-
1.
公开(公告)号:US07884107B2
公开(公告)日:2011-02-08
申请号:US11769030
申请日:2007-06-27
申请人: Yao Ma , Brian Robert Lahue , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Matthew Ernst Voss , Latha G. Nair , Yuan Tian , Ronald J. Doll , Zhuyan Guo , Corey O. Strickland , Rumin Zhang , Mark A. McCoy , Weidong Pan , Elise M. Siegel , Craig R. Gibeau
发明人: Yao Ma , Brian Robert Lahue , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Matthew Ernst Voss , Latha G. Nair , Yuan Tian , Ronald J. Doll , Zhuyan Guo , Corey O. Strickland , Rumin Zhang , Mark A. McCoy , Weidong Pan , Elise M. Siegel , Craig R. Gibeau
IPC分类号: A61K31/54 , C07D413/00 , C07D403/00 , C07D405/00
CPC分类号: C07D409/14 , C07D401/06 , C07D401/14
摘要: In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明公开了作为HDM2蛋白的制备方法的抑制剂的新型化合物,包括一种或多种这样的化合物的药物组合物,治疗,预防,抑制与HDM2蛋白相关的一种或多种疾病的方法 或P53使用这些化合物或药物组合物。
-
2.
公开(公告)号:US08859776B2
公开(公告)日:2014-10-14
申请号:US13501685
申请日:2010-10-05
申请人: Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
发明人: Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
IPC分类号: C07D401/00 , A01N43/40 , C07D401/14 , C07D409/14
CPC分类号: C07D401/14 , C07D409/14
摘要: The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译: 本发明提供本文所述的式1的化合物或其药学上可接受的盐,溶剂合物或酯。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
-
公开(公告)号:US07705127B1
公开(公告)日:2010-04-27
申请号:US12249314
申请日:2008-10-10
申请人: Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人: Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号: C07K14/00
CPC分类号: C07K14/82 , C07K2299/00
摘要: The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译: 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
-
公开(公告)号:US07888474B2
公开(公告)日:2011-02-15
申请号:US12723184
申请日:2010-03-12
申请人: Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人: Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号: C07K14/00
CPC分类号: C07K14/82 , C07K2299/00
摘要: The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译: 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
-
公开(公告)号:US07652020B2
公开(公告)日:2010-01-26
申请号:US11142601
申请日:2005-06-01
申请人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, Jr. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, Jr. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号: A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245 , C07D413/00 , C07D241/36 , C07D471/00 , C07D295/00 , C07D471/02 , C07D401/00 , C07D513/00 , C07D277/22 , C07D277/62 , C07D263/30 , C07D261/06 , C07D235/00 , C07D209/04 , C07D207/00 , C07D205/00 , C07D409/00 , C07D307/00
CPC分类号: C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗由MMP,ADAM,TACE,TNF-α或其组合介导的疾病或病症。
-
公开(公告)号:US07446195B2
公开(公告)日:2008-11-04
申请号:US11505263
申请日:2006-08-16
申请人: Yongqi Deng , Lianyun Zhao , Gerald W. Shipps, Jr. , Patrick J. Curran , M. Arshad Siddiqui , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人: Yongqi Deng , Lianyun Zhao , Gerald W. Shipps, Jr. , Patrick J. Curran , M. Arshad Siddiqui , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号: C07D413/12 , C07D403/12 , C07D409/12 , C07D405/12
CPC分类号: C07D405/12 , C07D333/40 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译: 描述了细胞周期蛋白依赖性激酶2的抑制剂,包括抑制剂的组合物,以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法,抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
-
公开(公告)号:US07511063B2
公开(公告)日:2009-03-31
申请号:US11504869
申请日:2006-08-16
申请人: Yongqi Deng , Patrick J. Curran , Gerald W. Shipps, Jr. , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人: Yongqi Deng , Patrick J. Curran , Gerald W. Shipps, Jr. , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号: A61K31/47 , C07D215/14
CPC分类号: C07D409/04 , C07D215/48 , C07D215/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10
摘要: Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译: 描述了基于喹啉的细胞周期蛋白依赖性激酶2抑制剂,包括抑制剂的组合物,以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法,抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
-
公开(公告)号:US08546404B2
公开(公告)日:2013-10-01
申请号:US11810282
申请日:2007-06-05
申请人: Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr. , Neng-Yang Shih , Hugh Y. Zhu , Robert Sun , Joseph M. Kelly , Ronald J. Doll , Yang Nan , Tong Wang , Jagdish A. Desai , James J-S Wang , Youhao Dong , Vincent S. Madison , Li Xiao , Alan W. Hruza , M. Arshad Siddiqui , Ahmed A. Samatar , Sunil Paliwal , Hon-Chung Tsui , Azim Alan Celebi , Yiji Wu , Sobhana Babu Boga , Abdul-Basit Alhassan , Xiaolei Gao , Liang Zhu , Mehul Patel
发明人: Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr. , Neng-Yang Shih , Hugh Y. Zhu , Robert Sun , Joseph M. Kelly , Ronald J. Doll , Yang Nan , Tong Wang , Jagdish A. Desai , James J-S Wang , Youhao Dong , Vincent S. Madison , Li Xiao , Alan W. Hruza , M. Arshad Siddiqui , Ahmed A. Samatar , Sunil Paliwal , Hon-Chung Tsui , Azim Alan Celebi , Yiji Wu , Sobhana Babu Boga , Abdul-Basit Alhassan , Xiaolei Gao , Liang Zhu , Mehul Patel
IPC分类号: A01N43/54 , C07D239/42 , C07D401/04
CPC分类号: C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要: Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译: 公开了式1.0的ERK抑制剂及其药学上可接受的盐,酯和溶剂化物。 Q是可以具有桥或稠合环的哌啶或哌嗪环。 哌啶环可以在环中具有双键。 所有其他取代基如本文所定义。 还公开了使用式1.0化合物治疗癌症的方法。
-
公开(公告)号:US08999966B2
公开(公告)日:2015-04-07
申请号:US13881050
申请日:2011-10-24
申请人: Sobhana Babu Boga , Joseph M. Kelly , Hugh Y. Zhu , Abdul-Basit Alhassan , Xin Yao , Xiaolei Gao , James J-S Wang , Jagdish A. Desai , Subrahmanyam Gudipati , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr.
发明人: Sobhana Babu Boga , Joseph M. Kelly , Hugh Y. Zhu , Abdul-Basit Alhassan , Xin Yao , Xiaolei Gao , James J-S Wang , Jagdish A. Desai , Subrahmanyam Gudipati , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr.
IPC分类号: A61K31/397 , A61K31/5377 , A61K31/506 , A61K31/4545 , A61K31/454 , A61K31/4523 , A61K31/4427 , A61K31/4439 , A61K31/444 , C07D413/14 , C07D401/14 , C07D403/14 , C07D221/00 , C07D221/02 , C07D211/80 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , A61K45/06
CPC分类号: C07D401/14 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridged monocyclic heterocycloalkyl ring, or a fused (monocyclic heterocycloalkyl ring) cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1).
摘要翻译: 公开了式(1)的ERK抑制剂及其药学上可接受的盐,其中:A是五元单环杂芳基环; 和B是单环杂环烷基环,或单环杂环烯基环,或桥连单环杂环烷基环,或稠合(单环杂环烷基环)环丙基环。 还公开了使用式(1)的化合物治疗癌症的方法。
-
公开(公告)号:US09351965B2
公开(公告)日:2016-05-31
申请号:US13994224
申请日:2011-12-16
申请人: Gerald W. Shipps, Jr. , Xiaohua Huang , Yongqi Deng , Liang Zhu , Alan B. Cooper , Binyuan Sun , Abdelghani Achab , Sie-Mun Lo
发明人: Gerald W. Shipps, Jr. , Xiaohua Huang , Yongqi Deng , Liang Zhu , Alan B. Cooper , Binyuan Sun , Abdelghani Achab , Sie-Mun Lo
IPC分类号: C07D231/56 , C07D401/04 , C07D471/04 , C07D401/14 , C07D403/14 , C07D417/04 , A61K31/416 , A61K31/4439 , A61K45/06 , A61K31/437
CPC分类号: A61K31/4439 , A61K31/416 , A61K31/437 , A61K45/06 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要: The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.
摘要翻译: 本发明提供式I化合物或其药学上可接受的盐,溶剂化物或酯,其中R,R 1,R 2,R 3,m如本文所定义。 这些化合物是ERK抑制剂。 还公开了包含上述化合物的药物组合物和使用其的癌症治疗方法。
-
-
-
-
-
-
-
-
-