公开(公告)号：US07077819B1

公开(公告)日：2006-07-18

申请号：US09868950

申请日：1999-12-23

申请人： Rainer Goldau ,  Thomas Graf ,  Malte Gross

发明人： Rainer Goldau ,  Thomas Graf ,  Malte Gross

IPC分类号： A61M37/00 ,  C02F1/44

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1617 ,  A61M1/1635 ,  A61M1/3609 ,  A61M2205/3303 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2230/65

摘要： The invention relates to a method for determining the volume of distribution of a blood component in the body of a living organism, especially the volume of distribution of urea, during an extracorporeal blood treatment. According to this method, the blood to be treated flows through the blood chamber (3) of a dialysis machine (1) in an extracorporeal circuit, said dialysis machine being divided into said blood chamber and a dialysing liquid chamber (4) by a semipermeable membrane (2). Dialysing liquid flows through the dialysing liquid chamber of the dialysis machine in a dialysing liquid channel. The method is based on the determination of the temporal change in the concentration of the blood component in the blood upstream of the dialysis machine using the temporal variation in a physical or chemical characteristic of the dialysing liquid upstream and downstream of the dialysis machine and the determination of the volume of distribution of the substance in the body of a living organism using the temporal variation in the concentration of the blood component in the blood. The invention also relates to a device for the extracorporeal blood treatment, comprising a device for determining the volume of distribution of a blood component in the body of a living organism.

摘要翻译： 本发明涉及一种用于在体外血液处理期间确定生物体内的血液成分的分布体积，特别是尿素分布体积的方法。 根据这种方法，待处理的血液流过体外循环中的透析机（1）的血液室（3），所述透析机通过半透膜分成所述血液室和透析液室（4） 膜（2）。 透析液体在透析液通道中透过透析机的透析液室。 该方法基于使用透析机上游和下游的透析液的物理或化学特性的时间变化来确定透析机上游血液中血液成分浓度的时间变化，并确定 使用血液中血液成分的浓度的时间变化的物质在活体的体内的分布体积。 本发明还涉及用于体外血液处理的装置，其包括用于确定活体内体内血液成分的分布体积的装置。

公开(公告)号：US06860866B1

公开(公告)日：2005-03-01

申请号：US09599334

申请日：2000-06-22

申请人： Thomas Graf ,  Christoph Bardorz ,  Malte Gross ,  Rainer Goldau

发明人： Thomas Graf ,  Christoph Bardorz ,  Malte Gross ,  Rainer Goldau

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  B01D61/28 ,  B01D61/34 ,  A61M37/00 ,  A61B5/00 ,  B01D35/00 ,  B01D63/00 ,  C02F1/44

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/50

摘要： A method and a device for determining the efficiency of a dialyzer of a dialysis machine during a dialysis treatment wherein the dialyzer is divided by a semipermeable membrane into a blood chamber and a dialysis fluid chamber and wherein the blood flows at a predetermined flow rate through the blood chamber and dialysis fluid flows at a predetermined flow rate through the dialysis fluid chamber. In use, the dialysance or clearance for a predetermined dialysis fluid flow rate and/or blood flow rate is measured, and then the dialysance or clearance for any dialysis fluid flow rate and blood flow rate is calculated.

摘要翻译： 一种用于在透析治疗期间确定透析机的透析器的效率的方法和装置，其中透析器被半透膜分成血液室和透析液室，并且其中血液以预定的流速通过 血液室和透析液以预定的流速流过透析液室。 在使用中，测量预定透析液流速和/或血流速度的透析或间隙，然后计算任何透析流体流速和血流速度的透析或间隙。

公开(公告)号：US08764987B2

公开(公告)日：2014-07-01

申请号：US13262407

申请日：2010-03-31

申请人： Malte Gross ,  Andreas Maierhofer

发明人： Malte Gross ,  Andreas Maierhofer

IPC分类号： B01D61/32 ,  B01D61/24 ,  B01D61/26 ,  B01D61/28 ,  A61M1/14

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/3609 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65

摘要： An apparatus and a method for the determination and regulation of the concentration of at least one dissolved substance in a fluid circuit, in which the fluid circuit includes at least two partial circuits separated by a filter in a semi-permeable manner, includes a detection unit for determining a concentration difference of at least one first dissolved substance, a determination unit for determining the influence of at least one second dissolved substance which is not identical to the at least one first dissolved substance, and a regulation unit for regulating the concentration of the at least one dissolved substance in the fluid circuit.

摘要翻译： 一种用于确定和调节流体回路中至少一种溶解物质的浓度的装置和方法，其中，所述流体回路包括以半渗透方式由过滤器隔开的至少两个部分回路，包括检测单元 用于确定至少一种第一溶解物质的浓度差的确定单元，用于确定与所述至少一种第一溶解物质不同的至少一种第二溶解物质的影​​响的判定单元，以及用于调节所述至少一种溶解物质浓度的调节单元 至少一种溶解物质在流体回路中。

公开(公告)号：US20070108128A1

公开(公告)日：2007-05-17

申请号：US10580869

申请日：2004-09-11

申请人： Pascal Kopperschmidt ,  Malte Gross

发明人： Pascal Kopperschmidt ,  Malte Gross

IPC分类号： B01D61/32

CPC分类号： A61M1/3441 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3609 ,  A61M1/3639 ,  A61M2230/207

摘要： A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.

摘要翻译： 一种方法和装置，其使用体外血液透析装置来识别血液体外处理期间体外血液回路中的血流的损伤，其中振荡压力信号的至少一次谐波振荡在体外传播的相位角 确定血液回路。 基于对压力信号的至少一次谐波振荡的相位角的特征修改，在体外血液回路中检测出血流的损伤。 可以将相位角的时间修改与预定义的阈值进行比较，并且如果相位角的修改值大于预定阈值，则检测损伤。 该方法和装置允许早期鉴定血液透析装置中血液的凝结，从而可以及时启动对策。

公开(公告)号：US08784353B2

公开(公告)日：2014-07-22

申请号：US13123290

申请日：2009-10-02

申请人： Andreas Maierhofer ,  Malte Gross

发明人： Andreas Maierhofer ,  Malte Gross

IPC分类号： A61M37/00 ,  A61M39/00 ,  A61M39/10 ,  A61M39/22 ,  A61M1/36

CPC分类号： A61M1/367 ,  A61M1/3656 ,  A61M1/3663 ,  A61M39/10 ,  A61M39/105 ,  A61M39/1055 ,  A61M39/22 ,  A61M39/223 ,  A61M2039/1044 ,  A61M2039/229 ,  A61M2205/3515 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/6018 ,  A61M2205/6054 ,  F16K11/074

摘要： A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.

摘要翻译： 具有体外血液回路的体外血液处理装置的血流的逆转装置，包括从病人通向血液处理单元的动脉血线和从血液处理单元导入患者的静脉血液管路。 此外，体外血液处理装置包括用于逆转血流的装置，并且包括确定在体外血液处理期间血液流动的逆转的方法。 用于反转体外血液处理装置的血流的装置包括相对于彼此旋转以逆转血流的两个阀体。 用于反转血流的装置包括用于从体外血液处理装置的读取单元接收电磁高频场的通信装置，并且用于产生表征可被读取的阀体读取的阀体的位置的至少一个标识符 设备。

公开(公告)号：US20110196279A1

公开(公告)日：2011-08-11

申请号：US13123290

申请日：2009-10-02

申请人： Andreas Maierhofer ,  Malte Gross

发明人： Andreas Maierhofer ,  Malte Gross

IPC分类号： A61M1/14

CPC分类号： A61M1/367 ,  A61M1/3656 ,  A61M1/3663 ,  A61M39/10 ,  A61M39/105 ,  A61M39/1055 ,  A61M39/22 ,  A61M39/223 ,  A61M2039/1044 ,  A61M2039/229 ,  A61M2205/3515 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/6018 ,  A61M2205/6054 ,  F16K11/074

摘要： A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.

摘要翻译： 具有体外血液回路的体外血液处理装置的血流的逆转装置，包括从病人通向血液处理单元的动脉血线和从血液处理单元导入患者的静脉血液管路。 此外，体外血液处理装置包括用于逆转血流的装置，并且包括确定在体外血液处理期间血液流动的逆转的方法。 用于反转体外血液处理装置的血流的装置包括相对于彼此旋转以逆转血流的两个阀体。 用于反转血流的装置包括用于从体外血液处理装置的读取单元接收电磁高频场的通信装置，并且用于产生表征可被读取的阀体读取的阀体的位置的至少一个标识符 设备。

公开(公告)号：US20110046534A1

公开(公告)日：2011-02-24

申请号：US12920636

申请日：2009-03-03

申请人： Malte Gross

发明人： Malte Gross

IPC分类号： A61M1/00 ,  A61B5/05

CPC分类号： A61M1/367 ,  A61M5/158 ,  A61M2005/1588 ,  A61M2205/15

摘要： The invention relates to the monitoring of an access to a patient at a puncture point, in particular the monitoring of the arterial and/or venous vascular access during an extracorporeal blood treatment. The device according to the invention is a magnetoelastic moisture sensor, which is embedded in an absorbent material and is laid on the puncture point. For the case in which infusion solution and/or blood exits from the puncture point, the incorrect seating of the puncture cannula can be recognized reliably using the device according to the invention. The absorbent material having the embedded magnetoelastic moisture sensor can be laid like conventional bandage material or a gauze bandage on the puncture point.

摘要翻译： 本发明涉及在穿刺点处对病人的进入的监测，特别是在体外血液处理期间监测动脉和/或静脉血管通路。 根据本发明的装置是一种磁弹性水分传感器，其被嵌入吸收材料中并铺设在穿刺点上。 对于输液和/或血液从穿刺点离开的情况，可以使用根据本发明的装置可靠地识别穿刺套管的错位。 具有嵌入式磁弹性湿度传感器的吸收材料可以像传统的绷带材料或纱布绷带放置在穿刺点上。

公开(公告)号：US06939471B2

公开(公告)日：2005-09-06

申请号：US10393361

申请日：2003-03-21

申请人： Malte Gross ,  Andreas Maierhofer

发明人： Malte Gross ,  Andreas Maierhofer

IPC分类号： A61M1/16 ,  B01D61/32 ,  A61M1/14 ,  B01D61/24 ,  B01D61/28

CPC分类号： A61M1/16 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/1654 ,  A61M1/1656 ,  A61M1/361 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52

摘要： A method for determining a treatment parameter on a haemofiltration device, as well as a haemofiltration device for applying the method, based on the recognition that a determination method known from haemodialysis can, with little modification, be transferred to haemofiltration. To this effect a physical-chemical characteristic of the substitution fluid and of the fluid which is removed from the haemofilter by way of an ultrafiltrate outlet pipe, is determined. Furthermore, this characteristic is acquired before, after or during a change of this characteristic in the substitution fluid, and is evaluated. As a result, the ion dialysance and thus the urea clearance of a haemofiltration device, which can also be operated as a haemodiafiltration device, can be determined.

摘要翻译： 基于认识到从血液透析已知的测定方法可以很少改进的方法转移到血液过滤中，用于确定血液净化装置上的治疗参数以及用于应用该方法的血液净化装置的方法。 为此，确定了取代流体和通过超滤出口管从除污机除去的流体的物理化学特性。 此外，在替代液中的该特性的变化之前，之后或期间获取该特性，并进行评价。 结果，可以确定也可以作为血液透析过滤装置操作的血液净化装置的离子透析性以及因此的尿素清除率。

公开(公告)号：US09215985B2

公开(公告)日：2015-12-22

申请号：US14111248

申请日：2012-04-10

申请人： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Maierhofer ,  Alfred Gagel

发明人： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Maierhofer ,  Alfred Gagel

IPC分类号： G01N21/00 ,  A61B5/00 ,  A61M1/36 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/64 ,  G01N21/65

CPC分类号： A61B5/0082 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/367 ,  G01N21/6486 ,  G01N21/65

摘要： A method of monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, that includes the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.

摘要翻译： 一种监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，其包括以下步骤：用至少第一照射波长的照射光照射用于治疗的透析液样品，检测 由至少第一检测波长的被照射样品发射的光，检测波长不同于第一照射波长，并且基于检测到的光来确定样品中至少一种分析物的存在和/或浓度。

公开(公告)号：US08465641B2

公开(公告)日：2013-06-18

申请号：US12452956

申请日：2008-07-30

申请人： Andreas Maierhofer ,  Alfred Gagel ,  Malte Gross

发明人： Andreas Maierhofer ,  Alfred Gagel ,  Malte Gross

IPC分类号： B01D61/30

CPC分类号： A61M1/1656 ,  A61M2205/15

摘要： A dialysis liquid circuit with conduits for conducting dialysis liquid and elements for detecting air in the dialysis liquid. The elements includes at least one gas sensor traversed continuously by the dialysis liquid, which is configured such that it measures at least one property of the dialysis liquid which depends on the presence of air bubbles in the dialysis liquid, and which is arranged downstream of a region to be monitored of the dialysis liquid circuit. During operation of the dialysis liquid circuit a negative pressure exists with respect to atmospheric pressure, and the elements includes an evaluation unit which is connected with the gas sensor and which is configured such that the property measured by means of the gas sensor is evaluated with regard to the presence of air bubbles in the dialysis liquid.

摘要翻译： 透析液回路，其具有用于透析液体的导管和用于检测透析液中的空气的元件。 这些元件包括由透析液连续穿过的至少一个气体传感器，其被配置为使得其测量透析液体的至少一个性质，其依赖于透析液体中的气泡的存在，并且其布置在 要监测透析液回路的区域。 在透析液体回路的运转中，相对于大气压存在负压，并且元件包括与气体传感器连接的评估单元，其被构造为使得通过气体传感器测量的性质被评估 到透析液体中存在气泡。