公开(公告)号：US11492326B2

公开(公告)日：2022-11-08

申请号：US16887416

申请日：2020-05-29

申请人： Givaudan SA

发明人： Feng Shi ,  Harry Renes ,  Esther Van Ommeren ,  Susanna Magdalena Vorster ,  Yili Wang ,  Adri De Klerk ,  Xiaogen Yang

IPC分类号： C07C235/74 ,  A23L2/56 ,  C07C233/47 ,  C07C233/49 ,  C07C233/52 ,  C07D207/16 ,  A23C9/13 ,  A23C9/156 ,  A23C11/10 ,  A23C15/12 ,  A23C19/09 ,  C12G3/06 ,  C12C5/02 ,  A23L27/20 ,  A23L27/50 ,  A23L27/60 ,  A23L23/10 ,  A23F5/24 ,  A23L19/18 ,  A23L27/21 ,  C07C323/59 ,  A23L19/20 ,  A23L7/161 ,  C07C237/22 ,  A23L11/50 ,  A23L11/65 ,  C07C233/18 ,  A23L23/00 ,  A23L13/50 ,  A23C13/12 ,  A23F5/46

摘要： A flavour composition comprising a compound according to the formula (I) or edible salts thereof, wherein R1 is an alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl group to which it is attached is a residue of a carboxylic acid, and NR2R3, in which R3 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular a proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.

公开(公告)号：US11464853B2

公开(公告)日：2022-10-11

申请号：US16076912

申请日：2017-02-24

申请人： Auckland UniServices Limited ,  Margaret Anne Brimble ,  Geoffrey Martyn Williams ,  Peter Roderick Dunbar

发明人： Margaret Anne Brimble ,  Geoffrey Martyn Williams ,  Peter Roderick Dunbar ,  Daniel Verdon

IPC分类号： C07K7/00 ,  A61K39/39 ,  C07C323/59 ,  A61P35/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12

摘要： The invention relates to amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, and pharmaceutical compositions comprising the conjugates. Methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the conjugates for the same, and uses of the conjugates in the manufacture of medicaments for the same are also contemplated.

公开(公告)号：US11091429B2

公开(公告)日：2021-08-17

申请号：US16887264

申请日：2020-05-29

申请人： Givaudan SA

发明人： Feng Shi ,  Harry Renes ,  Esther Van Ommeren ,  Susanna Magdalena Vorster ,  Yili Wang ,  Adri De Klerk ,  Xiaogen Yang

IPC分类号： C07C235/74 ,  A23L2/56 ,  C07C233/47 ,  C07C233/49 ,  C07C233/52 ,  C07D207/16 ,  A23C9/13 ,  A23C9/156 ,  A23C11/10 ,  A23C15/12 ,  A23C19/09 ,  C12G3/06 ,  C12C5/02 ,  A23L27/20 ,  A23L27/50 ,  A23L27/60 ,  A23L23/10 ,  A23F5/24 ,  A23L19/18 ,  A23L27/21 ,  C07C323/59 ,  A23L19/20 ,  A23L7/161 ,  C07C237/22 ,  A23L11/50 ,  C07C233/18 ,  A23L23/00 ,  A23L13/50 ,  A23C13/12 ,  A23F5/46

摘要： A flavour composition comprising a compound according to the formula (1) or edible salts thereof, wherein R1 is an alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl group to which it is attached is a residue of a carboxylic acid, and NR2R3, in which R3 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular a proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.

公开(公告)号：US20200347012A1

公开(公告)日：2020-11-05

申请号：US16807747

申请日：2020-03-03

申请人： Alzheon, Inc.

发明人： Petr Kocis ,  Martin Tolar ,  John Hey

IPC分类号： C07C309/26 ,  C07C309/19 ,  C07D207/14 ,  C07D207/16 ,  C07C317/50 ,  C07D401/06 ,  C07C323/59 ,  C07D403/12 ,  C07K5/00 ,  C07D233/26 ,  C07D403/06 ,  C07K5/078 ,  C07D401/12 ,  C07D209/20 ,  C07D295/185 ,  C07C323/60 ,  C07D211/58 ,  C07C309/27 ,  A61P25/28

摘要： Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.

公开(公告)号：US10758498B2

公开(公告)日：2020-09-01

申请号：US16186077

申请日：2018-11-09

申请人： David Michael Ott

发明人： David Michael Ott

IPC分类号： A61K31/10 ,  C07C323/59 ,  C07C319/24 ,  A23L33/10 ,  A61K31/198 ,  A61K47/54 ,  A61K9/48 ,  A61K33/06

摘要： Divalent salts of S-allylmercapto-N-acetylcysteine and related compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.

公开(公告)号：US20170368011A1

公开(公告)日：2017-12-28

申请号：US15665922

申请日：2017-08-01

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  C07D307/54 ,  A61K9/00 ,  C07D295/145 ,  C07D243/34 ,  C07D217/26 ,  C07D209/48 ,  C07D209/18 ,  C07D207/16 ,  C07C335/08 ,  C07C323/59 ,  C07C321/18 ,  C07C243/34 ,  C07D333/24 ,  C07C2601/14 ,  C07C2601/02

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20170247409A1

公开(公告)日：2017-08-31

申请号：US15516142

申请日：2015-07-09

申请人： UNIVERSITY OF HELSINKI

发明人： Vãnia M. MOREIRA ,  Adyary FALLARERO ,  Jari YLI-KAUHALUOMA ,  Pia VUORELA ,  Mikko VAHERMO

IPC分类号： C07K5/083 ,  A01N37/46 ,  A61K31/223 ,  C07C323/59 ,  C07D209/20 ,  A61K31/405 ,  A01N43/38 ,  C07K5/062 ,  A61K31/198 ,  C07C235/82 ,  C07D213/55 ,  A61K31/4406 ,  A01N43/40 ,  C07D213/89 ,  A61K31/4425 ,  C07C251/44 ,  A61K45/06 ,  C09D5/14 ,  C07C233/63

CPC分类号： C07K5/0806 ,  A01N37/46 ,  A01N43/38 ,  A01N43/40 ,  A61K31/198 ,  A61K31/223 ,  A61K31/405 ,  A61K31/4406 ,  A61K31/4425 ,  A61K38/00 ,  A61K45/06 ,  C07C233/63 ,  C07C235/82 ,  C07C237/22 ,  C07C251/44 ,  C07C323/59 ,  C07C2601/14 ,  C07C2603/26 ,  C07D209/20 ,  C07D213/55 ,  C07D213/89 ,  C07K5/06026 ,  C09D5/14 ,  Y02A50/473

摘要： The present invention relates to the field of wood rosin and resin acid derivatives and more particularly to abietane-type diterpenoids as well as different uses thereof. Furthermore, the present invention relates to methods of coating surfaces, preventing, reducing or inhibiting bacterial biofilm formation, and treating or preventing disorders caused by microbial growth and viability as well as bacterial colonization.

公开(公告)号：US09562007B2

公开(公告)日：2017-02-07

申请号：US13694447

申请日：2012-12-03

申请人： David Michael Ott

发明人： David Michael Ott

IPC分类号： A61K31/198 ,  C07C323/59 ,  C07C319/24 ,  A61K31/10 ,  A23L1/30 ,  A61K33/06

CPC分类号： A61K31/10 ,  A23L33/10 ,  A61K9/48 ,  A61K31/198 ,  A61K33/06 ,  A61K47/542 ,  C07C319/24 ,  C07C323/59 ,  A61K2300/00

摘要： Divalent salts of S-allylmercapto-N-acetylcysteine and related compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.

摘要翻译： 公开了S-烯丙基巯基-N-乙酰半胱氨酸和相关组合物的二价盐，其可以被施用以提供保护免于形成醛 - 蛋白质加合物，蛋白质羰基化，蛋白质聚集和所产生的神经炎症。 适用于使用这些组合物治疗的各种神经变性疾病包括阿尔茨海默氏病，老年性痴呆，帕金森病，多发性硬化，路易体病，周围神经病，脊髓损伤，中风和脑缺血。

公开(公告)号：US09376383B2

公开(公告)日：2016-06-28

申请号：US13760627

申请日：2013-02-06

申请人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07D243/34 ,  C07D207/16

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

摘要翻译： 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药​​妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。

公开(公告)号：US20150299117A1

公开(公告)日：2015-10-22

申请号：US14399524

申请日：2013-08-17

申请人： Mahesh KANDULA

发明人： Mahesh Kandula

IPC分类号： C07C323/59 ,  A61K47/48 ,  A61K31/202

CPC分类号： C07C323/59 ,  A61K31/202 ,  A61K47/54 ,  C07C323/52

摘要： The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing inflammation and lipid disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hypertriglyceridemia, steatohepatitis, cystinosis and inflammatory diseases.

摘要翻译： 本发明涉及式I和式II化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映体，立体异构体和水合物。 药物组合物包含有效量的式I或式II化合物; 并且用于治疗或预防炎症和脂质紊乱的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这种组合物可用于治疗高甘油三酯血症，脂肪性肝炎，胱氨酸尿症和炎性疾病。