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公开(公告)号：US10052068B2
公开(公告)日：2018-08-21
申请号：US14331522
申请日：2014-07-15
发明人： Cameron Piron , Josh Richmond , Gal Sela
CPC分类号： A61B5/6847 , A61B5/064 , A61B5/067 , A61B34/20 , A61B90/39 , A61B2017/00734 , A61B2034/2048 , A61B2034/2051 , A61B2034/2055 , A61B2034/2061 , A61B2034/2065 , A61B2034/2068 , A61B2090/3735 , A61B2090/3945 , A61B2090/397 , A61B2090/3983 , A61B2562/0261
摘要： An apparatus is provided having a proximal end, a distal end, and an outer surface. The apparatus comprises a handle portion located near the proximal end of the apparatus, a supporting arm attached to the proximal end of the apparatus, the supporting arm having a tracking marker, a flexible tip portion located at the distal end of the apparatus, and a plurality of sensors located on the outer surface of the apparatus. The plurality of sensors each provides a signal representing information that is useable for determining deformation of the flexible tip portion. The apparatus may be either a sheath for covering a medical tool or the apparatus may be a medical tool.
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公开(公告)号：US09681821B2
公开(公告)日：2017-06-20
申请号：US14903029
申请日：2015-02-19
发明人： Cameron Piron , Jeff Stainsby , Chad Harris
IPC分类号： A61B5/055 , A61B5/00 , A61B5/03 , G01R33/563
CPC分类号： A61B5/055 , A61B5/031 , A61B5/032 , A61B5/4058 , A61B5/4076 , A61B5/4809 , A61B2576/00 , G01R33/56341 , G01R33/56366
摘要： Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.
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公开(公告)号：US20160061808A1
公开(公告)日：2016-03-03
申请号：US14491158
申请日：2014-09-19
发明人： Aaron Cheung , Siu Wai Jacky Mak , Michael Wood , Cameron Piron
IPC分类号： G01N33/483 , A61B10/02 , G01N21/27 , G01N21/65 , G01N21/47
CPC分类号： G01N1/286 , A61B5/0075 , A61B5/4064 , A61B5/4836 , A61B10/0266 , G01N1/08 , G01N1/31 , G01N21/65 , G01N33/4833 , G01N2201/06113 , G01N2201/0826
摘要： The present invention provides a method and system for identification and isolation of cells from tissues using optical spectroscopy. The method includes accessing the cells using an access corridor, measuring the cells using optical spectroscopy, comparing the spectra of the cells to signature spectra, using the comparison to identify the cells and removing the cells into a container. The system includes an access corridor, a probe for measuring the cells, a resection tool, a collection tube and a collection container.
摘要翻译： 本发明提供一种使用光谱鉴定和分离细胞从组织中分离的方法和系统。 该方法包括使用存取走廊访问细胞，使用光谱法测量细胞，将细胞的光谱与特征谱进行比较，使用比较来鉴定细胞并将细胞移入容器中。 该系统包括通道走廊，用于测量细胞的探针，切除工具，收集管和收集容器。
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公开(公告)号：US20190307362A1
公开(公告)日：2019-10-10
申请号：US16449265
申请日：2019-06-21
发明人： Cameron Piron , Michael Wood , Gal Sela , Joshua Richmond , Murugathas Yuwaraj , Monroe M. Thomas , Wes Hodges , Simon Alexander , David Gallop , Alex Panther , Nishanthan Shanmugaratnam , William Lau
摘要： Navigation and simulation systems and methods for minimally invasive therapy in which the navigation system imports a planning method using patient specific pre-operative images. The navigation system uses intraoperative imaging during the medical procedure to update the preoperative images and provides images of tracked surgical tools along the surgical path prepared from the preoperative images.
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公开(公告)号：US10292771B2
公开(公告)日：2019-05-21
申请号：US14398649
申请日：2014-03-14
发明人： Michael Wood , Cameron Piron , Murugathas Yuwaraj , Gal Sela , Joshua Richmond , Stephen McFadyen
IPC分类号： A61B34/20 , A61B34/10 , A61B1/04 , A61B1/06 , A61B90/00 , A61B1/313 , A61B5/02 , A61B6/03 , A61B6/00 , A61B17/00 , G01J3/28 , G01J3/42 , G01J3/02 , A61B5/00 , A61B90/50 , A61B34/30 , A61B90/30 , A61B5/055
摘要： Systems, methods and devices are provided for illuminating tissue with monochromatic or broadband light and imaging light that has been reflected back from the tissue. Imaging may be white-light imaging or hyperspectral imaging. The system can be a stand-alone hyperspectral imaging system, integrated as part of an external video scope, or as an auxiliary imaging module on an external videoscope. Various elements of a video scope that is particularly suited for minimally invasive surgery is first presented and then its configurations suitable for hyperspectral imaging are explained.
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6.发明申请SYSTEMS AND METHODS FOR MEASURING GLOBAL GLYMPHATIC FLOW USING MAGNETIC RESONANCE IMAGING 有权使用磁共振成像测量全球GLYMPHAIC流量的系统和方法公开(公告)号：US20160367166A1
公开(公告)日：2016-12-22
申请号：US14903029
申请日：2015-02-19
发明人： Cameron Piron , Jeff Stainsby , Chad Harris
IPC分类号： A61B5/055 , G01R33/563 , A61B5/03
CPC分类号： A61B5/055 , A61B5/031 , A61B5/032 , A61B5/4058 , A61B5/4076 , A61B5/4809 , A61B2576/00 , G01R33/56341 , G01R33/56366
摘要： Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.
摘要翻译： 描述了使用磁共振成像（“MRI”）提供脑脊液全球血液流量（“CSF”）的定量测量的系统和方法。 一般来说，使用设计为对CSF的血液流动特别敏感的流敏MRI技术从受试者获得图像。 当受试者处于清醒状态时，并且当受试者处于睡眠状态时，可以获得血液流量的测量。 基于这两个测量，可以产生指示神经系统状态或疾病的生物标志物。
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公开(公告)号：US20140276007A1
公开(公告)日：2014-09-18
申请号：US14215780
申请日：2014-03-17
发明人： Gal Sela , Cameron Piron , Joshua Richmond
CPC分类号： A61B5/064 , A61B2034/2068 , A61B2090/363 , A61B2090/3983
摘要： A medical navigation system having a surgical pointer is provided. The surgical pointer is used in the medical navigation system. The surgical pointer comprises an external sheath and an internal tool having a proximal end and a distal end. The internal tool is contained at least partially within the external sheath. The internal tool has a tip at the distal end that extends beyond the external sheath. The tip engages a surface of a patient. The internal tool further has a tracking marker trackable by the navigation system. The surgical pointer further has a linking component contained at least partially within the external sheath and interfacing with the internal tool. The linking component is configured to control pressure exerted by the tip on the surface of the patient.
摘要翻译： 提供具有手术指针的医疗导航系统。 手术指针用于医疗导航系统。 手术指针包括外护套和具有近端和远端的内部工具。 内部工具至少部分地包含在外部护套内。 内部工具在远端处具有延伸超出外部护套的尖端。 尖端接合患者的表面。 内部工具还具有可由导航系统跟踪的跟踪标记。 手术指针还具有至少部分地包含在外部护套内并且与内部工具接合的连接部件。 连接部件构造成控制尖端施加在患者表面上的压力。
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公开(公告)号：US20200015908A1
公开(公告)日：2020-01-16
申请号：US16414957
申请日：2019-05-17
发明人： MICHAEL WOOD , Cameron Piron , Murugathas Yuwaraj , Gal Sela , Joshua Richmond , Stephen McFadyen
IPC分类号： A61B34/20 , G01J3/28 , G01J3/42 , G01J3/02 , A61B5/00 , A61B1/04 , A61B1/06 , A61B90/00 , A61B34/10 , A61B1/313 , A61B5/02 , A61B6/03 , A61B6/00 , A61B17/00
摘要： A hyperspectral imaging apparatus and methods for performing hyperspectral imaging of a surgical field, involving: an external optical imaging device for externally imaging internal tissue through a surgical access port, the access port having a port wall having a light-diffusing surface texture, whereby reflectance of the port wall is decreasable, and the external optical imaging device having an illuminated exoscope, the illuminated exoscope having: a longitudinal housing; an optical imaging assembly provided within the longitudinal housing; an imaging camera interfaced with the optical imaging assembly for detecting images collected by the optical imaging assembly; and one or more illumination sources supported by the longitudinal housing, wherein an illumination axis associated with each illumination source is offset from an imaging axis of the optical imaging assembly; a remote light source; a spectral filtering device in optical communication with the remote light source; and a light guide having a proximal end in optical communication with an output of the spectral filtering device and one or more distal ends, wherein each distal end is in optical communication with an illumination source.
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公开(公告)号：US09734632B2
公开(公告)日：2017-08-15
申请号：US15422683
申请日：2017-02-02
发明人： Monroe M. Thomas , Gal Sela , Cameron Piron , Joshua Richmond , Murugathas Yuwaraj , Wes Hodges , Simon Alexander , David Gallop , William Lau , Sheryl Thingvold , Kelly Dyer
IPC分类号： G06K9/00 , G06T19/00 , G06T7/00 , G06T19/20 , A61B34/10 , A61B5/055 , A61B5/00 , A61B6/03 , A61B8/08 , A61B6/00 , A61B34/20 , A61B5/05 , G06T1/60 , G06F3/0481 , G06F3/0484
CPC分类号： G06T19/003 , A61B5/0042 , A61B5/055 , A61B6/032 , A61B6/037 , A61B6/501 , A61B8/00 , A61B8/0808 , A61B34/10 , A61B34/20 , A61B2034/105 , A61B2034/107 , A61B2034/2051 , A61B2034/2055 , A61B2090/3735 , A61B2090/378 , G06F3/04815 , G06F3/04842 , G06F3/04847 , G06T1/60 , G06T7/0012 , G06T11/20 , G06T17/00 , G06T19/20 , G06T2200/04 , G06T2200/24 , G06T2207/10088 , G06T2207/20101 , G06T2207/30016 , G06T2207/30241 , G06T2210/41 , G06T2219/028
摘要： Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery.
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10.发明授权公开(公告)号：US10799316B2
公开(公告)日：2020-10-13
申请号：US14775759
申请日：2014-03-14
发明人： Gal Sela , Cameron Piron , Michael Wood , Joshua Richmond , Murugathas Yuwaraj , Stephen McFadyen , Monroe M. Thomas , Wes Hodges , Simon Alexander , David Gallop
摘要： Disclosed herein is a system and method for dynamic validation, correction of registration for surgical navigation during medical procedures on a patient which involves confirmation of registration between one or more previously registered virtual objects, such as surgical tools etc. in a common coordinate frame of a surgical navigation system and an operating room, and intra-operatively acquired imaging during the medical procedure in the common coordinate frame. The method includes displaying intra-operatively acquired imaging of the surgical field containing the one or more real objects corresponding to the one or more previously registered virtual objects, with the real objects being tracked by a tracking system. The method overlaying a virtual image containing the previously registered virtual objects onto the intra-operatively acquired imaging, from the point of view of the intra-operatively acquired imaging, and detecting for any misalignment between any one of the one or more previously registered virtual objects contained in the virtual image and its corresponding real object contained in the intra-operatively acquired imaging.
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