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1.发明授权公开(公告)号：US09421304B2
公开(公告)日：2016-08-23
申请号：US12195255
申请日：2008-08-20
申请人： Sonya Shortkroff , Joseph Khoury , Laurence J. B. Tarrant , Hans P. I. Claesson , Robert Lane Smith
发明人： Sonya Shortkroff , Joseph Khoury , Laurence J. B. Tarrant , Hans P. I. Claesson , Robert Lane Smith
CPC分类号： A61F2/02 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2002/30766 , A61F2240/001 , A61L27/24 , A61L27/26 , A61L27/3804 , A61L27/3817 , A61L27/3834 , A61L27/3839 , A61L27/3847 , A61L27/3852 , A61L27/386 , A61L27/3873 , A61L27/3878 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06 , A61L2430/20 , A61L2430/30 , A61L2430/32 , A61L2430/34
摘要： A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.
摘要翻译： 双组织植入物（DSTI）及其制备和使用方法，用于植入组织缺陷。 用于分化，生长和转化细胞，干细胞，间充质干细胞和骨髓干细胞的双重结构组织植入物。 DSTI包括主要支架和由可溶性胶原溶液组合的辅助支架，其与产生并定位在主要支架内的非离子表面活性剂组合。
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公开(公告)号：US20160206787A9
公开(公告)日：2016-07-21
申请号：US12195255
申请日：2008-08-20
申请人： Sonya Shortkroff , Joseph Khoury , Laurence J.B. Tarrant , Hans P.I. Claesson , Robert Lane Smith
发明人： Sonya Shortkroff , Joseph Khoury , Laurence J.B. Tarrant , Hans P.I. Claesson , Robert Lane Smith
IPC分类号： A61F2/02 , A61L27/56 , A61F2/30 , A61L27/52 , A61L27/26 , A61L27/54 , A61L27/24 , A61B17/08 , A61L27/38
CPC分类号： A61F2/02 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2002/30766 , A61F2240/001 , A61L27/24 , A61L27/26 , A61L27/3804 , A61L27/3817 , A61L27/3834 , A61L27/3839 , A61L27/3847 , A61L27/3852 , A61L27/386 , A61L27/3873 , A61L27/3878 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06 , A61L2430/20 , A61L2430/30 , A61L2430/32 , A61L2430/34
摘要： A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.
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3.发明申请Method For Improvement Of Differentiation Of Mesenchymal Stem Cells Using A Double-Structured Tissue Implant 有权使用双结构组织植入物改善间充质干细胞分化的方法公开(公告)号：US20090069903A1
公开(公告)日：2009-03-12
申请号：US12195255
申请日：2008-08-20
申请人： Sonya Shortkroff , Joseph Khoury , Laurence J.B. Tarrant , Hans P.I. Claesson , Robert Lane Smith
发明人： Sonya Shortkroff , Joseph Khoury , Laurence J.B. Tarrant , Hans P.I. Claesson , Robert Lane Smith
CPC分类号： A61F2/02 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2002/30766 , A61F2240/001 , A61L27/24 , A61L27/26 , A61L27/3804 , A61L27/3817 , A61L27/3834 , A61L27/3839 , A61L27/3847 , A61L27/3852 , A61L27/386 , A61L27/3873 , A61L27/3878 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06 , A61L2430/20 , A61L2430/30 , A61L2430/32 , A61L2430/34
摘要： A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.
摘要翻译： 双组织植入物（DSTI）及其制备和使用方法，用于植入组织缺陷。 用于分化，生长和转化细胞，干细胞，间充质干细胞和骨髓干细胞的双重结构组织植入物。 DSTI包括主要支架和由可溶性胶原溶液组合的辅助支架，其与产生并定位在主要支架内的非离子表面活性剂组合。
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4.发明申请公开(公告)号：US20170255966A1
公开(公告)日：2017-09-07
申请号：US15593785
申请日：2017-05-12
申请人： Joseph Khoury
发明人： Joseph Khoury
CPC分类号： G06Q30/0266 , B60W40/00 , G01C21/3617 , G01C21/3697 , G05D1/0088 , G06Q30/0205 , G06Q40/08 , G07C5/008 , G07C5/085 , G08G1/0112 , G08G1/012 , G08G1/0129 , H04L67/02 , H04L67/12 , H04L67/18 , H04L67/20 , H04L67/22 , H04L67/306 , H04L69/04
摘要： Systems and methods for efficiently addressing technical and privacy/authorization obstacles associated with tracking of individuals in a vehicle, and enabling route-based analysis to determine driving behavior, socio-demographics, future profitability, and interests of individuals or self-driving systems. Driving information is collected using a device associated with a driver and a vehicle or using data collected by systems of self-driving vehicles. The frequency and methods used for the collection of driving information can be modified based on location and movement of the device and based on previous classification of the driver or self-driving system, thereby enabling efficient use of bandwidth and battery and increasing accuracy of the classification. The driving information is encoded and transmitted to a server, where future typical route segments that the driver is likely to travel are predicted, and the driver, or the self-driving system, is classified into one or more groups based on the encoded driving information.
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5.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 有权改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20140315271A1
公开(公告)日：2014-10-23
申请号：US14238774
申请日：2012-08-22
IPC分类号： C12N13/00
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
摘要翻译： 包括二氧化钛，钛，钛合金和/或聚四氟乙烯（PTFE）的可植入物体的表面的生物活性的改善方法和由此制备的可植入物体形成加速的中性束，其由加速的气体 - 团簇离子束 （GCIB）在减压室中，将可植入物体引入减压室中，以及用GCIB衍生的中性光束照射所述可植入物体的表面的至少第一部分。
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公开(公告)号：US20130282136A1
公开(公告)日：2013-10-24
申请号：US13922787
申请日：2013-06-20
申请人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
发明人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
IPC分类号： A61L27/54
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2310/00359 , A61F2310/00976 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
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7.发明申请METHOD AND SYSTEM FOR STERILIZING OBJECTS BY THE APPLICATION OF BEAM TECHNOLOGY 审中-公开通过光束技术应用灭菌对象的方法和系统公开(公告)号：US20130022494A1
公开(公告)日：2013-01-24
申请号：US13358213
申请日：2012-01-25
IPC分类号： A61L2/08
CPC分类号： A61L2/087 , A61L2/20 , A61L12/10 , A61L2202/14 , A61L2202/24 , H01J37/08 , H01J37/20 , H01J37/30 , H01J2237/0812
摘要： Methods and systems for sterilization of objects by gas-cluster ion-beam (GCIB) irradiation or by accelerated Neutral Beam are disclosed. The sterilization may be in conjunction with other beneficial GCIB surface processing of the objects. The objects may be medical devices or surgically implantable medical prostheses. The accelerated Neutral Beam is derived from an accelerated GCIB.
摘要翻译： 公开了通过气体簇离子束（GCIB）照射或加速中性束对物体进行灭菌的方法和系统。 灭菌可以与对象的其他有益的GCIB表面处理结合使用。 物体可以是医疗装置或可手术植入的医疗假体。 加速中性光束来自加速GCIB。
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公开(公告)号：US06467319B1
公开(公告)日：2002-10-22
申请号：US09435591
申请日：1999-11-08
IPC分类号： B60R2502
CPC分类号： B60R25/02115 , Y10T70/5664 , Y10T70/5956
摘要： A remote key interlock system includes a locking device mounted on a steering column and a key actuated ignition switch located remote from the locking device, where a cable connects the locking device to the key actuated ignition switch. The locking device being engageable with a recess of a steering shaft housed within the steering column. The cable being either electrically insulated from one of the key actuated ignition switch and the locking device, or load bearing, or moveable.
摘要翻译： 遥控钥匙互锁系统包括安装在转向柱上的锁定装置和位于远离锁定装置的钥匙致动的点火开关，其中电缆将锁定装置连接到钥匙致动的点火开关。 锁定装置可与容纳在转向柱内的转向轴的凹部接合。 电缆与钥匙致动的点火开关和锁定装置中的一个电动绝缘，或负载承载，或可移动。
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9.发明申请公开(公告)号：US20180130095A1
公开(公告)日：2018-05-10
申请号：US15864711
申请日：2018-01-08
申请人： Joseph Khoury
发明人： Joseph Khoury
CPC分类号： G06Q30/0266 , B60W40/00 , B60W40/09 , G01C21/3617 , G01C21/3697 , G05D1/0088 , G06Q30/0205 , G06Q40/08 , G07C5/008 , G07C5/085 , G08G1/0112 , G08G1/012 , G08G1/0129 , H04L67/02 , H04L67/12 , H04L67/18 , H04L67/20 , H04L67/22 , H04L67/306 , H04L69/04
摘要： Systems and methods for efficiently addressing technical and privacy/authorization obstacles associated with tracking of individuals in a vehicle, and enabling route-based analysis to determine driving behavior, socio-demographics, future profitability, and interests of individuals or self-driving systems. Driving information is collected using a device associated with a driver and a vehicle or using data collected by systems of self-driving vehicles. The frequency and methods used for the collection of driving information can be modified based on location and movement of the device and based on previous classification of the driver or self-driving system, thereby enabling efficient use of bandwidth and battery and increasing accuracy of the classification. The driving information is encoded and transmitted to a server, where future typical route segments that the driver is likely to travel are predicted, and the driver, or the self-driving system, is classified into one or more groups based on the encoded driving information.
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10.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 有权改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20160228609A1
公开(公告)日：2016-08-11
申请号：US15130354
申请日：2016-04-15
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
摘要翻译： 包括二氧化钛，钛，钛合金和/或聚四氟乙烯（PTFE）的可植入物体的表面的生物活性的改善方法和由此制备的可植入物体形成加速的中性束，其由加速的气体 - 团簇离子束 （GCIB）在减压室中，将可植入物体引入减压室中，以及用GCIB衍生的中性光束照射所述可植入物体的表面的至少第一部分。
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