公开(公告)号：US20240358867A1

公开(公告)日：2024-10-31

申请号：US18687784

申请日：2022-08-31

申请人： DUKE UNIVERSITY ,  THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK

发明人： MICHAEL ZALUTSKY ,  YUTIAN FENG ,  GANESAN VAIDYANATHAN ,  BRIAN ZEGLIS ,  SAMANTHA SARRETT

IPC分类号： A61K51/10 ,  C07B59/00 ,  C07K1/107

CPC分类号： A61K51/1096 ,  A61K51/1045 ,  C07B59/00 ,  C07K1/1077 ,  A61K2121/00 ,  A61K2123/00 ,  C07B2200/05

摘要： The present disclosure provides, in part, methods for site-specific labeling of proteins/peptides with radiohalogens and compositions resulting from said methods.

公开(公告)号：US20240352017A1

公开(公告)日：2024-10-24

申请号：US18758953

申请日：2024-06-28

申请人： K36 Therapeutics, Inc.

发明人： Terrence Joseph Connolly ,  Chad Arthur Lewis

IPC分类号： C07D473/34 ,  A61K31/52 ,  C07B59/00

CPC分类号： C07D473/34 ,  A61K31/52 ,  C07B59/002

摘要： The invention provides deuterium-enriched piperidinyl-methyl-purine amines and related compounds, pharmaceutical compositions, their use for inhibiting NSD2, and their use in the treatment of a disease or condition, such as cancer.

公开(公告)号：US20240350999A1

公开(公告)日：2024-10-24

申请号：US18685604

申请日：2022-08-23

申请人： University of Delaware

发明人： Panagiotis Dimitrakellis ,  Fabio Cameli ,  Dionisios G. Vlachos

IPC分类号： B01J19/08 ,  C01B3/34 ,  C01B15/027 ,  C02F1/72 ,  C02F101/30 ,  C07B33/00

CPC分类号： B01J19/088 ,  C01B3/342 ,  C01B15/027 ,  C02F1/722 ,  C07B33/00 ,  B01J2219/0809 ,  B01J2219/083 ,  B01J2219/0884 ,  B01J2219/0896 ,  C01B2203/0211 ,  C01B2203/0861 ,  C02F2101/308

摘要： A reactor assembly for igniting and sustaining a plasma and method for performing a reaction. The assembly includes an elongated cylindrical inner electrode; a dielectric tube arranged helically around the elongated cylindrical inner electrode to form a helical reactor. The reactor assembly also includes an annular outer electrode arranged around at least a portion of the exterior of the helical reactor. The assembly includes a power source to provide a voltage across the elongated cylindrical inner electrode and the annular outer electrode. A process stream including at least a gas flows through the dielectric tube. The voltage is applied across the elongated cylindrical inner electrode and the annular outer electrode such that at least a portion of the flow of the process stream through the dielectric tube is exposed to the voltage and the plasma is ignited and sustained.

公开(公告)号：US20240350678A1

公开(公告)日：2024-10-24

申请号：US18687044

申请日：2022-08-26

申请人： NVISION IMAGING TECHNOLOGIES GMBH

发明人： Ilai SCHWARTZ ,  Michael KEIM ,  Stephan KNECHT

IPC分类号： A61K49/10 ,  C07B59/00

CPC分类号： A61K49/10 ,  C07B59/001 ,  C07B2200/05

摘要： The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

公开(公告)号：US12110263B2

公开(公告)日：2024-10-08

申请号：US17740260

申请日：2022-05-09

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, Jr. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  A61P25/00 ,  A61P31/04 ,  C07B59/00 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/42 ,  C07C245/08 ,  C07C247/16 ,  C07C247/18 ,  C07C317/28 ,  C07C323/40 ,  C07C323/42 ,  C07C381/00 ,  C07D213/65 ,  C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D257/04 ,  C07D261/12 ,  C07D401/12 ,  C07D413/12 ,  C07F5/02

CPC分类号： C07C233/62 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  A61P25/00 ,  A61P31/04 ,  C07B59/001 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/42 ,  C07C245/08 ,  C07C247/16 ,  C07C247/18 ,  C07C317/28 ,  C07C323/40 ,  C07C323/42 ,  C07C381/00 ,  C07D213/65 ,  C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D257/04 ,  C07D261/12 ,  C07D401/12 ,  C07D413/12 ,  C07F5/02 ,  C07C2601/08

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US12109277B2

公开(公告)日：2024-10-08

申请号：US18499758

申请日：2023-11-01

申请人： Theragnostics Limited

发明人： Philip Blower ,  Gregory Mullen

IPC分类号： A61K51/04 ,  A61B5/00 ,  A61K51/08 ,  A61P35/00 ,  C01G15/00 ,  C07B59/00 ,  C07C251/24 ,  C07F5/00

CPC分类号： A61K51/0478 ,  A61B5/0035 ,  A61K51/082 ,  A61K51/088 ,  A61P35/00 ,  C01G15/00 ,  C07B59/00 ,  C07C251/24 ,  C07F5/00

摘要： A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.

公开(公告)号：US12104022B2

公开(公告)日：2024-10-01

申请号：US17267156

申请日：2019-04-09

申请人： PEKING UNIVERSITY

发明人： Xinhua Wan ,  Xichong Ye ,  Bowen Li ,  Jie Zhang

IPC分类号： C08J3/215 ,  B03C1/005 ,  B03C1/01 ,  B03C1/015 ,  B03C1/02 ,  B03C1/035 ,  B03C1/28 ,  B82Y30/00 ,  C07B57/00 ,  C07C227/34 ,  C07C231/20 ,  C07C231/24 ,  C08F212/08 ,  C08F220/56 ,  C08F220/58 ,  C08F293/00 ,  C08J3/24 ,  C08K3/22 ,  C08K5/09 ,  C08K9/10 ,  B82Y25/00 ,  B82Y40/00 ,  C07C237/06 ,  C08F220/60

CPC分类号： C08J3/215 ,  B03C1/005 ,  B03C1/01 ,  B03C1/015 ,  B03C1/02 ,  B03C1/035 ,  B03C1/286 ,  C07B57/00 ,  C07C227/34 ,  C07C231/20 ,  C07C231/24 ,  C08F212/08 ,  C08F220/56 ,  C08F220/58 ,  C08F293/005 ,  C08J3/245 ,  C08K3/22 ,  C08K5/09 ,  C08K9/10 ,  B03C2201/18 ,  B03C2201/26 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07B2200/07 ,  C07C237/06 ,  C08F220/603 ,  C08F2438/03 ,  C08J2325/08 ,  C08K2003/2275 ,  C08K2201/003 ,  C08K2201/01 ,  C08K2201/011 ,  C07C227/34 ,  C07C229/36 ,  C07C227/34 ,  C07C229/22 ,  C07C231/20 ,  C07C237/06

摘要： A core-shell nanocomposite is formed by co-assembly of an amphiphilic polymer and hydrophobically modified magnetic nanoparticles, with its core being a hydrophobically modified magnetic nanomaterial and its shell being the amphiphilic polymer, wherein hydrophilic segments in the amphiphilic polymer are located at an outermost layer of the shell. The above composite can be used as additives in the crystallization of conglomerates and obtain optically pure crystals of both enantiomers in a single process. The key thereof is that the composite is used to enrich molecules with the same configuration while inhibit the crystallization of the other enantiomer in a supersaturated solution of conglomerates, such that a non-magnetic crystal and a magnetic crystal (which are enantiomers of each other) are generated in a unit operation. Optically pure crystals of both enantiomers with over 90 ee % can be obtained by one-time crystallization, and the total yield can be as high as 40%.

公开(公告)号：US20240317766A1

公开(公告)日：2024-09-26

申请号：US18659338

申请日：2024-05-09

申请人： Acerta Pharma B.V.

发明人： Paul Allen BETHEL ,  Lai Chun CHAN ,  Katie Grace COOPER ,  Robert John COX ,  Michael David GOLDEN ,  Shaun Alan HUGHES ,  Lucinda Victoria JACKSON ,  Kirsty Jane MILLARD ,  Andrew John PHILLIPS ,  Alexander James TELFORD ,  Jerry EVARTS ,  Michael Joseph LAWLER ,  Remy E. J. N. LITJENS ,  Peter Johannes Servaas Savio VAN EIJK ,  Mathilda Maria Henrica VERSTAPPEN ,  Frank L. M. VOS ,  Eric Jurriën ZIJP ,  Qiu JUNYING ,  Rustam Ferdinand GARREY ,  David Allen SHORT ,  Angang WANG

IPC分类号： C07D487/04 ,  C07B63/00

CPC分类号： C07D487/04 ,  C07B63/00 ,  C07B2200/13

摘要： The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

公开(公告)号：US12098115B2

公开(公告)日：2024-09-24

申请号：US18228192

申请日：2023-07-31

申请人： University of Florida Research Foundation, Inc.

发明人： Alexander James Grenning

IPC分类号： C07C255/31 ,  C07B37/02 ,  C07C253/30 ,  C07C255/47 ,  C07C403/18 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72

CPC分类号： C07C253/30 ,  C07B37/02 ,  C07C255/31 ,  C07C255/47 ,  C07C403/18 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/30 ,  C07C2602/32 ,  C07C2602/34 ,  C07C2603/30

摘要： In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20240315128A1

公开(公告)日：2024-09-19

申请号：US18668318

申请日：2024-05-20

申请人： Shijiazhuang Chengzhi Yonghua Display Material Co., Ltd.

发明人： Zaifeng XIE ,  Tianyu WEI ,  Songyuan LIU

IPC分类号： H10K85/60 ,  C07B59/00 ,  H10K50/15

CPC分类号： H10K85/633 ,  C07B59/004 ,  H10K50/15 ,  H10K85/615 ,  H10K85/636 ,  H10K85/654 ,  H10K85/6572 ,  H10K85/6574 ,  H10K85/6576 ,  H10K85/658 ,  C07B2200/05

摘要： The present invention discloses a compound containing a carbazole derivative and an organic electroluminescent device comprising the compound. The structure of the compound containing the carbazole derivative is one of the following structures. The compound has a relatively high hole transport rate, a relatively high HOMO energy level value, and a relatively good thermal stability. When the compound containing the carbazole derivative as provided by the present invention is applied to a hole transport layer of an organic electroluminescent device, the hole transport layer can improve the luminous efficiency of the organic electroluminescent device, reduce the driving voltage of the organic electroluminescent device, prolong the lifetime of the organic electroluminescent device, and overcome the defects in the prior art.