公开(公告)号：US09879000B2

公开(公告)日：2018-01-30

申请号：US14685732

申请日：2015-04-14

申请人： GRÜNENTHAL GMBH

发明人： Stefan Schunk ,  Melanie Reich ,  Florian Jakob ,  Nils Damann ,  Michael Haurand ,  Achim Kless ,  Marc Rogers ,  Kathy MacKenzie

IPC分类号： C07D405/04 ,  C07D309/02 ,  C07D413/04 ,  C07D309/08 ,  C07D405/12

CPC分类号： C07D413/04 ,  C07D309/08 ,  C07D405/04 ,  C07D405/12

摘要： The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

公开(公告)号：US09314778B2

公开(公告)日：2016-04-19

申请号：US14585852

申请日：2014-12-30

申请人： Virent, Inc.

发明人： Brian Blank ,  Randy Cortright ,  Taylor Beck ,  Elizabeth Woods ,  Mike Jehring

IPC分类号： C07D315/00 ,  B01J27/195 ,  B01J23/42 ,  B01J23/44 ,  B01J23/652 ,  B01J23/888 ,  B01J37/02 ,  C10G3/00 ,  C07C27/04 ,  B01J21/06 ,  B01J23/30 ,  B01J23/62 ,  C07C49/00 ,  C07D307/08 ,  C07D307/33 ,  C07D307/36 ,  C07D309/02 ,  C07D309/04 ,  C07D309/06 ,  C07D407/04 ,  B01J37/08

CPC分类号： B01J27/195 ,  B01J21/063 ,  B01J21/066 ,  B01J23/30 ,  B01J23/42 ,  B01J23/44 ,  B01J23/626 ,  B01J23/6525 ,  B01J23/6527 ,  B01J23/888 ,  B01J23/8885 ,  B01J37/0201 ,  B01J37/08 ,  C07C27/04 ,  C07C49/00 ,  C07D307/08 ,  C07D307/33 ,  C07D307/36 ,  C07D309/02 ,  C07D309/04 ,  C07D309/06 ,  C07D407/04 ,  C10G3/42 ,  C10G3/50 ,  C10G2300/1014 ,  Y02P30/20

摘要： The present invention provides catalysts, methods, and reactor systems for converting oxygenated hydrocarbons to oxygenated compounds. The invention includes methods for producing cyclic ethers, monooxygenates, dioxygenates, ketones, aldehydes, carboxylic acids, and alcohols from oxygenated hydrocarbons, such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like, using catalysts containing palladium, molybdenum, tin, and tungsten. The oxygenated compounds produced are useful in the production of liquid fuels, chemicals, and other products.

公开(公告)号：US20110024682A1

公开(公告)日：2011-02-03

申请号：US12921895

申请日：2009-02-25

申请人： Markus Czanta ,  Michael Wittek ,  Lars Lietzau ,  Marcus Reuter ,  Brigitte Schuler

发明人： Markus Czanta ,  Michael Wittek ,  Lars Lietzau ,  Marcus Reuter ,  Brigitte Schuler

IPC分类号： C09K19/44 ,  C07D249/16 ,  C07D251/12 ,  C07D251/30 ,  C07D211/00 ,  C07D309/02 ,  C09K19/42

CPC分类号： C09K19/20 ,  C09K19/42 ,  C09K2019/0466 ,  Y10T428/10

摘要： The present invention relates to dielectrically positive liquid-crystalline media comprising in each case one or more compounds of the formula I in which the parameters have the respective meanings indicated in the specification, and optionally one or more further dielectrically positive compounds and optionally one or more further dielectrically neutral compounds, and to liquid-crystal displays containing these media, especially to active-matrix displays and in particular to TN, IPS and FFS displays.

摘要翻译： 本发明涉及电介质阳性液晶介质，其包括在每种情况下一种或多种式I化合物，其中参数具有说明书中指出的相应含义，以及任选的一种或多种另外的介电阳性化合物和任选的一种或多种 进一步的介电中性化合物，以及含有这些介质的液晶显示器，特别是有源矩阵显示器，特别是TN，IPS和FFS显示器。

公开(公告)号：US20100216915A1

公开(公告)日：2010-08-26

申请号：US11655894

申请日：2007-01-22

申请人： Paul D. Bloom

发明人： Paul D. Bloom

IPC分类号： C08L3/02 ,  C08L5/00 ,  C08K5/053 ,  C08K5/1535 ,  C08K5/1545 ,  C08K5/07 ,  C07D307/02 ,  C07C43/03 ,  C07C31/18 ,  C07D309/02 ,  C07D493/04 ,  C07C69/66 ,  C12P17/18 ,  C12P17/06 ,  C12P17/04 ,  C12P7/18 ,  C08L1/00

CPC分类号： C07C69/716 ,  C07D307/12 ,  C07D307/42 ,  C07D407/04

摘要： The present invention is directed to ester derivatives of levulinic acid that are useful as plasticizers and/or coalescent solvents in polymer compositions, compositions comprising the ester derivatives, methods of making the derivatives and the compositions, and the use of the derivatives as additives in polymer compositions.

摘要翻译： 本发明涉及乙酰丙酸的酯衍生物，其可用作聚合物组合物中的增塑剂和/或聚结剂溶剂，包含酯衍生物的组合物，制备衍生物和组合物的方法，以及衍生物作为聚合物中的添加剂的用途 组合物。

公开(公告)号：US07674807B2

公开(公告)日：2010-03-09

申请号：US10592361

申请日：2005-03-01

申请人： Katsuaki Wada ,  Takuya Gombuchi ,  Yasushi Yoneta ,  Yuichi Otsu ,  Katsuhiko Shibuya ,  Norihiko Nakakura ,  Rüdiger Fischer ,  Tetsuya Murata ,  Eiichi Shimojo

发明人： Katsuaki Wada ,  Takuya Gombuchi ,  Yasushi Yoneta ,  Yuichi Otsu ,  Katsuhiko Shibuya ,  Norihiko Nakakura ,  Rüdiger Fischer ,  Tetsuya Murata ,  Eiichi Shimojo

IPC分类号： A61K31/40 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/4196 ,  C07D211/06 ,  C07D241/10 ,  C07D249/04 ,  C07D249/08 ,  C07D233/96 ,  C07D207/32 ,  C07D335/02 ,  C07D333/02 ,  C07D307/02 ,  C07D309/02 ,  C07D309/32

CPC分类号： A01N43/653 ,  A01N43/36 ,  A01N43/54 ,  A01N43/56 ,  A01N43/78 ,  C07D207/333 ,  C07D231/08 ,  C07D231/12 ,  C07D231/18 ,  C07D231/20 ,  C07D233/64 ,  C07D233/68 ,  C07D239/30 ,  C07D249/08 ,  C07D249/12

摘要： Novel benzenedicarboxamides of the formula (I) wherein X represents hydrogen, halogen atom, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, C1-6alkylsulfenyl or C1-6alkylsulfonyl, R1 represents C1-6alkyl, C1-6alkylthio-C1-6alkyl, or C1-6alkyl, m represents 0 or 1, A represents O, S, SO, SO2, CH2 or CH(CH3), and Q represents a 5- or 6-membered heterocyclic group that contains at least one hetero atom selected from the group consisting of N, O and S and can be optionally substituted; processes for their preparation, their intermediates and their use as insecticides.

摘要翻译： 式（I）的新型苯二甲酰胺，其中X表示氢，卤素原子，硝基，C 1-6烷基磺酰氧基，C 1-6烷基亚磺酰基，C 1-6烷基亚磺酰基或C 1-6烷基磺酰基，R 1表示C 1-6烷基，C 1-6烷硫基-C 1-6烷基或C 1 -6-烷基，m表示0或1，A表示O，S，SO，SO 2，CH 2或CH（CH 3），Q表示含有至少一个选自以下的杂原子的5或6元杂环基： 的N，O和S，并且可以任选被取代; 其制备方法，其中间体及其作为杀虫剂的用途。

公开(公告)号：US20050239777A1

公开(公告)日：2005-10-27

申请号：US11024840

申请日：2004-12-30

申请人： Andrew Thomas ,  Craig Johnstone ,  Edward Clayton ,  Elaine Elizabeth Stokes ,  Jean-Jacques Lohmann ,  Laurent Andre Hennequin

发明人： Andrew Thomas ,  Craig Johnstone ,  Edward Clayton ,  Elaine Elizabeth Stokes ,  Jean-Jacques Lohmann ,  Laurent Andre Hennequin

IPC分类号： A61F13/00 ,  A61F13/02 ,  A61F13/15 ,  A61K20060101 ,  A61K31/505 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P43/00 ,  C07D20060101 ,  C07D207/00 ,  C07D211/00 ,  C07D239/72 ,  C07D239/93 ,  C07D239/94 ,  C07D309/02 ,  C07D317/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D43/02

CPC分类号： C07D401/12 ,  A61F13/02 ,  A61F13/023 ,  A61F2013/00221 ,  A61F2013/8408 ,  A61K31/517 ,  A61K31/541 ,  C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： The invention relates to quinazoline derivatives of formula (1) wherein m is an integer from 1 to 2; R1 represents hydrogen, hydroxy, halogeno, nitro, trifluoromethyl, cyano, C1-3alkyl, C1-3alkoxy, C1-3alkylthio, or —NR5R6 (wherein R5 and R6, which may be the same or different, each represents hydrogen or C1-3alkyl); R2 represents hydrogen, hydroxy, halogeno, methoxy, amino or nitro; R3 represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino or nitro; X1 represents —O—, —CH2—, —S—, —SO—, —SO2—, —NR7CO—, —CONR8—, —SO2NR9—, —NR10SO2— or —NR11— (wherein R7, R8, R9, R10 and R11 each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl); R4 represents an optionally substituted 5 or 6 membered saturated carbocyclic or heterocyclic group or a group which is alkenyl, alkynyl or optionally substituted alkyl, which alkyl group may contain a heteroatom linking group, which alkenyl, alkynyl or alkyl group may carry a terminal optionally substituted group selected from alkyl and a 5 or 6 membered saturated carbocyclic or heterocyclic group, and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

公开(公告)号：US5338865A

公开(公告)日：1994-08-16

申请号：US011104

申请日：1993-01-29

申请人： Yoshito Kishi ,  Francis G. Fang ,  Craig J. Forsyth ,  Paul M. Scola ,  Suk K. Yoon

发明人： Yoshito Kishi ,  Francis G. Fang ,  Craig J. Forsyth ,  Paul M. Scola ,  Suk K. Yoon

IPC分类号： C07D307/12 ,  A61K31/335 ,  A61K31/365 ,  A61K31/695 ,  A61P35/00 ,  C07D307/04 ,  C07D307/20 ,  C07D307/93 ,  C07D309/02 ,  C07D309/06 ,  C07D309/10 ,  C07D311/00 ,  C07D311/02 ,  C07D311/58 ,  C07D323/00 ,  C07D325/00 ,  C07D407/06 ,  C07D493/04 ,  C07D493/22 ,  C07F7/18 ,  C07D309/00

CPC分类号： C07D407/06 ,  C07D307/20 ,  C07D309/10 ,  C07D493/04 ,  C07D493/22

摘要： Novel chemical compounds that can be used to synthesize halichondrin B and norhalichondrin B, and related derivatives, are described. The synthesis of halichondrin B and norhalichondrin B from these compounds also is described.

摘要翻译： 描述了可用于合成软骨素B和去氢软脂素B及相关衍生物的新型化合物。 还描述了这些化合物的软组蛋白B和去氢软脂素B的合成。

公开(公告)号：US4022804A

公开(公告)日：1977-05-10

申请号：US596305

申请日：1975-07-16

申请人： Walter Boell

发明人： Walter Boell

IPC分类号： C07C67/00 ,  C07C313/00 ,  C07C315/00 ,  C07C317/04 ,  C07C317/08 ,  C07C317/10 ,  C07C317/12 ,  C07C317/14 ,  C07C317/18 ,  C07C317/44 ,  C07D307/18 ,  C07D309/02

CPC分类号： C07D307/18 ,  C07C315/00

摘要： A process for the manufacture of .beta.-bromoalkylsulfones and .beta.-bromoalkenylsulfones by addition reaction of sulfonic acid bromides with olefins or acetylenes in the presence of hydroperoxide and, optionally, of metal salts. Starting materials for further syntheses and for biologically active compounds may be obtained by subsequent dehydrobromination of the addition products.

摘要翻译： 通过在氢过氧化物和任选的金属盐的存在下，通过磺酸溴化物与烯烃或乙炔的加成反应制备β-溴代烷基砜和β-溴链烯基砜的方法。 用于进一步合成和用于生物活性化合物的原料可以通过随后的加成产物的脱溴化氢来获得。

公开(公告)号：US3772332A

公开(公告)日：1973-11-13

申请号：US3772332D

申请日：1972-04-12

申请人： ROUSSEL UCLAF

发明人： ALLAIS A ,  MEIER J ,  DUBE J

IPC分类号： C07D335/02 ,  C07D309/02 ,  C07D309/04 ,  C07D309/06 ,  A61K27/00 ,  C07D65/04

CPC分类号： C07D309/06 ,  C07D309/04

摘要： NOVEL COMPOUNDS OF THE FORMULA

(2-HAL,4-(R-OOC-Z-)PHENYL)-CH
WHEREIN X IS SELECTED FROM THE GROUP CONSISTING OF OXYGEN, SULFUR, SO AND SO2, R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ANION OF A NON-TOXIC; THERAPEUTICALLY ACCEPTABLE ORGANIC OR MINERAL BASE AND RESIDUE OF AN ALCOHOL, AN Z IS SELCETED FROM THE GROUP CONSISTING OF -CHR1- AND >C=R2 WHEREIN R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND STRAINGT OR BRANCHED ALKYL OF 1 TO 4 CARBON ATOMS, AND R2 IS A STRAIGHT OR BRANCHED ALKYLIDENE OF 1 TO 4 CARBON ATOMS AND HAL IS SELECTED FROM THE GROUP CONSISTING OF FLUORINE, BROMINE AND CHLORINE, WHICH COMPOUNDS WHICH CONTAIN AT LEAST ONE ASYMMETRIC CARBON ATOM CAN BE IN RACEMIC OR OPTICALLY ACTIVE GORM, AND THEIR PREPARATION WHICH COMPOUNDS HAVE ANALGESIC AND ANTIINFLAMMATORY ACTIVITY.

公开(公告)号：US20230210998A1

公开(公告)日：2023-07-06

申请号：US18148023

申请日：2022-12-29

申请人： Navidea Biopharmaceuticals, Inc.

发明人： David A. Ralph ,  Jeffrey Arnold

IPC分类号： A61K47/61 ,  C07D309/02 ,  C07D235/04

CPC分类号： A61K47/61 ,  C07D309/02 ,  C07D235/04

摘要： Methods, compounds, and compositions of conjugating anthracyclines to a carbohydrate polymer backbone via click chemistry are provided. The conjugation of anthracyclines utilizing a reaction between a hydrazone azide moiety and alkyne moiety provide for compositions with less crosslinking, and thereby increasing the efficacy of targeted drug delivery. The methods further provide for controlled loading of anthracycline to a carbohydrate polymer backbone.