公开(公告)号：US20100159513A1

公开(公告)日：2010-06-24

申请号：US12619790

申请日：2009-11-17

申请人： Qiong Cheng ,  Kevin Michael Croker ,  Kristin Ruebling-Jass ,  Hong Wang ,  Jianzhong Zhang

发明人： Qiong Cheng ,  Kevin Michael Croker ,  Kristin Ruebling-Jass ,  Hong Wang ,  Jianzhong Zhang

IPC分类号： C12P21/00 ,  C12N1/21

CPC分类号： C12P21/02

摘要： Several endogenous genes have been identified in Escherichia coli, the overexpression of which increases recombinant peptide production. Increasing the copy number of aroB, aroK, proB, or crl increases the amount of a recombinant peptide produced by a host cell. Recombinant host cells comprising at least one chimeric genetic construct encoding a peptide of interest and at least one genetic modification that increases recombinant peptide production are provided as well as methods of using such recombinant host cells

摘要翻译： 已经在大肠杆菌中鉴定了几种内源基因，其过表达增加了重组肽的产生。 增加aroB，aroK，proB或crl的拷贝数增加了由宿主细胞产生的重组肽的量。 提供了包含至少一种编码目的肽的嵌合基因构建体和至少一种提高重组肽产生的遗传修饰的重组宿主细胞以及使用这种重组宿主细胞的方法

公开(公告)号：US07662587B1

公开(公告)日：2010-02-16

申请号：US12398358

申请日：2009-03-05

申请人： Qiong Cheng ,  Kevin Michael Croker ,  Kristin Ruebling-Jass ,  Hong Wang

发明人： Qiong Cheng ,  Kevin Michael Croker ,  Kristin Ruebling-Jass ,  Hong Wang

IPC分类号： C12P21/06 ,  C12P21/04 ,  C12P1/00 ,  C12N15/74

CPC分类号： C12N15/70 ,  C07K14/245 ,  C07K2319/00 ,  C07K2319/50

摘要： Disrupting the expression of endogenous Escherichia host cell genes gcvA and spr provides mutant host cells having increased heterologous peptide production relative to control Escherichia host cells. Recombinant Escherichia host cells are provided as well as methods of using such host cells for heterologous peptide production.

摘要翻译： 破坏内源性大肠杆菌宿主细胞基因gcvA和spr的表达提供相对于对照大肠杆菌宿主细胞具有增加的异源肽产生的突变宿主细胞。 提供重组埃希氏杆菌宿主细胞以及使用这种宿主细胞进行异源肽生产的方法。

公开(公告)号：US08697654B2

公开(公告)日：2014-04-15

申请号：US12632831

申请日：2009-12-08

申请人： Qiong Cheng ,  Stephen R. Fahnestock ,  Hongxian He ,  Kristy N. Kostichka ,  Hong Wang

发明人： Qiong Cheng ,  Stephen R. Fahnestock ,  Hongxian He ,  Kristy N. Kostichka ,  Hong Wang

IPC分类号： A61K38/16 ,  A61K8/00 ,  A61Q5/00 ,  A61C9/00 ,  A61P17/00

CPC分类号： A61K47/48338 ,  A61K8/19 ,  A61K8/64 ,  A61K2800/94 ,  A61Q5/00 ,  A61Q5/065 ,  C07K14/001 ,  C07K2319/70 ,  G01N33/6803 ,  G06F19/16

摘要： Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.

摘要翻译： 对目标表面具有亲和性的短单链肽通常缺乏某些商业应用所需的结合耐久性。 提高耐久性的一种方法是通过使用肽接头连接在一起的结合序列来促进多价结合。 然而，所得到的单链结合肽通常具有接头熵。 已经发现，当将多个结合序列连接在一起时，使用刚性肽接头增强所得单链肽的结合亲和力。

公开(公告)号：US10420166B2

公开(公告)日：2019-09-17

申请号：US13542247

申请日：2012-07-05

申请人： Lixiang Xu ,  Hong Wang ,  Huarui Liang

发明人： Lixiang Xu ,  Hong Wang ,  Huarui Liang

IPC分类号： H04W76/30 ,  H04W8/08 ,  H04W36/00

摘要： Methods for avoiding handover failure are provided. The method includes determining, by a source Base Station (BS), to perform a handover of a User Equipment (UE); determining, by the source BS, whether a target BS connects with a user plane node serving the UE at the source BS; and releasing resources, when the target BS does not connect with the user plane node serving the UE at the source BS.

公开(公告)号：US10089263B2

公开(公告)日：2018-10-02

申请号：US15118501

申请日：2014-03-24

申请人： INTEL CORPORATION ,  Thiam Wah Loh ,  Gautham N. Chinya ,  Per Hammarlund ,  Reza Fortas ,  Hong Wang ,  Huajin Sun

发明人： Thiam Wah Loh ,  Gautham N. Chinya ,  Per Hammarlund ,  Reza Fortas ,  Hong Wang ,  Huajin Sun

IPC分类号： G06F13/24

摘要： A processor is disclosed and includes at least one core including a first core, and interrupt delay logic. The interrupt delay logic is to receive a first interrupt at a first time and delay the first interrupt from being processed by a first time delay that begins at the first time, unless the first interrupt is pending at a second time when a second interrupt is processed by the first core. If the first interrupt is pending at the second time, the interrupt delay logic is to indicate to the first core to begin to process the first interrupt prior to completion of the first time delay. Other embodiments are disclosed and claimed.

公开(公告)号：US20180225118A1

公开(公告)日：2018-08-09

申请号：US15943614

申请日：2018-04-02

申请人： Ed Grochowski ,  Hong Wang ,  John P. Shen ,  Perry H. Wang ,  Jamison D. Collins ,  James Held ,  Partha Kundu ,  Raya Leviathan ,  Tin-Fook Ngai

发明人： Ed Grochowski ,  Hong Wang ,  John P. Shen ,  Perry H. Wang ,  Jamison D. Collins ,  James Held ,  Partha Kundu ,  Raya Leviathan ,  Tin-Fook Ngai

IPC分类号： G06F9/30 ,  G06F9/38

CPC分类号： G06F9/30003 ,  G06F9/30087 ,  G06F9/3009 ,  G06F9/30101 ,  G06F9/3013 ,  G06F9/384 ,  G06F9/3851

摘要： A method and system to provide user-level multithreading are disclosed. The method according to the present techniques comprises receiving programming instructions to execute one or more shared resource threads (shreds) via an instruction set architecture (ISA). One or more instruction pointers are configured via the ISA; and the one or more shreds are executed simultaneously with a microprocessor, wherein the microprocessor includes multiple instruction sequencers.

公开(公告)号：US09867157B2

公开(公告)日：2018-01-09

申请号：US12527328

申请日：2008-02-13

申请人： Bing Bu ,  Xiaoqiang Li ,  Chunying Sun ,  Hong Wang ,  Lixiang Xu ,  Yanmin Zhu

发明人： Bing Bu ,  Xiaoqiang Li ,  Chunying Sun ,  Hong Wang ,  Lixiang Xu ,  Yanmin Zhu

IPC分类号： H04W60/06 ,  H04W76/06

CPC分类号： H04W60/06 ,  H04W76/32

摘要： A method for detachment of a mobile set within the equivalent route area moving between the communication systems comprising steps of: during the detachment process is implemented between a mobile set and a service node in one communication system, the service node generates one or more messages and transmits it to the service nodes in one or more communication system within the ERA. If the message is transmitted to the service node within the ERA of only one communication system, this service node transmits this message or the message generated according to this message to the service nodes within the ERA of the other communication system. With the method proposed in present invention, when a mobile is detached from two or more communication systems which share the same ERA, the service nodes in all communication systems within the ERA can still correctly manage the relevant information on this mobile set.

公开(公告)号：US20170020717A1

公开(公告)日：2017-01-26

申请号：US15273117

申请日：2016-09-22

申请人： Hong Wang

发明人： Hong Wang

IPC分类号： A61F6/04

CPC分类号： A61F6/04

摘要： A condom of embodiments of the disclosed technology has a tip and base with cords connecting the two, creating portals where the urethra is exposed and fully capable of feeling abrasion with other objects. The base ring is oppositely disposed from the tip and an extreme other end of the condom. The base ring also extends circumferentially and in parallel to a largest circumference of the solid tip, when the cord extends perpendicularly to the largest circumference of the solid tip and the base ring. The largest circumference of the circle referred to herein, in embodiments of the disclosed technology, is a portion of the tip which is closest to the base ring.

摘要翻译： 所公开技术的实施例的避孕套具有尖端和底部，其具有连接两者的线，创建出口的位置，其中尿道被暴露并且完全能够感受到与其它物体的磨损。 基座环从尖端和避孕套的极端另一端相对设置。 当绳索垂直于固体末端和基环的最大圆周延伸时，基环也周向地并且平行于固体末端的最大圆周延伸。 在所公开的技术的实施例中，这里提到的圆的最大圆周是尖端的最靠近基环的部分。

公开(公告)号：US09198891B2

公开(公告)日：2015-12-01

申请号：US13111769

申请日：2011-05-19

申请人： Timothy Cardozo ,  Hong Wang ,  David Ron

发明人： Timothy Cardozo ,  Hong Wang ,  David Ron

IPC分类号： A61K49/00 ,  A61K31/225 ,  A61K31/24 ,  A61K31/4166 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/433 ,  A61K31/496 ,  A61K31/519 ,  A61K31/536 ,  C07D207/416 ,  C07D239/42 ,  C07D249/12 ,  C07D265/22 ,  C07D277/44 ,  C07D277/54 ,  C07D277/66 ,  C07D307/54 ,  C07D317/60 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12 ,  C07D417/14 ,  C07D487/04 ,  C12Q1/48 ,  G06F19/00 ,  G06F19/16

CPC分类号： A61K31/225 ,  A61K31/24 ,  A61K31/4166 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/433 ,  A61K31/496 ,  A61K31/519 ,  A61K31/536 ,  C07D207/416 ,  C07D239/42 ,  C07D249/12 ,  C07D265/22 ,  C07D277/44 ,  C07D277/54 ,  C07D277/66 ,  C07D307/54 ,  C07D317/60 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12 ,  C07D417/14 ,  C07D487/04 ,  C12Q1/485 ,  G06F19/16 ,  G06F19/706

摘要： The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK. The present invention further relates to compounds that can be used for inhibition of PERK, for example human PERK, and methods related to treatment of PERK-mediated diseases.

摘要翻译： 本发明涉及鉴定可用于抑制蛋白激酶样内质网蛋白激酶（PERK）的化合物的方法。 该方法包括提供包含PERK活性结构域的第一模型，其中所述活性域选自跨越SEQ ID NO：1的氨基酸残基Asp144至氨基酸残基Ser191的肽和包含氨基酸的肽 提供一种或多种候选化合物，评估候选化合物与第一模型之间的接触，以确定一种或多种候选化合物中的哪一种具有结合和/或适合的能力 第一模型，以及鉴定基于所述评估具有结合和/或适合第一模型的能力的化合物，作为潜在地可用于抑制PERK的化合物。 本发明还涉及可用于抑制PERK的化合物，例如人PERK，以及与治疗PERK介导的疾病有关的方法。

公开(公告)号：US20150153329A1

公开(公告)日：2015-06-04

申请号：US14616295

申请日：2015-02-06

申请人： Lidia L. Demchyshyn ,  Hong Wang

发明人： Lidia L. Demchyshyn ,  Hong Wang

IPC分类号： G01N33/50 ,  G01N33/74

CPC分类号： G01N33/5082 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/605 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2500/10

摘要： Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.

摘要翻译： 本文公开了一种用于在用GLP-2或GLP-2配体处理时测量肠组织的收缩性的方法。 还公开了一种直接测量GLP-2或GLP-2配体活性的测定法，并允许在天然组织中筛选推定的GLP-2配体。