公开(公告)号：US11648750B2

公开(公告)日：2023-05-16

申请号：US16944877

申请日：2020-07-31

申请人： IMMUNOLIGHT, LLC

发明人： Zakaryae Fathi ,  Frederic A. Bourke, Jr. ,  Harold Walder

IPC分类号： B32B7/12 ,  B32B27/16 ,  B32B5/02 ,  B32B5/18 ,  B32B5/26 ,  B32B7/06 ,  B32B9/02 ,  B32B9/04 ,  B32B17/00 ,  B32B18/00 ,  B32B21/04 ,  B32B25/04 ,  B32B27/08 ,  B32B27/30 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36 ,  B32B37/12 ,  B32B38/00 ,  C09J11/06 ,  C09J133/00 ,  C09J133/06 ,  H01L23/00 ,  C09J7/10

CPC分类号： B32B7/12 ,  B32B5/02 ,  B32B5/18 ,  B32B5/26 ,  B32B7/06 ,  B32B9/025 ,  B32B9/04 ,  B32B9/043 ,  B32B17/00 ,  B32B18/00 ,  B32B21/042 ,  B32B25/045 ,  B32B27/08 ,  B32B27/16 ,  B32B27/302 ,  B32B27/304 ,  B32B27/308 ,  B32B27/32 ,  B32B27/322 ,  B32B27/34 ,  B32B27/36 ,  B32B37/12 ,  B32B38/0008 ,  C09J7/10 ,  C09J11/06 ,  C09J133/00 ,  C09J133/06 ,  H01L24/00 ,  H01L24/03 ,  H01L24/05 ,  H01L24/29 ,  H01L24/83 ,  B32B2037/1253 ,  B32B2255/26 ,  B32B2305/18 ,  B32B2307/202 ,  B32B2307/204 ,  B32B2307/21 ,  B32B2307/3065 ,  B32B2307/41 ,  B32B2307/412 ,  B32B2307/422 ,  B32B2307/50 ,  B32B2307/546 ,  B32B2307/548 ,  B32B2307/552 ,  B32B2307/706 ,  B32B2307/72 ,  B32B2307/748 ,  B32B2307/75 ,  B32B2310/0806 ,  B32B2439/00 ,  B32B2439/70 ,  B32B2439/80 ,  B32B2457/14 ,  B32B2479/00 ,  B32B2605/003 ,  B32B2605/08 ,  H01L24/27 ,  H01L24/32 ,  H01L24/94 ,  H01L2224/0383 ,  H01L2224/03831 ,  H01L2224/04026 ,  H01L2224/05791 ,  H01L2224/05887 ,  H01L2224/2711 ,  H01L2224/2732 ,  H01L2224/27334 ,  H01L2224/27416 ,  H01L2224/27418 ,  H01L2224/27436 ,  H01L2224/27618 ,  H01L2224/27622 ,  H01L2224/293 ,  H01L2224/2919 ,  H01L2224/2929 ,  H01L2224/29083 ,  H01L2224/29291 ,  H01L2224/29387 ,  H01L2224/32145 ,  H01L2224/32225 ,  H01L2224/32245 ,  H01L2224/32258 ,  H01L2224/83009 ,  H01L2224/83591 ,  H01L2224/83687 ,  H01L2224/83851 ,  H01L2224/83855 ,  H01L2224/83868 ,  H01L2224/83874 ,  H01L2224/94 ,  H01L2924/0569

摘要： A method of and system for adhesive bonding by a) providing a polymerizable adhesive composition on a surface of an element to be bonded to form an assembly; b) irradiating the assembly with radiation at a first wavelength capable of vulcanization of bonds in the polymerizable adhesive composition by activation of sulfur-containing compound with at least one selected from x-ray, e-beam, visible, or infrared light to thereby generate ultraviolet light in the polymerizable adhesive composition; and c) adhesively joining two or more components together by way of the polymerizable adhesive composition, and a curable polymer for use therein.

公开(公告)号：US11173467B2

公开(公告)日：2021-11-16

申请号：US16017535

申请日：2018-06-25

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. Bourke, Jr.

IPC分类号： B01J19/12 ,  A23L3/26 ,  A61L2/00 ,  C02F1/30 ,  C02F1/72 ,  A23L5/30 ,  B01J19/08 ,  A61L2/08 ,  A61L2/10 ,  A61L2/16 ,  C08J3/28 ,  G21K5/00 ,  C02F1/32 ,  A61K41/00 ,  A61N5/06 ,  A61N5/10 ,  B01J23/50 ,  B01J23/52 ,  B01J31/02 ,  B01J31/22 ,  B01J35/00 ,  B01J37/00 ,  B01J37/02 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  A23L2/50 ,  A23L3/28 ,  C08J3/24 ,  C08J7/18 ,  G02B5/00 ,  A61M1/36 ,  C12H1/06 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US10682624B2

公开(公告)日：2020-06-16

申请号：US16238443

申请日：2019-01-02

申请人： IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

发明人： Frederic A. Bourke, Jr. ,  Tuan Vo-Dinh

IPC分类号： B01J19/12 ,  A23L3/26 ,  A61L2/00 ,  C02F1/30 ,  C02F1/72 ,  A23L5/30 ,  B01J19/08 ,  A61L2/08 ,  A61L2/10 ,  A61L2/16 ,  C08J3/28 ,  G21K5/00 ,  C02F1/32 ,  A61K41/00 ,  A61N5/06 ,  A61N5/10 ,  B01J23/50 ,  B01J23/52 ,  B01J31/02 ,  B01J31/22 ,  B01J35/00 ,  B01J37/00 ,  B01J37/02 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  A23L2/50 ,  A23L3/28 ,  C08J3/24 ,  C08J7/18 ,  G02B5/00 ,  A61M1/36 ,  C12H1/06 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00

摘要： A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

公开(公告)号：US10593642B2

公开(公告)日：2020-03-17

申请号：US16252060

申请日：2019-01-18

申请人： IMMUNOLIGHT, LLC.

发明人： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC分类号： H01L23/29 ,  C09J9/02 ,  H01L23/00 ,  C09J11/02 ,  C09J163/00

摘要： A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US10398777B2

公开(公告)日：2019-09-03

申请号：US15600921

申请日：2017-05-22

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. Bourke, Jr.

IPC分类号： A61K31/37 ,  A61K41/00 ,  A61K31/35 ,  A61K45/06 ,  A61K31/714 ,  A61K47/02 ,  A61F7/00 ,  A61H23/00 ,  A61K31/366 ,  A61N2/02 ,  A61N5/06 ,  A61N5/10

摘要： Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.

公开(公告)号：US10363541B2

公开(公告)日：2019-07-30

申请号：US15587601

申请日：2017-05-05

申请人： IMMUNOLIGHT, LLC.

发明人： Frederic A. Bourke, Jr.

IPC分类号： B01J19/12 ,  A23L3/26 ,  A61L2/00 ,  B01J19/08 ,  C02F1/30 ,  C02F1/72 ,  A61L2/08 ,  A61L2/10 ,  A61L2/16 ,  C08J3/28 ,  G21K5/00 ,  C02F1/32 ,  A61K41/00 ,  A61N5/06 ,  A61N5/10 ,  A23L5/30 ,  B01J23/50 ,  B01J23/52 ,  B01J31/02 ,  B01J31/22 ,  B01J35/00 ,  B01J37/00 ,  B01J37/02 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  A23L2/50 ,  A23L3/28 ,  C08J3/24 ,  C08J7/18 ,  G02B5/00 ,  A61M1/36 ,  C12H1/06 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US10074627B2

公开(公告)日：2018-09-11

申请号：US15455573

申请日：2017-03-10

申请人： Immunolight, LLC

发明人： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC分类号： H01L23/00 ,  H01L25/065 ,  H01L23/522 ,  C09J11/04 ,  C09J11/06 ,  C09J9/02 ,  C09J4/00 ,  B32B7/14 ,  B32B3/26 ,  B32B9/04

CPC分类号： H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/7769 ,  C09K11/777 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2924/00014 ,  H01L2924/00

摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US09682250B2

公开(公告)日：2017-06-20

申请号：US15226567

申请日：2016-08-02

申请人： IMMUNOLIGHT, LLC.

发明人： Frederic A. Bourke, Jr.

IPC分类号： A61N5/10 ,  A23L3/26 ,  A61L2/00 ,  B01J19/08 ,  B01J19/12 ,  C02F1/30 ,  C02F1/72 ,  A61L2/08 ,  A61L2/10 ,  A61L2/16 ,  C08J3/28 ,  G21K5/00 ,  C02F1/32 ,  A61K41/00 ,  A61N5/06 ,  A23L5/30 ,  B82Y20/00

CPC分类号： A61N5/10 ,  A23L2/50 ,  A23L3/26 ,  A23L3/263 ,  A23L3/28 ,  A23L5/32 ,  A23V2002/00 ,  A61K41/0057 ,  A61K41/0066 ,  A61L2/0011 ,  A61L2/0047 ,  A61L2/0076 ,  A61L2/082 ,  A61L2/088 ,  A61L2/10 ,  A61L2/16 ,  A61L2202/21 ,  A61L2202/22 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1098 ,  B01J19/082 ,  B01J19/085 ,  B01J19/12 ,  B01J19/123 ,  B01J19/125 ,  B01J19/127 ,  B01J19/128 ,  B01J23/50 ,  B01J23/52 ,  B01J31/0275 ,  B01J31/2295 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/004 ,  B01J37/0072 ,  B01J37/0221 ,  B01J2219/0877 ,  B01J2219/0879 ,  B01J2219/0892 ,  B01J2219/1203 ,  B01J2231/005 ,  B01J2531/005 ,  B01J2531/008 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C02F1/30 ,  C02F1/302 ,  C02F1/305 ,  C02F1/307 ,  C02F1/32 ,  C02F1/725 ,  C02F2305/10 ,  C08J3/24 ,  C08J3/28 ,  C08J7/18 ,  C08J2300/00 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  C09J2205/31 ,  C12H1/06 ,  G02B5/008 ,  G21K5/00 ,  Y02W10/37 ,  Y10S977/774 ,  Y10S977/777 ,  Y10S977/896 ,  Y10S977/915 ,  Y10T156/10

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US09526914B2

公开(公告)日：2016-12-27

申请号：US14716394

申请日：2015-05-19

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC分类号： A61B5/00 ,  A61N5/06 ,  A61K49/00 ,  A61L2/08 ,  A61N1/40 ,  A61N5/02

CPC分类号： A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

摘要： Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.

摘要翻译： 用于修改目标结构的产品，组成，系统和方法。 所述方法可以以非侵入性方式进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并施加引发能量，从而产生作用或改变 目标结构直接或通过调制剂。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过施加起始能量来直接地或经由能量调节剂，任选地在一种或多种等离子体激元活性剂的存在下活化可光活化剂，从而对目标结构产生影响或改变。

公开(公告)号：US11901331B2

公开(公告)日：2024-02-13

申请号：US17647275

申请日：2022-01-06

申请人： IMMUNOLIGHT, LLC

发明人： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC分类号： C08K3/00 ,  H01L23/00 ,  B41J2/175 ,  C09J4/00 ,  A61B17/00 ,  A61L24/06 ,  B32B37/12 ,  B32B37/18 ,  B32B38/00 ,  C09J133/08 ,  C09K11/02 ,  C09K11/77 ,  H01L25/065 ,  H01L25/00 ,  B32B3/26 ,  B32B7/14 ,  B32B9/04 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  H01L23/522

CPC分类号： H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/777 ,  C09K11/7769 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2224/48091 ,  H01L2924/00014 ,  H01L2224/73265 ,  H01L2224/32225 ,  H01L2224/48227 ,  H01L2924/00 ,  H01L2924/15311 ,  H01L2224/73265 ,  H01L2224/32225 ,  H01L2224/48227 ,  H01L2924/00 ,  H01L2924/15311 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2224/83192 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2924/07811 ,  H01L2924/00 ,  H01L2924/1461 ,  H01L2924/00 ,  H01L2224/92125 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2224/83192 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00

摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.