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102 条记录 (耗时 0.058 秒)

    Compositions, methods and kits for treating a contact lens
    1.
    发明授权
    Compositions, methods and kits for treating a contact lens 有权

    公开(公告)号：US11529309B2

    公开(公告)日：2022-12-20

    申请号：US16096603

    申请日：2017-04-28

    申请人： University of Houston System

    发明人： Guoting Qin ,  Chengzhi Cai

    IPC分类号： A61K31/496 ,  A61K9/00 ,  A61L12/10 ,  C07C271/12 ,  C07C271/14 ,  C07D215/56

    摘要： Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

    Compounds having a secondary or tertiary hydroxy or halide group separated from a primary carbamate group by three or more carbon atoms and a method of making the same
    7.
    发明申请
    Compounds having a secondary or tertiary hydroxy or halide group separated from a primary carbamate group by three or more carbon atoms and a method of making the same 失效
    具有通过三个或更多个碳原子与伯氨基甲酸酯基分离的仲羟基或卤代基的化合物及其制备方法

    公开(公告)号：US20040087738A1

    公开(公告)日：2004-05-06

    申请号：US10285634

    申请日：2002-10-31

    发明人： Walter H. Ohrbom ,  Craig S. Schang

    IPC分类号： C08G018/00 ,  C07C271/14 ,  C07C271/16

    CPC分类号： C09D175/04 ,  C07C271/16 ,  C08G18/3831 ,  C08G71/04

    摘要： Provided is a compound having one or more structures of the formula: 1 wherein X is a primary carbamate group, Y is a hydroxy or halide group, n is an integer of 2 or more, nnull is an integer of 1 or more, and R0, R1, R2, R3, R4 and R5 may be H or a group selected from alkyl groups, aliphatic groups, cycloaliphatic groups, aromatic groups and mixtures thereof, with the provisos that at least one R1 or R2 group is selected from the group consisting of aliphatic groups, cycloaliphatic groups, and aromatic groups, and in substantially all structures primary carbamate group X is attached to a carbon atom having a lower degree of substitution than a carbon atom to which functional group Y is attached. The invention provides a method of making the claimed compound.

    摘要翻译： 本发明提供具有一个或多个下式结构的化合物：其中X是伯氨基甲酸酯基团，Y是羟基或卤化物基团，n是2以上的整数，n'是1以上的整数，R 0 ，R 1，R 2，R 3，R 4和R 5可以是H或选自烷基，脂族基团，脂环族基团，芳族基团及其混合物的基团，条件是至少一个R 1或R 2基团选自 的脂族基团，脂环族基团和芳族基团，并且在基本上所有结构中，伯氨基甲酸酯基团X连接到具有较低官能团Y所连接的碳原子的取代度低的碳原子。 本发明提供一种制备所要求保护的化合物的方法。

    Per(poly)fluorinated polyoxyethylated carbamates
    8.
    发明授权
    Per(poly)fluorinated polyoxyethylated carbamates 失效
    每（聚）氟化聚氧乙基化氨基甲酸酯

    公开(公告)号：US6160161A

    公开(公告)日：2000-12-12

    申请号：US214159

    申请日：1998-12-23

    申请人： Hedi Trabelsi ,  Wolfgang Roehlke ,  Peter Reuter ,  Massimo Napoli ,  Philippe Lucas ,  Kenneth Charles Lowe ,  Giampaolo Gambaretto ,  Ralf-Peter Franke ,  Carl Martin Edwards ,  Lino Conte ,  Aime Cambon

    发明人： Hedi Trabelsi ,  Wolfgang Roehlke ,  Peter Reuter ,  Massimo Napoli ,  Philippe Lucas ,  Kenneth Charles Lowe ,  Giampaolo Gambaretto ,  Ralf-Peter Franke ,  Carl Martin Edwards ,  Lino Conte ,  Aime Cambon

    IPC分类号： C07C291/14 ,  A61K9/00 ,  A61K9/107 ,  B01F17/00 ,  C07C271/14 ,  C07C271/18 ,  C08G18/71

    CPC分类号： A61K9/0026 ,  A61K9/1075 ,  B01F17/0042 ,  C07C271/14 ,  C07C271/18

    摘要： Per(poly)fluorinated polyoxyethylated carbamates of general formula (I) in which R.sub.F represents a perfluorinated group containing between 1 and 18 carbon atoms, W represents an oxo group or nothing, n is an integer from 1 to 10, m is from values 2 to 6, 80 or not defined, R is an alkyl group, R.sub.F W(CH.sub.2).sub.n+1 NHC(O)-- in which R.sub.F and W are as defined above, --(CHCH.sub.3 CH.sub.2 O).sub.30 (CH.sub.2 CH.sub.2).sub.80 C(O)NH(CH.sub.2).sub.n+1 R.sub.F in which R.sub.F is a perfluorinated group containing from 1 to 18 carbon atoms, R' is a hydrogen atom, an alkyl group containing between 1 and 18 carbon atoms which is optionally substituted, an optionally substituted aryl or aralkyl group, an allyl, methallyl or propargyl group or a perfluorinated chain having between 1 and 18 carbon atoms. These compounds can be used as anti-thrombosis agents or as surfactants or cosurfactants for phospholipids intended for the preparation or stabilization of fluorocarbon emulsions, notably emulsions for biomedical applications.

    摘要翻译： PCT No.PCT / GB97 / 01704 Sec。 371日期1999年3月5日 102（e）1999年3月5日PCT Filted 1997年6月24日PCT公布。 出版物WO97 / 49675 日期1997年12月31日通式（I）的聚（多）氟化聚氧乙基化氨基甲酸酯，其中RF表示含有1至18个碳原子的全氟化基团，W表示氧代基或无，n为1至10的整数， m为2至6,80或未定义，R为烷基，RFW（CH2）n + 1NHC（O） - ，其中RF和W如上所定义， - （CHCH 3 CH 2 O）30（CH 2 CH 2） O）NH（CH 2）n + 1RF，其中RF是含有1至18个碳原子的全氟化基团，R'是氢原子，任选被取代的含有1至18个碳原子的烷基，任选取代的芳基 或芳烷基，烯丙基，甲代烯丙基或炔丙基或具有1至18个碳原子的全氟化链。 这些化合物可用作抗血栓形成剂或作为用于制备或稳定氟碳乳液的磷脂的表面活性剂或辅助表面活性剂，特别是用于生物医学应用的乳剂。