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    Method for monitoring and prognosis of disease course of gastrointestinal tumors
    1.
    发明授权
    Method for monitoring and prognosis of disease course of gastrointestinal tumors 有权
    监测和预测胃肠道肿瘤病程的方法

    公开(公告)号：US07358060B2

    公开(公告)日：2008-04-15

    申请号：US10491523

    申请日：2003-01-31

    申请人： Reinhard von Wasielewski ,  Michael Mengel ,  Rüdiger Ridder ,  Peter Martin

    发明人： Reinhard von Wasielewski ,  Michael Mengel ,  Rüdiger Ridder ,  Peter Martin

    IPC分类号： C12Q1/00 ,  G01N33/574 ,  G01N33/48

    CPC分类号： C12Q1/485 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57484

    摘要： The present invention provides a method for diagnosis, monitoring and prognosticating the disease course of gastrointestinal tumors, comprising determining the level of a cyclin dependent kinase inhibitor (CK1) in a sample and diagnosing the disease and/or recurrence of the disease or prognosticating the disease course from the level of said CK1 in the examined tumor cells. Furthermore the present invention provides a method for tailoring a suitable therapy for gastrointestinal tumors. Another aspect of the present invention are test kits for research and diagnostic purposes.

    摘要翻译： 本发明提供了一种用于诊断，监测和预测胃肠道肿瘤的疾病过程的方法，包括确定样品中细胞周期蛋白依赖性激酶抑制剂（CK1）的水平并诊断疾病和/或疾病复发或预测疾病 从所检查的肿瘤细胞中CK1的水平。 此外，本发明提供了一种适合胃肠肿瘤治疗的方法。 本发明的另一方面是用于研究和诊断目的的测试试剂盒。

    Method for prediction of the progression risk of tumors
    2.
    发明授权
    Method for prediction of the progression risk of tumors 有权
    预测肿瘤进展风险的方法

    公开(公告)号：US08728745B2

    公开(公告)日：2014-05-20

    申请号：US13062185

    申请日：2009-09-04

    申请人： Peter Martin ,  Rüdiger Ridder

    发明人： Peter Martin ,  Rüdiger Ridder

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  C12Q2600/118 ,  G01N33/57496 ,  G01N2333/4704 ,  G01N2333/4706 ,  G01N2800/50 ,  G01N2800/56

    摘要： The present invention concerns a method for predicting the potential for aggressive growth and/or the risk to progress to high grade cancer for tumors in cell based detection procedures. In one aspect the invention concerns the detection of overexpression of cyclin-dependent kinase inhibitor gene products as a tool for predicting the progression risk and/or potential for aggressive growth of tumors. In a second aspect the invention concerns predicting the progression risk and/or potential for aggressive growth in tumors on the basis of the simultaneous co-detection of the presence of overexpression of cyclin-dependent kinase inhibitor gene products together with the expression of markers for active cell proliferation. Further the invention concerns preparations of probes for diagnosis namely for predicting the progression risk and/or the potential for aggressive growth of tumors.

    摘要翻译： 本发明涉及一种用于在基于细胞的检测程序中预测侵袭性生长的潜力和/或进展为高等级肿瘤的风险的方法。 一方面，本发明涉及检测细胞周期蛋白依赖性激酶抑制剂基因产物的过表达，作为预测肿瘤侵袭性生长的进展风险和/或潜力的工具。 在第二方面，本发明涉及基于同时共检测细胞周期蛋白依赖性激酶抑制剂基因产物的过表达以及活性标志物的表达来预测肿瘤侵袭性生长的进展风险和/或潜力 细胞增殖。 此外，本发明涉及用于诊断的探针的准备，即用于预测肿瘤的进展风险和/或潜在的侵袭性生长。

    METHOD FOR PREDICTION OF THE PROGRESSION RISK OF TUMORS
    3.
    发明申请
    METHOD FOR PREDICTION OF THE PROGRESSION RISK OF TUMORS 有权
    预测肿瘤进展风险的方法

    公开(公告)号：US20110183333A1

    公开(公告)日：2011-07-28

    申请号：US13062185

    申请日：2009-09-04

    申请人： Peter Martin ,  Rüdiger Ridder

    发明人： Peter Martin ,  Rüdiger Ridder

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  C12Q2600/118 ,  G01N33/57496 ,  G01N2333/4704 ,  G01N2333/4706 ,  G01N2800/50 ,  G01N2800/56

    摘要： The present invention concerns a method for predicting the potential for aggressive growth and/or the risk to progress to high grade cancer for tumors in cell based detection procedures. In one aspect the invention concerns the detection of overexpression of cyclin-dependent kinase inhibitor gene products as a tool for predicting the progression risk and/or potential for aggressive growth of tumors. In a second aspect the invention concerns predicting the progression risk and/or potential for aggressive growth in tumors on the basis of the simultaneous co-detection of the presence of overexpression of cyclin-dependent kinase inhibitor gene products together with the expression of markers for active cell proliferation. Further the invention concerns preparations of probes for diagnosis namely for predicting the progression risk and/or the potential for aggressive growth of tumors.

    摘要翻译： 本发明涉及一种用于在基于细胞的检测程序中预测侵袭性生长的潜力和/或进展为高等级肿瘤的风险的方法。 一方面，本发明涉及检测细胞周期蛋白依赖性激酶抑制剂基因产物的过表达，作为预测肿瘤侵袭性生长的进展风险和/或潜力的工具。 在第二方面，本发明涉及基于同时共检测细胞周期蛋白依赖性激酶抑制剂基因产物的过表达以及活性标志物的表达来预测肿瘤侵袭性生长的进展风险和/或潜力 细胞增殖。 此外，本发明涉及用于诊断的探针的准备，即用于预测肿瘤的进展风险和/或潜在的侵袭性生长。

    METHODS, SYSTEMS AND APPARATUS FOR PROMOTING THE POURABILITY OF SEMI-FROZEN AND SEMI-FLUIDIC BEVERAGES FROM BEVERAGE CONTAINERS
    6.
    发明申请
    METHODS, SYSTEMS AND APPARATUS FOR PROMOTING THE POURABILITY OF SEMI-FROZEN AND SEMI-FLUIDIC BEVERAGES FROM BEVERAGE CONTAINERS 审中-公开
    从饮料容器中提取半冷冻和半液体饮料的可行性的方法，系统和装置

    公开(公告)号：US20110199852A1

    公开(公告)日：2011-08-18

    申请号：US12705698

    申请日：2010-02-15

    申请人： Peter Martin

    发明人： Peter Martin

    IPC分类号： B01F11/00

    CPC分类号： A47J43/0716 ,  A47G19/12 ,  A47J43/046 ,  A47J43/0727

    摘要： A beverage container for a blender includes one or more vibrating mechanisms coupled to a bottom portion of the beverage container or integrated within one or more walls of the beverage container. After a beverage has been blended, the one or more vibrating mechanisms are activated as the beverage is being poured. Vibrations from the one or more vibrating mechanisms are mechanically transmitted to the beverage container, thereby promoting the pourability of the beverage from the beverage container, including dislodging ingredients in the beverage that became lodged or trapped in crevices of the beverage container during the prior blending process, and freeing up beverage ingredients that accumulated at the bottom of the beverage container during the prior blending process.

    摘要翻译： 用于搅拌器的饮料容器包括联接到饮料容器的底部或集成在饮料容器的一个或多个壁内的一个或多个振动机构。 在混合饮料之后，随着饮料被倒出，一个或多个振动机构被激活。 来自一个或多个振动机构的振动机械地传递到饮料容器，从而促进饮料从饮料容器中的倾倒性，包括在先前共混过程中在饮料中被移入或被捕获在饮料容器的裂缝中的成分 并且在先前的混合过程中释放积聚在饮料容器底部的饮料成分。

    Many million pixel image sensor
    8.
    发明授权
    Many million pixel image sensor 有权
    许多百万像素图像传感器

    公开(公告)号：US07906826B2

    公开(公告)日：2011-03-15

    申请号：US11904782

    申请日：2007-09-28

    申请人： Peter Martin ,  Paul Johnson ,  Chris Sexton

    发明人： Peter Martin ,  Paul Johnson ,  Chris Sexton

    IPC分类号： H01L31/062

    CPC分类号： H01L27/14634 ,  G03F7/70433 ,  G03F7/70475 ,  H01L27/14643 ,  H01L27/14647 ,  H01L27/14652 ,  H01L27/14683

    摘要： A CMOS image sensor with a many million pixel count. Applicants have developed techniques for combining its continuous layer photodiode CMOS sensor technology with CMOS integrated circuit lithography stitching techniques to provide digital cameras with an almost unlimited number of pixels. A preferred CMOS stitching technique exploits the precise alignment accuracy of CMOS stepper processes by using specialized mask sets to repeatedly produce a single pixel array pattern many times on a single silicon wafer with no pixel array discontinuities. The single array patterns are stitched together lithographically to form a pixel array of many million pixels. A continuous multilayer photodiode layer is deposited over the top of the many million pixel array to provide a many million pixel sensor with a fill factor of 100 percent or substantially 100 percent.

    摘要翻译： 具有数百万像素数的CMOS图像传感器。 申请人已经开发出将连续层光电二极管CMOS传感器技术与CMOS集成电路光刻拼接技术相结合的技术，为数码相机提供几乎无限数量的像素。 优选的CMOS拼接技术利用CMOS步进工艺的精确对准精度通过使用专门的掩模组在单个硅晶片上多次重复产生单个像素阵列图案，而不存在像素阵列不连续性。 将单阵列图案光刻地缝合在一起以形成数百万像素的像素阵列。 连续的多层光电二极管层沉积在数百万像素阵列的顶部，以提供百万像素传感器，其填充因子为100％或基本为100％。

    ANGULAR CONTACT ROLLING-ELEMENT BEARING, ESPECIALLY DOUBLE ROW BALL ROLLER BEARING IN TANDEM ARRANGEMENT
    9.
    发明申请
    ANGULAR CONTACT ROLLING-ELEMENT BEARING, ESPECIALLY DOUBLE ROW BALL ROLLER BEARING IN TANDEM ARRANGEMENT 失效
    角接触滚子元件轴承，特别是双向滚珠轴承，在TANDEM ARRANGE

    公开(公告)号：US20110033149A1

    公开(公告)日：2011-02-10

    申请号：US12989263

    申请日：2009-04-02

    申请人： Andreas Bohr ,  Horst Doeppling ,  Heinrich Hofmann ,  Peter Martin

    发明人： Andreas Bohr ,  Horst Doeppling ,  Heinrich Hofmann ,  Peter Martin

    IPC分类号： F16C33/48

    CPC分类号： F16C19/38 ,  F16C19/505 ,  F16C33/36 ,  F16C33/485 ,  F16C33/585

    摘要： A double roller bearing which has an outer and inner bearing ring and ball rollers, which have lateral faces and are arranged next to each other in rows, arranged between the bearing rings. The rollers roll in raceways incorporated into the inner face of the outer bearing ring and outer face of the inner bearing ring. The raceways run in parallel and have pressure angle axes that are pitched at a pressure angle relative to a bearing radial axis. The rollers have a distance relative to each other which excludes mutual frictional contacts. For this purpose, the distance of the pressure angle axes of the raceways is enlarged and both rows of rollers are guided in separate bearing cages, while the raceway of the rollers of the row with the larger reference circle arranged on the inner bearing ring has a one-sided axial extension using the distance.

    摘要翻译： 一种具有外轴承圈和内滚子轴承的双滚子轴承，其具有横向面并彼此排成一列布置在轴承环之间。 辊子滚动在并入到外轴承环的内表面和内轴承环的外表面的滚道中。 滚道平行运行并具有相对于轴承径向轴线以压力角倾斜的压力角轴。 辊子具有相对于彼此的距离，排除相互摩擦接触。 为此，滚道的压力角轴线的距离增大，两列滚子分开的轴承保持架被引导，而排列在内轴承环上的具有较大基准圆的列的滚道的滚道具有 单向轴向延伸使用距离。

    Visible/near infrared image sensor array
    10.
    发明授权
    Visible/near infrared image sensor array 失效
    可见/近红外图像传感器阵列

    公开(公告)号：US07436038B2

    公开(公告)日：2008-10-14

    申请号：US10785833

    申请日：2004-02-23

    申请人： Michael G. Engelmann ,  Calvin Chao ,  Tzu-Chiang Hsieh ,  Peter Martin ,  Milam Pender

    发明人： Michael G. Engelmann ,  Calvin Chao ,  Tzu-Chiang Hsieh ,  Peter Martin ,  Milam Pender

    IPC分类号： H01L31/00

    CPC分类号： G01J5/02 ,  G01J5/024 ,  G01J5/026 ,  G01J5/04 ,  G01J5/046 ,  G01J5/22 ,  G01J5/52 ,  G01J2005/0077 ,  H01L27/14609 ,  H01L27/14621 ,  H01L27/1463 ,  H01L27/14632 ,  H01L27/14636 ,  H01L27/14643 ,  H01L27/14645 ,  H01L27/14649 ,  H01L27/14687 ,  H01L27/14689 ,  H01L27/14692 ,  H01L31/03685 ,  H01L31/03687 ,  H01L31/1055 ,  H01L31/109 ,  H01L31/113 ,  H04N5/2351 ,  H04N5/2353 ,  H04N5/33 ,  H04N5/332 ,  H04N5/365 ,  H04N5/3651 ,  H04N5/374 ,  H04N5/37455 ,  H04N5/378 ,  Y02E10/545 ,  Y02E10/548

    摘要： A MOS or CMOS sensor for high performance imaging in broad spectral ranges including portions of the infrared spectral band. These broad spectral ranges may also include portions or all of the visible spectrum, therefore the sensor has both daylight and night vision capabilities. The sensor includes a continuous multi-layer photodiode structure on a many pixel MOS or CMOS readout array where the photodiode structure is chosen to include responses in the near infrared spectral ranges. A preferred embodiment incorporates a microcrystalline copper indium diselenide/cadmium sulfide photodiode structure on a CMOS readout array. An alternate preferred embodiment incorporates a microcrystalline silicon germanium photodiode structure on a CMOS readout array. Each of these embodiments provides night vision with image performance that greatly surpasses the GEN III night vision technology in terms of enhanced sensitivity, pixel size and pixel count. Further advantages of the invention include low electrical bias voltages, low power consumption, compact packaging, and radiation hardness. In special preferred embodiments CMOS stitching technology is used to provide multi-million pixel focal plane array sensors. One embodiments of the invention made without stitching is a two-million pixel sensor. Other preferred embodiments available using stitching techniques include sensors with 250 million (or more) pixels fabricated on a single wafer. A particular application of these very high pixel count sensors is as a focal plane array for a rapid beam steering telescope in a low earth orbit satellite useful for tracking over a 1500-meter wide track with a resolution of 0.3 meter.

    摘要翻译： 一种用于在宽光谱范围内进行高性能成像的MOS或CMOS传感器，包括红外光谱带的部分。 这些宽光谱范围还可以包括可见光谱的部分或全部，因此传感器具有日光和夜视能力。 该传感器包括在多个像素MOS或CMOS读出阵列上的连续多层光电二极管结构，其中光电二极管结构被选择为包括在近红外光谱范围内的响应。 优选实施例在CMOS读出阵列上结合微晶铜铟二硒化物/硫化镉光电二极管结构。 替代的优选实施例在CMOS读出阵列上结合了微晶硅锗光电二极管结构。 这些实施例中的每一个为增强的灵敏度，像素尺寸和像素数量提供了大大超过GEN III夜视技术的图像性能的夜视。 本发明的另外的优点包括低偏置电压，低功耗，紧凑的封装和辐射硬度。 在特别优选实施例中，CMOS拼接技术用于提供数百万像素焦平面阵列传感器。 没有拼接的本发明的一个实施例是200万像素传感器。 使用缝合技术可获得的其它优选实施例包括在单个晶片上制造的具有2.5亿（或更多）像素的传感器。 这些非常高的像素数传感器的特定应用是用于在低地球轨道卫星中的快速波束转向望远镜的焦平面阵列，其用于在分辨率为0.3米的1500米宽的轨道上进行跟踪。