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    Malignant and non-malignant disease treatment with Ras antagonists
    4.
    发明授权
    Malignant and non-malignant disease treatment with Ras antagonists 有权
    恶性和非恶性疾病治疗与Ras拮抗剂

    公开(公告)号：US09309203B2

    公开(公告)日：2016-04-12

    申请号：US14350303

    申请日：2012-10-05

    申请人： PISCES THERAPEUTICS, LLC

    发明人： James H. Wikel ,  Michael J. Brownstein

    IPC分类号： C07D233/20 ,  A61K31/41 ,  C07D239/06 ,  C07D257/04 ,  C07D285/06 ,  C07D333/38 ,  C07D333/40

    CPC分类号： C07D239/06 ,  C07D233/20 ,  C07D257/04 ,  C07D285/06 ,  C07D333/38 ,  C07D333/40

    摘要： The present disclosure describes new inhibitors or antagonists of Ras useful for the treatment of conditions resulting from Ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition. The present disclosure also describes a method for inhibiting such Ras-induced or mediated cellular processes. The method entails administering a Ras antagonist in an amount effective to inhibit such cellular processes.

    摘要翻译： 本公开描述了用于治疗由Ras诱导或介导的细胞过程（包括细胞增殖，分化，凋亡，衰老和存活）引起的病症的新的抑制剂或拮抗剂。 这些细胞过程可能与非恶性或恶性疾病，病症或病理状况相关。 本公开还描述了抑制这种Ras诱导或介导的细胞过程的方法。 该方法需要以有效抑制这种细胞过程的量施用Ras拮抗剂。

    ARTICLES AND METHODS COMPRISING PERSISTENT CARBENES AND RELATED COMPOSITIONS
    5.
    发明申请
    ARTICLES AND METHODS COMPRISING PERSISTENT CARBENES AND RELATED COMPOSITIONS 有权
    包含耐久性碳和相关组合物的文章和方法

    公开(公告)号：US20140275555A1

    公开(公告)日：2014-09-18

    申请号：US14210187

    申请日：2014-03-13

    申请人： Massachusetts Institute of Technology

    发明人： Jeremiah A. Johnson ,  Aleksandr V. Zhukhovitskiy

    IPC分类号： C07D233/20 ,  C07D403/10 ,  C07D403/14

    CPC分类号： C07D233/20 ,  C07D233/06 ,  C07D403/10 ,  C07D403/14 ,  C08F292/00

    摘要： Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.

    摘要翻译： 提供了包含持续卡宾的制品和方法以及相关组合物。 在一些实施方案中，持久卡宾可以与基底的一部分（例如，基底上的表面的至少一部分）相关联。 在某些实施方案中，持久卡宾与底物的缔合可用于影响底物的某些性质（例如，表面化学，稳定性）。 在一些情况下，持续卡宾可以在与一部分底物缔合后进行官能化。 在一些实施方案中，持久卡宾和至少一种次级化合物可与底物的一部分缔合。 本发明的制品和方法可用于涉及电子学，感测，微细加工，纳米技术，仿制和药物递送等应用。

    PROCESS FOR PRODUCING ALPHA-HYDROXYKETONE COMPOUND
    6.
    发明申请
    PROCESS FOR PRODUCING ALPHA-HYDROXYKETONE COMPOUND 审中-公开
    生产α-羟基酮酮化合物的方法

    公开(公告)号：US20130281709A1

    公开(公告)日：2013-10-24

    申请号：US13979441

    申请日：2012-01-27

    申请人： Koji Hagiya

    发明人： Koji Hagiya

    IPC分类号： C07C319/20 ,  C07D233/20

    CPC分类号： C07C319/20 ,  B01J31/0239 ,  B01J31/0244 ,  B01J2231/342 ,  C07C45/72 ,  C07C45/75 ,  C07D233/06 ,  C07D233/20 ,  C07C323/22 ,  C07C49/17 ,  C07C49/82

    摘要： An object of the present invention is to produce an α-hydroxyketone compound easily and effectively. Provided is a process for producing an α-hydroxyketone compound comprising a stirring step of stirring one or more aldehyde compounds or polymers thereof in the presence of a base and an imidazolinium salt represented by the formula (1): wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group optionally having a substituent or an aryl group optionally having a substituent, or R1 and R2 are bound to each other to form a ring together with carbon atoms to which they bind, R3 and R4 each independently represent an aryl group having one or more electron withdrawing groups, and X− represents an anion.

    摘要翻译： 本发明的目的是容易且有效地制备α-羟基酮化合物。 提供一种制备α-羟基酮化合物的方法，其包括在碱和式（1）表示的咪唑啉鎓盐存在下搅拌一种或多种醛化合物或其聚合物的搅拌步骤：其中R1和R2各自独立地表示 氢原子，任选具有取代基的烷基或任选具有取代基的芳基，或R 1和R 2彼此结合形成环，与它们所键合的碳原子一起形成环，R 3和R 4各自独立地表示芳基 基团，具有一个或多个吸电子基团，X-表示阴离子。