公开(公告)号：US09115663B2

公开(公告)日：2015-08-25

申请号：US13528104

申请日：2012-06-20

申请人： Tony Nicosia ,  Edward A. Ramberger ,  Charles Zellner ,  David Klosterman ,  John Chapin ,  Karl Lingerfelt ,  Michael Simpson ,  Andrew Stampor

发明人： Tony Nicosia ,  Edward A. Ramberger ,  Charles Zellner ,  David Klosterman ,  John Chapin ,  Karl Lingerfelt ,  Michael Simpson ,  Andrew Stampor

IPC分类号： G01M17/00 ,  G06F7/00 ,  G06F19/00 ,  F02D41/24 ,  F02D41/14 ,  F02D41/34

CPC分类号： F02D41/2422 ,  F02D41/1454 ,  F02D41/2409 ,  F02D41/2435 ,  F02D41/34 ,  F02D2200/0406 ,  F02D2200/0411 ,  F02D2400/11

摘要： Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.

摘要翻译： 在正常运行条件下优化车辆性能的系统和方法。 响应于从传感器接收的数据，车辆系统在闭环中调整一个或多个车辆操作参数。 便携式车辆通信接口模块选择性地附接到车辆而不阻碍车辆的正常操作。 当连接到车辆时，车辆通信接口模块记录车辆系统在闭环操作中进行的调整。 然后将这些记录值用于更新车辆系统使用的校准信息作为默认值。

公开(公告)号：US20120259533A1

公开(公告)日：2012-10-11

申请号：US13528104

申请日：2012-06-20

申请人： Tony Nicosia ,  Edward A. Ramberger ,  David Klosterman ,  Charles Zellner ,  Andrew Stampor ,  Michael Simpson ,  John Chapin ,  Karl Lingerfelt

发明人： Tony Nicosia ,  Edward A. Ramberger ,  David Klosterman ,  Charles Zellner ,  Andrew Stampor ,  Michael Simpson ,  John Chapin ,  Karl Lingerfelt

IPC分类号： F02D28/00 ,  F02D41/30 ,  F02D41/26

CPC分类号： F02D41/2422 ,  F02D41/1454 ,  F02D41/2409 ,  F02D41/2435 ,  F02D41/34 ,  F02D2200/0406 ,  F02D2200/0411 ,  F02D2400/11

摘要： Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.

摘要翻译： 在正常运行条件下优化车辆性能的系统和方法。 响应于从传感器接收的数据，车辆系统在闭环中调整一个或多个车辆操作参数。 便携式车辆通信接口模块选择性地附接到车辆而不阻碍车辆的正常操作。 当连接到车辆时，车辆通信接口模块记录车辆系统在闭环操作中进行的调整。 然后将这些记录值用于更新车辆系统使用的校准信息作为默认值。

公开(公告)号：US20110288722A1

公开(公告)日：2011-11-24

申请号：US12841569

申请日：2010-07-22

申请人： Tony Nicosia ,  Edward A. Ramberger ,  David Klosterman ,  Charles Zellner ,  Andrew Stampor ,  Michael Simpson ,  John Chapin ,  Karl Lingerfelt

发明人： Tony Nicosia ,  Edward A. Ramberger ,  David Klosterman ,  Charles Zellner ,  Andrew Stampor ,  Michael Simpson ,  John Chapin ,  Karl Lingerfelt

IPC分类号： G06F19/00

CPC分类号： F02D41/2422 ,  F02D41/1454 ,  F02D41/2409 ,  F02D41/2435 ,  F02D41/34 ,  F02D2200/0406 ,  F02D2200/0411 ,  F02D2400/11

摘要： Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.

摘要翻译： 在正常运行条件下优化车辆性能的系统和方法。 响应于从传感器接收的数据，车辆系统在闭环中调整一个或多个车辆操作参数。 便携式车辆通信接口模块选择性地附接到车辆而不阻碍车辆的正常操作。 当连接到车辆时，车辆通信接口模块记录车辆系统在闭环操作中进行的调整。 然后将这些记录值用于更新车辆系统使用的校准信息作为默认值。

公开(公告)号：US08224519B2

公开(公告)日：2012-07-17

申请号：US12841569

申请日：2010-07-22

申请人： Tony Nicosia ,  Edward Ramberger ,  Charles Zellner ,  David Klosterman ,  John Chapin ,  Karl Lingerfelt ,  Michael Simpson ,  Andrew Stampor

发明人： Tony Nicosia ,  Edward Ramberger ,  Charles Zellner ,  David Klosterman ,  John Chapin ,  Karl Lingerfelt ,  Michael Simpson ,  Andrew Stampor

IPC分类号： G01M17/00 ,  G01F7/00 ,  G06F19/00 ,  B60T7/12

CPC分类号： F02D41/2422 ,  F02D41/1454 ,  F02D41/2409 ,  F02D41/2435 ,  F02D41/34 ,  F02D2200/0406 ,  F02D2200/0411 ,  F02D2400/11

摘要： Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.

摘要翻译： 在正常运行条件下优化车辆性能的系统和方法。 响应于从传感器接收的数据，车辆系统在闭环中调整一个或多个车辆操作参数。 便携式车辆通信接口模块选择性地附接到车辆而不阻碍车辆的正常操作。 当连接到车辆时，车辆通信接口模块记录车辆系统在闭环操作中的调整。 然后将这些记录值用于更新车辆系统使用的校准信息作为默认值。

公开(公告)号：US09283230B2

公开(公告)日：2016-03-15

申请号：US13984841

申请日：2011-08-15

申请人： Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

发明人： Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

IPC分类号： A61K31/5415 ,  C07D279/20 ,  C07D309/04 ,  C07C309/05 ,  A61K9/20 ,  C07C309/04 ,  A61K9/28 ,  C07C309/30 ,  C07C309/35

CPC分类号： A61K31/5415 ,  A61K9/0053 ,  A61K9/2095 ,  A61K9/2893 ,  A61L2/0052 ,  C07C303/32 ,  C07C309/04 ,  C07C309/05 ,  C07C309/30 ,  C07C309/35 ,  C07D279/20 ,  Y02A50/393 ,  Y02A50/411

摘要： The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

摘要翻译： 本发明涉及通式（I）的化合物：其中：R 1和R 9各自独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R 3NA和R 3NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; 并且其中：RA和RB各自独立地选自：C 1-4烷基，卤代C 1-4烷基和C 6-10芳基; 或RA和RB连接形成选自以下的基团：C 1-6亚烷基和C 6-10亚芳基; 和其药学上可接受的盐，其可用于治疗例如阿尔茨海默氏病。 在其它方面，本发明还涉及3,7-二氨基-10H-吩噻嗪鎓盐的新配方。

公开(公告)号：US20130315992A1

公开(公告)日：2013-11-28

申请号：US13984841

申请日：2011-08-15

申请人： Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

发明人： Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

IPC分类号： C07D279/20 ,  C07C309/30 ,  A61K9/28 ,  C07C309/35 ,  A61K9/20 ,  C07C309/04 ,  C07C309/05

CPC分类号： A61K31/5415 ,  A61K9/0053 ,  A61K9/2095 ,  A61K9/2893 ,  A61L2/0052 ,  C07C303/32 ,  C07C309/04 ,  C07C309/05 ,  C07C309/30 ,  C07C309/35 ,  C07D279/20 ,  Y02A50/393 ,  Y02A50/411

摘要： The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

摘要翻译： 本发明涉及通式（I）的化合物：其中：R 1和R 9各自独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R 3NA和R 3NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; 并且其中：RA和RB各自独立地选自：C 1-4烷基，卤代C 1-4烷基和C 6-10芳基; 或RA和RB连接形成选自以下的基团：C 1-6亚烷基和C 6-10亚芳基; 和其药学上可接受的盐，其可用于治疗例如阿尔茨海默氏病。 在其它方面，本发明还涉及3,7-二氨基-10H-吩噻嗪鎓盐的新配方。

公开(公告)号：US20060281067A1

公开(公告)日：2006-12-14

申请号：US11151964

申请日：2005-06-14

申请人： Michael Simpson ,  Michael Paulus ,  Gary Sayler ,  Bruce Applegate ,  Steven Ripp

发明人： Michael Simpson ,  Michael Paulus ,  Gary Sayler ,  Bruce Applegate ,  Steven Ripp

IPC分类号： C12Q1/00 ,  C12M1/34

CPC分类号： C12Q1/02 ,  A61B5/0031 ,  C12Q1/66 ,  G01N21/763 ,  G01N33/74 ,  G01N33/84 ,  Y10S435/808 ,  Y10S435/849 ,  Y10S435/879 ,  Y10S435/909 ,  Y10S436/805

摘要： An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode configuration including a plurality of spaced apart electrodes disposed on an active region of the photodetector is preferably used to raise efficiency.

摘要翻译： 一种集成的微量发光计包括具有至少一个n阱/ p-衬底结光电检测器的集成电路芯片，用于将接收的光接收到光电流中，以及用于处理光电流的芯片上的检测器。 优选地，使用包括设置在光电检测器的有源区上的多个间隔开的电极的分布式电极配置来提高效率。

公开(公告)号：US20060116763A1

公开(公告)日：2006-06-01

申请号：US11000728

申请日：2004-12-01

申请人： Michael Simpson

发明人： Michael Simpson

IPC分类号： A61F2/16 ,  A61B3/00 ,  A61F9/013

CPC分类号： A61F2/1613 ,  A61F2/164

摘要： The present invention provides an intraocular lens (IOL) having an optic with a posterior and an anterior refractive surfaces, at least one of which has an aspherical profile, typically characterized by a non-zero conic constant, for controlling the aberrations of a patient's eye in which the IOL is implanted. Preferably, the IOL's asphericity, together with the aberrations of the patient's eye, cooperate to provide an image contrast characterized by a calculated modulation transfer function (MTF) of at least about 0.25 and a depth of field of at least about 0.75 Diopters.

摘要翻译： 本发明提供一种眼内透镜（IOL），其具有具有后折射表面和前折射表面的光学元件，其至少一个具有非球面轮廓，通常以非零锥形常数为特征，用于控制患者眼睛的像差 其中植入IOL。 优选地，IOL的非球面性以及患者眼睛的像差协同提供以计算出的至少约0.25的调制传递函数（MTF）和至少约0.75屈光度的景深的特征的图像对比。

公开(公告)号：US20050176245A1

公开(公告)日：2005-08-11

申请号：US10774699

申请日：2004-02-09

申请人： Anatoli Melechko ,  Timothy McKnight ,  Michael Guillorn ,  Bojan Ilic ,  Vladimir Merkulov ,  Mitchel Doktycz ,  Douglas Lowndes ,  Michael Simpson

发明人： Anatoli Melechko ,  Timothy McKnight ,  Michael Guillorn ,  Bojan Ilic ,  Vladimir Merkulov ,  Mitchel Doktycz ,  Douglas Lowndes ,  Michael Simpson

IPC分类号： B01D67/00 ,  B01D71/02 ,  B01J23/755 ,  B01L3/00 ,  H01L21/44

CPC分类号： B01D67/0062 ,  B01D67/0069 ,  B01D67/0072 ,  B01D71/02 ,  B01D71/027 ,  B01D2323/24 ,  B01D2325/08 ,  B01J23/755 ,  B01J35/0013 ,  B01J35/006 ,  B01J37/0238 ,  B01J37/342 ,  B01L3/5027 ,  B01L2300/0663 ,  B01L2300/0896 ,  B81B2201/058 ,  B81B2203/0361 ,  B81C1/00119 ,  B82Y30/00 ,  Y10S977/70 ,  Y10S977/781 ,  Y10S977/784 ,  Y10T428/13 ,  Y10T428/1303 ,  Y10T428/1352 ,  Y10T428/1359 ,  Y10T428/139 ,  Y10T428/24174 ,  Y10T428/24273 ,  Y10T428/24322 ,  Y10T428/2902 ,  Y10T428/2991 ,  Y10T428/31504 ,  Y10T428/31678

摘要： Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. A method includes depositing a catalyst particle on a surface of a substrate to define a deterministically located position; growing an aligned elongated nanostructure on the substrate, an end of the aligned elongated nanostructure coupled to the substrate at the deterministically located position; coating the aligned elongated nanostructure with a conduit material; removing a portion of the conduit material to expose the catalyst particle; removing the catalyst particle; and removing the elongated nanostructure to define a nanoconduit.

摘要翻译： 使用确定性生长的牺牲纳米模板描述了用于纳米转移和纳米应用的方法，制造商，机器和组合物。 一种方法包括在衬底的表面上沉积催化剂颗粒以限定确定性定位的位置; 在衬底上生长对准的细长纳米结构，对准的细长纳米结构的端部在确定性位置处耦合到衬底; 用导管材料涂覆对准的细长纳米结构; 去除所述导管材料的一部分以暴露所述催化剂颗粒; 除去催化剂颗粒; 并移除细长的纳米结构以限定纳米管。

公开(公告)号：US20050170553A1

公开(公告)日：2005-08-04

申请号：US11089098

申请日：2005-03-24

申请人： Vladimir Merkulov ,  Anatoli Melechko ,  Michael Guillorn ,  Douglas Lowndes ,  Michael Simpson

发明人： Vladimir Merkulov ,  Anatoli Melechko ,  Michael Guillorn ,  Douglas Lowndes ,  Michael Simpson

IPC分类号： A61K9/14 ,  B82B1/00 ,  C01B31/02 ,  C23C16/26 ,  D01F9/127 ,  G01N33/543 ,  H01J1/304 ,  H01J1/62 ,  H01J37/32 ,  H01L21/44 ,  H01L21/8234 ,  H01L21/8244 ,  H01L29/06 ,  H01L31/0328 ,  H01L31/0336 ,  H01L31/072 ,  H01L31/109

CPC分类号： G01N33/5438 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B2202/08 ,  D01F9/127 ,  Y10S977/843 ,  Y10S977/891 ,  Y10S977/943 ,  Y10T428/24628

摘要： Systems and methods are described for controlled alignment of catalyticaly grown nanostructures in a large-scale synthesis process. An apparatus includes an electrode including: a protruding section defining an edge; and a nonprotruding section coupled to the protruding section, where the edge is adapted to deflect an electric field generated with the electrode and at least one section selected from the group consisting of the protruding section and the nonprotruding section is adapted to support a substrate for the growth of elongated nanostructures.

摘要翻译： 描述了用于在大规模合成过程中催化生长的纳米结构的受控比对的系统和方法。 一种设备包括：电极，包括：限定边缘的突出部分; 以及联接到突出部分的非侵入部分，其中边缘适于偏转由电极产生的电场，并且从由突出部分和非侵入部分组成的组中选择的至少一个部分适于支撑用于 细长纳米结构的生长。