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公开(公告)号:US4756884A
公开(公告)日:1988-07-12
申请号:US880793
申请日:1986-07-01
申请人: Robert S. Hillman , Michael E. Cobb , Jim Allen , Ian Gibbons , Vladimir Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jim Allen , Ian Gibbons , Vladimir Ostoich , Laura J. Winfrey
IPC分类号: G01N15/14 , B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , B29C65/48 , G01N15/10 , G01N21/00 , G01N21/01 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N31/22 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/53 , G01N33/543 , G01N33/86 , G01N35/00 , G01N35/02 , G01N37/00 , G01N11/04
CPC分类号: G01N33/4905 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B01L3/50273 , B01L3/502746 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/71 , G01N21/82 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2200/0689 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2400/0406 , B01L2400/0694 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366 , Y10S366/03 , Y10S435/81
摘要: Methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the device.
摘要翻译: 提供的方法和装置涉及至少一个室,至少一个毛细管,以及涉及提供可检测信号的系统中的至少一个试剂。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及用于该装置的各种控制装置。
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公开(公告)号:US5004923A
公开(公告)日:1991-04-02
申请号:US472130
申请日:1990-01-30
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/49 , G01N33/543 , G01N35/00
CPC分类号: B01L3/5027 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0816 , B01L2300/0822 , B01L2300/0825 , B01L2300/0864 , B01L2400/0406 , B01L3/502715 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US5300779A
公开(公告)日:1994-04-05
申请号:US931719
申请日:1992-08-18
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/543 , G01N33/86 , G01N35/00 , G01N31/22
CPC分类号: B01F5/0646 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , G01N33/86 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0654 , B01L2300/0681 , B01L2300/0816 , B01L2300/0825 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/0694 , B01L3/502723 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/0092 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US5204525A
公开(公告)日:1993-04-20
申请号:US732689
申请日:1991-07-19
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/543 , G01N33/86 , G01N35/00
CPC分类号: B29C65/08 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B01L3/5027 , B29C66/30223 , B29C66/54 , G01N21/82 , G01N33/4905 , G01N33/86 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0816 , B01L2300/0825 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/73921 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US5144139A
公开(公告)日:1992-09-01
申请号:US732596
申请日:1991-07-19
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/543 , G01N33/86 , G01N35/00
CPC分类号: B01F15/0232 , B01F13/0059 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , G01N21/82 , G01N33/4905 , G01N33/86 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2200/0684 , B01L2300/0816 , B01L2300/0825 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L3/5025 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/73921 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US4948961A
公开(公告)日:1990-08-14
申请号:US177625
申请日:1988-04-05
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/49 , G01N33/543 , G01N35/00
CPC分类号: B01F15/0232 , B01F13/0059 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0694 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutiniation particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US5164598A
公开(公告)日:1992-11-17
申请号:US651283
申请日:1991-02-05
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/543 , G01N33/86 , G01N35/00
CPC分类号: B01F5/0646 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , G01N33/86 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0654 , B01L2300/0681 , B01L2300/0816 , B01L2300/0825 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/0694 , B01L3/502723 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/0092 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
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公开(公告)号:US5140161A
公开(公告)日:1992-08-18
申请号:US734597
申请日:1991-07-23
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/49 , G01N33/543 , G01N35/00
CPC分类号: B01L3/5027 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B29C65/08 , B29C66/30223 , B29C66/54 , G01N21/82 , G01N33/4905 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0816 , B01L2300/0825 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/086 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/73921 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastics devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US4963498A
公开(公告)日:1990-10-16
申请号:US144416
申请日:1988-01-15
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/49 , G01N33/543 , G01N35/00
CPC分类号: B01F5/0618 , B01F13/0059 , B01F15/0232 , B01F5/0646 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2200/0621 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0688 , B01L2400/0694 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366 , Y10S366/03 , Y10S435/81 , Y10T436/2575
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及用于该装置的各种控制装置。
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公开(公告)号:US5077017A
公开(公告)日:1991-12-31
申请号:US117791
申请日:1987-11-05
CPC分类号: G01N1/38 , B01F13/0818 , B01F15/04 , G01N33/04 , Y10T436/25625
摘要: A dilution and mixing cartridge comprising a sample application site, a mixing chamber in fluid receiving relationship to the sample application site, a diluent application site in fluid donating relationship to the mixing chamber, a first valve means selectively preventing flow from the diluent application site to the mixing chamber, and a mixture isolating chamber hydrostatically connected to the mixing chamber is provided along with a method for using this cartridge to sequentially dilute a sample with the same or different diluents.
摘要翻译: 一种稀释和混合筒,包括样品施加部位,与样品施加部位处于流体接收关系的混合室,与混合室具有流体供给关系的稀释剂施加部位,选择性地防止从稀释剂施用部位流向 混合室以及静态连接到混合室的混合物隔离室以及使用该滤筒依次稀释具有相同或不同稀释剂的样品的方法。
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