公开(公告)号：US07485308B2

公开(公告)日：2009-02-03

申请号：US11493347

申请日：2006-07-26

申请人： Rachel E. Meyers ,  Kyle J. MacBeth ,  Rory A. J. Curtis ,  Laura A. Rudolph-Owen ,  Nadine S. Weich ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph M. Carroll

发明人： Rachel E. Meyers ,  Kyle J. MacBeth ,  Rory A. J. Curtis ,  Laura A. Rudolph-Owen ,  Nadine S. Weich ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph M. Carroll

IPC分类号： A61K39/00 ,  C12P21/06

CPC分类号： C12N9/001 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1048 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/48 ,  C12N9/80 ,  C12N2799/021 ,  C12Q1/32 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2500/10 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。 本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。 本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20100150901A1

公开(公告)日：2010-06-17

申请号：US12288677

申请日：2008-10-22

申请人： Rachel E. Meyers ,  Kyle J. MacBeth ,  Rory A.J. Curtis ,  Laura A. Rudolph-Owen ,  Nadine S. Weich ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph M. Carroll

发明人： Rachel E. Meyers ,  Kyle J. MacBeth ,  Rory A.J. Curtis ,  Laura A. Rudolph-Owen ,  Nadine S. Weich ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph M. Carroll

IPC分类号： A61K39/395 ,  C07H21/02 ,  C12N5/10 ,  C07K16/00 ,  C12P21/00 ,  G01N33/53 ,  C07H21/04 ,  C12Q1/68 ,  A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  A61K31/7105 ,  A61K31/713 ,  A61K31/711 ,  A61P35/00

CPC分类号： C12N9/001 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1048 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/48 ,  C12N9/80 ,  C12N2799/021 ,  C12Q1/32 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2500/10 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。 本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。 本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20110182879A1

公开(公告)日：2011-07-28

申请号：US12828319

申请日：2010-07-01

申请人： Rachel E. Meyers ,  Mark Williamson ,  Kevin R. Leiby ,  Rosana Kapeller-Libermann ,  Peter J. Olandt ,  Kyle J. MacBeth ,  Laura A. Rudolph-Owen ,  Fong-Ying Tsai ,  John J. Hunter

发明人： Rachel E. Meyers ,  Mark Williamson ,  Kevin R. Leiby ,  Rosana Kapeller-Libermann ,  Peter J. Olandt ,  Kyle J. MacBeth ,  Laura A. Rudolph-Owen ,  Fong-Ying Tsai ,  John J. Hunter

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/10 ,  C07K14/435 ,  C07K16/18 ,  C12P21/02 ,  G01N33/50 ,  G01N33/53 ,  A61K38/02 ,  A61P43/00

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1007 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1096 ,  C12N9/93 ,  C12Q1/48 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y602/01001 ,  C12Y602/01016

摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。 本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。 本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US07301016B2

公开(公告)日：2007-11-27

申请号：US10184648

申请日：2002-06-27

申请人： Rachel E. Meyers ,  Mark Williamson ,  Kevin R. Leiby ,  Rosana Kapeller-Libermann ,  Peter J. Olandt ,  Kyle J. MacBeth ,  Laura A. Rudolph-Owen ,  Fong-Ying Tsai ,  John J. Hunter

发明人： Rachel E. Meyers ,  Mark Williamson ,  Kevin R. Leiby ,  Rosana Kapeller-Libermann ,  Peter J. Olandt ,  Kyle J. MacBeth ,  Laura A. Rudolph-Owen ,  Fong-Ying Tsai ,  John J. Hunter

IPC分类号： C07H1/00 ,  C07H5/00 ,  C07H19/00 ,  C07H21/00 ,  C07H21/02 ,  C08B37/00 ,  C12Q1/68 ,  C12P21/06 ,  C12P19/34 ,  C12N1/12 ,  C12N1/20 ,  C12N15/00 ,  C12N15/06

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1007 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1096 ,  C12N9/93 ,  C12Q1/48 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y602/01001 ,  C12Y602/01016

摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252和53320核酸分子，其编码新的人转移酶家族成员 。 本发明还提供反义核酸分子，含有33877,47179,26886,25552,32132,32244,23680,3262,47174,60491,46743,27417,27960,32252或53320核酸分子的重组表达载体，宿主细胞 已经引入了表达载体的非人类转基因动物以及其中已经引入了33877,47179,26886,25552,32232,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320基因的非人类转基因动物，或 中断了 本发明还进一步提供了分离的33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179， 26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US20090263860A1

公开(公告)日：2009-10-22

申请号：US11980299

申请日：2007-10-30

申请人： Rachel E. Meyers ,  Mark J. Williamson ,  Rosana Kapeller-Libermann ,  Kyle J. MacBeth ,  John Joseph Hunter ,  Laura A. Rudolph-Owen ,  Rajasekhar Bandaru ,  Fong-Ying Tsai

发明人： Rachel E. Meyers ,  Mark J. Williamson ,  Rosana Kapeller-Libermann ,  Kyle J. MacBeth ,  John Joseph Hunter ,  Laura A. Rudolph-Owen ,  Rajasekhar Bandaru ,  Fong-Ying Tsai

IPC分类号： C12P21/02 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06

CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K48/00 ,  C07K2319/00

摘要： The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 gene has been introduced or disrupted. The invention still further provides isolated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 proteins, fusion proteins, antigenic peptides and anti-13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863 和32252个核酸分子。 本发明还提供反义核酸分子，重组表达载体，其含有13237,18480,2245,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216575,42755,32229 ，22325,46863和32252核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中13237,18480,2362,46169,3677,26320,46869,38166,16836,46867,21617,26173,26169， 已经引入或破坏了55562,39228,62088,4675,23155,21657,42755,32229,22325,46863或32252基因。 本发明还进一步提供分离的13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863或32252蛋白质 ，融合蛋白，抗原肽和抗-13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216547,42755,32229,22325,46863 或32252抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20090068187A1

公开(公告)日：2009-03-12

申请号：US11903752

申请日：2007-09-24

申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Fong-Ying Tsai ,  Martin R. Hodge ,  Rachel E. Meyers ,  Kyle J. MacBeth ,  Rajasekhar Bandaru

发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Fong-Ying Tsai ,  Martin R. Hodge ,  Rachel E. Meyers ,  Kyle J. MacBeth ,  Rajasekhar Bandaru

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/10 ,  C07K14/705 ,  C07K16/28 ,  C12P21/02 ,  C12Q1/68 ,  A61K31/7088 ,  A61K38/17 ,  G01N33/567 ,  G01N33/68 ,  C12N5/06 ,  C07K1/113 ,  A61K38/02

CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K2319/00 ,  C07K2319/02 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1205

摘要： The invention provides isolated nucleic acids molecules, designated 14275, 54420, 8797, 27439, 68730, 69112 or 52908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14275, 54420, 8797, 27439, 68730, 69112 or 52908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14275, 54420, 8797, 27439, 68730, 69112 or 52908 gene has been introduced or disrupted. The invention still further provides isolated 14275, 54420, 8797, 27439, 68730, 69112 or 52908 proteins, fusion proteins, antigenic peptides and anti-14275, 54420, 8797, 27439, 68730, 69112 or 52908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为14275,54420,8797,27439,67830,69112或52908核酸分子。 本发明还提供反义核酸分子，含有14275,54420,8797,27439,67830,69112或52908核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中14275， 54420,8797,27439,67830,69112或52908基因被引入或破坏。 本发明还进一步提供分离的14275,54420,8797,27439,68730,69112或52908蛋白，融合蛋白，抗原肽和抗-14275,54420,8797,27439,68730,69112或52908抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20100136010A1

公开(公告)日：2010-06-03

申请号：US12288465

申请日：2008-10-21

申请人： Rosana Kappeller-Libermann ,  David White ,  Keith E. Robison ,  Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

发明人： Rosana Kappeller-Libermann ,  David White ,  Keith E. Robison ,  Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

IPC分类号： A61K39/395 ,  A61K38/45 ,  A61K38/46 ,  A61K38/48 ,  C12Q1/68 ,  G01N33/53 ,  C12Q1/34 ,  C12P21/00 ,  C12N5/10 ,  C12N5/00 ,  A61K38/00 ,  A61K38/17 ,  A61K31/713 ,  A61K31/7088 ,  C07K14/435 ,  C07K16/40 ,  C07H21/04 ,  A61P31/12 ,  A61P9/00 ,  A61P35/00 ,  A61P19/08 ,  A61P7/00

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US07098015B2

公开(公告)日：2006-08-29

申请号：US10386414

申请日：2003-03-11

申请人： Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

发明人： Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

IPC分类号： C12N9/16 ,  C12N15/54 ,  C12N15/62 ,  C12N15/79

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US07235634B2

公开(公告)日：2007-06-26

申请号：US10767308

申请日：2004-01-29

申请人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

发明人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

IPC分类号： C07K14/00

CPC分类号： C12N9/48

摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

公开(公告)号：US06383780B1

公开(公告)日：2002-05-07

申请号：US09443795

申请日：1999-11-19

申请人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

发明人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

IPC分类号： C12P2106

CPC分类号： C12N9/48

摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。