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    FOAMED ISOCYANATE-BASED POLYMER
    7.
    发明申请
    FOAMED ISOCYANATE-BASED POLYMER 审中-公开

    公开(公告)号：US20180002478A1

    公开(公告)日：2018-01-04

    申请号：US15637792

    申请日：2017-06-29

    申请人： Proprietect L.P.

    发明人： Derrick William Smith ,  Thomas Robert Beamish ,  Paul David Hurrell

    IPC分类号： C08G18/08 ,  C08G18/42 ,  C08G101/00

    CPC分类号： C08G18/0876 ,  C08G18/163 ,  C08G18/4247 ,  C08G18/6523 ,  C08G18/7607 ,  C08G2101/0008 ,  C08L75/04

    摘要： There is described a foamed isocyanate-based polymer derived from a reaction mixture comprising: an isocyanate; a polyol composition comprising a first prescribed amount of polymer particles dispersed in a base polyol; a second prescribed amount of biomass-based carbonaceous particulate material; and a blowing agent. In one embodiment, the foamed isocyanate-based polymer having an Indentation Force Deflection when measured pursuant to ASTM D3574-11 which is within about 15% as that of a reference foam produced by omitting the biomass-based carbonaceous particulate material from the reaction mixture and increasing the amount of polymer particles in the polymer polyol composition to equal the sum of the first prescribed amount and the second prescribed amount. In another embodiment, the foamed polymer has a cellular matrix comprising a plurality of interconnected struts, the biomass-based carbonaceous particulate material conferring to the cellular matrix a load efficiency of at least about 5 Newtons/weight % of biomass-based carbonaceous particulate material. A process to produce the foamed isocyanate-based polymer is also described. A polyol-based dispersion to produce the foamed isocyanate-based polymer is also described. It has been discovered that a relatively expensive petroleum-based copolymer polyol can be fully substituted by a relative inexpensive bio-based (amorphous carbon) dispersion with no significant compromise in important physical properties in the resulting polyurethane foam.

    FOAMED POLYURETHANE POLYMERS FOR THE REGENERATION OF CONNECTIVE TISSUE
    9.
    发明申请
    FOAMED POLYURETHANE POLYMERS FOR THE REGENERATION OF CONNECTIVE TISSUE 审中-公开
    用于再生连接组织的泡沫聚氨酯聚合物

    公开(公告)号：US20170044344A1

    公开(公告)日：2017-02-16

    申请号：US15305904

    申请日：2015-04-15

    申请人： TENSIVE S.R.L.

    发明人： Irini GERGES ,  Federico MARTELLO ,  Margherita TAMPLENIZZA ,  Alessandro TOCCHIO

    IPC分类号： C08J9/08 ,  A61L27/56 ,  A61L27/18 ,  C08G18/08 ,  A61L27/12 ,  C08G18/40 ,  C08G18/73 ,  C08G18/16 ,  C08J9/00 ,  C08K3/32 ,  C08G18/66

    CPC分类号： C08J9/08 ,  A61L27/12 ,  A61L27/18 ,  A61L27/56 ,  C08G18/0847 ,  C08G18/0852 ,  C08G18/14 ,  C08G18/163 ,  C08G18/165 ,  C08G18/4081 ,  C08G18/6677 ,  C08G18/73 ,  C08G2101/00 ,  C08G2230/00 ,  C08J9/0066 ,  C08J2203/02 ,  C08J2205/06 ,  C08J2205/10 ,  C08J2207/10 ,  C08J2375/08 ,  C08K3/32 ,  C08K2003/325 ,  C08L75/04

    摘要： The present invention relates to a method of synthesis and the use of foamed, cross-linked polyurethane polymers, as a three-dimensional support called a “scaffold” for cell cultures in vitro and for in vivo implantation for the regeneration of connective tissues such as adipose tissue, osteochondral tissue and bone tissue. In particular, the invention relates to a method of preparing polymers or foamed polyurethane co polymers, having improved hydrophilia, which involves the use of two types of catalyst, one for the cross-linking reaction and one for the foaming reaction and the use of at least one polar aprotic high-boiling solvent. Said method comprises the following steps in sequence: a) providing a solution of a polyol or a mixture of polyols in a solvent or mixture of solvents; b) heating the solution in step a) to a temperature higher than the softening temperature of the polymer precursors; c) optionally adding an organic or inorganic filler material; d) adding to the mixture in step c) an aliphatic poly-isocyanate or a mixture of poly-aliphatic isocyanates; e) adding to the mixture in step (d)) a porogenic additive; f) adding to the mixture in step e) simultaneously a cross-linking catalyst of polyols with poly-isocyanates and a foaming catalyst to form a foamed polyurethane polymer or co-polymer; g) isolating the foamed polyurethane polymer or co-polymer produced in step f).

    摘要翻译： 本发明涉及一种合成和使用发泡的交联聚氨酯聚合物的方法，作为体外用于细胞培养物的体外植入的称为“支架”的三维支架，用于再结合组织如 脂肪组织，骨软骨组织和骨组织。 特别地，本发明涉及一种制备具有改进的亲水性的聚合物或泡沫聚氨酯共聚物的方法，其涉及使用两种类型的催化剂，一种用于交联反应，一种用于发泡反应和使用 至少一种极性非质子高沸点溶剂。 所述方法包括以下步骤：a）在溶剂或溶剂混合物中提供多元醇或多元醇混合物的溶液; b）将步骤a）中的溶液加热到高于聚合物前体的软化温度的温度; c）任选地加入有机或无机填料; d）在步骤c）中向混合物中加入脂族聚异氰酸酯或多脂族异氰酸酯的混合物; e）在步骤（d）中向混合物中加入致孔剂; f）在步骤e）中向混合物中加入多元醇与聚异氰酸酯的交联催化剂和发泡催化剂以形成发泡聚氨酯聚合物或共聚物; g）分离步骤f）中产生的泡沫聚氨酯聚合物或共聚物。