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10 条记录 (耗时 0.055 秒)

    Autonulling DC bridge for real-time sensor transduction and voltage measurements
    2.
    发明授权
    Autonulling DC bridge for real-time sensor transduction and voltage measurements 失效
    用于实时传感器转换和电压测量的自动调节直流电桥

    公开(公告)号：US5461322A

    公开(公告)日：1995-10-24

    申请号：US102835

    申请日：1993-08-06

    申请人： Paul P. Bey, Jr. ,  Thomas L. Fare ,  David J. Yonce

    发明人： Paul P. Bey, Jr. ,  Thomas L. Fare ,  David J. Yonce

    IPC分类号： G01N27/02 ,  G01R17/06 ,  G01R17/02

    CPC分类号： G01N27/02 ,  G01R17/06

    摘要： A feedback operated DC bridge circuit for monitoring the voltage variations in a voltage divider circuit using a voltage controlled resistance component to reach a null balance across the bridge. Amplification is provided at higher accuracy near the null point when the voltage difference across the bridge is zero. The feedback bridge circuit includes an integrator which directly drives the controlling component to the value of the resistance in an unknown branch to force the null condition. The voltage controlled component (configured as a discrete metal oxide semiconductor device or bipolar junction transistor) and the balancing scheme are suitable for microfabrication and provides noise-rejection enhancement. The interconnected integral feedback of the autonulling DC bridge enables both a neural network for pre-processing sensor input in a spatial domain as well as general analog computation that mimics a first order differential equation in the form of the system state equation.

    摘要翻译： 一个反馈操作的直流电桥电路，用于使用电压控制的电阻分量来监测分压器电路中的电压变化，以达到跨桥的零平衡。 当桥上的电压差为零时，在零点附近以更高的精度提供放大。 反馈桥接电路包括一个积分器，它将控制分量直接驱动到未知分支中的电阻值，以迫使空值。 电压控制部件（配置为离散金属氧化物半导体器件或双极结型晶体管）和平衡方案适用于微细加工，并提供噪声抑制。 自动直流电桥的互连整体反馈使神经网络能够预处理空间域中的传感器输入以及以系统状态方程式的形式模拟一阶微分方程的一般模拟计算。

    Autonulling AC bridge using differential and integration feedback
    5.
    发明授权
    Autonulling AC bridge using differential and integration feedback 失效
    使用差分和积分反馈自动调节交流电桥

    公开(公告)号：US5264798A

    公开(公告)日：1993-11-23

    申请号：US783904

    申请日：1991-10-29

    申请人： Paul P. Bey, Jr. ,  Thomas L. Fare

    发明人： Paul P. Bey, Jr. ,  Thomas L. Fare

    IPC分类号： G01N27/02 ,  G01R17/06

    CPC分类号： G01R17/06 ,  G01N27/028

    摘要： A self-contained autonulling bridge circuit based on phase-sensitive deteon of an impedance to be measured is described. The system utilizes a feedback structure to control a variable impedance in order to establish the null of the bridge. The system utilizes a voltage-variable impedance having both resistance and capacitance and provides the phase sensitive relationship in the control means in order to provide highly accurate measurement of an unknown test impedance. The ability to measure small changes in impedance provides particularly useful application to the area of biological sensor impedance measurement or electrochemical impedance measurement using silicon-based devices.

    摘要翻译： 描述了一种基于待测量阻抗的相敏检测的独立自适应桥接电路。 该系统利用反馈结构来控制可变阻抗，以建立桥的零点。 该系统利用具有电阻和电容两者的电压可变阻抗，并在控制装置中提供相位敏感关系，以便提供未知测试阻抗的高精度测量。 测量阻抗变化小的能力为使用硅基器件的生物传感器阻抗测量或电化学阻抗测量领域提供了特别有用的应用。

    Method of fabricating a receptor-based sensor
    6.
    发明授权
    Method of fabricating a receptor-based sensor 失效
    制造基于受体的传感器的方法

    公开(公告)号：US5225374A

    公开(公告)日：1993-07-06

    申请号：US820123

    申请日：1992-01-14

    申请人： Thomas L. Fare ,  Frances S. Ligler

    发明人： Thomas L. Fare ,  Frances S. Ligler

    IPC分类号： G01N27/49 ,  G01N33/543

    CPC分类号： G01N33/5438 ,  G01N27/3277 ,  B01J2219/00734

    摘要： This invention relates to a semiconductor substrate having a porous surfacend to the amperometric receptor-based sensors formed with the substrate. More specifically, this invention pertains to the substrate in the form of a bipolar junction transistor having a porous hydrophilic surface directly on its base wherein the surface forms a support for an amperometric sensor. The invention also pertains to the methods of making and using the substrate and sensor.

    摘要翻译： 本发明涉及一种具有多孔表面的半导体衬底和与衬底形成的基于电流接收器的传感器。 更具体地说，本发明涉及一种双极结型晶体管形式的衬底，其基底上具有多孔亲水表面，其中表面形成电流传感器的支撑。 本发明还涉及制造和使用基底和传感器的方法。

    Extraction and diagnostic fluid devices, systems and methods of use
    7.
    发明授权
    Extraction and diagnostic fluid devices, systems and methods of use 有权
    提取和诊断流体装置，系统和使用方法

    公开(公告)号：US08979770B2

    公开(公告)日：2015-03-17

    申请号：US12280504

    申请日：2007-02-15

    申请人： Thomas L. Fare ,  Deborah A. Kessler ,  Kristopher A. Kilian

    发明人： Thomas L. Fare ,  Deborah A. Kessler ,  Kristopher A. Kilian

    IPC分类号： B65D81/00 ,  A61B5/00 ,  A01N1/02 ,  C12N15/10

    CPC分类号： C12N15/1017

    摘要： The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane that reversibly binds RNA and a plurality of ports that are removably attached to a reagent pack and waste receptacle via a valving system controlled by a control unit.

    摘要翻译： 本发明提供了用于从含有白血球（例如全血）的生物样品中分离RNA的装置，系统和方法。 所述装置具有装置主体，其包括具有选择性地结合白细胞的第一膜的第一腔室，具有可逆地结合RNA的第二膜的第二腔室和可移除地连接到试剂盒和废物容器的多个端口， 由控制单元控制的阀门系统。

    EXTRACTION AND DIAGNOSTIC FLUID DEVICES, SYSTEMS AND METHODS OF USE
    8.
    发明申请
    EXTRACTION AND DIAGNOSTIC FLUID DEVICES, SYSTEMS AND METHODS OF USE 有权
    提取和诊断流体装置，系统和使用方法

    公开(公告)号：US20090280470A1

    公开(公告)日：2009-11-12

    申请号：US12280504

    申请日：2007-02-15

    申请人： Thomas L. Fare ,  Deborah A. Kessler ,  Kristopher A. Killian

    发明人： Thomas L. Fare ,  Deborah A. Kessler ,  Kristopher A. Killian

    IPC分类号： A01N1/02 ,  C12M1/00

    CPC分类号： C12N15/1017

    摘要： The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane that reversibly binds RNA and a plurality of ports that are removably attached to a reagent pack and waste receptacle via a valving system controlled by a control unit.

    摘要翻译： 本发明提供了用于从含有白血球（例如全血）的生物样品中分离RNA的装置，系统和方法。 所述装置具有装置主体，其包括具有选择性地结合白细胞的第一膜的第一腔室，具有可逆地结合RNA的第二膜的第二腔室和可移除地连接到试剂盒和废物容器的多个端口， 由控制单元控制的阀门系统。

    Receptor-based sensor
    10.
    发明授权
    Receptor-based sensor 失效
    基于受体的传感器

    公开(公告)号：US5111221A

    公开(公告)日：1992-05-05

    申请号：US544442

    申请日：1990-06-27

    申请人： Thomas L. Fare ,  Frances S. Ligler

    发明人： Thomas L. Fare ,  Frances S. Ligler

    IPC分类号： G01N27/49 ,  G01N33/543

    CPC分类号： G01N33/5438 ,  G01N27/3277 ,  B01J2219/00734 ,  Y10S438/96

    摘要： This invention relates to a semiconductor substrate having a porous surfacend to the amperometric receptor-based sensors formed with the substrate. More specifically, this invention pertains to the substrate in the form of a bipolar junction transistor having a porous hydrophilic surface directly on its base wherein the surface forms a support for an amperometric sensor. The invention also pertains to the methods of making and using the substrate and sensor.

    摘要翻译： 本发明涉及一种具有多孔表面的半导体衬底和与衬底形成的基于电流接收器的传感器。 更具体地说，本发明涉及一种双极结型晶体管形式的衬底，其基底上具有多孔亲水表面，其中表面形成电流传感器的支撑。 本发明还涉及制造和使用基底和传感器的方法。