Patent search ipc:C07C217/54 Page 1

1.

发明公开
METHOD FOR INHIBITING OR DISRUPTING BIOFILM FORMATION, OR REDUCING BIOFILM 审中-公开

公开(公告)号：US20230365491A1

公开(公告)日：2023-11-16

申请号：US18352955

申请日：2023-07-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Yoram Cohen , Micha Fridman , Roymon Joseph , Alissa Naugolny , Mark Feldman , Ido M. Herzog , Dana Kaizerman

IPC: C07C217/54 , A61K31/138 , A61K31/4178 , A61K31/66 , A61K45/06 , C02F1/50 , C07D233/60 , C07F9/54 , C09D5/16

CPC classification number: C07C217/54 , A61K31/138 , A61K31/4178 , A61K31/66 , A61K45/06 , C02F1/50 , C07D233/60 , C07F9/5407 , C09D5/1687 , C02F2303/20

Abstract: Cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives are capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition. A composition for inhibiting or disrupting biofilm, e.g., bacterial or fungal biofilm, formation, or reducing biofilm, can include a pharmaceutically acceptable carrier, and a cationic pillar[n]ene.

2.

发明授权
Cationic pillararenes and uses thereof 有权

公开(公告)号：US11161801B2

公开(公告)日：2021-11-02

申请号：US15751786

申请日：2016-08-03

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Yoram Cohen , Micha Fridman , Roymon Joseph , Alissa Naugolny , Mark Feldman , Ido M. Herzog , Dana Kaizerman

IPC: C02F1/50 , C07C217/54 , C07D233/60 , C07F9/54 , C09D5/16 , A61K31/138 , A61K31/4178 , A61K31/66 , A61K45/06

Abstract: The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.

3.

发明申请
TREATMENT AND DIAGNOSIS OF MELANOMA 有权

公开(公告)号：US20210220306A1

公开(公告)日：2021-07-22

申请号：US17201493

申请日：2021-03-15

Applicant: The Rockefeller University

Inventor： Sohail Tavazoie , Nora Pencheva

IPC: A61K31/195 , C07F9/6506 , A61K38/17 , A61K45/06 , A61K31/18 , A61K31/265 , A61K31/415 , A61K31/4164 , A61K31/47 , A61K31/5377 , G01N33/574 , A61K31/136 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/675 , C07C217/54 , C07D233/64 , C12Q1/6886

Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.

4.

发明授权
Characterization of the cocrystal products formed by metoprolol and dabigatran bases with L-theanine 有权

公开(公告)号：US09896411B2

公开(公告)日：2018-02-20

申请号：US15353927

申请日：2016-11-17

Applicant: THEAPRIN PHARMACEUTICALS INC.

Inventor： Harry G. Brittain , Philip V. Felice

IPC: C07D401/12 , C07C237/08 , C07C217/54 , A61K9/00 , A61K31/138 , A61K31/198 , A61K31/4439 , A61K9/14

CPC classification number: A61K9/0056 , A61K9/0019 , A61K9/0053 , A61K9/145 , A61K31/138 , A61K31/198 , A61K31/4439 , C07C217/32 , C07C229/24 , C07C237/06 , C07D401/12

Abstract: Methods of making cocrystal compositions of metoprolol and dabigatran bases with enantiomers of theanine.

5.

发明申请
STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE 有权
Title translation: 稳定的固体形式和包含CITRATE

公开(公告)号：US20160347705A1

公开(公告)日：2016-12-01

申请号：US15115133

申请日：2015-10-26

Applicant: F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A

Inventor： Pierluigi PADOVAN , Lorenzo CARUANA , Nicolas TESSON

IPC: C07C217/54 , C07C213/08 , C07C53/10 , C07C59/265

CPC classification number: C07C217/54 , C07B2200/13 , C07C51/412 , C07C53/10 , C07C59/265 , C07C213/08 , C07C217/18

Abstract: The present invention refers to new solid forms of Enclomiphene citrate and Enclomiphene base, processes for preparing thereof and uses.

Abstract translation: 本发明涉及新型固体形式的枸橼酸塞米芬和内罗米芬碱，其制备方法及用途。

6.

发明授权
(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors 有权
Title translation: （杂芳基）芳基环丙胺化合物作为LSD1抑制剂

公开(公告)号：US09469597B2

公开(公告)日：2016-10-18

申请号：US14352719

申请日：2012-10-22

Applicant: ORYZON GENOMICS, S.A.

Inventor： Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , María de los Ángeles Estiarte Martínez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria

IPC: C07C211/36 , C07C209/28 , C07D295/135 , C07D213/38 , C07C275/26 , C07D207/14 , C07C271/24 , C07C273/18 , C07C211/38 , C07C269/00 , C07D277/28 , C07D213/74 , C07D231/12 , C07D295/096 , C07D295/26 , C07D213/30 , C07D307/52 , C07C311/08 , C07C311/21 , C07C211/37 , C07C215/46 , C07C217/54

CPC classification number: C07C211/36 , C07B2200/07 , C07C209/28 , C07C211/37 , C07C211/38 , C07C211/40 , C07C213/00 , C07C215/46 , C07C215/64 , C07C217/54 , C07C217/74 , C07C269/00 , C07C271/24 , C07C273/00 , C07C273/18 , C07C275/26 , C07C311/08 , C07C311/21 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/14 , C07D213/30 , C07D213/38 , C07D213/57 , C07D213/73 , C07D213/74 , C07D231/12 , C07D231/56 , C07D277/28 , C07D295/096 , C07D295/135 , C07D295/26 , C07D307/52 , C07D333/20

Abstract: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and theft use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.

Abstract translation: 本发明涉及（异）芳基环丙胺化合物，特别包括本文所述和定义的式（I）化合物和治疗中的盗窃用途，包括例如治疗或预防癌症，神经疾病或病症，或病毒感染。

7.

发明授权
Styrenyl derivative compounds for treating ophthalmic diseases and disorders 有权

公开(公告)号：US09421210B2

公开(公告)日：2016-08-23

申请号：US14630897

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott , Vladimir Aleksandrovich Kuska , Anna Gall , Mark W. Orme , Jennifer Gage , Thomas L. Little, Jr. , Qin Jiang , Lana Michele Rossiter , Kevin F. McGee, Jr. , Ryo Kubota

IPC: C07C211/27 , C07C217/18 , A61K31/5375 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07D295/03 , C07C225/06 , C07C323/33 , C07D207/06 , C07D211/14 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495

CPC classification number: A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

8.

发明申请
STORE OVERLOAD-INDUCED CALCIUM RELEASE INHIBITORS AND METHODS FOR PRODUCING AND USING THE SAME 审中-公开
Title translation: 存储过载诱导的钙释放抑制剂及其生产和使用方法

公开(公告)号：US20160214973A1

公开(公告)日：2016-07-28

申请号：US14915368

申请日：2014-09-27

Applicant: Tom BACK , Wayne CHEN , Chris Smith , Dawei Jiang , UTI Limited Partnership

Inventor： Tom Back , Wayne Chen , Chris Smith , Dawei Jiang

IPC: C07D419/12 , C07D413/12 , C07C217/54 , C07D279/20 , C07D279/34 , C07D215/227 , C07D209/08 , C07D231/56 , C07D235/08 , C07D405/12 , C07D281/10 , C07D265/36 , C07D279/16 , C07C233/20 , C07D209/88

CPC classification number: C07D419/12 , C07C217/28 , C07C217/32 , C07C217/34 , C07C217/38 , C07C217/54 , C07C217/92 , C07C233/20 , C07C2603/18 , C07C2603/74 , C07D209/08 , C07D209/88 , C07D215/227 , C07D231/56 , C07D235/06 , C07D235/08 , C07D265/36 , C07D279/16 , C07D279/20 , C07D279/34 , C07D281/10 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/06

Abstract: The present invention provides compounds having store overload-induced Ca2+ release (SOICR) inhibitory activity and methods for producing and using the same. In particular, compounds of the invention is of the formula: R1—X1-L-X2—R2, wherein R1, X1, L, X2, and R2 are those defined herein.

Abstract translation: 本发明提供具有储存过量诱导的Ca2 +释放（SOICR）抑制活性的化合物及其制备和使用方法。特别地，本发明的化合物具有下式：R1-X1-L-X2-R2，其中R1，X1，L，X2和R2是本文定义的那些。