公开(公告)号：US07413713B2

公开(公告)日：2008-08-19

申请号：US10283215

申请日：2002-10-30

申请人： Tadashi Sano ,  Ryo Miyake ,  Akira Koide ,  Norihide Saho ,  Akiomi Kono ,  Takeshi Harada

发明人： Tadashi Sano ,  Ryo Miyake ,  Akira Koide ,  Norihide Saho ,  Akiomi Kono ,  Takeshi Harada

IPC分类号： B01J10/00 ,  B01J10/02 ,  B01J12/00 ,  B01J12/02 ,  B01J14/00

CPC分类号： B01F15/00149 ,  B01F3/04503 ,  B01F5/0471 ,  B01F13/0059 ,  B01F15/00123 ,  B01F15/00344 ,  B01J4/001 ,  B01J10/002 ,  B01J14/00 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25 ,  Y10T436/2575 ,  Y10T436/25875

摘要： A reaction apparatus comprises a first supply flow channel having a fine flow channel cross sectional area for a liquid pressurized by a pressurizing device, a gas supply flow channel having a fine flow channel cross sectional area for supplying a gas, a two-phase flow channel having a fine flow channel cross sectional area in communication with a joined portion for the first supply flow channel and the second supply flow channel for flowing a gas/liquid two-phase fluid, a gas bubble reaction flow channel in communication with the exit of the gas/liquid two-phase channel and having a flow channel cross sectional area larger than that of the gas/liquid two-phase flow channel, and a liquid discharge flow channel for discharging the liquid in the gas bubble reaction flow channel. Therefore, in the reaction apparatus, a stable mixing ratio of a gas to a liquid can be obtained and the mixing speed of the gas to the liquid is increased.

摘要翻译： 反应装置包括：第一供给流路，其具有用于由加压装置加压的液体的细流路截面积;气体供给流路，具有用于供给气体的细流路截面积;二相流路 具有与用于第一供给流动通道的接合部分和用于使气体/液体两相流体流动的第二供应流动通道的细流动通道横截面积，与气体/液体两相流体流动的气泡反应流动通道， 气体/液体两相通道，并且具有大于气/液二相流动通道的流动通道横截面积，以及用于排出气泡反应流动通道中的液体的液体排出流动通道。 因此，在反应装置中，可以获得气体与液体的稳定的混合比，并且气体与液体的混合速度提高。

公开(公告)号：US07374726B2

公开(公告)日：2008-05-20

申请号：US10694810

申请日：2003-10-29

申请人： Tadashi Sano ,  Ryo Miyake ,  Akira Koide ,  Takeshi Harada

发明人： Tadashi Sano ,  Ryo Miyake ,  Akira Koide ,  Takeshi Harada

IPC分类号： B01J10/00 ,  B01L3/02

CPC分类号： B01F13/0062 ,  B01F3/0807 ,  B01F5/0453 ,  B01F5/0682 ,  B01F13/0066 ,  B01F2005/0031 ,  B01J19/0093 ,  B01J2219/00837 ,  B01J2219/0084 ,  B01J2219/00891 ,  B01J2219/00923 ,  B01L3/5027 ,  B01L2200/0636 ,  G01N35/08 ,  Y10T137/2224 ,  Y10T137/2564 ,  Y10T436/255

摘要： In a chemical reactor, a gas and a liquid which are in trace volumes are used to produce air bubbles and thus increase the interface area between the gas and liquid, substantially enhancing the efficiency of reaction between the gas and liquid. The chemical reactor comprises the following: a sheath flow forming block which forms a plurality of alternating sheath flows with two mutually unmixable fluids; a plurality of inlet ports through which said two fluids flow into the sheath flow forming block; a contraction zone which simultaneously contracts a plurality of sheath flows formed in the sheath flow forming block; and reaction flow channels each of which is connected with said contraction zone and is smaller in width than the sheath flow forming block.

摘要翻译： 在化学反应器中，使用微量的气体和液体来产生气泡，从而增加了气体和液体之间的界面面积，从而显着提高了气体和液体之间的反应效率。 化学反应器包括以下：鞘流形成块，其形成具有两个相互不可混合流体的多个交替护套流; 多个入口，所述两种流体通过所述入口流入所述鞘流形成块; 收缩区，其同时收缩形成在鞘流形成块中的多个鞘流; 以及每个与所述收缩区连接的反应流动通道，并且宽度小于鞘流形成块。

公开(公告)号：US20050087562A1

公开(公告)日：2005-04-28

申请号：US10855431

申请日：2004-05-28

申请人： Akira Koide ,  Ryo Miyake ,  Yasuo Ito ,  Yoshishige Endo

发明人： Akira Koide ,  Ryo Miyake ,  Yasuo Ito ,  Yoshishige Endo

IPC分类号： A61K8/02 ,  A61K8/00 ,  B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B01F13/10 ,  B65B3/26 ,  B65C3/08 ,  B65C9/46 ,  B67C3/02 ,  B67D1/00 ,  B67D7/02 ,  B67D7/74 ,  B67D1/16

CPC分类号： B01F13/0066 ,  B01F5/0453 ,  B01F5/0456 ,  B01F5/0458 ,  B01F5/0475 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/1055 ,  B01F2215/0031 ,  B65C3/08 ,  B65C9/46 ,  B67D1/0044 ,  B67D1/005 ,  B67D7/02 ,  B67D7/743

摘要： A mixed liquid manufacturing apparatus comprises: an information input unit, in which information of an object, to which a mixed liquid is offered, is input; a material storage system that stores a plurality of materials for a mixed liquid; a product information system that selects kinds and quantities of the stored materials on the basis of the input information of the object, to which a mixed liquid is offered; a liquid transfer unit, by which the selected materials are taken out from the material storage system; a mixing unit, in which the materials supplied from the liquid transfer unit are mixed; an injection unit, by which the mixed liquid is injected into a mixed liquid container; an input unit, by which matters being declared on a label of the mixed liquid container are input; and a label formation unit, in which the input matters are printed on the label and the label is stuck on the mixed liquid container, and wherein the label formation unit begins printing before the injection unit completes injection of the mixed liquid into the container.

摘要翻译： 混合液体制造装置包括：信息输入单元，其中输入有提供混合液体的物体的信息; 存储用于混合液体的多种材料的材料储存系统; 产品信息系统，其基于提供混合液体的对象的输入信息来选择所存储的材料的种类和数量; 液体转移单元，通过所述液体转移单元将所选择的材料从所述材料储存系统中取出; 混合单元，其中从所述液体转移单元供应的材料混合; 注射单元，通过该注射单元将混合液体注入混合液体容器中; 输入在混合液体容器的标签上声明事项的输入单元; 以及标签形成单元，其中将输入物品印刷在标签上并且标签粘贴在混合液体容器上，并且其中标签形成单元在注射单元完成将混合液体注入容器之前开始印刷。

公开(公告)号：US07111652B2

公开(公告)日：2006-09-26

申请号：US10855431

申请日：2004-05-28

申请人： Akira Koide ,  Ryo Miyake ,  Yasuo Ito ,  Yoshishige Endo

发明人： Akira Koide ,  Ryo Miyake ,  Yasuo Ito ,  Yoshishige Endo

IPC分类号： B65B1/04

CPC分类号： B01F13/0066 ,  B01F5/0453 ,  B01F5/0456 ,  B01F5/0458 ,  B01F5/0475 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/1055 ,  B01F2215/0031 ,  B65C3/08 ,  B65C9/46 ,  B67D1/0044 ,  B67D1/005 ,  B67D7/02 ,  B67D7/743

摘要： A mixed liquid manufacturing apparatus comprises: an information input unit, in which information of an object, to which a mixed liquid is offered, is input; a material storage system that stores a plurality of materials for a mixed liquid; a product information system that selects kinds and quantities of the stored materials on the basis of the input information of the object, to which a mixed liquid is offered; a liquid transfer unit, by which the selected materials are taken out from the material storage system; a mixing unit, in which the materials supplied from the liquid transfer unit are mixed; an injection unit, by which the mixed liquid is injected into a mixed liquid container; an input unit, by which matters being declared on a label of the mixed liquid container are input; and a label formation unit, in which the input matters are printed on the label and the label is stuck on the mixed liquid container, and wherein the label formation unit begins printing before the injection unit completes injection of the mixed liquid into the container.

摘要翻译： 混合液体制造装置包括：信息输入单元，其中输入有提供混合液体的物体的信息; 存储用于混合液体的多种材料的材料储存系统; 产品信息系统，其基于提供混合液体的对象的输入信息来选择所存储的材料的种类和数量; 液体转移单元，通过所述液体转移单元将所选择的材料从所述材料储存系统中取出; 混合单元，其中从所述液体转移单元供应的材料混合; 注射单元，通过该注射单元将混合液体注入混合液体容器中; 输入在混合液体容器的标签上声明事项的输入单元; 以及标签形成单元，其中将输入物品印刷在标签上并且标签粘贴在混合液体容器上，并且其中标签形成单元在注射单元完成将混合液体注入容器之前开始印刷。

公开(公告)号：US06283730B1

公开(公告)日：2001-09-04

申请号：US09441230

申请日：1999-11-16

申请人： Yasuhiko Sasaki ,  Yasuhiro Yoshimura ,  Akira Koide ,  Ryo Miyake ,  Naruo Watanabe ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Yasuhiko Ishida ,  Tomonari Morioka

发明人： Yasuhiko Sasaki ,  Yasuhiro Yoshimura ,  Akira Koide ,  Ryo Miyake ,  Naruo Watanabe ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Yasuhiko Ishida ,  Tomonari Morioka

IPC分类号： F04B1700

CPC分类号： F04B43/043

摘要： A micro pump is made compact and can prevent members constituting the micro pump from being chemically reacted with a working fluid, and a method of producing the same. After each of substrates constituting the micro pump is formed by a member containing a silicone as a main composition and a plurality of metal membranes are formed on a whole of a bonding surface of each of the substrates so as to form bonding surfaces, the bonding surfaces are cleaned, and the bonding surfaces are opposed to each other under a vacuum condition, overlapped, heated and pressed so as to be bonded. The valve portion has a beam and a protrusion for sealing as provided in the valve side, whereby a pressure applied to the protrusion becomes smaller than the bonding pressure.

摘要翻译： 微型泵制造紧凑，并且可以防止构成微型泵的构件与工作流体发生化学反应，及其制造方法。 在构成微型泵的基板的每一个由含有硅酮作为主要成分的构件形成，并且在每个基板的整个接合表面上形成多个金属膜以形成接合表面， 被清洁，并且粘合表面在真空条件下彼此相对，重叠，加热和压制以便粘合。 阀部具有设置在阀侧的梁和用于密封的突起，由此施加到突起的压力变得小于接合压力。

公开(公告)号：US06197255B1

公开(公告)日：2001-03-06

申请号：US09398046

申请日：1999-09-17

申请人： Ryo Miyake ,  Yoshihiro Nagaoka ,  Akira Koide ,  Naruo Watanabe ,  Yasuhiko Sasaki ,  Hajime Kato ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida ,  Takeshi Shibuya ,  Yasuhiro Yoshimura

发明人： Ryo Miyake ,  Yoshihiro Nagaoka ,  Akira Koide ,  Naruo Watanabe ,  Yasuhiko Sasaki ,  Hajime Kato ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida ,  Takeshi Shibuya ,  Yasuhiro Yoshimura

IPC分类号： G01N3502

CPC分类号： G01N35/00663 ,  B01F11/0283 ,  G01N35/025 ,  G01N2035/00673 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A chemical analyzing apparatus comprises a reaction cell holder which holds a plurality of reaction cells that are supplied with samples and reagents at a predetermined position, a measurer for measuring characteristics of the sample, a plurality of reagent containers, a liquid deliverer provided below each of the plurality of reagent containers, one or more sound wave generators provided outside the reaction cells, and storage containers for storing cleansing liquid with different contamination states. The cleansing liquid with different contamination states is reused according to the contamination levels of the reaction cells.

摘要翻译： 化学分析装置包括：反应池保持器，其保持在预定位置处供给样品和试剂的多个反应池，用于测量样品特性的测量器，多个试剂容器，下方设置的液体输送器 多个试剂容器，设置在反应室外的一个或多个声波发生器和用于存储具有不同污染状态的清洁液的储存容器。 具有不同污染状态的清洁液体根据反应池的污染水平重新使用。

公开(公告)号：US07204961B2

公开(公告)日：2007-04-17

申请号：US09259306

申请日：1999-03-01

申请人： Akira Koide ,  Ryo Miyake ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Tomonari Morioka

发明人： Akira Koide ,  Ryo Miyake ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Tomonari Morioka

IPC分类号： B01L3/02 ,  G01N1/10 ,  F04B23/06 ,  F16K16/00 ,  F16K7/07

CPC分类号： F04B43/043 ,  F04B53/1042 ,  Y10T137/87788 ,  Y10T137/87893 ,  Y10T436/2575

摘要： Provided is a liquid feed apparatus for feeding liquid by operating a diaphragm at a high frequency, in which an inlet valve and an outlet valve are integrally incorporated with a liquid feed chamber, the positions of the valve are shifted into peripheral parts of the liquid feed chamber so as to allow fluid to smoothly flow from the inlet to the outlet in order to prevent air bubbles from causing pressure fluctuation during liquid feed, from remaining in the liquid feed chamber. Further, the valve has a center beam structure in which a protrusion having a height greater than several micron meters, is formed in the seat part of the valve so as to deform a center beam for pressurizing the valve in order to enhance the shut-off ability of the valve, and the center beam has a small surface area in the direction of displacement of the valve.

摘要翻译： 本发明提供一种液体供给装置，其通过以高频操作隔膜，其中入口阀和出口阀与液体供给室一体地结合在一起，阀的位置移动到液体进料的周边部分 以允许流体从入口到出口平滑地流动，以防止气泡在液体进料期间引起压力波动，从而保留在液体进料室中。 此外，阀具有中心梁结构，其中高度大于几微米的突起形成在阀的阀座部分中，以便使用于加压阀的中心梁变形，以便增强切断 阀的能力和中心梁在阀的位移方向上具有小的表面积。

公开(公告)号：US07118662B2

公开(公告)日：2006-10-10

申请号：US10041597

申请日：2002-01-10

申请人： Hironobu Yamakawa ,  Ryo Miyake ,  Yasuhiko Sasaki ,  Akira Koide

发明人： Hironobu Yamakawa ,  Ryo Miyake ,  Yasuhiko Sasaki ,  Akira Koide

IPC分类号： G01N27/447 ,  G01N27/26

CPC分类号： G01N27/44721 ,  G01N27/44791

摘要： The windows 5a, 5b are configured so that the thickness of the upper and lower parts of the substrate formed therein with the channels becomes thinner in these parts than in other parts. An air space is defined in the vicinity of the one side wall of the channel within a part where the first outgoing window 5a is formed, so as to serve as a window, and the second outgoing window 5b has a shape such as to be recessed inward from the one side wall of the planar plate 10, in comparison with the other part thereof. Further, the fluorescence transmission path 6b is also formed on opposite sides with air spaces. It is noted that a rod-like fiber or the like may be embedded in the planar plate 10 on the outgoing side of the planar plate 10 at the time of forming the separation channel 21 and the like.

摘要翻译： 窗口5a，5b构造成使得在其中形成有通道的基板的上部和下部的厚度在这些部分比在其它部分中更薄。 在形成第一输出窗口5a的部分内的通道的一个侧壁的附近限定空气空间，以便用作窗口，并且第二出口窗口5b具有如下形状： 与平板10的一个侧壁向内凹入，与其他部分相比较。 此外，荧光传输路径6b也形成在具有空气空间的相对侧上。 注意，在形成分离通道21等时，可以在平板10的出口侧的平板10中嵌入棒状纤维等。

公开(公告)号：US06599477B1

公开(公告)日：2003-07-29

申请号：US09136070

申请日：1998-08-19

申请人： Ryo Miyake ,  Akira Koide ,  Takeo Takagi ,  Takao Terayama ,  Yasushi Nomura ,  Hiroshi Mitsumaki

发明人： Ryo Miyake ,  Akira Koide ,  Takeo Takagi ,  Takao Terayama ,  Yasushi Nomura ,  Hiroshi Mitsumaki

IPC分类号： G01N3504

CPC分类号： G01N35/1002 ,  F04B43/043 ,  G01N35/025 ,  G01N35/1016 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A chemically analyzing apparatus includes a plurality of reaction containers, a reaction container holder for holding the plurality of reaction containers and for supplying a sample and reagent at predetermined positions, a plurality of reagent containers for holding reagent adapted to be supplied into the reaction containers, a reagent container holder provided above the reaction container holder, for holding the plurality of reagent containers, a measuring part for measuring physical properties of the sample, a liquid feed mechanism provided in a lower part of each of the plurality of reagent containers, for supplying a predetermined quantity of reagent from each of the reagent container into the associated reaction containers by means of the liquid feed mechanism. With this arrangement, it is possible to provide a chemically analyzing apparatus incorporating a reagent supply mechanism which can prevent reagent from being uselessly consumed, which does not substantially require washing liquid, which does not require periodical disassembly and washing, and which can easily change the feed quantity of reagent.

摘要翻译： 化学分析装置包括多个反应容器，用于保持多个反应容器并用于在预定位置供应样品和试剂的反应容器保持器，用于保持适于供应到反应容器中的试剂的多个试剂容器， 设置在反应容器保持器上方的用于保持多个试剂容器的试剂容器保持器，用于测量样品的物理性质的测量部件，设置在多个试剂容器的每个的下部的液体供给机构，用于供给 通过液体供给机构将来自每个试剂容器的预定量的试剂输送到相关联的反应容器中。 通过这种布置，可以提供一种化学分析装置，其包括试剂供给机构，该试剂供给机构能够防止不需要定期拆卸和洗涤的基本上不需要洗涤液的试剂被无用地消耗，并且可以容易地改变 试剂的供料量。

公开(公告)号：US06193933B1

公开(公告)日：2001-02-27

申请号：US09179090

申请日：1998-10-27

申请人： Yasuhiko Sasaki ,  Ryo Miyake ,  Akira Koide ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida

发明人： Yasuhiko Sasaki ,  Ryo Miyake ,  Akira Koide ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida

IPC分类号： G01N3500

CPC分类号： G01N35/00663 ,  G01N35/1002 ,  G01N2035/00673 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： Heretofore, there has been demanded an automatic analysis apparatus which can prevent cross-contamination between reagents, which can prevent dust and gas from entering a reagent supply device, which can always know a remaining quantity of the reagent while can reduce the quantity of waste. According to the present invention, there is provided an automatic analysis apparatus in which a reagent supply device for supplying a reagent from a reagent container into a reaction container is removably attached to the reagent container, a protective door is provided in the reagent supply port in order to aim at preventing dust from entering the reagent supply device, and further the reagent container and the reagent supply device are provided with recording mediums for recording therein conditions thereof, a time of replacement thereof or the like, and which can inform whether the setting is proper or not.

摘要翻译： 迄今为止，已经要求能够防止试剂之间的交叉污染的自动分析装置，其可以防止灰尘和气体进入试剂供应装置，这可以总是知道试剂的剩余量，同时可以减少废物的量。 根据本发明，提供了一种自动分析装置，其中用于将试剂从试剂容器供给到反应容器中的试剂供应装置可移除地附接到试剂容器，在试剂供应口中设置有保护门 为了防止灰尘进入试剂供应装置，进一步地，试剂容器和试剂供应装置设置有用于在其中记录条件的记录介质，其更换时间等，并且可以通知设置 是否适用