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1.Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译: 氨基酸衍生物,含有这些化合物的药物组合物及其制备方法公开(公告)号:US6114390A
公开(公告)日:2000-09-05
申请号:US950113
申请日:1997-10-14
申请人: Wolfhard Engel , Wolfgang Eberlein , Klaus Rudolf , Henri Doods , Heike-Andrea Wieland , Klaus-Dieter Willim , Michael Entzeroth , Wolfgang Wienen
发明人: Wolfhard Engel , Wolfgang Eberlein , Klaus Rudolf , Henri Doods , Heike-Andrea Wieland , Klaus-Dieter Willim , Michael Entzeroth , Wolfgang Wienen
IPC分类号: A61K38/00 , C07C257/18 , C07C275/24 , C07C275/56 , C07C279/14 , C07C279/24 , C07C279/36 , C07C307/06 , C07C311/35 , C07D209/08 , C07D209/18 , C07D209/24 , C07D209/42 , C07D209/44 , C07D223/20 , C07D233/26 , C07D233/36 , C07D233/72 , C07D233/88 , C07D235/06 , C07D235/08 , C07D239/46 , C07D249/14 , C07D271/06 , C07D307/85 , C07K5/078 , A61K31/17 , C07C275/14
CPC分类号: C07D235/06 , C07C257/18 , C07C275/24 , C07C275/56 , C07C279/14 , C07C279/24 , C07C279/36 , C07C307/06 , C07C311/35 , C07D209/08 , C07D209/18 , C07D209/24 , C07D209/42 , C07D209/44 , C07D223/20 , C07D233/26 , C07D233/36 , C07D233/72 , C07D233/88 , C07D235/08 , C07D239/47 , C07D249/14 , C07D271/06 , C07D307/85 , C07K5/06139 , A61K38/00
摘要: NPY-antagonistic compounds of the formula ##STR1## Exemplary are: (A) (R)-N-[[4-(Aminocarbonylaminomethyl)phenyl]methyl]-N.sup.2 -bis(4-hydroxyphenyl)acetyl]-argininamide-trifluoracetate;(B) (R)-N-[[4-(Aminocarbonylaminomethyl)phenyl]methyl]-N.sup.2 -[bis(4-chlorphenyl)acetyl]-argininamide-trifluoracetate;(C) (R)-N-[[4-Aminocarbonylaminomethyl)phenyl]methyl]-N.sup.2 -(diphenylacetyl)-argininamide-trifluoracetate;(D) (R)-N.sup.2 -(Diphenylacetyl)-N-[[4-(ethoxycarbonylmethylamino-carbonylaminomethyl)phenyl]methyl]-argininamide-trifluoroacetate;(E) (R,S)-N.sup.5 -(Aminoiminomethyl)-N.sup.2 -(diphenylacetyl)-N-[(4-hy-droxyphenyl)methyl]-N.sup.5 -methyl-ornithinamide-hydrochloride;(F) (R)-N-[[4-(Aminocarbonylmethyl)phenyl]methyl]-N.sup.2 -(diphenyl-acetyl)-argininamide-diacetate;(G) (R)-N.sup.2 -(Diphenylacetyl)-N-[[4-(ethylaminocarbonylamino-methyl)-phenyl]methyl]-argininamide-bis-(trifluoroacetate); and,(H) (R)-N.sup.2 -(Diphenylacetyl)-N-[[4-(ethoxycarbonylamino-carbonylaminomethyl)phenyl]methyl]-argininamide-trifluoroacetate.
摘要翻译: 式(A)(R)-N - [[4-(氨基羰基氨基甲基)苯基]甲基] -N2-双(4-羟基苯基)乙酰基] - 炔丙酰胺 - 三氟乙酸盐; (B)(R)-N - [[4-(氨基羰基氨基甲基)苯基]甲基] -N 2 - [双(4-氯苯基)乙酰基] - 炔丙酰胺 - 三氟乙酸盐; (C)(R)-N - [[4-氨基羰基氨基甲基)苯基]甲基] -N2-(二苯基乙酰基) - 炔丙酰胺 - 三氟乙酸盐; (D)(R)-N2-(二苯基乙酰基)-N - [[4-(乙氧基羰基甲基氨基 - 羰基氨基甲基)苯基]甲基] - 炔丙酰胺 - 三氟乙酸盐; (E)(R,S)-N5-(氨基亚氨基甲基)-N2-(二苯基乙酰基)-N - [(4-羟基苯基)甲基] -N5-甲基 - 鸟氨酰胺 - 盐酸盐; (F)(R)-N - [[4-(氨基羰基甲基)苯基]甲基] -N2-(二苯基 - 乙酰基) - 鸟氨酰胺 - 二乙酸酯; (G)(R)-N2-(二苯基乙酰基)-N - [[4-(乙基氨基羰基氨基 - 甲基) - 苯基]甲基] - 炔丙酰胺 - 双 - (三氟乙酸盐) 和(H)(R)-N2-(二苯基乙酰基)-N - [[4-(乙氧基羰基氨基 - 羰基氨基甲基)苯基]甲基] - 炔丙酰胺 - 三氟乙酸盐。
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2.Amino acid derivatives, medicaments containing said compounds and methods of producing said compounds 失效
标题翻译: 氨基酸衍生物,含有所述化合物的药物和制备所述化合物的方法公开(公告)号:US06040289A
公开(公告)日:2000-03-21
申请号:US77663
申请日:1998-05-29
申请人: Wolfgang Eberlein , Wolfhard Engel , Klaus Rudolf , Henri Doods , Heike-Andrea Wieland , Klaus-Dieter Willim
发明人: Wolfgang Eberlein , Wolfhard Engel , Klaus Rudolf , Henri Doods , Heike-Andrea Wieland , Klaus-Dieter Willim
IPC分类号: C07D277/20 , A61K31/00 , A61K31/165 , A61K31/22 , A61K31/223 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/425 , A61K31/426 , A61K31/44 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/14 , A61P9/00 , A61P13/00 , A61P13/12 , A61P25/08 , A61P35/00 , A61P43/00 , C07C279/14 , C07C279/22 , C07C279/24 , C07D209/18 , C07D213/72 , C07D213/75 , C07D213/81 , C07D277/42 , C07D277/48 , A61K38/00 , A01N37/18
CPC分类号: C07D213/75 , C07C279/22 , C07C279/24 , C07D209/18 , C07D213/81 , C07D277/48
摘要: The invention relates to new amino acid derivatives of general formula ##STR1## wherein R, U, V, Y, n, m and R.sup.1 to R.sup.3 are defined as in claim 1, their tautomers, diastereomers, enantiomers, mixtures thereof and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly selective NPY-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.
摘要翻译: PCT No.PCT / EP96 / 05214 Sec。 371日期:1998年5月29日 102(e)日期1998年5月29日PCT提交1996年11月26日PCT公布。 第WO97 / 19914号公报 日期1996年6月5日本发明涉及通式的新氨基酸衍生物,其中R,U,V,Y,n,m和R 1至R 3如权利要求1所定义,其互变异构体,非对映异构体,对映体,其混合物和盐 特别是其与无机或有机酸或碱的生理上可接受的盐,其具有有价值的药理学性质,特别是选择性的NPY拮抗性质,含有这些化合物的药物组合物,其用途及其制备方法。
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3.Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译: 氨基酸衍生物,含有这些化合物的药物组合物及其制备方法公开(公告)号:US5807875A
公开(公告)日:1998-09-15
申请号:US763504
申请日:1996-12-11
申请人: Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Henri Doods , Heike Andrea Wieland , Klaus-Dieter Willim , Jurgen Krause , Horst Dollinger , Franz Esser , Gerd Schnorrenberg , Michael Entzeroth , Wolfgang Wienen
发明人: Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Henri Doods , Heike Andrea Wieland , Klaus-Dieter Willim , Jurgen Krause , Horst Dollinger , Franz Esser , Gerd Schnorrenberg , Michael Entzeroth , Wolfgang Wienen
IPC分类号: A61K31/155 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/454 , A61K31/47 , A61K38/00 , A61P9/12 , A61P43/00 , C07C237/22 , C07C237/42 , C07C255/60 , C07C257/12 , C07C257/14 , C07C257/18 , C07C259/10 , C07C259/18 , C07C261/04 , C07C275/40 , C07C279/10 , C07C279/12 , C07C279/14 , C07C279/18 , C07C279/36 , C07C307/02 , C07C307/10 , C07C311/08 , C07C311/15 , C07C311/19 , C07C311/39 , C07C311/42 , C07D209/14 , C07D209/16 , C07D209/42 , C07D209/44 , C07D211/28 , C07D213/38 , C07D213/55 , C07D215/12 , C07D215/38 , C07D223/20 , C07D233/24 , C07D233/48 , C07D233/54 , C07D233/64 , C07D233/66 , C07D233/72 , C07D233/88 , C07D235/06 , C07D235/08 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D271/06 , C07D271/07 , C07D295/15 , C07D333/20 , C07D333/36 , C07D401/12 , C07D471/04 , C07K5/072 , C07C273/00 , C07C275/00
CPC分类号: C07D233/64 , C07C237/22 , C07C237/42 , C07C255/60 , C07C257/12 , C07C257/14 , C07C257/18 , C07C259/10 , C07C259/18 , C07C261/04 , C07C275/40 , C07C279/14 , C07C279/18 , C07C279/36 , C07C307/02 , C07C307/10 , C07C311/08 , C07C311/19 , C07C311/39 , C07C311/42 , C07D209/16 , C07D209/42 , C07D209/44 , C07D213/38 , C07D215/38 , C07D223/20 , C07D233/24 , C07D233/48 , C07D233/72 , C07D233/88 , C07D235/06 , C07D249/12 , C07D249/14 , C07D271/07 , C07D295/15 , C07D333/20 , C07D471/04 , C07K5/06095 , A61K38/00 , C07C2101/08 , C07C2101/14 , C07C2103/18 , C07C2103/74
摘要: Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R,S)-N.sup.2 -(diphenylacetyl)-N-�(4-hydroxyphenyl)methyl!-N.sup.5 -(1H-imidazol-2-yl)-ornithinamide.
摘要翻译: 氨基酸衍生物,适用于治疗肥胖症。 以下化合物是以下类别的示例:(R,S)-N 2 - (二苯基乙酰基)-N - [(4-羟基苯基)甲基] -N 5 - (1H-咪唑-2-基) - 甲硅烷基酰胺。
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4.Amino acid derivatives, medicaments containing said compounds and methods of producing them 失效
标题翻译: 氨基酸衍生物,含有所述化合物的药物及其制备方法公开(公告)号:US5962530A
公开(公告)日:1999-10-05
申请号:US77629
申请日:1998-05-29
申请人: Wolfhard Engel , Wolfgang Eberlein , Klaus Rudolf , Henri Doods , Heike-Andrea Wieland , Klaus-Dieter Willim
发明人: Wolfhard Engel , Wolfgang Eberlein , Klaus Rudolf , Henri Doods , Heike-Andrea Wieland , Klaus-Dieter Willim
IPC分类号: G01N33/534 , A61K31/00 , A61K31/165 , A61P5/24 , C07C279/18 , C07C279/24 , G01N33/60 , G01N33/68 , A01N47/28 , A01N37/18 , C07C233/31 , C07C275/18
CPC分类号: C07C279/18 , C07C279/24 , G01N33/60 , G01N33/68 , C07C2101/14
摘要: The invention relates to new amino acid derivatives of general formula ##STR1## wherein R, U, V, Y, n, m and R.sup.1 to R.sup.3 are defined as in claim 1, their tautomers, diastereomers, enantiomers, mixtures thereof and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly selective NPY-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.
摘要翻译: PCT No.PCT / EP96 / 05217 Sec。 371日期:1998年5月29日 102(e)日期1998年5月29日PCT提交1996年11月26日PCT公布。 第WO97 / 19913号公报 日期1996年6月5日本发明涉及通式的新氨基酸衍生物,其中R,U,V,Y,n,m和R 1至R 3如权利要求1所定义,其互变异构体,非对映异构体,对映体,其混合物和盐 特别是其与无机或有机酸或碱的生理上可接受的盐,其具有有价值的药理学性质,特别是选择性的NPY拮抗性质,含有这些化合物的药物组合物,其用途及其制备方法。
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5.Amino acid derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of obesity 失效
标题翻译: 氨基酸衍生物,含有这些化合物的药物组合物及其在治疗肥胖症中的应用公开(公告)号:US5616620A
公开(公告)日:1997-04-01
申请号:US458093
申请日:1995-06-01
申请人: Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Henri Doods , Heike A. Wieland , Klaus-Dieter Willim , Jurgen Krause , Horst Dollinger , Franz Esser , Gerd Schnorrenberg , Michael Entzeroth , Wolfgang Wienen
发明人: Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Henri Doods , Heike A. Wieland , Klaus-Dieter Willim , Jurgen Krause , Horst Dollinger , Franz Esser , Gerd Schnorrenberg , Michael Entzeroth , Wolfgang Wienen
IPC分类号: A61K31/155 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/454 , A61K31/47 , A61K38/00 , A61P9/12 , A61P43/00 , C07C237/22 , C07C237/42 , C07C255/60 , C07C257/12 , C07C257/14 , C07C257/18 , C07C259/10 , C07C259/18 , C07C261/04 , C07C275/40 , C07C279/10 , C07C279/12 , C07C279/14 , C07C279/18 , C07C279/36 , C07C307/02 , C07C307/10 , C07C311/08 , C07C311/15 , C07C311/19 , C07C311/39 , C07C311/42 , C07D209/14 , C07D209/16 , C07D209/42 , C07D209/44 , C07D211/28 , C07D213/38 , C07D213/55 , C07D215/12 , C07D215/38 , C07D223/20 , C07D233/24 , C07D233/48 , C07D233/54 , C07D233/64 , C07D233/66 , C07D233/72 , C07D233/88 , C07D235/06 , C07D235/08 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D271/06 , C07D271/07 , C07D295/15 , C07D333/20 , C07D333/36 , C07D401/12 , C07D471/04 , C07K5/072 , C07C273/00 , C07C275/00
CPC分类号: C07D233/64 , C07C237/22 , C07C237/42 , C07C255/60 , C07C257/12 , C07C257/14 , C07C257/18 , C07C259/10 , C07C259/18 , C07C261/04 , C07C275/40 , C07C279/14 , C07C279/18 , C07C279/36 , C07C307/02 , C07C307/10 , C07C311/08 , C07C311/19 , C07C311/39 , C07C311/42 , C07D209/16 , C07D209/42 , C07D209/44 , C07D213/38 , C07D215/38 , C07D223/20 , C07D233/24 , C07D233/48 , C07D233/72 , C07D233/88 , C07D235/06 , C07D249/12 , C07D249/14 , C07D271/07 , C07D295/15 , C07D333/20 , C07D471/04 , C07K5/06095 , A61K38/00 , C07C2101/08 , C07C2101/14 , C07C2103/18 , C07C2103/74
摘要: Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-argininamide-acetate.
摘要翻译: 氨基酸衍生物,适用于治疗肥胖症。 以下化合物是以下类别的示例:(R)-N 2 - (二苯基乙酰基)-N - [(4-羟基苯基)甲基] - 炔丙酰胺 - 乙酸酯。
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6.Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation 失效
标题翻译: 浓缩二氮杂酮,其制备方法和含有这些化合物的药物,用于治疗中枢神经系统疾病和促进脑血液循环公开(公告)号:US5641772A
公开(公告)日:1997-06-24
申请号:US421108
申请日:1995-04-13
申请人: Wolfgang Eberlein , Gerhard Mihm , Wolfhard Engel , Klaus Rudolf , Henri Doods , Harald Ziegler , Michael Entzeroth
发明人: Wolfgang Eberlein , Gerhard Mihm , Wolfhard Engel , Klaus Rudolf , Henri Doods , Harald Ziegler , Michael Entzeroth
IPC分类号: A61K31/55 , A61K31/5513 , A61K31/5517 , A61P9/00 , A61P9/06 , A61P25/00 , A61P25/28 , C07D243/12 , C07D243/38 , C07D401/06 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D495/04 , C07D495/14 , C07D243/10
CPC分类号: C07D401/06 , C07D471/04 , C07D487/04 , C07D495/04
摘要: New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R.sup.1 to R.sup.7 are as defined herein, as well as the salts thereof with inorganic or organic acids and processes for preparing them.These compounds are useful for improving or normalising arteriosclerotically induced disorders of cerebral blood flow, for treating diseases of the central nervous system, particularly Alzheimer's disease and Parkinson's disease, and as vagal pacemakers for treating bradycardia and bradyarrhythmia, and also for improving memory performance.
摘要翻译: (I)其中B表示二价基团之一的新的浓缩二氮杂酮通式I(I)其中B表示二价基团之一,其中X, m,n和R 1至R 7如本文所定义,以及其与无机或有机酸的盐及其制备方法。 这些化合物可用于改善或归一化动脉硬化诱导的脑血流紊乱,用于治疗中枢神经系统疾病,特别是阿尔茨海默病和帕金森病,以及用于治疗心动过缓和缓慢心律失常的迷走神经心脏起搏器,以及用于改善记忆性能。
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公开(公告)号:US5610155A
公开(公告)日:1997-03-11
申请号:US457061
申请日:1995-06-01
申请人: Wolfgang Eberlein , Gerhard Mihm , Wolfhard Engel , Klaus Rudolf , Henri Doods , Harald Ziegler , Michael Entzeroth
发明人: Wolfgang Eberlein , Gerhard Mihm , Wolfhard Engel , Klaus Rudolf , Henri Doods , Harald Ziegler , Michael Entzeroth
IPC分类号: C07D401/06 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/55 , C07D243/10
CPC分类号: C07D401/06 , C07D471/04 , C07D487/04 , C07D495/04
摘要: New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R.sup.1 to R.sup.7 are as defined herein, as well as the salts thereof with inorganic or organic acids and processes for preparing them.These compounds are useful for improving or normalising arteriosclerotically induced disorders of cerebral blood flow, for treating diseases of the central nervous system, particularly Alzheimer's disease and Parkinson's disease, and as vagal pacemakers for treating bradycardia and bradyarrhythmia, and also for improving memory performance.
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8.Use of CGRP antagonists and CGRP release inhibitors for combating menopausal hot flushes 有权
标题翻译: 使用CGRP拮抗剂和CGRP释放抑制剂来对抗更年期热潮红公开(公告)号:US06521609B1
公开(公告)日:2003-02-18
申请号:US09614343
申请日:2000-07-12
申请人: Henri Doods , Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel
发明人: Henri Doods , Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel
IPC分类号: A61K31454
CPC分类号: A61K31/445 , A61K31/00 , A61K31/496 , A61K31/513 , A61K31/5415 , A61K31/551
摘要: A method for treating menopausal hot flushes using CGRP antagonists and/or CGRP release inhibitors and the corresponding pharmaceutical compositions containing as active substance one or more CGRP antagonists and/or CGRP release inhibitors, and the preparation thereof.
摘要翻译: 一种使用CGRP拮抗剂和/或CGRP释放抑制剂治疗绝经期潮热的方法以及含有一种或多种CGRP拮抗剂和/或CGRP释放抑制剂作为活性物质的相应药物组合物及其制备方法。
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9.Use of CGRP antagonists in treatment and prevention of hot flushes in prostate cancer patients 审中-公开
标题翻译: 使用CGRP拮抗剂治疗和预防前列腺癌患者的热潮红公开(公告)号:US20050032783A1
公开(公告)日:2005-02-10
申请号:US10881892
申请日:2004-06-30
申请人: Henri Doods , Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel , Mats Hammar , Anna-Clara Spetz
发明人: Henri Doods , Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel , Mats Hammar , Anna-Clara Spetz
IPC分类号: A61K31/00 , A61K31/4045 , A61K31/422 , A61K31/517 , A61K31/5513 , A61K45/06
CPC分类号: A61K45/06 , A61K31/00 , A61K31/4045 , A61K31/422 , A61K31/517 , A61K31/5513 , A61K2300/00
摘要: The invention relates to a method of treatment or prevention of hot flushes in men who underwent castration, e.g. due to androgen ablation treatment in prostate cancer therapy, comprising administration of an effective amount of a CGRP antagonist and/or of a CGRP release inhibitor to the patient, and to the use of said active compounds for the manufacture of a pharmaceutical composition intended to be used in this method.
摘要翻译: 本发明涉及一种治疗或预防接受阉割的男性热潮红的方法,例如, 由于在前列腺癌治疗中的雄激素消除治疗,包括向患者施用有效量的CGRP拮抗剂和/或CGRP释放抑制剂,以及使用所述活性化合物来制备旨在成为 用于此方法。
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10.Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof 有权
标题翻译: 环丙烷CGRP拮抗剂,含有这些化合物的药物及其制造方法公开(公告)号:US07407963B2
公开(公告)日:2008-08-05
申请号:US11169078
申请日:2005-06-27
申请人: Wolfgang Eberlein , Wolfhard Engel , Klaus Rudolf , Henri Doods , Gerhard Hallermayer , Eckhart Bauer
发明人: Wolfgang Eberlein , Wolfhard Engel , Klaus Rudolf , Henri Doods , Gerhard Hallermayer , Eckhart Bauer
IPC分类号: A61K31/517 , A61K31/454 , C07D403/02 , C07D239/72
CPC分类号: C07D401/04 , C07D471/04
摘要: A compound of general formula (I) wherein R and R1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing the compound, their use, and processes for preparing them.
摘要翻译: 其中R和R 1如本文所定义的通式(I)的化合物或其互变异构体,非对映异构体,对映异构体或其盐,特别是其生理上可接受的盐,其具有有价值的药理学性质, 特别是CGRP拮抗性质,含有该化合物的药物组合物,其用途及其制备方法。
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