公开(公告)号：US09283230B2

公开(公告)日：2016-03-15

申请号：US13984841

申请日：2011-08-15

Applicant: Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

Inventor： Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

IPC: A61K31/5415 ,  C07D279/20 ,  C07D309/04 ,  C07C309/05 ,  A61K9/20 ,  C07C309/04 ,  A61K9/28 ,  C07C309/30 ,  C07C309/35

CPC classification number: A61K31/5415 ,  A61K9/0053 ,  A61K9/2095 ,  A61K9/2893 ,  A61L2/0052 ,  C07C303/32 ,  C07C309/04 ,  C07C309/05 ,  C07C309/30 ,  C07C309/35 ,  C07D279/20 ,  Y02A50/393 ,  Y02A50/411

Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

Abstract translation: 本发明涉及通式（I）的化合物：其中：R 1和R 9各自独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R 3NA和R 3NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; 并且其中：RA和RB各自独立地选自：C 1-4烷基，卤代C 1-4烷基和C 6-10芳基; 或RA和RB连接形成选自以下的基团：C 1-6亚烷基和C 6-10亚芳基; 和其药学上可接受的盐，其可用于治疗例如阿尔茨海默氏病。 在其它方面，本发明还涉及3,7-二氨基-10H-吩噻嗪鎓盐的新配方。

公开(公告)号：US09115663B2

公开(公告)日：2015-08-25

申请号：US13528104

申请日：2012-06-20

Applicant: Tony Nicosia ,  Edward A. Ramberger ,  Charles Zellner ,  David Klosterman ,  John Chapin ,  Karl Lingerfelt ,  Michael Simpson ,  Andrew Stampor

Inventor： Tony Nicosia ,  Edward A. Ramberger ,  Charles Zellner ,  David Klosterman ,  John Chapin ,  Karl Lingerfelt ,  Michael Simpson ,  Andrew Stampor

IPC: G01M17/00 ,  G06F7/00 ,  G06F19/00 ,  F02D41/24 ,  F02D41/14 ,  F02D41/34

CPC classification number: F02D41/2422 ,  F02D41/1454 ,  F02D41/2409 ,  F02D41/2435 ,  F02D41/34 ,  F02D2200/0406 ,  F02D2200/0411 ,  F02D2400/11

Abstract: Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.

Abstract translation: 在正常运行条件下优化车辆性能的系统和方法。 响应于从传感器接收的数据，车辆系统在闭环中调整一个或多个车辆操作参数。 便携式车辆通信接口模块选择性地附接到车辆而不阻碍车辆的正常操作。 当连接到车辆时，车辆通信接口模块记录车辆系统在闭环操作中进行的调整。 然后将这些记录值用于更新车辆系统使用的校准信息作为默认值。

公开(公告)号：US20130315992A1

公开(公告)日：2013-11-28

申请号：US13984841

申请日：2011-08-15

Applicant: Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

Inventor： Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

IPC: C07D279/20 ,  C07C309/30 ,  A61K9/28 ,  C07C309/35 ,  A61K9/20 ,  C07C309/04 ,  C07C309/05

CPC classification number: A61K31/5415 ,  A61K9/0053 ,  A61K9/2095 ,  A61K9/2893 ,  A61L2/0052 ,  C07C303/32 ,  C07C309/04 ,  C07C309/05 ,  C07C309/30 ,  C07C309/35 ,  C07D279/20 ,  Y02A50/393 ,  Y02A50/411

Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

Abstract translation: 本发明涉及通式（I）的化合物：其中：R 1和R 9各自独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R 3NA和R 3NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; 并且其中：RA和RB各自独立地选自：C 1-4烷基，卤代C 1-4烷基和C 6-10芳基; 或RA和RB连接形成选自以下的基团：C 1-6亚烷基和C 6-10亚芳基; 和其药学上可接受的盐，其可用于治疗例如阿尔茨海默氏病。 在其它方面，本发明还涉及3,7-二氨基-10H-吩噻嗪鎓盐的新配方。

公开(公告)号：US20060281067A1

公开(公告)日：2006-12-14

申请号：US11151964

申请日：2005-06-14

Applicant: Michael Simpson ,  Michael Paulus ,  Gary Sayler ,  Bruce Applegate ,  Steven Ripp

Inventor： Michael Simpson ,  Michael Paulus ,  Gary Sayler ,  Bruce Applegate ,  Steven Ripp

IPC: C12Q1/00 ,  C12M1/34

CPC classification number: C12Q1/02 ,  A61B5/0031 ,  C12Q1/66 ,  G01N21/763 ,  G01N33/74 ,  G01N33/84 ,  Y10S435/808 ,  Y10S435/849 ,  Y10S435/879 ,  Y10S435/909 ,  Y10S436/805

Abstract: An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode configuration including a plurality of spaced apart electrodes disposed on an active region of the photodetector is preferably used to raise efficiency.

Abstract translation: 一种集成的微量发光计包括具有至少一个n阱/ p-衬底结光电检测器的集成电路芯片，用于将接收的光接收到光电流中，以及用于处理光电流的芯片上的检测器。 优选地，使用包括设置在光电检测器的有源区上的多个间隔开的电极的分布式电极配置来提高效率。

公开(公告)号：US20060116763A1

公开(公告)日：2006-06-01

申请号：US11000728

申请日：2004-12-01

Applicant: Michael Simpson

Inventor： Michael Simpson

IPC: A61F2/16 ,  A61B3/00 ,  A61F9/013

CPC classification number: A61F2/1613 ,  A61F2/164

Abstract: The present invention provides an intraocular lens (IOL) having an optic with a posterior and an anterior refractive surfaces, at least one of which has an aspherical profile, typically characterized by a non-zero conic constant, for controlling the aberrations of a patient's eye in which the IOL is implanted. Preferably, the IOL's asphericity, together with the aberrations of the patient's eye, cooperate to provide an image contrast characterized by a calculated modulation transfer function (MTF) of at least about 0.25 and a depth of field of at least about 0.75 Diopters.

Abstract translation: 本发明提供一种眼内透镜（IOL），其具有具有后折射表面和前折射表面的光学元件，其至少一个具有非球面轮廓，通常以非零锥形常数为特征，用于控制患者眼睛的像差 其中植入IOL。 优选地，IOL的非球面性以及患者眼睛的像差协同提供以计算出的至少约0.25的调制传递函数（MTF）和至少约0.75屈光度的景深的特征的图像对比。

公开(公告)号：US20050176245A1

公开(公告)日：2005-08-11

申请号：US10774699

申请日：2004-02-09

Applicant: Anatoli Melechko ,  Timothy McKnight ,  Michael Guillorn ,  Bojan Ilic ,  Vladimir Merkulov ,  Mitchel Doktycz ,  Douglas Lowndes ,  Michael Simpson

Inventor： Anatoli Melechko ,  Timothy McKnight ,  Michael Guillorn ,  Bojan Ilic ,  Vladimir Merkulov ,  Mitchel Doktycz ,  Douglas Lowndes ,  Michael Simpson

IPC: B01D67/00 ,  B01D71/02 ,  B01J23/755 ,  B01L3/00 ,  H01L21/44

CPC classification number: B01D67/0062 ,  B01D67/0069 ,  B01D67/0072 ,  B01D71/02 ,  B01D71/027 ,  B01D2323/24 ,  B01D2325/08 ,  B01J23/755 ,  B01J35/0013 ,  B01J35/006 ,  B01J37/0238 ,  B01J37/342 ,  B01L3/5027 ,  B01L2300/0663 ,  B01L2300/0896 ,  B81B2201/058 ,  B81B2203/0361 ,  B81C1/00119 ,  B82Y30/00 ,  Y10S977/70 ,  Y10S977/781 ,  Y10S977/784 ,  Y10T428/13 ,  Y10T428/1303 ,  Y10T428/1352 ,  Y10T428/1359 ,  Y10T428/139 ,  Y10T428/24174 ,  Y10T428/24273 ,  Y10T428/24322 ,  Y10T428/2902 ,  Y10T428/2991 ,  Y10T428/31504 ,  Y10T428/31678

Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. A method includes depositing a catalyst particle on a surface of a substrate to define a deterministically located position; growing an aligned elongated nanostructure on the substrate, an end of the aligned elongated nanostructure coupled to the substrate at the deterministically located position; coating the aligned elongated nanostructure with a conduit material; removing a portion of the conduit material to expose the catalyst particle; removing the catalyst particle; and removing the elongated nanostructure to define a nanoconduit.

Abstract translation: 使用确定性生长的牺牲纳米模板描述了用于纳米转移和纳米应用的方法，制造商，机器和组合物。 一种方法包括在衬底的表面上沉积催化剂颗粒以限定确定性定位的位置; 在衬底上生长对准的细长纳米结构，对准的细长纳米结构的端部在确定性位置处耦合到衬底; 用导管材料涂覆对准的细长纳米结构; 去除所述导管材料的一部分以暴露所述催化剂颗粒; 除去催化剂颗粒; 并移除细长的纳米结构以限定纳米管。

公开(公告)号：US20050170553A1

公开(公告)日：2005-08-04

申请号：US11089098

申请日：2005-03-24

Applicant: Vladimir Merkulov ,  Anatoli Melechko ,  Michael Guillorn ,  Douglas Lowndes ,  Michael Simpson

Inventor： Vladimir Merkulov ,  Anatoli Melechko ,  Michael Guillorn ,  Douglas Lowndes ,  Michael Simpson

IPC: A61K9/14 ,  B82B1/00 ,  C01B31/02 ,  C23C16/26 ,  D01F9/127 ,  G01N33/543 ,  H01J1/304 ,  H01J1/62 ,  H01J37/32 ,  H01L21/44 ,  H01L21/8234 ,  H01L21/8244 ,  H01L29/06 ,  H01L31/0328 ,  H01L31/0336 ,  H01L31/072 ,  H01L31/109

CPC classification number: G01N33/5438 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B2202/08 ,  D01F9/127 ,  Y10S977/843 ,  Y10S977/891 ,  Y10S977/943 ,  Y10T428/24628

Abstract: Systems and methods are described for controlled alignment of catalyticaly grown nanostructures in a large-scale synthesis process. An apparatus includes an electrode including: a protruding section defining an edge; and a nonprotruding section coupled to the protruding section, where the edge is adapted to deflect an electric field generated with the electrode and at least one section selected from the group consisting of the protruding section and the nonprotruding section is adapted to support a substrate for the growth of elongated nanostructures.

Abstract translation: 描述了用于在大规模合成过程中催化生长的纳米结构的受控比对的系统和方法。 一种设备包括：电极，包括：限定边缘的突出部分; 以及联接到突出部分的非侵入部分，其中边缘适于偏转由电极产生的电场，并且从由突出部分和非侵入部分组成的组中选择的至少一个部分适于支撑用于 细长纳米结构的生长。

公开(公告)号：US10729171B2

公开(公告)日：2020-08-04

申请号：US14129879

申请日：2012-06-27

Applicant: Graham Penrose ,  Michael Malthouse ,  David Wake ,  Gary Fulcher ,  Michael Simpson ,  Aaron Brookbank ,  Gordon Grierson ,  Jon Hindley ,  John Sampson ,  Rabya Khan-Dar ,  Karl Kaljura ,  Lean Ho Ong ,  John Richardson ,  John Major ,  Richard Young

Inventor： Graham Penrose ,  Michael Malthouse ,  David Wake ,  Gary Fulcher ,  Michael Simpson ,  Aaron Brookbank ,  Gordon Grierson ,  Jon Hindley ,  John Sampson ,  Rabya Khan-Dar ,  Karl Kaljura ,  Lean Ho Ong ,  John Richardson ,  John Major ,  Richard Young

IPC: A24D3/04 ,  A24D3/06 ,  A24D3/14

Abstract: A smoking article filter (20) comprises a recess (25) to receive a filter insert unit (30). The filter insert unit (30) is secured to the filter (20) once inserted. The filter (20) and the filter insert unit (30) may comprise additives such as flavourants, colourants or sorbents.

公开(公告)号：US20070171362A1

公开(公告)日：2007-07-26

申请号：US11444112

申请日：2006-08-23

Applicant: Michael Simpson ,  Mutlu Karakelle ,  Steve Vannoy ,  Xiaoxiao Zhang ,  Xin Hong ,  Jihong Xie

Inventor： Michael Simpson ,  Mutlu Karakelle ,  Steve Vannoy ,  Xiaoxiao Zhang ,  Xin Hong ,  Jihong Xie

IPC: G02C7/02

CPC classification number: A61F2/1654 ,  A61F2/1618 ,  G02C7/042 ,  G02C7/044 ,  G02C2202/20

Abstract: In one aspect, the present invention provides a method of designing a diffractive ophthalmic lens (e.g., an intraocular lens (IOL)) that includes providing an optic having an anterior refractive surface and a posterior refractive surface, wherein the optic provides a far-focus power (e.g., in a range of about 18 to about 26 Diopters (D)). A truncated diffractive structure can be disposed on at least one of the surfaces for generating a near-focus add power (e.g., in a range of about 3 D to about 4 D). And the diffractive structure can be adjusted so as to obtain a desired distribution of optical energy between the near and far foci for a range of pupil sizes.

Abstract translation: 一方面，本发明提供了一种设计衍射眼用透镜（例如，眼内透镜（IOL））的方法，其包括提供具有前折射表面和后折射表面的光学元件，其中所述光学元件提供远焦点 功率（例如，在约18至约26屈光度（D）的范围内）。 截面的衍射结构可以设置在至少一个表面上，用于产生近焦点添加功率（例如，在约3D至约4D的范围内）。 并且可以调整衍射结构，以便在一定范围的瞳孔尺寸之间获得近焦点和远焦点之间期望的光能分布。

公开(公告)号：US20060244904A1

公开(公告)日：2006-11-02

申请号：US11397332

申请日：2006-04-04

Applicant: Xin Hong ,  Jihong Xie ,  Stephen Van Noy ,  Dan Stanley ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Michael Simpson

Inventor： Xin Hong ,  Jihong Xie ,  Stephen Van Noy ,  Dan Stanley ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Michael Simpson

IPC: G02C7/04

CPC classification number: A61F2/1613 ,  A61F2/1637 ,  G02C7/02

Abstract: In one aspect, the present invention provide an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior optical surface and a posterior optical surface, where the optic provides an optical power in a range of about 16 D to about 25 D as measured in a medium having an index of refraction substantially similar to that of the eye's aqueous humor (e.g., about 1.336). At least one of the optical surfaces is characterized by an aspherical base profile such that the optic exhibits a negative spherical aberration in a range of about −0.202 microns to about −0.190 microns across the power range.

Abstract translation: 一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有前光学表面和后光学表面的光学元件，其中所述光学元件提供在约16D至约25D的范围内的光焦度 如在具有基本上类似于眼睛房水的折射率的介质中测量的（例如，约1.336）。 至少一个光学表面的特征在于非球面基部轮廓，使得光学器件在功率范围内在约-0.202微米至约-0.190微米的范围内呈现负球面像差。