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19 条记录 (耗时 0.02 秒)

    Object having a microbicide coating, method for the production thereof and use of the same
    4.
    发明授权
    Object having a microbicide coating, method for the production thereof and use of the same 有权
    具有杀微生物剂涂层的物体，其制造方法及其用途

    公开(公告)号：US07279173B2

    公开(公告)日：2007-10-09

    申请号：US10415396

    申请日：2001-07-13

    申请人： Thomas Schiestel ,  Hermann Schirra ,  Helmut Schmidt ,  Detmar Buxmann

    发明人： Thomas Schiestel ,  Hermann Schirra ,  Helmut Schmidt ,  Detmar Buxmann

    IPC分类号： A01N25/10 ,  A01N59/16

    CPC分类号： C09D183/08 ,  C09D4/00 ,  C09D5/14 ,  C09D183/02 ,  C09D183/04 ,  C08G77/00 ,  C08L2666/52

    摘要： A microbicidally coated article, especially a container, having on at least part of it a coating comprising an organically modified inorganic matrix comprising silver colloids which is obtainable by application of a coating composition comprising a) a hydrolysate or condensate based on at least one hydrolysable silane with at least one non-hydrolysable substituent and b) a silver compound to the surface of the article and treatment with heat and/or radiation to form the silver colloid coating. Articles coated in accordance with the invention are therefore particularly suitable for purposes of disinfection, preservation, cosmetic, pharmaceutical or medical purposes. Articles from the pharmaceutical or medical sector, especially containers for pharmaceuticals or articles or components which come into contact with the human body and are required to be free from germs, are preferred fields of application.

    摘要翻译： 一种杀微生物涂覆的制品，特别是容器，其至少部分具有包含有机改性的无机基质的涂层，其包含银胶体，其可通过施用涂料组合物获得，所述涂料组合物包含：a）基于至少一种可水解硅烷的水解产物或缩合物 与至少一种不可水解的取代基和b）一种银化合物到制品的表面并用热和/或辐射进行处理以形成银胶体涂层。 因此，根据本发明涂覆的制品特别适用于消毒，保存，化妆品，医药或医疗目的。 优选的药物或医疗领域的药物，尤其是与人体接触并被要求不含细菌的药物或制品或成分的容器。

    Identification of antigen epitopes
    6.
    发明申请
    Identification of antigen epitopes 审中-公开
    抗原表位的鉴定

    公开(公告)号：US20070154953A1

    公开(公告)日：2007-07-05

    申请号：US10547533

    申请日：2004-03-03

    申请人： Herwig Brunner ,  Gunter Tover ,  Thomas Schiestel ,  Claudia Muller ,  Thomas Flad

    发明人： Herwig Brunner ,  Gunter Tover ,  Thomas Schiestel ,  Claudia Muller ,  Thomas Flad

    IPC分类号： G01N33/567 ,  G01N33/555 ,  G01N33/53

    CPC分类号： G01N33/543 ,  G01N33/6893

    摘要： The present invention relates to methods for identifying and/or detecting T-cell epitopes of a protein antigen, to methods for preparing peptide vaccines against a protein antigen, to methods for controlling the quality of receptor/ligand complexes and/or their components, to methods for preparing nanoparticles having at least one immobilized receptor unit or an immobilized receptor, to methods for preparing nanoparticles having immobilized receptor/ligand complexes, in particular peptide-presenting MHC molecules, to methods for enriching and/or isolating specific CD4+-T- or CD8+-T-lymphocytes from peripheral blood mononuclear cells, to methods for priming a CD8+-T-lymphocyte reaction in vitro, to nanoparticles having an immobilized receptor unit, in particular an immobilized chain of an MHC molecule, to nanoparticles having an immobilized receptor, in particular an immobilized MHC molecule, to nanoparticles having an immobilized receptor/ligand complex, in particular a peptide-presenting MHC molecule, to a peptide vaccine, to a kit for identifying and/or detecting T-cell epitopes of a protein antigen, and to the use of the nanoparticles for identifying and/or detecting T-cell epitopes, for preparing peptide vaccines, for enriching and/or isolating specific T-lymphocytes and for priming a CD8+-T-lymphocyte reaction in vitro.

    摘要翻译： 本发明涉及用于鉴定和/或检测蛋白质抗原的T细胞表位的方法，用于制备针对蛋白质抗原的肽疫苗的方法，以及用于控制受体/配体复合物和/或其组分的质量的方法， 用于制备具有至少一个固定化受体单元或固定化受体的纳米颗粒的方法，制备具有固定化受体/配体复合物，特别是肽呈递MHC分子的纳米颗粒的方法，用于富集和/或分离特异性CD4 + 来自外周血单核细胞的 -T-或CD8 + T淋巴细胞，以及用于在体外引发CD8 + T淋巴细胞反应的方法， 具有固定化受体单元，特别是MHC分子的固定化链的纳米颗粒具有固定化受体特别是固定的MHC分子的纳米颗粒具有固定的受体/配体复合物的纳米颗粒 ，特别是提供肽的MHC分子，用于肽疫苗，用于鉴定和/或检测蛋白质抗原的T细胞表位的试剂盒，以及使用纳米颗粒鉴定和/或检测T细胞表位 用于制备肽疫苗，用于富集和/或分离特异性T淋巴细胞和用于在体外引发CD8 + T淋巴细胞反应。

    Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating
    7.
    发明授权
    Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating 有权
    用耐水解涂层制备无团聚的纳米级氧化铁颗粒的方法

    公开(公告)号：US06183658B2

    公开(公告)日：2001-02-06

    申请号：US09171065

    申请日：1998-10-09

    申请人： Christoph Lesniak ,  Thomas Schiestel ,  Rüdiger Nass ,  Helmut Schmidt

    发明人： Christoph Lesniak ,  Thomas Schiestel ,  Rüdiger Nass ,  Helmut Schmidt

    IPC分类号： C09D1700

    CPC分类号： B82Y30/00 ,  C01G49/02 ,  C01P2004/64 ,  C01P2006/80 ,  C01P2006/90 ,  C09C1/24 ,  C09C3/006 ,  C09C3/045 ,  C09C3/12 ,  Y10T428/2995

    摘要： A process for preparing an agglomerate-free suspension of nanosize iron-containing oxide particles coated in a stable manner comprises preparing an aqueous suspension of nanosize iron-containing oxide particles which are partially or completely in the form of agglomerates; adding a trialkoxysilane and a water-miscible polar organic solvent which has a boiling point at least 10° C. higher than the boiling point of water; treating the resulting suspension with ultrasound until at least 70% of the particles present are in the range of ±20% of the average particle diameter; removing the water by distillation under the action of ultrasound; and separating the non-disintegrated agglomerates.

    摘要翻译： 制备以稳定方式包被的纳米尺寸含铁氧化物颗粒的无附聚物悬浮液的方法包括制备部分或全部为附聚物形式的纳米级含铁氧化物颗粒的水性悬浮液; 加入沸点比水的沸点高至少10℃的三烷氧基硅烷和水混溶性极性有机溶剂; 用超声波处理所得到的悬浮液，直到存在的颗粒的至少70％在平均粒径的±20％的范围内; 在超声波作用下通过蒸馏除去水分; 并分离未崩解的附聚物。