公开(公告)号：US5564419A

公开(公告)日：1996-10-15

申请号：US269950

申请日：1994-06-30

Applicant: Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

Inventor： Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

IPC: G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/64 ,  G01N21/80 ,  G01N21/84 ,  G01N33/49 ,  G01N33/497 ,  G01N35/00 ,  G01N35/10 ,  A61B5/00

CPC classification number: G01N33/4925 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6428 ,  G01N33/497 ,  G01N2021/036 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N21/80 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288 ,  Y10T436/207497

Abstract: In a method of photometric in vitro determination of the content of oxygen in a blood sample, a blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container of a sampling device. The sample container has a measuring chamber containing a luminophor, the luminescence of which is quenched in the presence of oxygen. The luminophor is excited by irradiation with radiation from a radiation source. The luminescence emitted by the excited luminophor is detected by a radiation detector and the oxygen content determined on the basis of the radiation detected by the radiation detector. A sampling device and a system for photometric in vitro determination of oxygen in a blood sample are also described.

Abstract translation: 在光度测定血液样品中的氧含量的方法中，将血液样品直接从体内局部转移到采样装置的至少部分透明的样品容器中。 样品容器具有含有发光体的测量室，其发光在氧气存在下淬火。 发光体被来自辐射源的辐射照射而激发。 由激发的发光体发射的发光由辐射检测器检测，并且基于由辐射检测器检测的辐射确定的氧含量。 还描述了用于血液样品中的氧的体外测定的取样装置和系统。

公开(公告)号：US5293770A

公开(公告)日：1994-03-15

申请号：US634111

申请日：1990-12-21

Applicant: Steffen T. Hansen ,  Poul R. Sorensen

Inventor： Steffen T. Hansen ,  Poul R. Sorensen

IPC: G01N27/26 ,  G01N1/00 ,  G01N21/00 ,  G01N27/28 ,  G01N27/40 ,  G01N27/404 ,  G01N27/416 ,  G01N33/00

CPC classification number: G01N27/4163 ,  Y10T436/10

Abstract: In one embodiment the calibration device (1) comprises a housing (2) which by means of a removable lid (8) and a rupturable barrier layer (3) is divided into a calibration chamber (4) and a second chamber (10). The calibration chamber (4) contains a calibration fluid (5)--e.g. a dry gas--while second chamber (10) contains a second fluid (11)--e.g. a wetting agent. Immediately prior to a calibration process the lid (8) is removed, whereafter a sensor with its measuring surface in front is inserted through the second chamber (10) into the housing (2) until it abuts against a shoulder (6) in the housing (2). This causes the barrier layer (3) to rupture and the second fluid (11) to contact the calibration fluid (5). Hereafter the calibration process can take place. In another embodiment the device (1) further comprises a membrane (12) which is accommodated in the second chamber (10) and is adapted to be secured to the sensor during the insertion of the sensor into the housing (2). The disclosed device--which is particularly suited for use in calibrating sensors for transcutaneous registering of the contents of CO.sub.2 and/or O.sub.2 in blood--is self-contained, and can be made in a very compact design, making it very well suited for use in connection with portable equipment. The device is also suitable for being manufactured in the form of a disposable unit.

Abstract translation: PCT No.PCT / DK89 / 00092 Sec。 371 1990年12月21日第 102（e）1990年12月21日的PCT PCT 1989年4月20日提交PCT公布。 出版物WO90 / 01160 在一个实施例中，校准装置（1）包括通过可移除盖（8）的壳体（2），并且可破裂的阻挡层（3）被分成校准室（4）和 第二室（10）。 校准室（4）包含校准流体（5），例如。 干燥的气体 - 而第二室（10）包含第二流体（11），例如。 润湿剂。 在校准过程之前，立即取下盖子（8），然后将其前面具有测量表面的传感器通过第二腔室（10）插入到壳体（2）中，直到它抵靠壳体中的肩部（6） （2）。 这导致阻挡层（3）破裂并且第二流体（11）接触校准流体（5）。 以后可以进行校准过程。 在另一个实施例中，装置（1）还包括容纳在第二室（10）中的膜（12），并且适于在将传感器插入壳体（2）期间固定到传感器。 所公开的装置 - 特别适合用于校准用于血液中二氧化碳和/或氧气的内容物的经皮登记的传感器 - 是独立的，并且可以以非常紧凑的设计制造，使其非常适合于使用 与便携式设备有关。 该装置还适于以一次性单元的形式制造。

公开(公告)号：US5208147A

公开(公告)日：1993-05-04

申请号：US884703

申请日：1992-05-18

Applicant: Henrik Kagenow ,  Anne R. Eisenhardt

Inventor： Henrik Kagenow ,  Anne R. Eisenhardt

IPC: B01L3/00 ,  G01N27/28 ,  G01N33/487 ,  G01N35/00

CPC classification number: G01N35/00594 ,  B01L3/502 ,  B01L3/508 ,  G01N27/3271 ,  G01N35/00693 ,  Y10T436/144444 ,  Y10T436/25375

Abstract: A measuring device, intended for measurements on whole blood, comprises a sample fluid chamber for containing a blood sample, ion-selective potentiometric electrodes for measurement of the concentrations of sodium and potassium ions, a reference potentiometric electrode, an optical sensor for measuring the concentration of glucose by means of a color reaction, a cuvette having a window permitting spectrophotometric measurement of the level of haemoglobin, a conditioning (calibration) fluid chamber in which the ion-selective electrodes and the reference electrode are exposed to a conditioning (calibration) fluid comprising known concentrations of sodium and potassium ions (thereby facilitating calibration of the response of the ion-selective electrodes), a rupturable pack containing the conditioning fluid and from which the fluid is released into the conditioning fluid chamber upon application of pressure to the pack, and a wall part which partly defines the sample fluid chamber and has weakened areas which are ruptured upon movement of the sensors (i.e. the electrodes and the glucose sensor) so as bring the sensors into contact with the blood sample and which establishes a seal around the sensors.

Abstract translation: 用于全血测量的测量装置包括用于容纳血液样品的样品流体室，用于测量钠和钾离子浓度的离子选择性电位电极，参考电位电极，用于测量浓度的光学传感器 的葡萄糖，具有允许分光光度测量血红蛋白水平的窗口的比色皿，调节（校准）流体室，其中离子选择性电极和参比电极暴露于调理（校准）流体 包括已知浓度的钠和钾离子（从而有助于校准离子选择性电极的响应），包含调理流体的可破裂的包装，并且在向包装施加压力时将流体释放到调节流体室中， 以及部分地限定样品流体室并具有的壁部分 在传感器移动时破裂的区域（即， 电极和葡萄糖传感器），以便使传感器与血液样品接触并且在传感器周围建立密封。

公开(公告)号：US4995391A

公开(公告)日：1991-02-26

申请号：US821872

申请日：1986-01-24

Applicant: Ole J. Jensen ,  Steen G. Melberg

Inventor： Ole J. Jensen ,  Steen G. Melberg

IPC: G01N27/30 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1477

CPC classification number: A61B5/14539 ,  A61B5/1491

Abstract: An electrode device for the determination of the partial pressure of CO.sub.2, Pco.sub.2, in particular an electrode device for transcutaneous determination of Pco.sub.2.The interior electrolyte of the electrode device is adapted to the exterior electrolyte in such a manner that the potential difference measured over the exterior reference electrode and the interior reference electrode is substantially temperature-independent with a temperature dependence for the CO.sub.2 partial pressure determination in the range of -1%/.degree.C.-+1%.degree.C.The interior electrolyte preferably contains a pH-buffer system based on phenyl phosphonic acid.

Abstract translation: 用于确定CO 2分压Pco2的电极装置，特别是用于经皮确定Pco2的电极装置。 电极装置的内部电解质适于外部电解质，使得在外部参考电极和内部参考电极上测量的电位差基本上与温度不依赖于在该范围内的CO 2分压确定的温度依赖性 为-1％/℃〜+ 1％℃。内部电解质优选含有基于苯基膦酸的pH缓冲体系。

公开(公告)号：US4867797A

公开(公告)日：1989-09-19

申请号：US273110

申请日：1988-11-16

Applicant: Holger B. Thomasen ,  Anne R. Eisenhardt

Inventor： Holger B. Thomasen ,  Anne R. Eisenhardt

IPC: C11D3/386 ,  G01N33/50

CPC classification number: C11D3/38618 ,  G01N33/50

Abstract: Subtilisin or subtilisin-like enzymes are used in rinse solutions for apparatus analyzing protein-containing biological liquids, such as blood analysis apparatus, to obviate measuring errors ascribable to protein deposits. A preferred rinse solution contains subtilisin, a borate buffer, and germicides.

Abstract translation: 枯草杆菌蛋白酶或枯草杆菌蛋白酶样酶用于设备分析蛋白质生物液体如血液分析仪器的冲洗溶液中，以消除归因于蛋白质沉积物的测量误差。 优选的冲洗溶液含有枯草杆菌蛋白酶，硼酸盐缓冲液和杀菌剂。

公开(公告)号：US4836907A

公开(公告)日：1989-06-06

申请号：US129428

申请日：1987-11-25

Applicant: Knud G. Pedersen

Inventor： Knud G. Pedersen

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1477 ,  A61B5/1491 ,  A61B10/00 ,  G01N27/404 ,  G01N27/416 ,  G01N27/49

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  G01N27/404

Abstract: An electrochemical electrode device for simultaneously measuring the partial pressures of two gasses in a medium of limited gas availability one of which is measured potentiometrically and another one of which is measured polarographically comprises an electrode body (18) constituting a reference electrode relative to a pH-electrode (19) of a potentiometric electrode system, and a anode relative to a cathode (20) of a polarographic electrode system. Furthermore, the electrode device comprises an electrolyte solution (28) enclosed between the electrode body and a membrane (30). The membrane comprises a basic membrane layer (31), preferably of polytetrafluoroethylene (PTFE) or fluoroethylenepropylene (FEP) of a thickness of about 12 .mu.m, and a covering (32), preferably a polypropylene layer of a thickness of about 15 .mu.m, which covers part of the basic membrane layer so that an uncovered area (34) is constituted in front of the pH-electrode. The uncovered area constitutes a first membrane part showing high permeability to the first gas and constitutes together with the potentiometric electrode system and the electrolyte solution a first measuring system for measuring the partial pressure of the first gas. A covered area of the basic membrane layer constitutes together with its covering a second membrane part showing low permeability to the second gas and is arranged in front of the exposed measuring surface of the cathode so as to restrict the diffusion of the second gas to the cathode and together with the polarographic electrode system and the electrolyte solution to constitute a second measuring system for measuring the partial pressure of the second gas.

Abstract translation: 一种电化学电极装置，用于同时测量在有限气体可利用性的介质中的两种气体的分压，其中一种是电势测量的，另一种是极谱测量的，其包括构成参比电极的电极体（18），相对于pH- 电极电极系统的电极（19）和相对于极谱电极系统的阴极（20）的阳极。 此外，电极装置包括封闭在电极体和膜（30）之间的电解质溶液（28）。 膜包括厚度约12μm的优选聚四氟乙烯（PTFE）或氟乙烯丙烯（FEP）的基本膜层（31）和厚度约15μm的覆盖物（32），优选聚丙烯层 ，其覆盖基本膜层的一部分，使得在pH电极的前方构成未覆盖区域（34）。 未覆盖区域构成第一膜部分，其显示对第一气体的高渗透性，并与电位电极系统和电解质溶液一起构成用于测量第一气体的分压的第一测量系统。 基本膜层的覆盖区域与其覆盖物一起构成显示对第二气体的低渗透性的第二膜部分，并且布置在阴极的暴露的测量表面的前面，以限制第二气体向阴极的扩散 并与极谱电极系统和电解质溶液一起构成用于测量第二气体的分压的第二测量系统。

公开(公告)号：US4519402A

公开(公告)日：1985-05-28

申请号：US526899

申请日：1983-08-26

Applicant: Jorgen Andersen

Inventor： Jorgen Andersen

IPC: A61M5/315 ,  A61B5/15 ,  B01L3/02 ,  G01N1/00 ,  A61B5/14

CPC classification number: A61B5/150213 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/153 ,  A61B5/150259

Abstract: A syringe for collecting a sample of blood or another liquid comprises a syringe cylinder and a piston arranged displaceably therein. One or more axially extending recesses are formed in the inner wall of the syringe cylinder axially spaced from the inner end thereof. The recess or recesses contain a material which is pervious to gas and impervious to liquid, such as a hydrophobic material, a hydrophilic material with capillary effect, or a material which swells when contacted by liquid. The sample collecting chamber within the cylinder may be vented to the atmosphere by placing the piston in the recessed area of the cylinder. Arterial blood may then pass into the syringe under arterial blood pressure, and the flow of blood into the syringe is automatically stopped when the sample collecting chamber of the syringe has been filled, because blood cannot pass the liquid impervious material arranged in the recesses. The axial innermost portion of the inner cylinder wall, which is not recessed, may cooperate with the piston in a conventional manner so as to provide a suction effect within the blood collecting chamber, if desired.

Abstract translation: 用于收集血液或另一种液体样本的注射器包括注射器筒和在其中可置换地排列的活塞。 在注射器筒的内壁中形成有一个或多个轴向延伸的凹部，其轴向与其内端间隔开。 凹部或凹部包含可渗透气体并且不透液体的材料，例如疏水性材料，具有毛细作用的亲水材料，或当与液体接触时溶胀的材料。 通过将活塞放置在气缸的凹陷区域中，气缸内的样品收集室可以排放到大气中。 然后动脉血可以在动脉血压下进入注射器，当注射器的样品收集室已经被填充时，由于血液不能通过布置在凹槽中的液体不可渗透的材料，所以进入注射器的血液流动自动停止。 如果需要，内筒壁的轴向最内部未被凹入，可以以常规方式与活塞配合，以便在血液收集腔内提供抽吸效果。

公开(公告)号：US4336000A

公开(公告)日：1982-06-22

申请号：US108659

申请日：1979-12-31

Applicant: Hans Jorgensen ,  Ib O. Sinnerup ,  Ole E. Danborg

Inventor： Hans Jorgensen ,  Ib O. Sinnerup ,  Ole E. Danborg

IPC: B01L3/02 ,  F04B13/00 ,  F04B53/06 ,  F04B39/00 ,  F04B21/00 ,  G01N1/14

CPC classification number: F04B13/00 ,  B01L3/0206 ,  F04B53/06

Abstract: The invention relates to a method of removing air or gas bubbles tending to collect in the "dead space" of a piston burette or another liquid dosage piston pump during operation thereof. The venting is performed by sucking a substantial volume of air into the pump cylinder in addition to a certain amount of liquid, and the air and part of the liquid within the pump cylinder is thereafter discharged therefrom. A piston dosage pump for carrying out this method comprises a valve mechanism by means of which the pump cylinder may be selectively communicated not only with a liquid inlet conduit and a liquid outlet conduit, but also with an air inlet passage.

Abstract translation: 本发明涉及在操作期间去除活性滴定管或其它液体剂量活塞泵的“死空间”中倾倒的空气或气泡的方法。 除了一定量的液体之外，通过将大量空气吸入泵筒中进行排气，然后从泵筒内排出空气和一部分液体。 用于实施该方法的活塞剂量泵包括阀机构，泵机构可以不仅与液体入口导管和液体出口导管选择性地连通，而且还可以与空气入口通道连通。

公开(公告)号：US4160714A

公开(公告)日：1979-07-10

申请号：US898933

申请日：1978-04-21

Applicant: Jorgen Andersen ,  Ole Nielsen

Inventor： Jorgen Andersen ,  Ole Nielsen

IPC: G01N27/403 ,  G01N27/28

CPC classification number: G01N27/403

Abstract: A block-shaped measuring chamber unit, especially for use in electrochemical measuring apparatuses for defining measuring chambers therein. The block-shaped unit has oppositely directed or otherwise differently orientated surface parts each defining a depression to be used as a measuring chamber. These depressions are interconnected by means of straight bores or passages extending through the block-shaped unit. The block-shaped unit is preferably made from machinable glass-ceramic.

Abstract translation: 一种块状测量室单元，特别用于在其中限定测量室的电化学测量装置中。 块状单元具有相反的方向或以其他方式取向的表面部分，每个表面部分限定用作测量室的凹陷。 这些凹陷通过延伸穿过块形单元的直孔或通道相互连接。 块状单元优选地由可机加工的玻璃陶瓷制成。

公开(公告)号：US5288646A

公开(公告)日：1994-02-22

申请号：US720531

申请日：1991-06-21

Applicant: Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

Inventor： Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

IPC: G01N33/49 ,  G01N21/03 ,  G01N21/11 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76 ,  G01N21/77 ,  G01N21/80 ,  G01N21/84 ,  G01N33/48 ,  G01N33/497 ,  G01N33/84 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N21/03 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N21/05 ,  G01N21/80 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: A sampling device for photometric determination of the content of an analyte in a sample of whole blood has at least one measuring chamber having locally transparent wall parts, at least one wall part being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber, with a transparent body having a radiation transmission characteristic dependent upon the concentration of a predetermined analyte in the whole blood sample disposed between the wall parts. The sampling device is employed in an analyzer for photometric determination of the content of analyte in a sample of whole blood and in a method of photometric in vitro determination of the content of an analyte in a sample of whole blood. In the method, a sample of whole blood is transferred directly from an in vivo locality to the sampling device, the measuring chamber therein is deformed in a controlled manner to substantially drain the whole blood from the measuring chamber, radiation is transmitted through the substantially drained measuring chamber, detected, and the analyte content determined. A measuring chamber for photometric determination of an analyte in a sample of whole blood has locally transparent wall parts, at least one being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber, and a transparent body disposed between the wall parts. The measuring chamber is employed in an analyzer and in a method for the photometric determination of an analyte in a sample of whole blood.

Abstract translation: PCT No.PCT / DK89 / 00301 Sec。 371日期1991年6月21日 102（e）1991年6月21日PCT 1989年12月21日PCT PCT。 公开号WO90 / 07109 日本1990年6月28日。用于光度测定全血样品中分析物含量的采样装置具有至少一个具有局部透明壁部分的测量室，至少一个壁部分可充分变形， 来自测量室的全血样本，具有取决于设置在壁部之间的全血样品中的预定分析物的浓度的透射特性的透明体。 采样装置用于测量全血样品中分析物含量的光度测定仪和全血样品中分析物含量的光度测定方法。 在该方法中，将全血样品直接从体内局部转移到采样装置，其中的测量室以受控的方式变形，从而从测量室基本上排出全部血液，辐射通过基本排出的 测量室，检测，并确定分析物含​​量。 用于光度测定全血样品中的分析物的测量室具有局部透明的壁部分，至少一个可充分变形以促进全血样品从测量室排出，以及设置在壁部之间的透明体。 测量室用于分析仪和全血样品中的分析物的光度测定方法。