公开(公告)号：US20240335574A1

公开(公告)日：2024-10-10

申请号：US18294090

申请日：2022-08-02

申请人： Board of Regents, The University of Texas System

发明人： Ryan Bitar ,  William Phillips

IPC分类号： A61K51/12 ,  A61K41/00 ,  A61K49/00 ,  A61K49/04

CPC分类号： A61K51/1265 ,  A61K41/00 ,  A61K49/0091 ,  A61K49/0438

摘要： Certain embodiments are directed to Lipid Emulsions in Alginate Microspheres, e.g., Lipiodol Emulsion in Alginate Microspheres (LEAMs), as a chemoembolic agent. A oil in water emulsion of lipiodol can be stabilized within alginate microspheres at very high concentrations. These emulsion in alginate microspheres can be manufactured to any size range from 20 microns to 5000 microns. In certain aspects, an ultrasonic nozzle technology is used to manufacture small size microspheres of average diameter 50 microns. In other aspects, needle extrusion systems are used to manufacture large LEAMs termed Mega-LEAMs.

公开(公告)号：US12108225B2

公开(公告)日：2024-10-01

申请号：US18315618

申请日：2023-05-11

申请人： Celanese EVA Performance Polymers LLC

发明人： Christian Schneider

IPC分类号： A61K9/50 ,  A61K38/39 ,  A61K38/47 ,  A61K49/04 ,  G10L21/0232 ,  G10L21/028 ,  H04R3/00 ,  H04R3/04 ,  H04R5/04 ,  G10L21/0216

CPC分类号： H04R3/005 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5073 ,  A61K9/5089 ,  A61K38/39 ,  A61K38/47 ,  A61K49/04 ,  C12Y304/22032 ,  C12Y304/22033 ,  G10L21/0232 ,  G10L21/028 ,  H04R3/04 ,  H04R5/04 ,  G10L2021/02166

摘要： An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed. The membrane polymer matrix contains a hydrophobic polymer in combination with a hydrophilic compound, and the weight ratio of the hydrophobic polymer to the hydrophilic compound within the membrane polymer matrix ranges from about 0.25 to about 200.

公开(公告)号：US20240316220A1

公开(公告)日：2024-09-26

申请号：US18614277

申请日：2024-03-22

申请人： Boston Scientific Scimed, Inc.

发明人： Yen-Hao Hsu ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi

IPC分类号： A61K49/04 ,  A61K49/00 ,  A61M5/19

CPC分类号： A61K49/0442 ,  A61K49/0073 ,  A61K49/0438 ,  A61M5/19

摘要： In some aspects, the present disclosure pertains to systems for forming a crosslinked polymer composition, the systems comprising (a) an iodinated multifunctional compound comprising either a plurality of electron-rich dienophile-containing moieties or a plurality of electron-poor diene-containing moieties and (b) a multifunctional multi-arm polymer comprising either a plurality of electron-poor diene-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-rich dienophile-containing moieties or a plurality of electron-rich dienophile-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-poor diene-containing moieties, wherein the crosslinked polymer composition is formed by a cycloaddition reaction occurring between the iodinated multifunctional compound and the multifunctional multi-arm polymer. Other aspects of the present disclosure pertain to crosslinked networks formed by such systems and to methods of treatment using such systems.

公开(公告)号：US12077450B2

公开(公告)日：2024-09-03

申请号：US17367919

申请日：2021-07-06

申请人： Board of Trustees of Michigan State University

发明人： Shatadru Chakravarty ,  Erik M. Shapiro

IPC分类号： C01G35/00 ,  A61K47/69 ,  A61K49/04 ,  B82Y30/00 ,  B82Y40/00 ,  G01N23/046

CPC分类号： C01G35/00 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0428 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2004/64 ,  C01P2004/84 ,  G01N23/046

摘要： A nanoparticle composition is provided. The nanoparticle composition includes a plurality of nanoparticles, each nanoparticle of the plurality having a core including tantalum oxide, and a covalent coating covalently bound to the core. The covalent coating includes a surface modifier selected from the group consisting of (3-aminopropyl)trimethoxy silane (APTMS), (3-aminopropyl)triethoxy silane (APTES), APTMS-methoxy-poly(ethylene-glycol)-succinimidyl glutarate (APTMS-m-PEG-glutarate), APTES-methoxy-poly(ethylene-glycol)-succinimidyl glutarate (APTES-m-PEG-glutarate), 2-[methoxy (polyethyleneoxy)-9-12-propyl] trimethoxysilane (PEG-Silane), hexadecyltriethoxy silane, and combinations thereof. Methods of synthesizing and using the nanoparticle composition are also provided.

公开(公告)号：US12042772B2

公开(公告)日：2024-07-23

申请号：US18370462

申请日：2023-09-20

申请人： Devicor Medical Products, Inc.

发明人： Timothy Zimmer ,  Michelle Louise Johnson ,  Stephen D. Stallard

IPC分类号： B01F31/00 ,  A61B90/00 ,  A61K49/22 ,  B01F23/23 ,  B01F31/65 ,  B01F35/22 ,  A47K5/12 ,  A61B8/08 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61L31/14 ,  A61L31/18 ,  B01F101/00 ,  C08J9/30

CPC分类号： B01F31/65 ,  A61B90/39 ,  A61K49/226 ,  B01F23/2319 ,  B01F35/2206 ,  A47K5/1217 ,  A61B8/481 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2090/3987 ,  A61K49/006 ,  A61K49/04 ,  A61K49/1803 ,  A61L31/145 ,  A61L31/146 ,  A61L31/148 ,  A61L31/18 ,  B01F2101/2202 ,  C08J9/30 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2300/16

摘要： A method and system are used to enhance a marker material to include a plurality of air bubbles. The method of manufacturing a marker includes enhancing a marker material to include a plurality of air bubbles using at least a first EFD and a second EFD. The method may include cycling repeatedly through a transfer process between a first container and a second container. A system for enhancing a marker material includes a transfer apparatus configured to receive a marker material and a selected amount of air. The system comprises a first EFD coupled to a first end of the transfer apparatus and a second EFD coupled to a second end of the transfer apparatus.

公开(公告)号：US20240193776A1

公开(公告)日：2024-06-13

申请号：US18586224

申请日：2024-02-23

申请人： CLEERLY, INC.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Shant Malkasian ,  Ben Hootnick

IPC分类号： G06T7/00 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10

CPC分类号： G06T7/0012 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20240117315A1

公开(公告)日：2024-04-11

申请号：US18331353

申请日：2023-06-08

申请人： Mesoblast International Sárl

发明人： Samson TOM ,  Christopher TON ,  Alla DANILKOVITCH

IPC分类号： C12N5/0775 ,  A61K35/28 ,  A61K41/00 ,  A61K47/69 ,  A61K49/04 ,  A61K49/18 ,  B82Y5/00

CPC分类号： C12N5/0663 ,  A61K35/28 ,  A61K41/0038 ,  A61K41/0052 ,  A61K47/6901 ,  A61K49/0423 ,  A61K49/1827 ,  B82Y5/00 ,  A61M37/00 ,  C12N2511/00

摘要： The present invention provides preparations of MSCs with important therapeutic potential. The MSC cells are non-primary cells with an antigen profile comprising less than about 1.25% CD45+ cells (or less than about 0.75% CD45+), at least about 95% CD105+ cells, and at least about 95% CD166+ cells. Optionally, MSCs of the present preparations are isogenic and can be expanded ex vivo and cryopreserved and thawed, yet maintain a stable and uniform phenotype. Methods are taught here of expanding these MSCs to produce a clinical scale therapeutic preparations and medical uses thereof.

公开(公告)号：US20240091402A1

公开(公告)日：2024-03-21

申请号：US18502950

申请日：2023-11-06

申请人： Arsenal Medical, Inc.

发明人： Jeffrey Groom ,  Craig Wiltsey ,  Quynh Pham ,  Nikhita Mansukhani ,  Courtney Guertin ,  Lee Core ,  Upma Sharma

IPC分类号： A61L24/06 ,  A61K47/02 ,  A61K47/34 ,  A61K49/04 ,  A61L24/00 ,  A61L24/02 ,  A61L24/04 ,  C08L83/04

CPC分类号： A61L24/06 ,  A61K47/02 ,  A61K47/34 ,  A61K49/04 ,  A61K49/0409 ,  A61L24/0021 ,  A61L24/02 ,  A61L24/043 ,  A61L24/046 ,  C08L83/04 ,  A61L2400/06 ,  A61L2430/36

摘要： The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

公开(公告)号：US11911041B2

公开(公告)日：2024-02-27

申请号：US17366620

申请日：2021-07-02

申请人： MicroVention, Inc.

发明人： Aaron Baldwin ,  Ami Mehta ,  Jonathan Lam

IPC分类号： A61B17/12 ,  C08F20/26 ,  A61K31/785 ,  A61K49/04 ,  C08L33/14 ,  A61B17/00 ,  A61B90/00

CPC分类号： A61B17/12181 ,  A61B17/12186 ,  A61K31/785 ,  A61K49/0438 ,  A61K49/0442 ,  C08F20/26 ,  A61B2017/00938 ,  A61B2017/00942 ,  A61B2090/3933 ,  A61B2090/3966 ,  C08L33/14

摘要： Described herein are compositions comprising, a polymer; a non-physiological solution; and a visualization agent; wherein the polymer is soluble in the non-physiological solution and insoluble at physiological conditions. Methods of preparing the compositions are disclosed as well as methods of using these compositions to treat vascular conditions.

公开(公告)号：US11896415B2

公开(公告)日：2024-02-13

申请号：US17654883

申请日：2022-03-15

申请人： CLEERLY, INC.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC分类号： A61B6/00 ,  G06T7/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/14 ,  A61B8/12 ,  A61B5/00 ,  A61K49/04 ,  G06F18/10 ,  G06V10/74 ,  G06V10/764 ,  G06V10/82 ,  G06V10/20 ,  G06V10/24

CPC分类号： A61B6/504 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/467 ,  A61B6/481 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V10/82 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.