公开(公告)号：US07485308B2

公开(公告)日：2009-02-03

申请号：US11493347

申请日：2006-07-26

申请人： Rachel E. Meyers ,  Kyle J. MacBeth ,  Rory A. J. Curtis ,  Laura A. Rudolph-Owen ,  Nadine S. Weich ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph M. Carroll

发明人： Rachel E. Meyers ,  Kyle J. MacBeth ,  Rory A. J. Curtis ,  Laura A. Rudolph-Owen ,  Nadine S. Weich ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph M. Carroll

IPC分类号： A61K39/00 ,  C12P21/06

CPC分类号： C12N9/001 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1048 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/48 ,  C12N9/80 ,  C12N2799/021 ,  C12Q1/32 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2500/10 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。 本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。 本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20100150901A1

公开(公告)日：2010-06-17

申请号：US12288677

申请日：2008-10-22

申请人： Rachel E. Meyers ,  Kyle J. MacBeth ,  Rory A.J. Curtis ,  Laura A. Rudolph-Owen ,  Nadine S. Weich ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph M. Carroll

发明人： Rachel E. Meyers ,  Kyle J. MacBeth ,  Rory A.J. Curtis ,  Laura A. Rudolph-Owen ,  Nadine S. Weich ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph M. Carroll

IPC分类号： A61K39/395 ,  C07H21/02 ,  C12N5/10 ,  C07K16/00 ,  C12P21/00 ,  G01N33/53 ,  C07H21/04 ,  C12Q1/68 ,  A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  A61K31/7105 ,  A61K31/713 ,  A61K31/711 ,  A61P35/00

CPC分类号： C12N9/001 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1048 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/48 ,  C12N9/80 ,  C12N2799/021 ,  C12Q1/32 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2500/10 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。 本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。 本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US07696316B2

公开(公告)日：2010-04-13

申请号：US11583766

申请日：2006-10-19

申请人： Rosana Kapeller-Libermann ,  John Joseph Hunter ,  Rachel E. Meyers ,  Laura A. Rudolph-Owen ,  Rory A. J. Curtis ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Katherine M. Galvin ,  Miyoung Chun ,  Mark J. Williamson ,  Inmaculada Silos-Santiago ,  Rajasekhar Bandaru

发明人： Rosana Kapeller-Libermann ,  John Joseph Hunter ,  Rachel E. Meyers ,  Laura A. Rudolph-Owen ,  Rory A. J. Curtis ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Katherine M. Galvin ,  Miyoung Chun ,  Mark J. Williamson ,  Inmaculada Silos-Santiago ,  Rajasekhar Bandaru

IPC分类号： C07K14/00 ,  C07H21/04 ,  C12P21/04 ,  C12P21/06

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C12N9/1235

摘要： The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 gene has been introduced or disrupted. The invention still further provides isolated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 proteins, fusion proteins, antigenic peptides and anti-21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为21910,5663,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555和593核酸 分子。 本发明还提供反义核酸分子，含有21910,5663,55053,2504,15977,14760,25501,17903,3700,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,3855的重组表达载体 和593个核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中21910,5663,5553,2504,15977,14760,25501,17903,3720,21529,26176， 已经引入或破坏了18610,33217,21967，h1983，m1983,38555或593基因。 本发明还进一步提供分离的21910,5563,4560,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555或593蛋白，融合蛋白， 抗原肽和抗-19910,563634,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,56638,18610,33217,21967，h1983，m1983,38555或593抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20110182879A1

公开(公告)日：2011-07-28

申请号：US12828319

申请日：2010-07-01

申请人： Rachel E. Meyers ,  Mark Williamson ,  Kevin R. Leiby ,  Rosana Kapeller-Libermann ,  Peter J. Olandt ,  Kyle J. MacBeth ,  Laura A. Rudolph-Owen ,  Fong-Ying Tsai ,  John J. Hunter

发明人： Rachel E. Meyers ,  Mark Williamson ,  Kevin R. Leiby ,  Rosana Kapeller-Libermann ,  Peter J. Olandt ,  Kyle J. MacBeth ,  Laura A. Rudolph-Owen ,  Fong-Ying Tsai ,  John J. Hunter

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/10 ,  C07K14/435 ,  C07K16/18 ,  C12P21/02 ,  G01N33/50 ,  G01N33/53 ,  A61K38/02 ,  A61P43/00

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1007 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1096 ,  C12N9/93 ,  C12Q1/48 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y602/01001 ,  C12Y602/01016

摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。 本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。 本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US07301016B2

公开(公告)日：2007-11-27

申请号：US10184648

申请日：2002-06-27

申请人： Rachel E. Meyers ,  Mark Williamson ,  Kevin R. Leiby ,  Rosana Kapeller-Libermann ,  Peter J. Olandt ,  Kyle J. MacBeth ,  Laura A. Rudolph-Owen ,  Fong-Ying Tsai ,  John J. Hunter

发明人： Rachel E. Meyers ,  Mark Williamson ,  Kevin R. Leiby ,  Rosana Kapeller-Libermann ,  Peter J. Olandt ,  Kyle J. MacBeth ,  Laura A. Rudolph-Owen ,  Fong-Ying Tsai ,  John J. Hunter

IPC分类号： C07H1/00 ,  C07H5/00 ,  C07H19/00 ,  C07H21/00 ,  C07H21/02 ,  C08B37/00 ,  C12Q1/68 ,  C12P21/06 ,  C12P19/34 ,  C12N1/12 ,  C12N1/20 ,  C12N15/00 ,  C12N15/06

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1007 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1096 ,  C12N9/93 ,  C12Q1/48 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y602/01001 ,  C12Y602/01016

摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252和53320核酸分子，其编码新的人转移酶家族成员 。 本发明还提供反义核酸分子，含有33877,47179,26886,25552,32132,32244,23680,3262,47174,60491,46743,27417,27960,32252或53320核酸分子的重组表达载体，宿主细胞 已经引入了表达载体的非人类转基因动物以及其中已经引入了33877,47179,26886,25552,32232,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320基因的非人类转基因动物，或 中断了 本发明还进一步提供了分离的33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179， 26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US07070947B2

公开(公告)日：2006-07-04

申请号：US10170789

申请日：2002-06-13

申请人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

发明人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

IPC分类号： C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N9/14 ,  C12Q1/34

CPC分类号： C12N9/12 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1205 ,  C12N9/14 ,  C12N9/16 ,  C12N9/6424 ,  C12N9/6427 ,  C12N9/6437 ,  C12Q1/34 ,  C12Q1/44 ,  C12Y207/01001 ,  C12Y301/02015 ,  C12Y304/21004 ,  C12Y304/21021 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5041 ,  G01N33/6893 ,  G01N2500/00

摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, hexokinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族的分离的核酸分子，命名为2504,15977,14760,53070,15985,5042,56583,21953，m32404,14089和23436核酸分子 成员，己糖激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供了反义核酸分子，含有2504,15977,14760,53070,15985,5042,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞， 和非人类转基因动物，其中引入或破坏了2504,15977,14760,53070,15985,550365,26583,21953，m32404,14089或23436基因。 本发明还进一步提供分离的2504,15977,14760,53070,15985,5038,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗2504,15977,14760,53070,15985,50365， 26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US07282360B2

公开(公告)日：2007-10-16

申请号：US11636948

申请日：2006-12-11

申请人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

发明人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

IPC分类号： C12N9/20 ,  C12N15/00 ,  C12N1/20 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K16/40 ,  C12N9/12 ,  C12N9/16 ,  C12N9/48 ,  C12N9/6424 ,  C12N9/6427 ,  C12N9/6472 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人类蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US20090324608A1

公开(公告)日：2009-12-31

申请号：US11899343

申请日：2007-09-05

申请人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

发明人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

IPC分类号： C12N15/52 ,  C12N15/85 ,  C12N5/10 ,  C12N9/12 ,  C12N9/48 ,  C12N9/76 ,  C07K16/40 ,  C12P21/02 ,  C12N9/99 ,  A61K38/02 ,  A61K39/395 ,  C12Q1/68

摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US06939698B2

公开(公告)日：2005-09-06

申请号：US10074527

申请日：2002-02-12

申请人： Peter J. Olandt ,  Rachel E. Meyers ,  Katherine M. Galvin

发明人： Peter J. Olandt ,  Rachel E. Meyers ,  Katherine M. Galvin

IPC分类号： C12N9/10 ,  C12Q1/48 ,  G01N33/573 ,  C12P21/06 ,  C07H21/04 ,  C12N9/00

CPC分类号： G01N33/573 ,  C12N9/1048 ,  C12Q1/48 ,  G01N2333/91091 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2500/20

摘要： The invention provides isolated nucleic acids molecules, designated 33945 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33945 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33945 gene has been introduced or disrupted. The invention still further provides isolated 33945 proteins, fusion proteins, antigenic peptides and anti-33945 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的糖基转移酶家族成员的分离的核酸分子，命名为33945核酸分子。 本发明还提供了反义核酸分子，含有33945个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了33945基因的非人转基因动物。 本发明还进一步提供了分离的33945蛋白，融合蛋白，抗原肽和抗33945抗体。 还提供了利用本发明组合物的诊断和治疗方法。