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公开(公告)号：US20100279936A1
公开(公告)日：2010-11-04
申请号：US12376417
申请日：2007-08-16
IPC分类号： A61K38/23
CPC分类号： C07D213/40 , C07B2200/07 , C07C211/29 , C07C211/30 , C07C211/49 , C07C215/24 , C07C215/28 , C07C215/30 , C07C215/50 , C07C215/54 , C07C217/46 , C07C217/58 , C07C217/62 , C07C229/30 , C07C229/34 , C07C229/38 , C07C233/36 , C07C233/38 , C07C233/62 , C07C235/10 , C07C235/60 , C07C237/16 , C07C255/30 , C07C255/58 , C07C271/20 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C311/05 , C07C311/18 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/12 , C07D209/08 , C07D211/46 , C07D211/58 , C07D211/62 , C07D231/12 , C07D263/32 , C07D295/13 , C07D295/182 , C07D309/08 , C07D309/10 , C07D317/28 , C07D317/58 , C07D333/20 , C07D333/58 , C07F7/081 , C07F7/1804
摘要： The invention relates to novel compounds according to formula Ia and Ib; (Formula Ia and Ib) wherein A represents substituted or unsubstituted C1-10heteroaryl, C6-14aryl or C6-10heterocycloalkylaryl; R1 is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, C1-6amino, C3-6 cycloalkyl, or C1-6heterocycloalkyl, each of which are optionally substituted; X represents —CR3R4—(CR5R6)n—(CR7═CR8)m—(C6-14aryl)r-(C1-10heteroaryl)s-(CR9R10)p—(CR11═CR12)q, R2 represents C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, C1-6amino, C1-12alkylsilyl, C6-30alkylarylsilyl, C1-10heteroaryl, C6-14aryl, C1-10heterocycloalkyl, C1-10heterocycloalkenyl, C1-8cycloalkyl, C1-18cycloalkenyl, each of which is optionally substituted, or R2 represents hydrogen, carboxy, or hydroxy; or a pharmaceutically acceptable salt, solvate, or ester thereof; to processes for the preparation thereof, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, wherein said compounds being useful, e.g. in the treatment of diseases associated with disturbances of CaSR activity, such as hyperparathyroidism.
摘要翻译： 本发明涉及根据式Ia和Ib的新化合物; （式Ia和Ib）其中A表示取代或未取代的C1-10杂芳基，C6-14芳基或C6-10杂环烷基芳基; R 1是C 1-6烷基，C 2-6烯基，C 2-6炔基，C 1-6羟基烷基，C 1-6卤代烷基，C 1-6氨基，C 3-6环烷基或C 1-6杂环烷基，其各自任选被取代; X表示-CR3R4-（CR5R6）n-（CR7 = CR8）m-（C6-14芳基）r-（C1-10杂芳基）s-（CR9R10）p-（CR11 = CR12）q，R2表示C1-6烷基，C2 6-烯基，C 2-6炔基，C 1-6羟基烷基，C 1-6卤代烷基，C 1-6氨基，C 1-12烷基甲硅烷基，C 6-30烷基芳基甲硅烷基，C 1-10杂芳基，C 6-14芳基，C 1-10杂环烷基，C 1-10杂环烯基，C 1-8环烷基， ，其各自任选被取代，或R 2表示氢，羧基或羟基; 或其药学上可接受的盐，溶剂化物或酯; 涉及用于制备其的所述化合物，用于治疗的所述化合物，包含所述化合物的药物组合物，其中所述化合物是有用的。 治疗与CaSR活动相关的疾病，如甲状旁腺功能亢进。
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公开(公告)号：US20100317582A1
公开(公告)日：2010-12-16
申请号：US12744137
申请日：2008-11-20
IPC分类号： A61K38/23 , C07C211/30 , A61K31/137 , C07D295/027 , A61K31/5375 , C07D271/06 , A61K31/4245 , A61P25/28 , A61P9/10 , A61P13/12 , A61K31/59
CPC分类号： C07D295/182 , C07C211/35 , C07C211/36 , C07C211/48 , C07C215/28 , C07C217/52 , C07C217/74 , C07C233/05 , C07C233/41 , C07C237/24 , C07C237/30 , C07C237/32 , C07C237/34 , C07C237/36 , C07C237/40 , C07C239/14 , C07C255/03 , C07C255/32 , C07C255/50 , C07C257/18 , C07C259/10 , C07C259/18 , C07C271/44 , C07C309/15 , C07C311/05 , C07C311/08 , C07C311/37 , C07C311/51 , C07C317/32 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/12 , C07D209/20 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/80 , C07D231/12 , C07D231/40 , C07D233/61 , C07D233/90 , C07D263/22 , C07D271/06 , C07D295/088 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/195 , C07D295/26 , C07D305/08 , C07D307/12 , C07D307/52 , C07D307/68 , C07D307/79 , C07D309/10 , C07D319/18 , C07D333/38 , C07D333/40 , C07D333/58 , C07D413/04 , C07D413/06 , C07D417/06
摘要： The invention relates to novel cyclic hydrocarbon compounds and derivatives thereof, processes for the preparation thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.
摘要翻译： 本发明涉及新的环烃化合物及其衍生物，其制备方法，用作药物的所述化合物，用于治疗的所述化合物，包含所述化合物的药物组合物，涉及用所述化合物治疗疾病的方法 ，以及所述化合物在制备药物中的用途。
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公开(公告)号：US09487494B2
公开(公告)日：2016-11-08
申请号：US12744137
申请日：2008-11-20
IPC分类号： C07D295/182 , C07C211/35 , C07C211/36 , C07C211/48 , C07C215/28 , C07C217/52 , C07C217/74 , C07C233/05 , C07C233/41 , C07C237/24 , C07C237/30 , C07C237/32 , C07C237/34 , C07C237/36 , C07C237/40 , C07C239/14 , C07C255/03 , C07C255/32 , C07C255/50 , C07C257/18 , C07C259/10 , C07C259/18 , C07C271/44 , C07C309/15 , C07C311/05 , C07C311/08 , C07C311/37 , C07C311/51 , C07C317/32 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/12 , C07D209/20 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/80 , C07D231/12 , C07D231/40 , C07D233/61 , C07D233/90 , C07D263/22 , C07D271/06 , C07D295/088 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/195 , C07D295/26 , C07D305/08 , C07D307/12 , C07D307/52 , C07D307/68 , C07D307/79 , C07D309/10 , C07D319/18 , C07D333/38 , C07D333/40 , C07D333/58 , C07D413/04 , C07D413/06 , C07D417/06
CPC分类号： C07D295/182 , C07C211/35 , C07C211/36 , C07C211/48 , C07C215/28 , C07C217/52 , C07C217/74 , C07C233/05 , C07C233/41 , C07C237/24 , C07C237/30 , C07C237/32 , C07C237/34 , C07C237/36 , C07C237/40 , C07C239/14 , C07C255/03 , C07C255/32 , C07C255/50 , C07C257/18 , C07C259/10 , C07C259/18 , C07C271/44 , C07C309/15 , C07C311/05 , C07C311/08 , C07C311/37 , C07C311/51 , C07C317/32 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/12 , C07D209/20 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/80 , C07D231/12 , C07D231/40 , C07D233/61 , C07D233/90 , C07D263/22 , C07D271/06 , C07D295/088 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/195 , C07D295/26 , C07D305/08 , C07D307/12 , C07D307/52 , C07D307/68 , C07D307/79 , C07D309/10 , C07D319/18 , C07D333/38 , C07D333/40 , C07D333/58 , C07D413/04 , C07D413/06 , C07D417/06
摘要： The invention relates to novel cyclic hydrocarbon compounds and derivatives thereof, processes for the preparation thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.
摘要翻译： 本发明涉及新的环烃化合物及其衍生物，其制备方法，用作药物的所述化合物，用于治疗的所述化合物，包含所述化合物的药物组合物，涉及用所述化合物治疗疾病的方法 ，以及所述化合物在制备药物中的用途。
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公开(公告)号：US08034811B2
公开(公告)日：2011-10-11
申请号：US10580967
申请日：2004-12-02
申请人： Jef Fensholdt , Jacob Thorhauge , Bjarne Nørremark
发明人： Jef Fensholdt , Jacob Thorhauge , Bjarne Nørremark
IPC分类号： A61K31/5377 , C07D295/04
CPC分类号： C07D417/12 , C07C259/10 , C07D213/38 , C07D213/53 , C07D213/61 , C07D213/84 , C07D233/22 , C07D261/04 , C07D295/192 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12
摘要： The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R1, A, R9, X, B, R8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer.
摘要翻译： 本发明涉及通式I的化合物，其中D，E，F，G，W，Y，R 1，A，R 9，X，B，R 8如本文所定义，及其药学上可接受的盐，水合物或溶剂合物， 单独使用或与一种或多种其它药学活性化合物组合在治疗中，用于治疗与失调的血管生成相关的疾病，例如癌症。
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5.发明授权公开(公告)号：US08765676B2
公开(公告)日：2014-07-01
申请号：US13322514
申请日：2010-05-26
IPC分类号： C07D211/16 , A61K31/33 , A61P19/00 , C07D213/643 , C07D257/04 , C07D265/30 , C07D277/22 , C07D317/62 , A61K38/23 , A61K38/00 , C07K14/585
CPC分类号： C07D211/16 , A61K31/33 , C07D213/643 , C07D257/04 , C07D265/30 , C07D277/22 , C07D317/62 , C07D319/18 , C07D321/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： Calcium-sensing receptor (CaSR) modulating substituted cyclopentylene compounds represented in formula I (wherein X is CH or N) and pharmaceutical compositions thereof are useful for treating diseases.
摘要翻译： 调节取代的式I化合物（其中X为CH或N）的取代环戊烯化合物及其药物组合物可用于治疗疾病的钙感受因受体（CaSR）。
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6.发明申请NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF 失效新型钙感受体调节化合物及其药物用途公开(公告)号：US20120122784A1
公开(公告)日：2012-05-17
申请号：US13322514
申请日：2010-05-26
IPC分类号： A61K38/23 , C07D231/12 , C07D319/18 , C07D307/79 , C07C317/32 , C07D277/28 , C07D215/14 , C07D471/04 , C07D265/36 , C07C317/24 , C07D211/58 , C07D213/64 , C07D257/04 , C07C311/17 , C07D211/46 , C07C235/80 , A61K31/36 , A61K31/415 , A61K31/357 , A61K31/343 , A61K31/145 , A61K31/426 , A61K31/47 , A61K31/437 , A61K31/538 , A61K31/397 , A61P35/00 , A61P9/00 , A61P13/12 , A61P1/00 , A61P25/00 , A61P7/06 , A61P19/08 , A61P19/10 , A61P25/28 , A61P1/12 , A61K31/593 , A61K31/566 , C07D317/58
CPC分类号： C07D211/16 , A61K31/33 , C07D213/643 , C07D257/04 , C07D265/30 , C07D277/22 , C07D317/62 , C07D319/18 , C07D321/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： The invention relates to novel calcium-sensing receptor (CaSR) modulating substituted cyclopentylene compounds represented in formula I and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.
摘要翻译： 本发明涉及用于治疗的所述化合物，用于治疗的所述化合物，包含所述化合物的药物组合物的新型钙感受受体（CaSR）调节式I表示的取代的环戊烯化合物及其衍生物， 用所述化合物治疗疾病，以及所述化合物在制备药物中的用途。
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7.发明授权公开(公告)号：US08785494B2
公开(公告)日：2014-07-22
申请号：US13322522
申请日：2010-05-26
申请人： Bjarne Nørremark
发明人： Bjarne Nørremark
IPC分类号： A61K31/21 , A61K31/215 , A61K31/195 , A61K31/135
CPC分类号： A61K31/195 , C07C229/46 , C07C2601/08 , A61K31/215 , A61K31/135 , C07C227/18 , C07C69/738 , C07C67/343
摘要： The invention relates to novel calcium-sensing receptor (CaSR) modulating trifluoromethylphenylene cyclopentylene compounds represented in formula (I) and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.
摘要翻译： 本发明涉及将用于治疗的所述化合物，用于治疗的所述化合物，包含所述化合物的药物组合物的式（I）所示的三氟甲基亚苯基亚环戊基化合物及其衍生物的新型钙感受受体（CaSR） 涉及用所述化合物治疗疾病的方法，以及所述化合物在制备药物中的用途。
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8.发明申请NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF 失效新型钙感受体调节化合物及其药物用途公开(公告)号：US20120129926A1
公开(公告)日：2012-05-24
申请号：US13322522
申请日：2010-05-26
申请人： Bjarne Nørremark
发明人： Bjarne Nørremark
IPC分类号： A61K31/216 , C07C219/28 , C07F5/04 , C07C69/738 , C07C49/697 , C07C49/747 , C07C25/13 , C07C69/65 , A61K31/195 , A61K31/137 , A61P35/00 , A61P9/00 , A61P13/12 , A61P1/00 , A61P25/00 , A61P5/20 , A61P19/10 , A61P25/28 , C07C229/46
CPC分类号： A61K31/195 , C07C229/46 , C07C2601/08 , A61K31/215 , A61K31/135 , C07C227/18 , C07C69/738 , C07C67/343
摘要： The invention relates to novel calcium-sensing receptor (CaSR) modulating trifluoromethylphenylene cyclopentylene compounds represented in formula (I) and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.
摘要翻译： 本发明涉及将用于治疗的所述化合物，用于治疗的所述化合物，包含所述化合物的药物组合物的式（I）所示的三氟甲基亚苯基亚环戊基化合物及其衍生物的新型钙感受受体（CaSR） 涉及用所述化合物治疗疾病的方法，以及所述化合物在制备药物中的用途。
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