microfluidic device (1) comprising a hydrophilic microchannel structure (2) in which there is a functional unit that comprises a microconduit I (17) in which there is an inlet end (16), an outlet end (18), and a capillary stop function I (24) in the form of a local non-wettable surface area (44). The capillary stop function (24) defines a segment of microconduit I (17). Microconduit I (17) is within at least a part of this segment (46) divided into two or more microchannels (42). A part of the non-wettable surface area (44a,b) is associated with an inner wall of each of the microchannels (42).
摘要翻译: 一种微流体装置(1),包括亲水性微通道结构(2),其中存在包括其中存在入口端(16),出口端(18)和毛细管(18)的微管I(17)的功能单元 停止功能I(24)以局部不可润湿表面区域(44)的形式。 毛细管停止功能(24)限定了微管I(17)的一段。 微通道I(17)在该段(46)的至少一部分内分成两个或更多个微通道(42)。 不可润湿表面区域(44a,b)的一部分与每个微通道(42)的内壁相关联。
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公开(公告)号:US07833478B2
公开(公告)日:2010-11-16
申请号:US11871614
申请日:2007-10-12
申请人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人: Per Andersson , Gunnar Ekstrand , Gerald Jesson
摘要: A centrifugal-based microfluidic device (1) that comprises a hydrophilic microchannel structure (2) in which there is a A) a separation microcavity I (4) that comprises i) a liquid inlet I (5), and ii) a liquid outlet I (6) that is at a level below the level of liquid inlet I (5) and above the level of the bottom (8) of the microcavity (4) thereby defining a lower part (4b) and an upper part (4a) of the microcavity (4), and B) a microconduit I (17) that has an inlet end I (16) directly connected to liquid outlet I (6), and an outlet end I (18) that is at a lower level than inlet end I (6). A capillary valve I (24) is associated with microconduit I (17). The flow direction through liquid outlet I (6) is directed upwards and/or liquid outlet I (6) is placed in a downwardly turned part of an inner wall of the separation microcavity (4), and/or the part of microconduit I (17) next to liquid outlet I (6) is directed upwards.
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