公开(公告)号：US07774931B2

公开(公告)日：2010-08-17

申请号：US11414139

申请日：2006-04-28

申请人： Yu-Chong Tai ,  Damien C. Rodger ,  Wen Li ,  Mark Humayun ,  James D. Weiland ,  Hossein Ameri ,  Armand R. Tanguay, Jr.

发明人： Yu-Chong Tai ,  Damien C. Rodger ,  Wen Li ,  Mark Humayun ,  James D. Weiland ,  Hossein Ameri ,  Armand R. Tanguay, Jr.

IPC分类号： H05K3/30

CPC分类号： A61N1/0543 ,  A61F9/08 ,  A61N1/36046 ,  Y10T29/49002 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49156 ,  Y10T29/49224

摘要： Intraocular retinal prosthesis devices and methods for fabricating the same. A prosthesis device includes a cable region that connects an electrode array region with a power and data management region. The electrode array region includes one or more arrays of exposed electrodes, and the power and data management region includes various power and control elements. The power and data management elements, in one aspect, include an RF coil or coils and circuit arrangements and/or chips configured to provide drive signals to the electrodes via a cable and receive power and signals from the RF coil or coils. Each region includes elements fabricated on or in a single polymer layer during the same fabrication process.

摘要翻译： 眼内视网膜假体装置及其制造方法。 假体装置包括将电极阵列区域与功率和数据管理区域连接的电缆区域。 电极阵列区域包括一个或多个暴露电极阵列，功率和数据管理区域包括各种功率和控制元件。 功率和数据管理元件在一个方面包括RF线圈或线圈以及经配置以通过电缆向电极提供驱动信号并且从RF线圈或线圈接收功率和信号的电路布置和/或芯片。 每个区域包括在相同的制造过程中在单个聚合物层上或在单个聚合物层中制造的元件。

公开(公告)号：US07684868B2

公开(公告)日：2010-03-23

申请号：US11272382

申请日：2005-11-10

申请人： Yu-Chong Tai ,  Damien C. Rodger ,  Wen Li ,  Mark Humayun ,  James D. Weiland

发明人： Yu-Chong Tai ,  Damien C. Rodger ,  Wen Li ,  Mark Humayun ,  James D. Weiland

IPC分类号： A61N1/40

CPC分类号： H01F7/06 ,  H01F5/06 ,  H01F17/0006 ,  H01F38/14 ,  H01F2007/068 ,  H01L21/6835 ,  H01L2221/68345 ,  H04B5/00 ,  H04B5/0031 ,  H04B5/0037 ,  H04B5/0093

摘要： This invention relates to the design and fabrication of micro electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields.

摘要翻译： 本发明涉及在诸如生物医学，微流体学和化学分析领域的各种领域中的应用的微机电系统（MEMS）的设计和制造。

公开(公告)号：US07326649B2

公开(公告)日：2008-02-05

申请号：US11130814

申请日：2005-05-16

申请人： Damien C. Rodger ,  Mark Humayun ,  Yu-Chong Tai ,  James D. Weiland

发明人： Damien C. Rodger ,  Mark Humayun ,  Yu-Chong Tai ,  James D. Weiland

IPC分类号： H01L21/44

CPC分类号： H05K1/032 ,  A61N1/04 ,  A61N1/0543 ,  A61N1/0551 ,  H05K1/0393 ,  H05K3/0041 ,  H05K3/007 ,  H05K3/048 ,  H05K3/467 ,  H05K3/4682 ,  H05K2201/0179 ,  H05K2203/016

摘要： Method for manufacturing a parylene-based electrode array that includes an underlying parylene layer, one or more patterned electrode layers comprising a conductive material such as a metal, and one or more overlying parylene layers. The overlying parylene is etched away or otherwise processed to expose the electrodes where stimulation or recording is to occur. All other conductive material in the device is occluded from the environment by the two layers of parylene surrounding it.

摘要翻译： 制造聚对二甲苯基电极阵列的方法，其包括下面的聚对二甲苯层，一个或多个图案化的电极层，包括导电材料如金属和一个或多个上覆的聚对二甲苯层。 将上覆的聚对二甲苯蚀刻掉或以其他方式处理，以暴露要进行刺激或记录的电极。 器件中的所有其他导电材料都被周围的两层聚对二甲苯从环境中吸收。

公开(公告)号：US20110270352A1

公开(公告)日：2011-11-03

申请号：US13097534

申请日：2011-04-29

申请人： Devyani Nanduri ,  Mark S. Humayun ,  James D. Weiland ,  Jessy Dorn ,  Robert J. Greenberg

发明人： Devyani Nanduri ,  Mark S. Humayun ,  James D. Weiland ,  Jessy Dorn ,  Robert J. Greenberg

IPC分类号： A61F9/08

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： Methods of electrically stimulating percepts in a patient with a visual prosthesis are discussed. Changes in amplitude of stimulation increase both the perceived brightness and the perceived size of the precept. Changes in frequency of stimulation change the perceived brightness without altering the perceived size of the percept. Hence, a source image may be mapped to a combination of amplitude and frequency that best induces the desired image.

摘要翻译： 讨论了在具有视觉假体的患者中电刺激感觉的方法。 刺激幅度的变化增加了感觉的亮度和感知的尺寸。 刺激频率的变化会改变感知亮度，而不会改变感知的感知尺寸。 因此，源图像可以被映射到最佳地诱导期望图像的幅度和频率的组合。

公开(公告)号：US20080119908A1

公开(公告)日：2008-05-22

申请号：US11943487

申请日：2007-11-20

申请人： Samip Shah ,  Amy Chu Peishuan Hines ,  Dao Min Zhou ,  Robert J. Greenberg ,  Mark S. Humayun ,  James D. Weiland

发明人： Samip Shah ,  Amy Chu Peishuan Hines ,  Dao Min Zhou ,  Robert J. Greenberg ,  Mark S. Humayun ,  James D. Weiland

IPC分类号： A61N1/05

CPC分类号： A61N1/0543

摘要： A critical element of a retinal prosthesis is the stimulating electrode array, which is placed in close proximity to the retina. It is via this interface that a retinal prosthesis electrically stimulates nerve cells to produce the perception of light. The impedance load seen by the current driver consists of the tissue resistance and the complex electrode impedance. The results show that the tissue resistance of the retina is significantly greater than that of the vitreous humor in the eye. Circuit models of the electrode-retina interface are used to parameterize the different contributors to the overall impedance.

摘要翻译： 视网膜假体的关键元件是刺激电极阵列，其被放置在靠近视网膜的位置。 通过该界面，视网膜假体电刺激神经细胞产生光的感知。 电流驱动器所看到的阻抗由组织电阻和复合电极阻抗组成。 结果表明，视网膜的组织电阻显着大于眼玻璃体液的组织电阻。 电极 - 视网膜界面的电路模型用于参数化整个阻抗的不同贡献者。

公开(公告)号：US08010202B2

公开(公告)日：2011-08-30

申请号：US11943487

申请日：2007-11-20

申请人： Samip Shah ,  Amy Chu Peishuan Hines ,  Dao Min Zhou ,  Robert J. Greenberg ,  Mark S. Humayun ,  James D. Weiland

发明人： Samip Shah ,  Amy Chu Peishuan Hines ,  Dao Min Zhou ,  Robert J. Greenberg ,  Mark S. Humayun ,  James D. Weiland

IPC分类号： A61N1/00

CPC分类号： A61N1/0543

摘要： A critical element of a retinal prosthesis is the stimulating electrode array, which is placed in close proximity to the retina. It is via this interface that a retinal prosthesis electrically stimulates nerve cells to produce the perception of light. The impedance load seen by the current driver consists of the tissue resistance and the complex electrode impedance. The results show that the tissue resistance of the retina is significantly greater than that of the vitreous humor in the eye. Circuit models of the electrode-retina interface are used to parameterize the different contributors to the overall impedance.

摘要翻译： 视网膜假体的关键元件是刺激电极阵列，其被放置在靠近视网膜的位置。 通过该界面，视网膜假体电刺激神经细胞产生光的感知。 电流驱动器所看到的阻抗由组织电阻和复合电极阻抗组成。 结果表明，视网膜的组织电阻显着大于眼玻璃体液的组织电阻。 电极 - 视网膜界面的电路模型用于参数化整个阻抗的不同贡献者。

公开(公告)号：US07810233B2

公开(公告)日：2010-10-12

申请号：US11545190

申请日：2006-10-10

申请人： Peter Krulevitch ,  Dennis L. Polla ,  Mariam N. Maghribi ,  Julie Hamilton ,  Mark S. Humayun ,  James D. Weiland

发明人： Peter Krulevitch ,  Dennis L. Polla ,  Mariam N. Maghribi ,  Julie Hamilton ,  Mark S. Humayun ,  James D. Weiland

IPC分类号： H05K3/30

CPC分类号： A61N1/0543 ,  H05K1/118 ,  H05K3/205 ,  H05K3/4007 ,  H05K2201/0162 ,  H05K2201/09481 ,  H05K2203/0733 ,  Y10S623/90 ,  Y10S623/901 ,  Y10S623/905 ,  Y10S623/926 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49139 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49165 ,  Y10T29/49169 ,  Y10T29/49224

摘要： An image is captured or otherwise converted into a signal in an artificial vision system. The signal is transmitted to the retina utilizing an implant. The implant consists of a polymer substrate made of a compliant material such as poly(dimethylsiloxane) or PDMS. The polymer substrate is conformable to the shape of the retina. Electrodes and conductive leads are embedded in the polymer substrate. The conductive leads and the electrodes transmit the signal representing the image to the cells in the retina. The signal representing the image stimulates cells in the retina.

摘要翻译： 图像被捕获或以其他方式转换成人造视觉系统中的信号。 使用植入物将信号传输到视网膜。 植入物由由诸如聚（二甲基硅氧烷）或PDMS的柔顺材料制成的聚合物基材组成。 聚合物基材与视网膜的形状一致。 电极和导电引线嵌入在聚合物基底中。 导电引线和电极将表示图像的信号传输到视网膜中的细胞。 表示图像的信号刺激视网膜中的细胞。

公开(公告)号：US20090287276A1

公开(公告)日：2009-11-19

申请号：US12466303

申请日：2009-05-14

申请人： Robert J. Greenberg ,  Mark S. Humayun ,  Matthew J. McMahon ,  Devyani Nanduri ,  James D. Weiland

发明人： Robert J. Greenberg ,  Mark S. Humayun ,  Matthew J. McMahon ,  Devyani Nanduri ,  James D. Weiland

IPC分类号： A61F9/08 ,  A61N1/36

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： The present invention is an improved method of stimulating visual neurons to create artificial vision. It has been found that varying current of visual stimulation can create varying percept brightness, varying percept size, and varying percept shape. By determining the attributes of predetermined current levels, and using those attributes to program a video processor, more accurate video preproduction can be obtained.The present invention also includes an electrode array having alternating large and small electrodes in rows at a 45 degree angle to horizontal in the visual field.

摘要翻译： 本发明是一种刺激视觉神经元以创建人造视觉的改进方法。 已经发现，视觉刺激的变化的电流可以产生变化的感知亮度，变化的感知尺寸和变化的感知形状。 通过确定预定电流电平的属性，并使用这些属性对视频处理器进行编程，可以获得更准确的视频预制。 本发明还包括具有在视野中与水平方向成45度角的行的交替的大电极和小电极的电极阵列。

公开(公告)号：US09061150B2

公开(公告)日：2015-06-23

申请号：US12043830

申请日：2008-03-06

申请人： Robert J. Greenberg ,  Alan Matthew Horsager ,  Mark S. Humayun ,  Kelly H. McClure ,  Matthew J. McMahon ,  Peter Meilstrup ,  Neha Jagdish Parikh ,  Arup Roy ,  James D. Weiland ,  Chunhong Zhou

发明人： Robert J. Greenberg ,  Alan Matthew Horsager ,  Mark S. Humayun ,  Kelly H. McClure ,  Matthew J. McMahon ,  Peter Meilstrup ,  Neha Jagdish Parikh ,  Arup Roy ,  James D. Weiland ,  Chunhong Zhou

IPC分类号： A61N1/36 ,  A61F9/08 ,  G06K9/46 ,  G06K9/60 ,  G09B21/00

CPC分类号： A61N1/36046 ,  A61F9/08 ,  G06K9/4604 ,  G06K9/4628 ,  G06K9/605 ,  G09B21/008

摘要： The present invention is a saliency-based apparatus and methods for visual prostheses. A saliency-based component processes video data output by a digital signal processor before the video data are input to the retinal stimulator. In a saliency-based method, an intensity stream is extracted from an input image, feature maps based on the intensity stream are developed, plural most salient regions of the input image are detected and one of the regions is selected as a highest saliency region.

摘要翻译： 本发明是用于视觉假体的基于显眼的装置和方法。 基于显眼的组件在将视频数据输入到视网膜刺激器之前处理由数字信号处理器输出的视频数据。 在基于显着性的方法中，从输入图像中提取强度流，基于强度流形成特征图，检测输入图像的多个最显着区域，并选择其中一个区域作为最高显着区域。

公开(公告)号：US08571671B2

公开(公告)日：2013-10-29

申请号：US13540137

申请日：2012-07-02

申请人： Samip Shah ,  Amy Chu Peishuan Hines ,  Dao Min Zhou ,  Robert J. Greenberg ,  Mark S. Humayun ,  James D. Weiland

发明人： Samip Shah ,  Amy Chu Peishuan Hines ,  Dao Min Zhou ,  Robert J. Greenberg ,  Mark S. Humayun ,  James D. Weiland

IPC分类号： A61N1/36

CPC分类号： A61N1/0543

摘要： A critical element of a retinal prosthesis is the stimulating electrode array, which is placed in close proximity to the retina. It is via this interface that a retinal prosthesis electrically stimulates nerve cells to produce the perception of light. The impedance load seen by the current driver consists of the tissue resistance and the complex electrode impedance. The results show that the tissue resistance of the retina is significantly greater than that of the vitreous humor in the eye. Circuit models of the electrode-retina interface are used to parameterize the different contributors to the overall impedance.

摘要翻译： 视网膜假体的关键元件是刺激电极阵列，其被放置在靠近视网膜的位置。 通过该界面，视网膜假体电刺激神经细胞产生光的感知。 电流驱动器所看到的阻抗由组织电阻和复合电极阻抗组成。 结果表明，视网膜的组织电阻显着大于眼玻璃体液的组织电阻。 电极 - 视网膜界面的电路模型用于参数化整个阻抗的不同贡献者。