公开(公告)号：US12104022B2

公开(公告)日：2024-10-01

申请号：US17267156

申请日：2019-04-09

申请人： PEKING UNIVERSITY

发明人： Xinhua Wan ,  Xichong Ye ,  Bowen Li ,  Jie Zhang

IPC分类号： C08J3/215 ,  B03C1/005 ,  B03C1/01 ,  B03C1/015 ,  B03C1/02 ,  B03C1/035 ,  B03C1/28 ,  B82Y30/00 ,  C07B57/00 ,  C07C227/34 ,  C07C231/20 ,  C07C231/24 ,  C08F212/08 ,  C08F220/56 ,  C08F220/58 ,  C08F293/00 ,  C08J3/24 ,  C08K3/22 ,  C08K5/09 ,  C08K9/10 ,  B82Y25/00 ,  B82Y40/00 ,  C07C237/06 ,  C08F220/60

CPC分类号： C08J3/215 ,  B03C1/005 ,  B03C1/01 ,  B03C1/015 ,  B03C1/02 ,  B03C1/035 ,  B03C1/286 ,  C07B57/00 ,  C07C227/34 ,  C07C231/20 ,  C07C231/24 ,  C08F212/08 ,  C08F220/56 ,  C08F220/58 ,  C08F293/005 ,  C08J3/245 ,  C08K3/22 ,  C08K5/09 ,  C08K9/10 ,  B03C2201/18 ,  B03C2201/26 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07B2200/07 ,  C07C237/06 ,  C08F220/603 ,  C08F2438/03 ,  C08J2325/08 ,  C08K2003/2275 ,  C08K2201/003 ,  C08K2201/01 ,  C08K2201/011 ,  C07C227/34 ,  C07C229/36 ,  C07C227/34 ,  C07C229/22 ,  C07C231/20 ,  C07C237/06

摘要： A core-shell nanocomposite is formed by co-assembly of an amphiphilic polymer and hydrophobically modified magnetic nanoparticles, with its core being a hydrophobically modified magnetic nanomaterial and its shell being the amphiphilic polymer, wherein hydrophilic segments in the amphiphilic polymer are located at an outermost layer of the shell. The above composite can be used as additives in the crystallization of conglomerates and obtain optically pure crystals of both enantiomers in a single process. The key thereof is that the composite is used to enrich molecules with the same configuration while inhibit the crystallization of the other enantiomer in a supersaturated solution of conglomerates, such that a non-magnetic crystal and a magnetic crystal (which are enantiomers of each other) are generated in a unit operation. Optically pure crystals of both enantiomers with over 90 ee % can be obtained by one-time crystallization, and the total yield can be as high as 40%.

公开(公告)号：US20240309178A1

公开(公告)日：2024-09-19

申请号：US18268461

申请日：2021-04-13

申请人： HINDUSTAN PETROLEUM CORPORATION LIMITED

发明人： Naresh KOTTARI ,  Sandip BHOWMIK ,  Venkatesan SANTHANAM ,  Ravi BALASUBRAMANIAM

IPC分类号： C08K5/20 ,  C07C231/02 ,  C07C231/24 ,  C07C233/36 ,  C08L95/00

CPC分类号： C08K5/20 ,  C07C231/02 ,  C07C231/24 ,  C07C233/36 ,  C08L95/00 ,  C08L2555/24

摘要： The present invention provides additive compound for warm mix asphalt (WMA) for the paving of road surfaces, whereby the additive compounds facilitate the mixing, lay down and compaction of asphalt mixes at low temperatures while retaining the mechanical properties of the asphalt composition. Further, the present invention provides a process of synthesis of the additive compounds. Additionally, the present invention provides a warm mix asphalt formulation involving the additive compounds and a method of preparation thereof. The chemical additives of the present invention are liquid surfactants that ensure reduction of internal friction during manufacturing, and subsequently formulations comprising these chemical additives results in reduction of compaction temperature of the bituminous mixtures.

公开(公告)号：US20240286110A1

公开(公告)日：2024-08-29

申请号：US18586453

申请日：2024-02-24

申请人： Chrom6 Technologies, LLC

发明人： Andrew E. Dadson

IPC分类号： B01J20/20 ,  B01D15/08 ,  B01J20/22 ,  B01J20/28 ,  B01J20/282 ,  B01J20/30 ,  B01J20/32 ,  C07C7/10 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24

CPC分类号： B01J20/20 ,  B01D15/08 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/282 ,  B01J20/3078 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3246 ,  B01J20/3293 ,  C07C7/10 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C07B2200/09

摘要： A chromatographic material of carbon microspheres is disclosed. The carbon microspheres may be surface-derivatized with an organic functional group, such as functional groups suitable for use in chromatographic process, such as C1 to C18 alkyl, including butyl (C4), octyl (C8), and octadecyl (C18), phenyl, amino, cyano, etc. The carbon microspheres may consist of nonporous carbon. The carbon microspheres may consist of porous carbon having a surface area in the range of 1 m2/g to 400 m2/g. A method of making carbon microspheres from a carbonizable polymeric material is disclosed. A method of bonding an organic functional group to a surface of the carbon microspheres is disclosed. HPLC columns may be prepared containing the chromatographic material of carbon microspheres. Such columns may be used to separate a compound of interest from a mixture of different compounds using a chromatographic process, such as HPLC.

公开(公告)号：US20240247843A1

公开(公告)日：2024-07-25

申请号：US18586850

申请日：2024-02-26

申请人： Supercritical Fluid Technologies, Inc.

发明人： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Kim Ferrara ,  Curtis Ebersold

IPC分类号： F25B25/00 ,  B01D15/16 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/04 ,  F25B7/00 ,  F25B9/00 ,  F25B9/10 ,  F25B49/02 ,  G01N30/20 ,  G01N30/30 ,  G01N30/54

CPC分类号： F25B25/005 ,  B01D15/165 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/041 ,  F25B7/00 ,  F25B9/002 ,  F25B9/008 ,  F25B9/10 ,  F25B49/02 ,  G01N30/30 ,  G01N30/54 ,  B04C2009/004 ,  C09K2205/106 ,  C09K2205/13 ,  C09K2205/132 ,  F25B2600/2513 ,  F25B2700/21171 ,  G01N30/20 ,  Y02P20/54

摘要： Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thomson coefficient.

公开(公告)号：US20240246900A1

公开(公告)日：2024-07-25

申请号：US18625045

申请日：2024-04-02

申请人： Io Therapeutics, Inc.

发明人： Vidyasagar Vuligonda

IPC分类号： C07C233/66 ,  A61K31/196 ,  C07C231/02 ,  C07C231/12 ,  C07C231/24 ,  C07C235/66

CPC分类号： C07C233/66 ,  A61K31/196 ,  C07C231/02 ,  C07C231/12 ,  C07C231/24 ,  C07C235/66

摘要： Provided herein are compounds and synthetic methods useful for preparing tetrahydronaphthalenol derivatives, and uses of the compounds prepared.

公开(公告)号：US20230234915A1

公开(公告)日：2023-07-27

申请号：US18157987

申请日：2023-01-23

申请人： KAO CHEMICALS GMBH

发明人： Thomas Myrdek ,  Jürgen Benade

IPC分类号： C07C231/22 ,  C07C231/14 ,  C07C231/24

CPC分类号： C07C231/22 ,  C07C231/14 ,  C07C231/24

摘要： The present invention relates to a process for obtaining amidated fatty acids or derivatives thereof good in color even after longer storage with low concentrations of undesired by-products. The present invention also relates to use of amidated fatty acids or derivatives thereof obtained by the process in the cosmetic applications. Further, the present invention also relates to use of amidated fatty acids or derivatives thereof obtained by the process in the industrial applications.

公开(公告)号：US11518741B2

公开(公告)日：2022-12-06

申请号：US16973022

申请日：2018-10-30

申请人： SHANGHAI PUYI CHEMICAL CO., LTD.

发明人： Hanrong Yang ,  Yantao Qi ,  Tao Li ,  Bo Wang

IPC分类号： C07D207/27 ,  C07C231/12 ,  C07C231/18 ,  C07C231/24 ,  C07C237/06 ,  C07D207/273

摘要： The present invention relates to a brivaracetam intermediate, a preparation method therefor, and a preparation method for brivaracetam. The steps of the method for preparing brivaracetam described in the present invention are short and the raw materials are cheap, moreover, the method is simple and highly effective without requiring isomer separation by means of column chromatography or asymmetric synthesis, being suitable for industrial large-scale production. In addition, disclosed by the present invention is a compound as shown in formula (II), which may be used for the synthesis of brivaracetam.

公开(公告)号：US11512043B2

公开(公告)日：2022-11-29

申请号：US17262735

申请日：2019-07-16

申请人： EVONIK OPERATIONS GMBH

发明人： Marcel Treskow ,  Doris Saal ,  Thorben Schütz ,  Steffen Krill

IPC分类号： C07C231/02 ,  C07C231/24 ,  C08F220/56

摘要： The invention relates to a process for preparing N-methyl(meth)acrylamide and to the uses thereof.

公开(公告)号：US20220213025A1

公开(公告)日：2022-07-07

申请号：US17614153

申请日：2020-12-23

申请人： SHOWA DENKO K.K.

发明人： Naoyuki TANAKA ,  Katsumi MIKAMI ,  Takamitsu KOBAYASHI

IPC分类号： C07C231/12 ,  C07C231/24

摘要： A method for producing a highly polymerizable N-vinyl carboxylic acid amide monomer includes (A) melting a crude N-vinyl carboxylic acid amide monomer comprising 50 to 88 mass % of an N-vinyl carboxylic acid amide monomer by heating, followed by cooling for precipitation, and subjecting precipitated N-vinyl carboxylic acid amide monomer crystals to solid-liquid separation (step (A)), and (B) further dissolving the N-vinyl carboxylic acid amide monomer crystals separated in the step (A) in a mixed solvent of ethyl acetate and an aliphatic hydrocarbon having 6 to 7 carbon atoms, then performing crystallization, performing solid-liquid separation, and recovering an N-vinyl carboxylic acid amide monomer purified product (step (B)), wherein a mass ratio of ethyl acetate/N-vinyl carboxylic acid amide monomer crystal in step (B) is 0.01 to 0.5, and a mass ratio of aliphatic hydrocarbon having 6 to 7 carbon atoms/N-vinyl carboxylic acid amide monomer crystal in step (B) is 0.5 to 3.0.

公开(公告)号：US20220105491A1

公开(公告)日：2022-04-07

申请号：US17551338

申请日：2021-12-15

申请人： Jiangnan University

发明人： Hongxin WANG ,  Jingyu CHEN ,  Shijia WU ,  Xinlin WEI ,  Xin HUANG ,  Li WANG

IPC分类号： B01J20/26 ,  C08F292/00 ,  B01J20/30 ,  C07C231/24 ,  C07C37/82 ,  A23F3/20 ,  B01D15/22

摘要： The disclosure discloses a nicotinamide dummy template surface molecularly imprinted polymer, a preparation method and application thereof, and belongs to the technical field of chemical materials. The preparation method of the disclosure includes the steps of preparing a modified silica gel carrier, preparing a dummy template surface molecularly imprinted polymer and the like. The disclosure uses nicotinamide, a structural analogue of imidacloprid and acetamiprid, as a dummy template to prepare a silica gel surface molecularly imprinted polymer. The polymer not only can effectively avoid pollution caused by the leakage of template molecules, but also can specifically remove imidacloprid and acetamiprid from water-soluble tea extracts. The removal rate of imidacloprid and acetamiprid is greater than 96% and 93%, respectively, and the loss of tea polyphenols in the extracts is less than 10%. In addition, the molecularly imprinted adsorption column prepared by the disclosure can be eluted with ethanol solution, and the eluted adsorption column can be recycled, so the disclosure can be well applied to the preparation technology of tea extracts and has good application prospects.